UniProtKB - P33724 (CAV1_CANLF)
Caveolin-1
CAV1
Functioni
GO - Molecular functioni
- ATPase binding Source: Ensembl
- identical protein binding Source: Ensembl
- inward rectifier potassium channel inhibitor activity Source: Ensembl
- ion channel binding Source: GO_Central
- molecular adaptor activity Source: GO_Central
- nitric-oxide synthase binding Source: Ensembl
- peptidase activator activity Source: Ensembl
- protein-containing complex binding Source: Ensembl
- protein heterodimerization activity Source: Ensembl
- protein kinase binding Source: GO_Central
- protein-macromolecule adaptor activity Source: Ensembl
- Rac GTPase binding Source: Ensembl
- signaling receptor binding Source: Ensembl
GO - Biological processi
- angiogenesis Source: Ensembl
- angiotensin-activated signaling pathway involved in heart process Source: Ensembl
- apoptotic signaling pathway Source: Ensembl
- basement membrane organization Source: Ensembl
- calcium ion transport Source: Ensembl
- caveola assembly Source: BHF-UCL
- caveolin-mediated endocytosis Source: Ensembl
- cell differentiation Source: GO_Central
- cellular response to exogenous dsRNA Source: Ensembl
- cellular response to hyperoxia Source: Ensembl
- cellular response to transforming growth factor beta stimulus Source: Ensembl
- cholesterol homeostasis Source: Ensembl
- inactivation of MAPK activity Source: Ensembl
- insulin receptor internalization Source: Ensembl
- lactation Source: Ensembl
- lipid storage Source: Ensembl
- mammary gland involution Source: Ensembl
- membrane depolarization Source: Ensembl
- negative regulation of anoikis Source: Ensembl
- negative regulation of canonical Wnt signaling pathway Source: Ensembl
- negative regulation of cytokine-mediated signaling pathway Source: Ensembl
- negative regulation of endothelial cell proliferation Source: GO_Central
- negative regulation of epithelial cell differentiation Source: Ensembl
- negative regulation of inward rectifier potassium channel activity Source: Ensembl
- negative regulation of necroptotic process Source: Ensembl
- negative regulation of nitric oxide biosynthetic process Source: Ensembl
- negative regulation of nitric-oxide synthase activity Source: Ensembl
- negative regulation of peptidyl-serine phosphorylation Source: Ensembl
- negative regulation of peptidyl-tyrosine autophosphorylation Source: Ensembl
- negative regulation of pinocytosis Source: Ensembl
- negative regulation of protein binding Source: Ensembl
- negative regulation of protein tyrosine kinase activity Source: GO_Central
- negative regulation of protein ubiquitination Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
- negative regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
- nitric oxide homeostasis Source: Ensembl
- positive regulation of calcium ion transport into cytosol Source: Ensembl
- positive regulation of canonical Wnt signaling pathway Source: Ensembl
- positive regulation of cell adhesion molecule production Source: Ensembl
- positive regulation of cell migration Source: Ensembl
- positive regulation of cholesterol efflux Source: Ensembl
- positive regulation of cold-induced thermogenesis Source: Ensembl
- positive regulation of ER-associated ubiquitin-dependent protein catabolic process Source: Ensembl
- positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
- positive regulation of gap junction assembly Source: Ensembl
- positive regulation of gene expression Source: Ensembl
- positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
- positive regulation of NF-kappaB transcription factor activity Source: Ensembl
- positive regulation of peptidyl-serine phosphorylation Source: Ensembl
- positive regulation of protein binding Source: Ensembl
- positive regulation of protein ubiquitination Source: Ensembl
- positive regulation of toll-like receptor 3 signaling pathway Source: Ensembl
- positive regulation of vasoconstriction Source: Ensembl
- posttranscriptional regulation of gene expression Source: Ensembl
- protein localization to basolateral plasma membrane Source: BHF-UCL
- protein localization to plasma membrane raft Source: BHF-UCL
- receptor internalization Source: UniProtKB
- receptor internalization involved in canonical Wnt signaling pathway Source: Ensembl
- receptor-mediated endocytosis of virus by host cell Source: Ensembl
- regulation of blood coagulation Source: Ensembl
- regulation of cell communication by electrical coupling involved in cardiac conduction Source: Ensembl
- regulation of cytosolic calcium ion concentration Source: GO_Central
- regulation of entry of bacterium into host cell Source: Ensembl
- regulation of fatty acid metabolic process Source: Ensembl
- regulation of heart rate by cardiac conduction Source: Ensembl
- regulation of membrane repolarization during action potential Source: Ensembl
