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Entry version 147 (02 Jun 2021)
Sequence version 2 (27 Jul 2011)
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Protein

DNA polymerase alpha subunit B

Gene

Pola2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (By similarity).

During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity).

The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA replication

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-113501, Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-MMU-174411, Polymerase switching on the C-strand of the telomere
R-MMU-174430, Telomere C-strand synthesis initiation
R-MMU-68952, DNA replication initiation
R-MMU-68962, Activation of the pre-replicative complex
R-MMU-69091, Polymerase switching
R-MMU-69166, Removal of the Flap Intermediate
R-MMU-69183, Processive synthesis on the lagging strand

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase alpha subunit B
Alternative name(s):
DNA polymerase alpha 70 kDa subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pola2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:99690, Pola2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001940361 – 600DNA polymerase alpha subunit BAdd BLAST600

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei126PhosphoserineBy similarity1
Modified residuei127PhosphothreonineCombined sources1
Modified residuei130PhosphothreonineCombined sources1
Modified residuei141PhosphoserineBy similarity1
Modified residuei147PhosphoserineBy similarity1
Modified residuei152PhosphoserineBy similarity1
Modified residuei154PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated in a cell cycle-dependent manner, in G2/M phase.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P33611

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P33611

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P33611

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P33611

PeptideAtlas

More...
PeptideAtlasi
P33611

PRoteomics IDEntifications database

More...
PRIDEi
P33611

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
277386

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P33611

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P33611

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024833, Expressed in telencephalon ventricular layer (mouse) and 293 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P33611, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P33611, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the alpha DNA polymerase complex (also known as the alpha DNA polymerase-primase complex) consisting of four subunits: the catalytic subunit POLA1, the regulatory subunit POLA2, and the primase complex subunits PRIM1 and PRIM2 respectively (By similarity). Within the complex, POLA1 directly interacts with PRIM2 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
202288, 3 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-2088, DNA polymerase alpha:primase complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P33611

Protein interaction database and analysis system

More...
IntActi
P33611, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000025752

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P33611, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P33611

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni107 – 165DisorderedSequence analysisAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi109 – 134Polar residuesSequence analysisAdd BLAST26
Compositional biasi140 – 165Polar residuesSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1625, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016784

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014923_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P33611

Identification of Orthologs from Complete Genome Data

More...
OMAi
PFLDIEH

Database of Orthologous Groups

More...
OrthoDBi
513979at2759

TreeFam database of animal gene trees

More...
TreeFami
TF314249

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.8.530, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007185, DNA_pol_a/d/e_bsu
IPR043034, DNA_pol_alpha_B_N_sf
IPR016722, DNA_pol_alpha_bsu
IPR013627, Pol_alpha_B_N

The PANTHER Classification System

More...
PANTHERi
PTHR23061, PTHR23061, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04042, DNA_pol_E_B, 1 hit
PF08418, Pol_alpha_B_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF018300, DNA_pol_alph_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P33611-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVSTQQLAE ELQIFGLDYE DSLLEKLAEL CVLYRQTEDG MVSELIAFCT
60 70 80 90 100
SAGKTCLTVD ILNSFEYEVL NKKLSKAWHS ASKDSGHAGT RDIVSIQELI
110 120 130 140 150
EAEEEEETLL SSYTTPSKGP LKRVSSTPET PLTKRSVAAR SPRQLLSPSS
160 170 180 190 200
FSPSATPSQK YTSRTNRGEV VTTFGSAQGL SWSGRGGSGS VSLKVVGDPE
210 220 230 240 250
PLTGSYKAMF QQLMGVREVL TSKIEELGSE LKEHHKIEAF TPLLVPAQEP
260 270 280 290 300
VILLGQIGCD SNGKLNSKSV ILEGDQEHSY GAQIPVDLSE LKEYSLFPGQ
310 320 330 340 350
VVIMEGFNTT GRRLTATKLY EGVPLPFYQP TEEEGASEQT MVVVACGPYT
360 370 380 390 400
TSDSITYDPL LDLIAIINRD QPDVCILFGP FLDAKHEQVE NCKLTSPFED
410 420 430 440 450
VFKQCLRTVI EGTRSSGSHL VFVPSLRDVH HEPVYPQPPF TFSELSREDK
460 470 480 490 500
KRVQFVSEPC SLSINGVMFG LTSTDLLFHI GAEEIFSSSG TSDRFSRVLK
510 520 530 540 550
HILTQRSYYP LYPPHEDMAI DYENFYTYAQ LPVTPDVFIV PSELRYFVKD
560 570 580 590 600
IFGCVCVNPG RLTKGQVGGT FGRLYLRRQP KAMDGGGRQG LSVAAQVVRI
Length:600
Mass (Da):66,214
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i79F94443EF33FAA9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8C2T6Q8C2T6_MOUSE
DNA polymerase alpha subunit B
Pola2
566Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494B9D2A0A494B9D2_MOUSE
DNA polymerase alpha subunit B
Pola2
417Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494B956A0A494B956_MOUSE
DNA polymerase alpha subunit B
Pola2
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494B9Z2A0A494B9Z2_MOUSE
DNA polymerase alpha subunit B
Pola2
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti346C → R in BAA02746 (PubMed:8463324).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D13546 mRNA Translation: BAA02746.1
AK150099 mRNA Translation: BAE29306.1
CH466612 Genomic DNA Translation: EDL33190.1
BC021424 mRNA Translation: AAH21424.1
BC064795 mRNA Translation: AAH64795.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS29485.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B46642

