Zinc finger protein MSN2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription factor activity, RNA polymerase II-specific Source: SGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Activator and repressor functions of the Mot3 transcription factor in the osmostress response of Saccharomyces cerevisiae."
    Martinez-Montanes F., Rienzo A., Poveda-Huertes D., Pascual-Ahuir A., Proft M.
    Eukaryotic Cell 12:636-647(2013) [PubMed] [Europe PMC] [Abstract]
  • "Msn2p, a zinc finger DNA-binding protein, is the transcriptional activator of the multistress response in Saccharomyces cerevisiae."
    Schmitt A.P., McEntee K.
    Proc. Natl. Acad. Sci. U.S.A. 93:5777-5782(1996) [PubMed] [Europe PMC] [Abstract]
• metal ion binding Source: UniProtKB-KW
• proximal promoter sequence-specific DNA binding Source: SGDInferred from direct assayⁱ
  • Ref.1

    "Two homologous zinc finger genes identified by multicopy suppression in a SNF1 protein kinase mutant of Saccharomyces cerevisiae."
    Estruch F., Carlson M.
    Mol. Cell. Biol. 13:3872-3881(1993) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  • Ref.4

    "The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress response element (STRE)."
    Martinez-Pastor M.T., Marchler G., Schueller C., Marchler-Bauer A., Ruis H., Estruch F.
    EMBO J. 15:2227-2235(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: CHARACTERIZATION.
  • "Msn2p, a zinc finger DNA-binding protein, is the transcriptional activator of the multistress response in Saccharomyces cerevisiae."
    Schmitt A.P., McEntee K.
    Proc. Natl. Acad. Sci. U.S.A. 93:5777-5782(1996) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• age-dependent response to oxidative stress involved in chronological cell aging Source: SGD <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Regulation of longevity and stress resistance by Sch9 in yeast."
    Fabrizio P., Pozza F., Pletcher S.D., Gendron C.M., Longo V.D.
    Science 292:288-290(2001) [PubMed] [Europe PMC] [Abstract]
• cellular response to blue light Source: SGDInferred from direct assayⁱ
  • "The yeast transcription factor Crz1 is activated by light in a Ca2+/calcineurin-dependent and PKA-independent manner."
    Bodvard K., Jorhov A., Blomberg A., Molin M., Kall M.
    PLoS ONE 8:e53404-e53404(2013) [PubMed] [Europe PMC] [Abstract]
• cellular response to methylmercury Source: SGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Overexpression of Bop3 confers resistance to methylmercury in Saccharomyces cerevisiae through interaction with other proteins such as Fkh1, Rts1, and Msn2."
    Hwang G.-W., Furuoya Y., Hiroshima A., Furuchi T., Naganuma A.
    Biochem. Biophys. Res. Commun. 330:378-385(2005) [PubMed] [Europe PMC] [Abstract]
• chromatin remodeling Source: SGDInferred from genetic interactionⁱ
  • "Different requirements of the SWI/SNF complex for robust nucleosome displacement at promoters of heat shock factor and Msn2- and Msn4-regulated heat shock genes."
    Erkina T.Y., Tschetter P.A., Erkine A.M.
    Mol. Cell. Biol. 28:1207-1217(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: SGDInferred from genetic interactionⁱ
  • "The Rpd3L HDAC complex is essential for the heat stress response in yeast."
    Ruiz-Roig C., Vieitez C., Posas F., de Nadal E.
    Mol. Microbiol. 76:1049-1062(2010) [PubMed] [Europe PMC] [Abstract]
  • "The RNA polymerase I subunit Rpa12p interacts with the stress-responsive transcription factor Msn4p to regulate lipid metabolism in budding yeast."
    Yadav K.K., Singh N., Rajvanshi P.K., Rajasekharan R.
    FEBS Lett. 590:3559-3573(2016) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment Source: SGDInferred from genetic interactionⁱ
  • "MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae."
    Medvedik O., Lamming D.W., Kim K.D., Sinclair D.A.
    PLoS Biol. 5:e261-e261(2007) [PubMed] [Europe PMC] [Abstract]
  • Ref.4

