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Protein

Caveolin-1

Gene

CAV1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation.Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CFA-203615 eNOS activation
R-CFA-203641 NOSTRIN mediated eNOS trafficking
R-CFA-210991 Basigin interactions
R-CFA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-CFA-5218920 VEGFR2 mediated vascular permeability

Names & Taxonomyi

Protein namesi
Recommended name:
Caveolin-1
Alternative name(s):
Vesicular integral-membrane protein VIP21
Gene namesi
Name:CAV1
Synonyms:CAV
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 14

Organism-specific databases

VGNCiVGNC:38751 CAV1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 104CytoplasmicSequence analysisAdd BLAST103
Intramembranei105 – 125HelicalSequence analysisAdd BLAST21
Topological domaini126 – 178CytoplasmicSequence analysisAdd BLAST53

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000047622 – 178Caveolin-1Add BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei5N6-acetyllysine; alternateBy similarity1
Cross-linki5Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Modified residuei6PhosphotyrosineBy similarity1
Modified residuei9PhosphoserineBy similarity1
Modified residuei14Phosphotyrosine; by ABL1By similarity1
Modified residuei25PhosphotyrosineBy similarity1
Cross-linki26Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki30Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei37PhosphoserineBy similarity1
Cross-linki39Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki47Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki57Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Lipidationi133S-palmitoyl cysteine1 Publication1
Lipidationi143S-palmitoyl cysteine1 Publication1
Lipidationi156S-palmitoyl cysteine1 Publication1

Post-translational modificationi

Phosphorylation of isoform Beta on serine residues is constitutive. Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress (By similarity).By similarity
Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP33724
PRIDEiP33724

PTM databases

iPTMnetiP33724
SwissPalmiP33724

Expressioni

Gene expression databases

BgeeiENSCAFG00000003404 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Interactioni

Subunit structurei

Homooligomer (PubMed:7568142). Interacts with BMX, BTK, GLIPR2, NOSTRIN, SNAP25 and STX1A. Interacts with PACSIN2. Interacts (via the N-terminus) with DPP4; the interaction is direct. Interacts with SLC7A9 (By similarity). Interacts with CTNNB1, CDH1 and JUP (PubMed:10816572). Interacts with TGFBR1. Interacts with CAVIN3 (via leucine-zipper domain) in a cholesterol-sensitive manner. Interacts with CAVIN1. Interacts with EHD2 in a cholesterol-dependent manner (By similarity). Forms a ternary complex with UBXN6 and VCP; mediates CAV1 targeting to lysosomes for degradation (By similarity).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CTNNB1P352225EBI-79998,EBI-491549From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi139896, 3 interactors
IntActiP33724, 5 interactors
STRINGi9615.ENSCAFP00000005060

Structurei

3D structure databases

SMRiP33724
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 94Required for homooligomerizationBy similarityAdd BLAST93
Regioni82 – 94Interaction with CAVIN3By similarityAdd BLAST13

Sequence similaritiesi

Belongs to the caveolin family.Curated

Phylogenomic databases

eggNOGiENOG410IV7A Eukaryota
ENOG4111HJR LUCA
GeneTreeiENSGT00390000014924
HOGENOMiHOG000036550
HOVERGENiHBG003422
InParanoidiP33724
KOiK06278
OMAiIYVHTFC
OrthoDBiEOG091G0M1R
TreeFamiTF315736

Family and domain databases

InterProiView protein in InterPro
IPR015504 CAV-1
IPR001612 Caveolin
IPR018361 Caveolin_CS
PANTHERiPTHR10844 PTHR10844, 1 hit
PTHR10844:SF18 PTHR10844:SF18, 1 hit
PfamiView protein in Pfam
PF01146 Caveolin, 1 hit
PROSITEiView protein in PROSITE
PS01210 CAVEOLIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket
Isoform Alpha (identifier: P33724-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMAEEMSEKQ VYDAHTKEID
60 70 80 90 100
LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY
110 120 130 140 150
RLLSALFGIP MALIWGIYFA ILSFLHIWAV VPCIKSFLIE IQCISRVYSI
160 170
YVHTFCDPFF EAVGKIFSNI RINMQKET
Length:178
Mass (Da):20,606
Last modified:February 1, 1994 - v1
Checksum:iDD77CE4D436E508D
GO
Isoform Beta (identifier: P33724-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Show »
Length:147
Mass (Da):17,157
Checksum:iE32E90B50FFC5B1F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0186911 – 31Missing in isoform Beta. CuratedAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12161 Genomic DNA Translation: CAA78151.1
U47060 mRNA Translation: AAA87050.1
DP000236 Genomic DNA Translation: AAR16266.1
PIRiA43419
RefSeqiNP_001003296.1, NM_001003296.1 [P33724-1]
XP_005628404.1, XM_005628347.2 [P33724-2]
XP_013974350.1, XM_014118875.1 [P33724-2]
UniGeneiCfa.3850

Genome annotation databases

EnsembliENSCAFT00000005462; ENSCAFP00000005060; ENSCAFG00000003404 [P33724-1]
GeneIDi403980
KEGGicfa:403980

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12161 Genomic DNA Translation: CAA78151.1
U47060 mRNA Translation: AAA87050.1
DP000236 Genomic DNA Translation: AAR16266.1
PIRiA43419
RefSeqiNP_001003296.1, NM_001003296.1 [P33724-1]
XP_005628404.1, XM_005628347.2 [P33724-2]
XP_013974350.1, XM_014118875.1 [P33724-2]
UniGeneiCfa.3850

3D structure databases

SMRiP33724
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi139896, 3 interactors
IntActiP33724, 5 interactors
STRINGi9615.ENSCAFP00000005060

PTM databases

iPTMnetiP33724
SwissPalmiP33724

Proteomic databases

PaxDbiP33724
PRIDEiP33724

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000005462; ENSCAFP00000005060; ENSCAFG00000003404 [P33724-1]
GeneIDi403980
KEGGicfa:403980

Organism-specific databases

CTDi857
VGNCiVGNC:38751 CAV1

Phylogenomic databases

eggNOGiENOG410IV7A Eukaryota
ENOG4111HJR LUCA
GeneTreeiENSGT00390000014924
HOGENOMiHOG000036550
HOVERGENiHBG003422
InParanoidiP33724
KOiK06278
OMAiIYVHTFC
OrthoDBiEOG091G0M1R
TreeFamiTF315736

Enzyme and pathway databases

ReactomeiR-CFA-203615 eNOS activation
R-CFA-203641 NOSTRIN mediated eNOS trafficking
R-CFA-210991 Basigin interactions
R-CFA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-CFA-5218920 VEGFR2 mediated vascular permeability

Gene expression databases

BgeeiENSCAFG00000003404 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

InterProiView protein in InterPro
IPR015504 CAV-1
IPR001612 Caveolin
IPR018361 Caveolin_CS
PANTHERiPTHR10844 PTHR10844, 1 hit
PTHR10844:SF18 PTHR10844:SF18, 1 hit
PfamiView protein in Pfam
PF01146 Caveolin, 1 hit
PROSITEiView protein in PROSITE
PS01210 CAVEOLIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAV1_CANLF
AccessioniPrimary (citable) accession number: P33724
Secondary accession number(s): A0M8U8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 12, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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