- regulation of ruffle assembly Source: Ensembl
- regulation of smooth muscle contraction Source: Ensembl
- regulation of the force of heart contraction by chemical signal Source: Ensembl
- regulation of ventricular cardiac muscle cell action potential Source: Ensembl
- response to bacterium Source: Ensembl
- response to calcium ion Source: Ensembl
- response to estrogen Source: Ensembl
- response to hypoxia Source: Ensembl
- response to ischemia Source: Ensembl
- response to progesterone Source: Ensembl
- skeletal muscle tissue development Source: Ensembl
- T cell costimulation Source: UniProtKB
- triglyceride metabolic process Source: Ensembl
- vasculogenesis Source: Ensembl
- vasoconstriction Source: Ensembl
- vesicle organization Source: BHF-UCL
Enzyme and pathway databases
Reactomei | R-CFA-203641, NOSTRIN mediated eNOS trafficking R-CFA-210991, Basigin interactions R-CFA-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane R-CFA-9009391, Extra-nuclear estrogen signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Caveolin-1Alternative name(s): Vesicular integral-membrane protein VIP21 |
Gene namesi | Name:CAV1 Synonyms:CAV |
Organismi | Canis lupus familiaris (Dog) (Canis familiaris) |
Taxonomic identifieri | 9615 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:38751, CAV1 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity
Golgi apparatus
- Golgi apparatus membrane By similarity; Peripheral membrane protein By similarity
- trans-Golgi network 1 Publication
Other locations
- caveola 2 Publications; Peripheral membrane protein By similarity
- Membrane raft By similarity
Note: Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: Ensembl
Endosome
- endosome Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: GO_Central
- Golgi membrane Source: UniProtKB-SubCell
Plasma Membrane
- caveola Source: UniProtKB
- caveolar macromolecular signaling complex Source: Ensembl
- integral component of plasma membrane Source: GO_Central
Other locations
- acrosomal membrane Source: Ensembl
- cell cortex Source: Ensembl
- cilium Source: Ensembl
- cytoplasmic vesicle Source: GO_Central
- exocytic vesicle Source: CAFA
- focal adhesion Source: Ensembl
- perinuclear region of cytoplasm Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 2 – 104 | CytoplasmicSequence analysisAdd BLAST | 103 | |
Intramembranei | 105 – 125 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 126 – 178 | CytoplasmicSequence analysisAdd BLAST | 53 |
Keywords - Cellular componenti
Cell membrane, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000004762 | 2 – 178 | Caveolin-1Add BLAST | 177 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 2 | PhosphoserineBy similarity | 1 | |
Modified residuei | 5 | N6-acetyllysine; alternateBy similarity | 1 | |
Cross-linki | 5 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity | ||
Modified residuei | 6 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 9 | PhosphoserineBy similarity | 1 | |
Modified residuei | 14 | Phosphotyrosine; by ABL1By similarity | 1 | |
Modified residuei | 25 | PhosphotyrosineBy similarity | 1 | |
Cross-linki | 26 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Cross-linki | 30 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Modified residuei | 37 | PhosphoserineBy similarity | 1 | |
Cross-linki | 39 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Cross-linki | 47 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Cross-linki | 57 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Lipidationi | 133 | S-palmitoyl cysteine1 Publication | 1 | |
Lipidationi | 143 | S-palmitoyl cysteine1 Publication | 1 | |
Lipidationi | 156 | S-palmitoyl cysteine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | P33724 |
PRIDEi | P33724 |
PTM databases
iPTMneti | P33724 |
SwissPalmi | P33724 |
Expressioni
Gene expression databases
Bgeei | ENSCAFG00000003404, Expressed in lung and 51 other tissues |
Interactioni
Subunit structurei
Homooligomer (PubMed:7568142).
Interacts with BMX, BTK, GLIPR2, NOSTRIN, SNAP25 and STX1A.
Interacts with PACSIN2; this interaction induces membrane tubulation (By similarity).
Interacts (via the N-terminus) with DPP4; the interaction is direct.
Interacts with SLC7A9 (By similarity).
Interacts with CTNNB1, CDH1 and JUP (PubMed:10816572).
Interacts with TGFBR1.
Interacts with CAVIN3 (via leucine-zipper domain) in a cholesterol-sensitive manner.
Interacts with CAVIN1.
Interacts with EHD2 in a cholesterol-dependent manner (By similarity).
Forms a ternary complex with UBXN6 and VCP; mediates CAV1 targeting to lysosomes for degradation (By similarity).
Interacts with ABCG1; this interaction regulates ABCG1-mediated cholesterol efflux (By similarity).
Interacts with NEU3; this interaction enhances NEU3 sialidase activity within caveola.
