CAV1

Functionⁱ

Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation.Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae.By similarity

GO - Molecular functionⁱ

ATPase binding Source: Ensembl
identical protein binding Source: Ensembl
inward rectifier potassium channel inhibitor activity Source: Ensembl
ion channel binding Source: Ensembl
nitric-oxide synthase binding Source: Ensembl
peptidase activator activity Source: Ensembl
protein binding, bridging Source: Ensembl
protein-containing complex scaffold activity Source: Ensembl
protein heterodimerization activity Source: Ensembl
protein kinase binding Source: Ensembl
Rac GTPase binding Source: Ensembl
signaling receptor binding Source: Ensembl
structural molecule activity
Source: UniProtKB
Inferred from direct assayⁱ
- 7568142

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

angiogenesis Source: Ensembl
angiotensin-activated signaling pathway involved in heart process Source: Ensembl
apoptotic signaling pathway Source: Ensembl
calcium ion transport Source: Ensembl
caveola assembly
Source: BHF-UCL
Inferred from direct assayⁱ
- 12743374
caveolin-mediated endocytosis Source: Ensembl
cellular response to exogenous dsRNA Source: Ensembl
cellular response to hyperoxia Source: Ensembl
cellular response to transforming growth factor beta stimulus Source: Ensembl
cholesterol homeostasis Source: Ensembl
inactivation of MAPK activity Source: Ensembl
lactation Source: Ensembl
lipid storage Source: Ensembl
mammary gland involution Source: Ensembl
membrane depolarization Source: Ensembl
negative regulation of anoikis Source: Ensembl
negative regulation of canonical Wnt signaling pathway Source: Ensembl
negative regulation of cytokine-mediated signaling pathway Source: Ensembl
negative regulation of endothelial cell proliferation Source: Ensembl
negative regulation of epithelial cell differentiation Source: Ensembl
negative regulation of inward rectifier potassium channel activity Source: Ensembl
negative regulation of necroptotic process Source: Ensembl
negative regulation of nitric oxide biosynthetic process Source: Ensembl
negative regulation of nitric-oxide synthase activity Source: Ensembl
negative regulation of peptidyl-serine phosphorylation Source: Ensembl
negative regulation of peptidyl-tyrosine autophosphorylation Source: Ensembl
negative regulation of pinocytosis Source: Ensembl
negative regulation of protein binding Source: Ensembl
negative regulation of protein tyrosine kinase activity Source: Ensembl
negative regulation of protein ubiquitination Source: Ensembl
negative regulation of transcription by RNA polymerase II Source: Ensembl
negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
negative regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
nitric oxide homeostasis Source: Ensembl
positive regulation of calcium ion transport into cytosol Source: Ensembl
positive regulation of canonical Wnt signaling pathway Source: Ensembl
positive regulation of cell adhesion molecule production Source: Ensembl
positive regulation of cell migration Source: Ensembl
positive regulation of cold-induced thermogenesis Source: Ensembl
positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
positive regulation of gap junction assembly Source: Ensembl
positive regulation of gene expression Source: Ensembl
positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
positive regulation of peptidyl-serine phosphorylation Source: Ensembl
positive regulation of protein binding Source: Ensembl
positive regulation of protein ubiquitination Source: Ensembl
positive regulation of toll-like receptor 3 signaling pathway Source: Ensembl
positive regulation of vasoconstriction Source: Ensembl
posttranscriptional regulation of gene expression Source: Ensembl
protein homooligomerization Source: Ensembl
protein localization to basolateral plasma membrane
Source: BHF-UCL
Inferred from direct assayⁱ
- 12743374
protein localization to plasma membrane raft
Source: BHF-UCL
Inferred from direct assayⁱ
- 12743374
receptor internalization Source: UniProtKB
receptor internalization involved in canonical Wnt signaling pathway Source: Ensembl
receptor-mediated endocytosis of virus by host cell Source: Ensembl
regulation of blood coagulation Source: Ensembl
regulation of cell communication by electrical coupling involved in cardiac conduction Source: Ensembl
regulation of entry of bacterium into host cell Source: Ensembl
regulation of fatty acid metabolic process Source: Ensembl
regulation of heart rate by cardiac conduction Source: Ensembl
regulation of membrane repolarization during action potential Source: Ensembl
regulation of ruffle assembly Source: Ensembl
regulation of smooth muscle contraction Source: Ensembl
regulation of the force of heart contraction by chemical signal Source: Ensembl
regulation of ventricular cardiac muscle cell action potential Source: Ensembl
response to bacterium Source: Ensembl
response to calcium ion Source: Ensembl
response to estrogen Source: Ensembl
response to hypoxia Source: Ensembl
response to ischemia Source: Ensembl
response to progesterone Source: Ensembl
skeletal muscle tissue development Source: Ensembl
T cell costimulation Source: UniProtKB
triglyceride metabolic process Source: Ensembl
vasculogenesis Source: Ensembl
vasoconstriction Source: Ensembl
vesicle organization
Source: BHF-UCL
Inferred from direct assayⁱ
- 12743374

