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Protein

Aldehyde-alcohol dehydrogenase

Gene

adhE

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has both aldehyde and alcohol dehydrogenase activities. Can use acetaldehyde, butyraldehyde, butanol and ethanol.1 Publication

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.1 Publication
A secondary alcohol + NAD+ = a ketone + NADH.1 Publication
An aldehyde + NAD+ + H2O = a carboxylate + NADH.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei244By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi420 – 425NADSequence analysis6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMultifunctional enzyme, Oxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciMetaCyc:AADCLOS-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde-alcohol dehydrogenase1 Publication
Short name:
AAD1 Publication
Including the following 2 domains:
Alcohol dehydrogenase1 Publication (EC:1.1.1.11 Publication)
Short name:
ADH1 Publication
Aldehyde dehydrogenase1 Publication (EC:1.2.1.31 Publication)
Short name:
ALDH1 Publication
Gene namesi
Name:adhE1 Publication
Synonyms:aad1 Publication
Ordered Locus Names:CA_P0162
Encoded oniPlasmid pSOL10 Publication
OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Taxonomic identifieri272562 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000814 Componenti: Plasmid pSOL1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000878391 – 862Aldehyde-alcohol dehydrogenaseAdd BLAST862

Proteomic databases

PRIDEiP33744

Expressioni

Inductioni

Induced during switch to solvent production.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP33744
SMRiP33744
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the aldehyde dehydrogenase family.Curated
In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.Curated

Phylogenomic databases

HOGENOMiHOG000025256
KOiK04072
OMAiWHKLPSS

Family and domain databases

CDDicd08178 AAD_C, 1 hit
Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR034789 AAD_C
IPR001670 ADH_Fe/GldA
IPR018211 ADH_Fe_CS
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR012079 Bifunc_Ald-ADH
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
PF00465 Fe-ADH, 1 hit
PIRSFiPIRSF000111 ALDH_ADH, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00913 ADH_IRON_1, 1 hit

Sequencei

Sequence statusi: Complete.

P33744-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVTTVKELD EKLKVIKEAQ KKFSCYSQEM VDEIFRNAAM AAIDARIELA
60 70 80 90 100
KAAVLETGMG LVEDKVIKNH FAGEYIYNKY KDEKTCGIIE RNEPYGITKI
110 120 130 140 150
AEPIGVVAAI IPVTNPTSTT IFKSLISLKT RNGIFFSPHP RAKKSTILAA
160 170 180 190 200
KTILDAAVKS GAPENIIGWI DEPSIELTQY LMQKADITLA TGGPSLVKSA
210 220 230 240 250
YSSGKPAIGV GPGNTPVIID ESAHIKMAVS SIILSKTYDN GVICASEQSV
260 270 280 290 300
IVLKSIYNKV KDEFQERGAY IIKKNELDKV REVIFKDGSV NPKIVGQSAY
310 320 330 340 350
TIAAMAGIKV PKTTRILIGE VTSLGEEEPF AHEKLSPVLA MYEADNFDDA
360 370 380 390 400
LKKAVTLINL GGLGHTSGIY ADEIKARDKI DRFSSAMKTV RTFVNIPTSQ
410 420 430 440 450
GASGDLYNFR IPPSFTLGCG FWGGNSVSEN VGPKHLLNIK TVAERRENML
460 470 480 490 500
WFRVPHKVYF KFGCLQFALK DLKDLKKKRA FIVTDSDPYN LNYVDSIIKI
510 520 530 540 550
LEHLDIDFKV FNKVGREADL KTIKKATEEM SSFMPDTIIA LGGTPEMSSA
560 570 580 590 600
KLMWVLYEHP EVKFEDLAIK FMDIRKRIYT FPKLGKKAML VAITTSAGSG
610 620 630 640 650
SEVTPFALVT DNNTGNKYML ADYEMTPNMA IVDAELMMKM PKGLTAYSGI
660 670 680 690 700
DALVNSIEAY TSVYASEYTN GLALEAIRLI FKYLPEAYKN GRTNEKAREK
710 720 730 740 750
MAHASTMAGM ASANAFLGLC HSMAIKLSSE HNIPSGIANA LLIEEVIKFN
760 770 780 790 800
AVDNPVKQAP CPQYKYPNTI FRYARIADYI KLGGNTDEEK VDLLINKIHE
810 820 830 840 850
LKKALNIPTS IKDAGVLEEN FYSSLDRISE LALDDQCTGA NPRFPLTSEI
860
KEMYINCFKK QP
Length:862
Mass (Da):95,321
Last modified:August 29, 2001 - v3
Checksum:iBE09E32B28DD08B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72831 Genomic DNA Translation: CAA51344.1
L14817 Genomic DNA Translation: AAD04638.1
AE001438 Genomic DNA Translation: AAK76907.1
PIRiA49346
RefSeqiNP_149325.1, NC_001988.2
WP_010890846.1, NC_001988.2

Genome annotation databases

EnsemblBacteriaiAAK76907; AAK76907; CA_P0162
GeneIDi1116167
KEGGicac:CA_P0162
PATRICifig|272562.8.peg.163

Similar proteinsi

Entry informationi

Entry nameiADHE_CLOAB
AccessioniPrimary (citable) accession number: P33744
Secondary accession number(s): Q45808, Q45809
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: August 29, 2001
Last modified: July 18, 2018
This is version 114 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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