By similarity2 PublicationsBinary interactionsi
Hide detailsP33724
With | #Exp. | IntAct |
---|---|---|
3a [P59632] from Severe acute respiratory syndrome coronavirus. | 5 | EBI-79998,EBI-15595051 |
CTNNB1 [P35222] from Homo sapiens. | 5 | EBI-79998,EBI-491549 |
GO - Molecular functioni
- ATPase binding Source: Ensembl
- identical protein binding Source: Ensembl
- ion channel binding Source: GO_Central
- nitric-oxide synthase binding Source: Ensembl
- protein heterodimerization activity Source: Ensembl
- protein kinase binding Source: GO_Central
- Rac GTPase binding Source: Ensembl
- signaling receptor binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 139896, 3 interactors |
IntActi | P33724, 6 interactors |
STRINGi | 9612.ENSCAFP00000005060 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 94 | Required for homooligomerizationBy similarityAdd BLAST | 93 | |
Regioni | 82 – 94 | Interaction with CAVIN3By similarityAdd BLAST | 13 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502QUK5, Eukaryota |
GeneTreei | ENSGT00950000183006 |
HOGENOMi | CLU_102582_0_0_1 |
InParanoidi | P33724 |
OMAi | SIRINMQ |
OrthoDBi | 1468974at2759 |
TreeFami | TF315736 |
Family and domain databases
InterProi | View protein in InterPro IPR015504, CAV-1 IPR001612, Caveolin IPR018361, Caveolin_CS |
PANTHERi | PTHR10844, PTHR10844, 1 hit PTHR10844:SF18, PTHR10844:SF18, 1 hit |
Pfami | View protein in Pfam PF01146, Caveolin, 1 hit |
PROSITEi | View protein in PROSITE PS01210, CAVEOLIN, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative initiation. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMAEEMSEKQ VYDAHTKEID
60 70 80 90 100
LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY
110 120 130 140 150
RLLSALFGIP MALIWGIYFA ILSFLHIWAV VPCIKSFLIE IQCISRVYSI
160 170
YVHTFCDPFF EAVGKIFSNI RINMQKET
The sequence of this isoform differs from the canonical sequence as follows:
1-31: Missing.
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A5F4D7T0 | A0A5F4D7T0_CANLF | Caveolin | CAV1 | 178 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018691 | 1 – 31 | Missing in isoform Beta. CuratedAdd BLAST | 31 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z12161 Genomic DNA Translation: CAA78151.1 U47060 mRNA Translation: AAA87050.1 DP000236 Genomic DNA Translation: AAR16266.1 |
PIRi | A43419 |
RefSeqi | NP_001003296.1, NM_001003296.1 [P33724-1] XP_005628404.1, XM_005628347.2 [P33724-2] XP_013974350.1, XM_014118875.1 [P33724-2] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative initiationSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z12161 Genomic DNA Translation: CAA78151.1 U47060 mRNA Translation: AAA87050.1 DP000236 Genomic DNA Translation: AAR16266.1 |
PIRi | A43419 |
RefSeqi | NP_001003296.1, NM_001003296.1 [P33724-1] XP_005628404.1, XM_005628347.2 [P33724-2] XP_013974350.1, XM_014118875.1 [P33724-2] |
3D structure databases
SMRi | P33724 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 139896, 3 interactors |
IntActi | P33724, 6 interactors |
STRINGi | 9612.ENSCAFP00000005060 |
PTM databases
iPTMneti | P33724 |
SwissPalmi | P33724 |
Proteomic databases
PaxDbi | P33724 |
PRIDEi | P33724 |
Genome annotation databases
Organism-specific databases
CTDi | 857 |
VGNCi | VGNC:38751, CAV1 |
Phylogenomic databases
eggNOGi | ENOG502QUK5, Eukaryota |
GeneTreei | ENSGT00950000183006 |
HOGENOMi | CLU_102582_0_0_1 |
InParanoidi | P33724 |
OMAi | SIRINMQ |
OrthoDBi | 1468974at2759 |
TreeFami | TF315736 |
Enzyme and pathway databases
Reactomei | R-CFA-203641, NOSTRIN mediated eNOS trafficking R-CFA-210991, Basigin interactions R-CFA-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane R-CFA-9009391, Extra-nuclear estrogen signaling |
Gene expression databases
Bgeei | ENSCAFG00000003404, Expressed in lung and 51 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR015504, CAV-1 IPR001612, Caveolin IPR018361, Caveolin_CS |
PANTHERi | PTHR10844, PTHR10844, 1 hit PTHR10844:SF18, PTHR10844:SF18, 1 hit |
Pfami | View protein in Pfam PF01146, Caveolin, 1 hit |
PROSITEi | View protein in PROSITE PS01210, CAVEOLIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CAV1_CANLF | |
Accessioni | P33724Primary (citable) accession number: P33724 Secondary accession number(s): A0M8U8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | February 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 181 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families