    "The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress response element (STRE)."
    Martinez-Pastor M.T., Marchler G., Schueller C., Marchler-Bauer A., Ruis H., Estruch F.
    EMBO J. 15:2227-2235(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: CHARACTERIZATION.
• positive regulation of transcription from RNA polymerase II promoter in response to acidic pH Source: SGDInferred from mutant phenotypeⁱ
  • "RGD1, encoding a RhoGAP involved in low-pH survival, is an Msn2p/Msn4p regulated gene in Saccharomyces cerevisiae."
    Gatti X., de Bettignies G., Claret S., Doignon F., Crouzet M., Thoraval D.
    Gene 351:159-169(2005) [PubMed] [Europe PMC] [Abstract]
  • "The SPI1 gene, encoding a glycosylphosphatidylinositol-anchored cell wall protein, plays a prominent role in the development of yeast resistance to lipophilic weak-acid food preservatives."
    Simoes T., Mira N.P., Fernandes A.R., Sa-Correia I.
    Appl. Environ. Microbiol. 72:7168-7175(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH Source: SGDInferred from genetic interactionⁱ
  • "The role of the protein kinase A pathway in the response to alkaline pH stress in yeast."
    Casado C., Gonzalez A., Platara M., Ruiz A., Arino J.
    Biochem. J. 438:523-533(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation Source: SGDInferred from genetic interactionⁱ
  • "MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae."
    Medvedik O., Lamming D.W., Kim K.D., Sinclair D.A.
    PLoS Biol. 5:e261-e261(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance Source: SGDInferred from genetic interactionⁱ
  • "Induction of neutral trehalase Nth1 by heat and osmotic stress is controlled by STRE elements and Msn2/Msn4 transcription factors: variations of PKA effect during stress and growth."
    Zahringer H., Thevelein J.M., Nwaka S.
    Mol. Microbiol. 35:397-406(2000) [PubMed] [Europe PMC] [Abstract]
  • "Arsenic toxicity to Saccharomyces cerevisiae is a consequence of inhibition of the TORC1 kinase combined with a chronic stress response."
    Hosiner D., Lempiainen H., Reiter W., Urban J., Loewith R., Ammerer G., Schweyen R., Shore D., Schuller C.
    Mol. Biol. Cell 20:1048-1057(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription from RNA polymerase II promoter in response to cold Source: SGDInferred from genetic interactionⁱ
  • "Yeast adapt to near-freezing temperatures by STRE/Msn2,4-dependent induction of trehalose synthesis and certain molecular chaperones."
    Kandror O., Bretschneider N., Kreydin E., Cavalieri D., Goldberg A.L.
    Mol. Cell 13:771-781(2004) [PubMed] [Europe PMC] [Abstract]
  • "Cold adaptation in budding yeast."
    Schade B., Jansen G., Whiteway M., Entian K.D., Thomas D.Y.
    Mol. Biol. Cell 15:5492-5502(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription from RNA polymerase II promoter in response to ethanol Source: SGDInferred from genetic interactionⁱ
  • Ref.4

    "The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress response element (STRE)."
    Martinez-Pastor M.T., Marchler G., Schueller C., Marchler-Bauer A., Ruis H., Estruch F.
    EMBO J. 15:2227-2235(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: CHARACTERIZATION.
• positive regulation of transcription from RNA polymerase II promoter in response to freezing Source: SGDInferred from genetic interactionⁱ
  • "Msn2p/Msn4p-activation is essential for the recovery from freezing stress in yeast."
    Izawa S., Ikeda K., Ohdate T., Inoue Y.
    Biochem. Biophys. Res. Commun. 352:750-755(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation Source: SGDInferred from genetic interactionⁱ
  • "The signaling pathways underlying starvation-induced upregulation of alpha-mannosidase Ams1 in Saccharomyces cerevisiae."
    Umekawa M., Ujihara M., Makishima K., Yamamoto S., Takematsu H., Wakayama M.
    Biochim. Biophys. Acta 1860:1192-1201(2016) [PubMed] [Europe PMC] [Abstract]
  • Ref.4

    "The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress response element (STRE)."
    Martinez-Pastor M.T., Marchler G., Schueller C., Marchler-Bauer A., Ruis H., Estruch F.
    EMBO J. 15:2227-2235(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: CHARACTERIZATION.
• positive regulation of transcription from RNA polymerase II promoter in response to heat stress Source: SGDInferred from mutant phenotypeⁱ
  • "Genomic expression programs in the response of yeast cells to environmental changes."
    Gasch A.P., Spellman P.T., Kao C.M., Carmel-Harel O., Eisen M.B., Storz G., Botstein D., Brown P.O.
    Mol. Biol. Cell 11:4241-4257(2000) [PubMed] [Europe PMC] [Abstract]
  • "Msn2p, a zinc finger DNA-binding protein, is the transcriptional activator of the multistress response in Saccharomyces cerevisiae."
    Schmitt A.P., McEntee K.
    Proc. Natl. Acad. Sci. U.S.A. 93:5777-5782(1996) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide Source: SGDInferred from mutant phenotypeⁱ
  • "Genomic expression programs in the response of yeast cells to environmental changes."
    Gasch A.P., Spellman P.T., Kao C.M., Carmel-Harel O., Eisen M.B., Storz G., Botstein D., Brown P.O.
    Mol. Biol. Cell 11:4241-4257(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure Source: SGDInferred from genetic interactionⁱ
  • "High hydrostatic pressure activates gene expression through Msn2/4 stress transcription factors which are involved in the acquired tolerance by mild pressure precondition in Saccharomyces cerevisiae."
    Domitrovic T., Fernandes C.M., Boy-Marcotte E., Kurtenbach E.
    FEBS Lett. 580:6033-6038(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription from RNA polymerase II promoter in response to increased salt Source: SGDInferred from genetic interactionⁱ
  • "Induction of neutral trehalase Nth1 by heat and osmotic stress is controlled by STRE elements and Msn2/Msn4 transcription factors: variations of PKA effect during stress and growth."
    Zahringer H., Thevelein J.M., Nwaka S.
    Mol. Microbiol. 35:397-406(2000) [PubMed] [Europe PMC] [Abstract]
  • "MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae."
    Medvedik O., Lamming D.W., Kim K.D., Sinclair D.A.
    PLoS Biol. 5:e261-e261(2007) [PubMed] [Europe PMC] [Abstract]
  • Ref.4

