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Protein

Protein S100-A3

Gene

S100A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi83Zinc1
Metal bindingi86Zinc1
Metal bindingi87Zinc1
Metal bindingi93Zinc1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 331; low affinitySequence analysisAdd BLAST14
Calcium bindingi63 – 742; high affinitySequence analysisAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A3
Alternative name(s):
Protein S-100E
S100 calcium-binding protein A3
Gene namesi
Name:S100A3
Synonyms:S100E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000188015.9
HGNCiHGNC:10493 S100A3
MIMi176992 gene
neXtProtiNX_P33764

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi30C → A: Abolishes calcium binding; when associated with Ala-68. 1 Publication1
Mutagenesisi68C → A: Abolishes calcium binding; when associated with Ala-30. 1 Publication1
Mutagenesisi81C → A: Increases affinity for calcium; when associated with Ala-99. 1 Publication1
Mutagenesisi99C → A: Increases affinity for calcium; when associated with Ala-81. 1 Publication1

Organism-specific databases

DisGeNETi6274
OpenTargetsiENSG00000188015
PharmGKBiPA34905

Polymorphism and mutation databases

BioMutaiS100A3
DMDMi464729

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001439722 – 101Protein S100-A3Add BLAST100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Disulfide bondi30 ↔ 681 Publication
Modified residuei51Citrulline; by PAD31 Publication1
Disulfide bondi81 ↔ 991 Publication

Post-translational modificationi

More than half of the arginine residues undergo citrullination by PAD1 and PAD2. Arg-51 is specifically citrullinated by PAD3 and promotes tetramerization.1 Publication

Keywords - PTMi

Acetylation, Citrullination, Disulfide bond

Proteomic databases

EPDiP33764
MaxQBiP33764
PaxDbiP33764
PeptideAtlasiP33764
PRIDEiP33764
ProteomicsDBi54924

PTM databases

iPTMnetiP33764

Expressioni

Tissue specificityi

Skin specific, specifically expressed at the inner endocuticle of hair fibers.1 Publication

Gene expression databases

BgeeiENSG00000188015 Expressed in 110 organ(s), highest expression level in hair follicle
CleanExiHS_S100A3
GenevisibleiP33764 HS

Organism-specific databases

HPAiHPA042674
HPA056140

Interactioni

Subunit structurei

Homodimer and homotetramer for the citrullinated form.1 Publication

Protein-protein interaction databases

BioGridi112182, 21 interactors
IntActiP33764, 6 interactors
STRINGi9606.ENSP00000357701

Structurei

Secondary structure

1101
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP33764
SMRiP33764
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP33764

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1Add BLAST36
Domaini50 – 85EF-hand 2Add BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J3DW Eukaryota
ENOG411196G LUCA
GeneTreeiENSGT00760000119034
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP33764
OMAiMTRPLEQ
OrthoDBiEOG091G10JX
PhylomeDBiP33764
TreeFamiTF332727

Family and domain databases

CDDicd00213 S-100, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR034325 S-100_dom
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
IPR028488 S100A3
PANTHERiPTHR11639:SF12 PTHR11639:SF12, 1 hit
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00303 S100_CABP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33764-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARPLEQAVA AIVCTFQEYA GRCGDKYKLC QAELKELLQK ELATWTPTEF
60 70 80 90 100
RECDYNKFMS VLDTNKDCEV DFVEYVRSLA CLCLYCHEYF KDCPSEPPCS

Q
Length:101
Mass (Da):11,713
Last modified:February 1, 1994 - v1
Checksum:iABCAF4B7E5F2E0A1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0610473R → K. Corresponds to variant dbSNP:rs36022742Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18948 mRNA Translation: CAA79471.1
Z18950 Genomic DNA Translation: CAA79473.1
BT006955 mRNA Translation: AAP35601.1
CR542163 mRNA Translation: CAG46960.1
CR542185 mRNA Translation: CAG46982.1
BX470102 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53306.1
CH471121 Genomic DNA Translation: EAW53307.1
BC012893 mRNA Translation: AAH12893.1
CCDSiCCDS1043.1
PIRiC48219
S70326
RefSeqiNP_002951.1, NM_002960.1
UniGeneiHs.557609

Genome annotation databases

EnsembliENST00000368712; ENSP00000357701; ENSG00000188015
ENST00000368713; ENSP00000357702; ENSG00000188015
GeneIDi6274
KEGGihsa:6274
UCSCiuc001fca.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18948 mRNA Translation: CAA79471.1
Z18950 Genomic DNA Translation: CAA79473.1
BT006955 mRNA Translation: AAP35601.1
CR542163 mRNA Translation: CAG46960.1
CR542185 mRNA Translation: CAG46982.1
BX470102 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53306.1
CH471121 Genomic DNA Translation: EAW53307.1
BC012893 mRNA Translation: AAH12893.1
CCDSiCCDS1043.1
PIRiC48219
S70326
RefSeqiNP_002951.1, NM_002960.1
UniGeneiHs.557609

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KSOX-ray1.70A/B1-101[»]
3NSIX-ray2.15A/B1-101[»]
3NSKX-ray1.55A/B1-101[»]
3NSLX-ray1.50A/B/C/D/E/F2-101[»]
3NSOX-ray1.45A/B1-101[»]
ProteinModelPortaliP33764
SMRiP33764
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112182, 21 interactors
IntActiP33764, 6 interactors
STRINGi9606.ENSP00000357701

PTM databases

iPTMnetiP33764

Polymorphism and mutation databases

BioMutaiS100A3
DMDMi464729

Proteomic databases

EPDiP33764
MaxQBiP33764
PaxDbiP33764
PeptideAtlasiP33764
PRIDEiP33764
ProteomicsDBi54924

Protocols and materials databases

DNASUi6274
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368712; ENSP00000357701; ENSG00000188015
ENST00000368713; ENSP00000357702; ENSG00000188015
GeneIDi6274
KEGGihsa:6274
UCSCiuc001fca.2 human

Organism-specific databases

CTDi6274
DisGeNETi6274
EuPathDBiHostDB:ENSG00000188015.9
GeneCardsiS100A3
H-InvDBiHIX0116376
HGNCiHGNC:10493 S100A3
HPAiHPA042674
HPA056140
MIMi176992 gene
neXtProtiNX_P33764
OpenTargetsiENSG00000188015
PharmGKBiPA34905
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3DW Eukaryota
ENOG411196G LUCA
GeneTreeiENSGT00760000119034
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP33764
OMAiMTRPLEQ
OrthoDBiEOG091G10JX
PhylomeDBiP33764
TreeFamiTF332727

Miscellaneous databases

EvolutionaryTraceiP33764
GeneWikiiS100A3
GenomeRNAii6274
PROiPR:P33764
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188015 Expressed in 110 organ(s), highest expression level in hair follicle
CleanExiHS_S100A3
GenevisibleiP33764 HS

Family and domain databases

CDDicd00213 S-100, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR034325 S-100_dom
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
IPR028488 S100A3
PANTHERiPTHR11639:SF12 PTHR11639:SF12, 1 hit
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00303 S100_CABP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS10A3_HUMAN
AccessioniPrimary (citable) accession number: P33764
Secondary accession number(s): D3DV51, Q6FGE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 7, 2018
This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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