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-CFA-203615 eNOS activation R-CFA-203641 NOSTRIN mediated eNOS trafficking R-CFA-210991 Basigin interactions R-CFA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane R-CFA-5218920 VEGFR2 mediated vascular permeability

Reactomeⁱ

R-CFA-203615 eNOS activation
R-CFA-203641 NOSTRIN mediated eNOS trafficking
R-CFA-210991 Basigin interactions
R-CFA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-CFA-5218920 VEGFR2 mediated vascular permeability

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Caveolin-1 Alternative name(s): Vesicular integral-membrane protein VIP21
Gene namesⁱ	Name:CAV1 Synonyms:CAV
Organismⁱ	Canis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifierⁱ	9615 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › Canis lupus
Proteomesⁱ	UP000002254 Componentⁱ: Chromosome 14

Organism-specific databases

VGNCⁱ	VGNC:38751 CAV1

VGNCⁱ

VGNC:38751 CAV1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	2 – 104	CytoplasmicSequence analysisAdd BLAST	103
Intramembraneⁱ	105 – 125	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	126 – 178	CytoplasmicSequence analysisAdd BLAST	53

Keywords - Cellular componentⁱ

Cell membrane, Golgi apparatus, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000004762	2 – 178	Caveolin-1Add BLAST		177

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineBy similarity	1
Modified residueⁱ	2	PhosphoserineBy similarity	1
Modified residueⁱ	5	N6-acetyllysine; alternateBy similarity	1
Cross-linkⁱ	5	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Modified residueⁱ	6	PhosphotyrosineBy similarity	1
Modified residueⁱ	9	PhosphoserineBy similarity	1
Modified residueⁱ	14	Phosphotyrosine; by ABL1By similarity	1
Modified residueⁱ	25	PhosphotyrosineBy similarity	1
Cross-linkⁱ	26	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linkⁱ	30	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residueⁱ	37	PhosphoserineBy similarity	1
Cross-linkⁱ	39	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linkⁱ	47	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linkⁱ	57	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Lipidationⁱ	133	S-palmitoyl cysteine1 Publication	1
Lipidationⁱ	143	S-palmitoyl cysteine1 Publication	1
Lipidationⁱ	156	S-palmitoyl cysteine1 Publication	1

Post-translational modificationⁱ

Phosphorylation of isoform Beta on serine residues is constitutive. Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress (By similarity).By similarity

Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation.By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	P33724
PRIDEⁱ	P33724

PTM databases

iPTMnetⁱ	P33724
SwissPalmⁱ	P33724

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSCAFG00000003404 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Bgeeⁱ

ENSCAFG00000003404 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Interactionⁱ

Subunit structureⁱ

Homooligomer (PubMed:7568142). Interacts with BMX, BTK, GLIPR2, NOSTRIN, SNAP25 and STX1A. Interacts with PACSIN2. Interacts (via the N-terminus) with DPP4; the interaction is direct. Interacts with SLC7A9 (By similarity). Interacts with CTNNB1, CDH1 and JUP (PubMed:10816572). Interacts with TGFBR1. Interacts with CAVIN3 (via leucine-zipper domain) in a cholesterol-sensitive manner. Interacts with CAVIN1. Interacts with EHD2 in a cholesterol-dependent manner (By similarity). Forms a ternary complex with UBXN6 and VCP; mediates CAV1 targeting to lysosomes for degradation (By similarity).By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CTNNB1	P35222	5	EBI-79998,EBI-491549	From Homo sapiens.

With

Entry

#Exp.

IntAct

Notes

CTNNB1

P35222

5

EBI-79998,EBI-491549

From Homo sapiens.

GO - Molecular functionⁱ

ATPase binding Source: Ensembl
identical protein binding Source: Ensembl
ion channel binding Source: Ensembl
nitric-oxide synthase binding Source: Ensembl
protein binding, bridging Source: Ensembl
protein-containing complex scaffold activity Source: Ensembl
protein heterodimerization activity Source: Ensembl
protein kinase binding Source: Ensembl
Rac GTPase binding Source: Ensembl
signaling receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	139896, 3 interactors
IntActⁱ	P33724, 5 interactors
STRINGⁱ	9615.ENSCAFP00000005060

Structureⁱ

3D structure databases

SMRⁱ	P33724
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	2 – 94	Required for homooligomerizationBy similarityAdd BLAST		93
Regionⁱ	82 – 94	Interaction with CAVIN3By similarityAdd BLAST		13

Sequence similaritiesⁱ

Belongs to the caveolin family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IV7A Eukaryota ENOG4111HJR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014924
HOGENOMⁱ	HOG000036550
HOVERGENⁱ	HBG003422
InParanoidⁱ	P33724
KEGG Orthology (KO) More...KOⁱ	K06278
OMAⁱ	IYVHTFC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0M1R
TreeFamⁱ	TF315736

Family and domain databases

InterProⁱ	View protein in InterPro IPR015504 CAV-1 IPR001612 Caveolin IPR018361 Caveolin_CS
PANTHERⁱ	PTHR10844 PTHR10844, 1 hit PTHR10844:SF18 PTHR10844:SF18, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01146 Caveolin, 1 hit
PROSITEⁱ	View protein in PROSITE PS01210 CAVEOLIN, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative initiation. Align Add to basket

Isoform Alpha (identifier: P33724-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMAEEMSEKQ VYDAHTKEID 
        60         70         80         90        100
LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY 
       110        120        130        140        150
RLLSALFGIP MALIWGIYFA ILSFLHIWAV VPCIKSFLIE IQCISRVYSI 
       160        170 
YVHTFCDPFF EAVGKIFSNI RINMQKET

Length:178

Mass (Da):20,606

Last modified:February 1, 1994 - v1

Checksum:ⁱDD77CE4D436E508D

GO

Isoform Beta (identifier: P33724-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-31: Missing.

« Hide

        10         20         30         40         50
MAEEMSEKQV YDAHTKEIDL VNRDPKHLND DVVKIDFEDV IAEPEGTHSF 
        60         70         80         90        100
DGIWKASFTT FTVTKYWFYR LLSALFGIPM ALIWGIYFAI LSFLHIWAVV 
       110        120        130        140 
PCIKSFLIEI QCISRVYSIY VHTFCDPFFE AVGKIFSNIR INMQKET

Show »

Length:147

Mass (Da):17,157

Checksum:ⁱE32E90B50FFC5B1F

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_018691	1 – 31	Missing in isoform Beta. CuratedAdd BLAST		31

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z12161 Genomic DNA Translation: CAA78151.1 U47060 mRNA Translation: AAA87050.1 DP000236 Genomic DNA Translation: AAR16266.1
PIRⁱ	A43419
NCBI Reference Sequences More...RefSeqⁱ	NP_001003296.1, NM_001003296.1 [P33724-1] XP_005628404.1, XM_005628347.2 [P33724-2] XP_013974350.1, XM_014118875.1 [P33724-2]
UniGeneⁱ	Cfa.3850