    "The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress response element (STRE)."
    Martinez-Pastor M.T., Marchler G., Schueller C., Marchler-Bauer A., Ruis H., Estruch F.
    EMBO J. 15:2227-2235(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: CHARACTERIZATION.
• positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation Source: SGDInferred from genetic interactionⁱ
  • "The signaling pathways underlying starvation-induced upregulation of alpha-mannosidase Ams1 in Saccharomyces cerevisiae."
    Umekawa M., Ujihara M., Makishima K., Yamamoto S., Takematsu H., Wakayama M.
    Biochim. Biophys. Acta 1860:1192-1201(2016) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress Source: SGDInferred from genetic interactionⁱ
  • "Transcriptional response to nitrosative stress in Saccharomyces cerevisiae."
    Horan S., Bourges I., Meunier B.
    Yeast 23:519-535(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation Source: SGDInferred from genetic interactionⁱ
  • "Zinc starvation induces a stress response in Saccharomyces cerevisiae that is mediated by the Msn2p and Msn4p transcriptional activators."
    Gauci V.J., Beckhouse A.G., Lyons V., Beh E.J., Rogers P.J., Dawes I.W., Higgins V.J.
    FEMS Yeast Res. 9:1187-1195(2009) [PubMed] [Europe PMC] [Abstract]
• regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction Source: SGDInferred from genetic interactionⁱ
  • "MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae."
    Medvedik O., Lamming D.W., Kim K.D., Sinclair D.A.
    PLoS Biol. 5:e261-e261(2007) [PubMed] [Europe PMC] [Abstract]
• replicative cell aging Source: SGDInferred from genetic interactionⁱ
  • "Chronological aging-independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiae."
    Fabrizio P., Pletcher S.D., Minois N., Vaupel J.W., Longo V.D.
    FEBS Lett. 557:136-142(2004) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MTVDHDFNSE DILFPIESMS SIQYVENNNP NNINNDVIPY SLDIKNTVLD 
        60         70         80         90        100
SADLNDIQNQ ETSLNLGLPP LSFDSPLPVT ETIPSTTDNS LHLKADSNKN 
       110        120        130        140        150
RDARTIENDS EIKSTNNASG SGANQYTTLT SPYPMNDILY NMNNPLQSPS 
       160        170        180        190        200
PSSVPQNPTI NPPINTASNE TNLSPQTSNG NETLISPRAQ QHTSIKDNRL 
       210        220        230        240        250
SLPNGANSNL FIDTNPNNLN EKLRNQLNSD TNSYSNSISN SNSNSTGNLN 
       260        270        280        290        300
SSYFNSLNID SMLDDYVSSD LLLNDDDDDT NLSRRRFSDV ITNQFPSMTN 
       310        320        330        340        350
SRNSISHSLD LWNHPKINPS NRNTNLNITT NSTSSSNASP NTTTMNANAD 
       360        370        380        390        400
SNIAGNPKNN DATIDNELTQ ILNEYNMNFN DNLGTSTSGK NKSACPSSFD 
       410        420        430        440        450
ANAMTKINPS QQLQQQLNRV QHKQLTSSHN NSSTNMKSFN SDLYSRRQRA 
       460        470        480        490        500
SLPIIDDSLS YDLVNKQDED PKNDMLPNSN LSSSQQFIKP SMILSDNASV 
       510        520        530        540        550
IAKVATTGLS NDMPFLTEEG EQNANSTPNF DLSITQMNMA PLSPASSSST 
       560        570        580        590        600
SLATNHFYHH FPQQGHHTMN SKIGSSLRRR KSAVPLMGTV PLTNQQNNIS 
       610        620        630        640        650
SSSVNSTGNG AGVTKERRPS YRRKSMTPSR RSSVVIESTK ELEEKPFHCH 
       660        670        680        690        700
ICPKSFKRSE HLKRHVRSVH SNERPFACHI CDKKFSRSDN LSQHIKTHKK 

HGDI                                                   

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Yeast chromosome XIII
   Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names
2. Yeast
   Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD