UniProtKB - P33748 (MSN2_YEAST)
Protein
Zinc finger protein MSN2
Gene
MSN2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Positive transcriptional factor that acts as a component of the stress responsive system. Recognizes and binds to the stress response element (STRE) which is involved in the response to various forms of stress (heat, oxidative, osmotic, etc.). Involved in the regulation of the CTT1, DDR2, HSP12 genes. May be regulated via WHI2-PSR1 complex phosphatase activity.
Miscellaneous
Present with 125 molecules/cell in log phase SD medium.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 647 – 665 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 19 | |
Zinc fingeri | 676 – 698 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- cis-regulatory region sequence-specific DNA binding Source: SGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: SGD
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- amino acid homeostasis Source: SGD
- cellular response to blue light Source: SGD
- chromatin remodeling Source: SGD
- positive regulation of transcription by RNA polymerase II Source: SGD
- positive regulation of transcription from RNA polymerase II promoter in response to acidic pH Source: SGD
- positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH Source: SGD
- positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation Source: SGD
- positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance Source: SGD
- positive regulation of transcription from RNA polymerase II promoter in response to cold Source: SGD
- positive regulation of transcription from RNA polymerase II promoter in response to ethanol Source: SGD
- positive regulation of transcription from RNA polymerase II promoter in response to freezing Source: SGD
- positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation Source: SGD
- positive regulation of transcription from RNA polymerase II promoter in response to heat stress Source: SGD
- positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide Source: SGD
- positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure Source: SGD
- positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation Source: SGD
- positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress Source: SGD
- regulation of transcription by RNA polymerase II Source: SGD
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: GO_Central
- response to starvation Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein MSN2Alternative name(s): Multicopy suppressor of SNF1 protein 2 |
Gene namesi | Name:MSN2 Ordered Locus Names:YMR037C ORF Names:YM9532.02C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000004640, MSN2 |
VEuPathDBi | FungiDB:YMR037C |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046810 | 1 – 704 | Zinc finger protein MSN2Add BLAST | 704 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 288 | PhosphoserineCombined sources | 1 | |
Modified residuei | 304 | PhosphoserineCombined sources | 1 | |
Modified residuei | 451 | PhosphoserineCombined sources | 1 | |
Modified residuei | 582 | PhosphoserineCombined sources | 1 | |
Modified residuei | 633 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P33748 |
PaxDbi | P33748 |
PRIDEi | P33748 |
PTM databases
iPTMneti | P33748 |
Interactioni
Subunit structurei
Interacts with WHI2.
1 PublicationProtein-protein interaction databases
BioGRIDi | 35209, 180 interactors |
DIPi | DIP-8185N |
IntActi | P33748, 64 interactors |
MINTi | P33748 |
STRINGi | 4932.YMR037C |
Miscellaneous databases
RNActi | P33748, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 261 – 269 | 9aaTAD1 Publication | 9 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 109 | Asp-rich (acidic)Add BLAST | 109 | |
Compositional biasi | 260 – 279 | Asp-rich (acidic)Add BLAST | 20 |
Domaini
The 9aaTAD motif (residues 261 to 269) is a transactivation domain present in a large number of yeast and animal transcription factors.1 Publication
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 647 – 665 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 19 | |
Zinc fingeri | 676 – 698 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000174779 |
HOGENOMi | CLU_024342_0_0_1 |
InParanoidi | P33748 |
OMAi | TANIMTI |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 2 hits |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 2 hits |
i Sequence
Sequence statusi: Complete.
P33748-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTVDHDFNSE DILFPIESMS SIQYVENNNP NNINNDVIPY SLDIKNTVLD
60 70 80 90 100
SADLNDIQNQ ETSLNLGLPP LSFDSPLPVT ETIPSTTDNS LHLKADSNKN
110 120 130 140 150
RDARTIENDS EIKSTNNASG SGANQYTTLT SPYPMNDILY NMNNPLQSPS
160 170 180 190 200
PSSVPQNPTI NPPINTASNE TNLSPQTSNG NETLISPRAQ QHTSIKDNRL
210 220 230 240 250
SLPNGANSNL FIDTNPNNLN EKLRNQLNSD TNSYSNSISN SNSNSTGNLN
260 270 280 290 300
SSYFNSLNID SMLDDYVSSD LLLNDDDDDT NLSRRRFSDV ITNQFPSMTN
310 320 330 340 350
SRNSISHSLD LWNHPKINPS NRNTNLNITT NSTSSSNASP NTTTMNANAD
360 370 380 390 400
SNIAGNPKNN DATIDNELTQ ILNEYNMNFN DNLGTSTSGK NKSACPSSFD
410 420 430 440 450
ANAMTKINPS QQLQQQLNRV QHKQLTSSHN NSSTNMKSFN SDLYSRRQRA
460 470 480 490 500
SLPIIDDSLS YDLVNKQDED PKNDMLPNSN LSSSQQFIKP SMILSDNASV
510 520 530 540 550
IAKVATTGLS NDMPFLTEEG EQNANSTPNF DLSITQMNMA PLSPASSSST
560 570 580 590 600
SLATNHFYHH FPQQGHHTMN SKIGSSLRRR KSAVPLMGTV PLTNQQNNIS
610 620 630 640 650
SSSVNSTGNG AGVTKERRPS YRRKSMTPSR RSSVVIESTK ELEEKPFHCH
660 670 680 690 700
ICPKSFKRSE HLKRHVRSVH SNERPFACHI CDKKFSRSDN LSQHIKTHKK
HGDI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L08838 Genomic DNA Translation: AAA34806.1 Z48502 Genomic DNA Translation: CAA88403.1 BK006946 Genomic DNA Translation: DAA09936.1 |
PIRi | S39004 |
RefSeqi | NP_013751.1, NM_001182534.1 |
Genome annotation databases
EnsemblFungii | YMR037C_mRNA; YMR037C; YMR037C |
GeneIDi | 855053 |
KEGGi | sce:YMR037C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L08838 Genomic DNA Translation: AAA34806.1 Z48502 Genomic DNA Translation: CAA88403.1 BK006946 Genomic DNA Translation: DAA09936.1 |
PIRi | S39004 |
RefSeqi | NP_013751.1, NM_001182534.1 |
3D structure databases
SMRi | P33748 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 35209, 180 interactors |
DIPi | DIP-8185N |
IntActi | P33748, 64 interactors |
MINTi | P33748 |
STRINGi | 4932.YMR037C |
PTM databases
iPTMneti | P33748 |
Proteomic databases
MaxQBi | P33748 |
PaxDbi | P33748 |
PRIDEi | P33748 |
Genome annotation databases
EnsemblFungii | YMR037C_mRNA; YMR037C; YMR037C |
GeneIDi | 855053 |
KEGGi | sce:YMR037C |
Organism-specific databases
SGDi | S000004640, MSN2 |
VEuPathDBi | FungiDB:YMR037C |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000174779 |
HOGENOMi | CLU_024342_0_0_1 |
InParanoidi | P33748 |
OMAi | TANIMTI |
Miscellaneous databases
PROi | PR:P33748 |
RNActi | P33748, protein |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 2 hits |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MSN2_YEAST | |
Accessioni | P33748Primary (citable) accession number: P33748 Secondary accession number(s): D6VZL2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | February 1, 1994 | |
Last modified: | February 10, 2021 | |
This is version 193 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XIII
Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names