Genome annotation databases

Ensemblⁱ	ENSCAFT00000005462; ENSCAFP00000005060; ENSCAFG00000003404 [P33724-1]
GeneIDⁱ	403980
KEGGⁱ	cfa:403980

Keywords - Coding sequence diversityⁱ

Alternative initiation

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P33724	Caveolin-1		HUMAN		178	UniRef90_Q03135
Caveolin-1		GORGO		178
Caveolin-1		CHLAE		178
Caveolin-1		COLGU		178
Caveolin-1		NOMLE		178
+62

Protein	Similar proteins		Species	Score	Length	Source
P33724	Caveolin-1		HUMAN		178	UniRef50_Q03135
Caveolin-1		GORGO		178
Caveolin-1		CHLAE		178
Caveolin-1		COLGU		178
Caveolin-1		NOMLE		178
+65

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z12161 Genomic DNA Translation: CAA78151.1 U47060 mRNA Translation: AAA87050.1 DP000236 Genomic DNA Translation: AAR16266.1
PIRⁱ	A43419
RefSeqⁱ	NP_001003296.1, NM_001003296.1 [P33724-1] XP_005628404.1, XM_005628347.2 [P33724-2] XP_013974350.1, XM_014118875.1 [P33724-2]
UniGeneⁱ	Cfa.3850

3D structure databases

SMRⁱ	P33724
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	139896, 3 interactors
IntActⁱ	P33724, 5 interactors
STRINGⁱ	9615.ENSCAFP00000005060

PTM databases

iPTMnetⁱ	P33724
SwissPalmⁱ	P33724

Proteomic databases

PaxDbⁱ	P33724
PRIDEⁱ	P33724

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSCAFT00000005462; ENSCAFP00000005060; ENSCAFG00000003404 [P33724-1]
GeneIDⁱ	403980
KEGGⁱ	cfa:403980

Organism-specific databases

CTDⁱ	857
VGNCⁱ	VGNC:38751 CAV1

Phylogenomic databases

eggNOGⁱ	ENOG410IV7A Eukaryota ENOG4111HJR LUCA
GeneTreeⁱ	ENSGT00390000014924
HOGENOMⁱ	HOG000036550
HOVERGENⁱ	HBG003422
InParanoidⁱ	P33724
KOⁱ	K06278
OMAⁱ	IYVHTFC
OrthoDBⁱ	EOG091G0M1R
TreeFamⁱ	TF315736

Enzyme and pathway databases

Reactomeⁱ	R-CFA-203615 eNOS activation R-CFA-203641 NOSTRIN mediated eNOS trafficking R-CFA-210991 Basigin interactions R-CFA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane R-CFA-5218920 VEGFR2 mediated vascular permeability

Reactomeⁱ

R-CFA-203615 eNOS activation
R-CFA-203641 NOSTRIN mediated eNOS trafficking
R-CFA-210991 Basigin interactions
R-CFA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-CFA-5218920 VEGFR2 mediated vascular permeability

Gene expression databases

Bgeeⁱ	ENSCAFG00000003404 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Bgeeⁱ

ENSCAFG00000003404 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

InterProⁱ	View protein in InterPro IPR015504 CAV-1 IPR001612 Caveolin IPR018361 Caveolin_CS
PANTHERⁱ	PTHR10844 PTHR10844, 1 hit PTHR10844:SF18 PTHR10844:SF18, 1 hit
Pfamⁱ	View protein in Pfam PF01146 Caveolin, 1 hit
PROSITEⁱ	View protein in PROSITE PS01210 CAVEOLIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CAV1_CANLF
Accessionⁱ	P33724Primary (citable) accession number: P33724 Secondary accession number(s): A0M8U8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
	Last sequence update:	February 1, 1994
	Last modified:	September 12, 2018
	This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

Help

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Proteomes

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Supporting data

UniProtKB - P33724 (CAV1_CANLF)

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Caveolin-1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Golgi apparatus

Other locations

Endoplasmic reticulum

Endosome

Golgi apparatus

Plasma Membrane

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

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Enzyme and pathway databases

Gene expression databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