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Protein

Protein S100-A5

Gene

S100A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 331; low affinityAdd BLAST14
Calcium bindingi60 – 712; high affinityAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • copper ion binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • zinc ion binding Source: UniProtKB

Keywordsi

LigandCalcium, Copper, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A5
Alternative name(s):
Protein S-100D
S100 calcium-binding protein A5
Gene namesi
Name:S100A5
Synonyms:S100D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000196420.7
HGNCiHGNC:10495 S100A5
MIMi176991 gene
neXtProtiNX_P33763

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6276
OpenTargetsiENSG00000196420
PharmGKBiPA34907

Polymorphism and mutation databases

BioMutaiS100A5
DMDMi20178321

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001439801 – 92Protein S100-A5Add BLAST92

Proteomic databases

PaxDbiP33763
PRIDEiP33763
ProteomicsDBi54923

PTM databases

iPTMnetiP33763
PhosphoSitePlusiP33763

Expressioni

Gene expression databases

BgeeiENSG00000196420 Expressed in 82 organ(s), highest expression level in cortex of kidney
CleanExiHS_S100A5
GenevisibleiP33763 HS

Organism-specific databases

HPAiHPA064184

Interactioni

Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiP33763, 1 interactor
MINTiP33763

Structurei

Secondary structure

192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP33763
SMRiP33763
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP33763

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini47 – 82EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IZNS Eukaryota
ENOG4111EF4 LUCA
GeneTreeiENSGT00760000119034
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP33763
OMAiLCLGEKM
OrthoDBiEOG091G10JX
PhylomeDBiP33763
TreeFamiTF332727

Family and domain databases

CDDicd00213 S-100, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR034325 S-100_dom
IPR028497 S100-A5
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PANTHERiPTHR11639:SF65 PTHR11639:SF65, 1 hit
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 1 hit
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P33763-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METPLEKALT TMVTTFHKYS GREGSKLTLS RKELKELIKK ELCLGEMKES
60 70 80 90
SIDDLMKSLD KNSDQEIDFK EYSVFLTMLC MAYNDFFLED NK
Length:92
Mass (Da):10,744
Last modified:April 16, 2002 - v2
Checksum:i49C2B1DAEC481561
GO
Isoform 2 (identifier: P33763-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPAAWILWAHSHSELHTVM

Note: No experimental confirmation available.
Show »
Length:110
Mass (Da):12,813
Checksum:iF117933AD2DAA71B
GO

Sequence cautioni

The sequence CAA79472 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA79475 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA79479 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00130554D → G. Corresponds to variant dbSNP:rs3795393Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0555061M → MPAAWILWAHSHSELHTVM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18954 mRNA Translation: CAA79479.1 Different initiation.
Z18949 Genomic DNA Translation: CAA79472.1 Different initiation.
Z18950 Genomic DNA Translation: CAA79475.1 Different initiation.
BX470102 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53317.1
BC093955 mRNA Translation: AAH93955.1
BC093957 mRNA Translation: AAH93957.1
CCDSiCCDS1041.2 [P33763-1]
RefSeqiNP_002953.2, NM_002962.1 [P33763-1]
XP_016857519.1, XM_017002030.1 [P33763-2]
XP_016857520.1, XM_017002031.1 [P33763-1]
XP_016857521.1, XM_017002032.1 [P33763-1]
UniGeneiHs.2960

Genome annotation databases

EnsembliENST00000368717; ENSP00000357706; ENSG00000196420 [P33763-1]
ENST00000368718; ENSP00000357707; ENSG00000196420 [P33763-1]
GeneIDi6276
KEGGihsa:6276
UCSCiuc001fbx.3 human [P33763-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiS10A5_HUMAN
AccessioniPrimary (citable) accession number: P33763
Secondary accession number(s): Q52LE7, Q5RHS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: April 16, 2002
Last modified: September 12, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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