Caveolin-1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATPase binding Source: Ensembl
• identical protein binding Source: Ensembl
• inward rectifier potassium channel inhibitor activity Source: Ensembl
• ion channel binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• nitric-oxide synthase binding Source: Ensembl
• peptidase activator activity Source: Ensembl
• protein binding, bridging Source: Ensembl
• protein-containing complex binding Source: Ensembl
• protein heterodimerization activity Source: Ensembl
• protein kinase binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• Rac GTPase binding Source: Ensembl
• signaling receptor binding Source: Ensembl

GO - Biological processⁱ

• angiogenesis Source: Ensembl
• angiotensin-activated signaling pathway involved in heart process Source: Ensembl
• apoptotic signaling pathway Source: Ensembl
• basement membrane organization Source: Ensembl
• calcium ion transport Source: Ensembl
• caveola assembly Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "The phosphorylation of caveolin-2 on serines 23 and 36 modulates caveolin-1-dependent caveolae formation."
    Sowa G., Pypaert M., Fulton D., Sessa W.C.
    Proc. Natl. Acad. Sci. U.S.A. 100:6511-6516(2003) [PubMed] [Europe PMC] [Abstract]
• caveolin-mediated endocytosis Source: Ensembl
• cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular calcium ion homeostasis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to exogenous dsRNA Source: Ensembl
• cellular response to hyperoxia Source: Ensembl
• cellular response to transforming growth factor beta stimulus Source: Ensembl
• cholesterol homeostasis Source: Ensembl
• inactivation of MAPK activity Source: Ensembl
• lactation Source: Ensembl
• lipid storage Source: Ensembl
• mammary gland involution Source: Ensembl
• membrane depolarization Source: Ensembl
• negative regulation of anoikis Source: Ensembl
• negative regulation of canonical Wnt signaling pathway Source: Ensembl
• negative regulation of cytokine-mediated signaling pathway Source: Ensembl
• negative regulation of endothelial cell proliferation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of epithelial cell differentiation Source: Ensembl
• negative regulation of inward rectifier potassium channel activity Source: Ensembl
• negative regulation of necroptotic process Source: Ensembl
• negative regulation of nitric oxide biosynthetic process Source: Ensembl
• negative regulation of nitric-oxide synthase activity Source: Ensembl
• negative regulation of peptidyl-serine phosphorylation Source: Ensembl
• negative regulation of peptidyl-tyrosine autophosphorylation Source: Ensembl
• negative regulation of pinocytosis Source: Ensembl
• negative regulation of protein binding Source: Ensembl
• negative regulation of protein tyrosine kinase activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of protein ubiquitination Source: Ensembl
• negative regulation of transcription by RNA polymerase II Source: Ensembl
• negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
• negative regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
• nitric oxide homeostasis Source: Ensembl
• positive regulation of calcium ion transport into cytosol Source: Ensembl
• positive regulation of canonical Wnt signaling pathway Source: Ensembl
• positive regulation of cell adhesion molecule production Source: Ensembl
• positive regulation of cell migration Source: Ensembl
• positive regulation of cold-induced thermogenesis Source: Ensembl
• positive regulation of ER-associated ubiquitin-dependent protein catabolic process Source: Ensembl
• positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
• positive regulation of gap junction assembly Source: Ensembl
• positive regulation of gene expression Source: Ensembl
• positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
• positive regulation of NF-kappaB transcription factor activity Source: Ensembl
• positive regulation of peptidyl-serine phosphorylation Source: Ensembl
• positive regulation of protein binding Source: Ensembl
• positive regulation of protein ubiquitination Source: Ensembl
• positive regulation of toll-like receptor 3 signaling pathway Source: Ensembl
• positive regulation of vasoconstriction Source: Ensembl
• posttranscriptional regulation of gene expression Source: Ensembl
• protein localization to basolateral plasma membrane Source: BHF-UCLInferred from direct assayⁱ
  • "The phosphorylation of caveolin-2 on serines 23 and 36 modulates caveolin-1-dependent caveolae formation."
    Sowa G., Pypaert M., Fulton D., Sessa W.C.
    Proc. Natl. Acad. Sci. U.S.A. 100:6511-6516(2003) [PubMed] [Europe PMC] [Abstract]
• protein localization to plasma membrane raft Source: BHF-UCLInferred from direct assayⁱ
  • "The phosphorylation of caveolin-2 on serines 23 and 36 modulates caveolin-1-dependent caveolae formation."
    Sowa G., Pypaert M., Fulton D., Sessa W.C.
    Proc. Natl. Acad. Sci. U.S.A. 100:6511-6516(2003) [PubMed] [Europe PMC] [Abstract]
• receptor internalization Source: UniProtKB
• receptor internalization involved in canonical Wnt signaling pathway Source: Ensembl
• receptor-mediated endocytosis of virus by host cell Source: Ensembl
• regulation of blood coagulation Source: Ensembl
• regulation of cell communication by electrical coupling involved in cardiac conduction Source: Ensembl
• regulation of entry of bacterium into host cell Source: Ensembl
• regulation of fatty acid metabolic process Source: Ensembl
• regulation of heart rate by cardiac conduction Source: Ensembl
• regulation of membrane repolarization during action potential Source: Ensembl
• regulation of ruffle assembly Source: Ensembl
• regulation of smooth muscle contraction Source: Ensembl
• regulation of the force of heart contraction by chemical signal Source: Ensembl
• regulation of ventricular cardiac muscle cell action potential Source: Ensembl
• response to bacterium Source: Ensembl
• response to calcium ion Source: Ensembl
• response to estrogen Source: Ensembl
• response to hypoxia Source: Ensembl
• response to ischemia Source: Ensembl
• response to progesterone Source: Ensembl
• skeletal muscle tissue development Source: Ensembl
• T cell costimulation Source: UniProtKB
• triglyceride metabolic process Source: Ensembl
• vasculogenesis Source: Ensembl
• vasoconstriction Source: Ensembl
• vesicle organization Source: BHF-UCLInferred from direct assayⁱ
  • "The phosphorylation of caveolin-2 on serines 23 and 36 modulates caveolin-1-dependent caveolae formation."
    Sowa G., Pypaert M., Fulton D., Sessa W.C.
    Proc. Natl. Acad. Sci. U.S.A. 100:6511-6516(2003) [PubMed] [Europe PMC] [Abstract]

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• ATPase binding Source: Ensembl
• identical protein binding Source: Ensembl
• ion channel binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• nitric-oxide synthase binding Source: Ensembl
• protein binding, bridging Source: Ensembl
• protein heterodimerization activity Source: Ensembl
• protein kinase binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• Rac GTPase binding Source: Ensembl
• signaling receptor binding Source: Ensembl

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMAEEMSEKQ VYDAHTKEID 
        60         70         80         90        100
LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY 
       110        120        130        140        150
RLLSALFGIP MALIWGIYFA ILSFLHIWAV VPCIKSFLIE IQCISRVYSI 
       160        170 
YVHTFCDPFF EAVGKIFSNI RINMQKET                         

        10         20         30         40         50
MAEEMSEKQV YDAHTKEIDL VNRDPKHLND DVVKIDFEDV IAEPEGTHSF 
        60         70         80         90        100
DGIWKASFTT FTVTKYWFYR LLSALFGIPM ALIWGIYFAI LSFLHIWAVV 
       110        120        130        140 
PCIKSFLIEI QCISRVYSIY VHTFCDPFFE AVGKIFSNIR INMQKET    

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families