NCBI Reference Sequences

More...
RefSeqi
NP_032919.2, NM_008893.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000025752; ENSMUSP00000025752; ENSMUSG00000024833

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
18969

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:18969

UCSC genome browser

More...
UCSCi
uc008ggb.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13546 mRNA Translation: BAA02746.1
AK150099 mRNA Translation: BAE29306.1
CH466612 Genomic DNA Translation: EDL33190.1
BC021424 mRNA Translation: AAH21424.1
BC064795 mRNA Translation: AAH64795.1
CCDSiCCDS29485.1
PIRiB46642
RefSeqiNP_032919.2, NM_008893.3

3D structure databases

SMRiP33611
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi202288, 3 interactors
ComplexPortaliCPX-2088, DNA polymerase alpha:primase complex
CORUMiP33611
IntActiP33611, 3 interactors
STRINGi10090.ENSMUSP00000025752

PTM databases

iPTMnetiP33611
PhosphoSitePlusiP33611

Proteomic databases

EPDiP33611
jPOSTiP33611
MaxQBiP33611
PaxDbiP33611
PeptideAtlasiP33611
PRIDEiP33611
ProteomicsDBi277386

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
18969

Genome annotation databases

EnsembliENSMUST00000025752; ENSMUSP00000025752; ENSMUSG00000024833
GeneIDi18969
KEGGimmu:18969
UCSCiuc008ggb.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23649
MGIiMGI:99690, Pola2

Phylogenomic databases

eggNOGiKOG1625, Eukaryota
GeneTreeiENSGT00390000016784
HOGENOMiCLU_014923_3_1_1
InParanoidiP33611
OMAiPFLDIEH
OrthoDBi513979at2759
TreeFamiTF314249

Enzyme and pathway databases

ReactomeiR-MMU-113501, Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-MMU-174411, Polymerase switching on the C-strand of the telomere
R-MMU-174430, Telomere C-strand synthesis initiation
R-MMU-68952, DNA replication initiation
R-MMU-68962, Activation of the pre-replicative complex
R-MMU-69091, Polymerase switching
R-MMU-69166, Removal of the Flap Intermediate
R-MMU-69183, Processive synthesis on the lagging strand

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
18969, 19 hits in 53 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Pola2, mouse

Protein Ontology

More...
PROi
PR:P33611
RNActiP33611, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000024833, Expressed in telencephalon ventricular layer (mouse) and 293 other tissues
ExpressionAtlasiP33611, baseline and differential
GenevisibleiP33611, MM

Family and domain databases

Gene3Di1.10.8.530, 1 hit
InterProiView protein in InterPro
IPR007185, DNA_pol_a/d/e_bsu
IPR043034, DNA_pol_alpha_B_N_sf
IPR016722, DNA_pol_alpha_bsu
IPR013627, Pol_alpha_B_N
PANTHERiPTHR23061, PTHR23061, 1 hit
PfamiView protein in Pfam
PF04042, DNA_pol_E_B, 1 hit
PF08418, Pol_alpha_B_N, 1 hit
PIRSFiPIRSF018300, DNA_pol_alph_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPOA2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P33611
Secondary accession number(s): Q8VDR3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: July 27, 2011
Last modified: June 2, 2021
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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