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Protein

NADH-quinone oxidoreductase subunit L

Gene

nuoL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • ATP synthesis coupled electron transport Source: InterPro
  • electron transport coupled proton transport Source: EcoCyc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandNAD, Ubiquinone

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:NUOL-MONOMER
MetaCyc:NUOL-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.D.1.1.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit L (EC:1.6.5.11)
Alternative name(s):
NADH dehydrogenase I subunit L
NDH-1 subunit L
NUO12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nuoL
Ordered Locus Names:b2278, JW2273
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

Escherichia coli strain K12 genome database

More...
EcoGenei
EG12092 nuoL

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 6PeriplasmicSequence analysis6
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 23HelicalSequence analysisAdd BLAST17
Topological domaini24 – 31CytoplasmicSequence analysis8
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Topological domaini53 – 74PeriplasmicSequence analysisAdd BLAST22
Transmembranei75 – 99HelicalSequence analysisAdd BLAST25
Topological domaini100 – 115CytoplasmicSequence analysisAdd BLAST16
Transmembranei116 – 133HelicalSequence analysisAdd BLAST18
Topological domaini134 – 210PeriplasmicSequence analysisAdd BLAST77
Transmembranei211 – 228HelicalSequence analysisAdd BLAST18
Topological domaini229 – 248CytoplasmicSequence analysisAdd BLAST20
Transmembranei249 – 267HelicalSequence analysisAdd BLAST19
Topological domaini268 – 281PeriplasmicSequence analysisAdd BLAST14
Transmembranei282 – 300HelicalSequence analysisAdd BLAST19
Topological domaini301 – 306CytoplasmicSequence analysis6
Transmembranei307 – 325HelicalSequence analysisAdd BLAST19
Topological domaini326 – 338PeriplasmicSequence analysisAdd BLAST13
Transmembranei339 – 356HelicalSequence analysisAdd BLAST18
Topological domaini357 – 373CytoplasmicSequence analysisAdd BLAST17
Transmembranei374 – 397HelicalSequence analysisAdd BLAST24
Topological domaini398 – 413PeriplasmicSequence analysisAdd BLAST16
Transmembranei414 – 437HelicalSequence analysisAdd BLAST24
Topological domaini438 – 454CytoplasmicSequence analysisAdd BLAST17
Transmembranei455 – 472HelicalSequence analysisAdd BLAST18
Topological domaini473 – 494PeriplasmicSequence analysisAdd BLAST22
Transmembranei495 – 514HelicalSequence analysisAdd BLAST20
Topological domaini515 – 589CytoplasmicSequence analysisAdd BLAST75
Transmembranei590 – 607HelicalSequence analysisAdd BLAST18
Topological domaini608 – 613PeriplasmicSequence analysis6

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001182131 – 613NADH-quinone oxidoreductase subunit LAdd BLAST613

Keywords - PTMi

Quinone

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P33607

PRoteomics IDEntifications database

More...
PRIDEi
P33607

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4260888, 94 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-243 Respiratory chain complex I

Database of interacting proteins

More...
DIPi
DIP-10388N

Protein interaction database and analysis system

More...
IntActi
P33607, 1 interactor

STRING: functional protein association networks

More...
STRINGi
316385.ECDH10B_2440

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P33607

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complex I subunit 5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105D65 Bacteria
COG1009 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000100570

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P33607

KEGG Orthology (KO)

More...
KOi
K00341

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P33607

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003945 NADHpl_OxRdtase_5
IPR018393 NADHpl_OxRdtase_5_subgr
IPR001750 ND/Mrp_mem
IPR001516 Proton_antipo_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00361 Proton_antipo_M, 1 hit
PF00662 Proton_antipo_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01435 NPOXDRDTASE5

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01974 NDH_I_L, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P33607-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNMLALTIIL PLIGFVLLAF SRGRWSENVS AIVGVGSVGL AALVTAFIGV
60 70 80 90 100
DFFANGEQTY SQPLWTWMSV GDFNIGFNLV LDGLSLTMLS VVTGVGFLIH
110 120 130 140 150
MYASWYMRGE EGYSRFFAYT NLFIASMVVL VLADNLLLMY LGWEGVGLCS
160 170 180 190 200
YLLIGFYYTD PKNGAAAMKA FVVTRVGDVF LAFALFILYN ELGTLNFREM
210 220 230 240 250
VELAPAHFAD GNNMLMWATL MLLGGAVGKS AQLPLQTWLA DAMAGPTPVS
260 270 280 290 300
ALIHAATMVT AGVYLIARTH GLFLMTPEVL HLVGIVGAVT LLLAGFAALV
310 320 330 340 350
QTDIKRVLAY STMSQIGYMF LALGVQAWDA AIFHLMTHAF FKALLFLASG
360 370 380 390 400
SVILACHHEQ NIFKMGGLRK SIPLVYLCFL VGGAALSALP LVTAGFFSKD
410 420 430 440 450
EILAGAMANG HINLMVAGLV GAFMTSLYTF RMIFIVFHGK EQIHAHAVKG
460 470 480 490 500
VTHSLPLIVL LILSTFVGAL IVPPLQGVLP QTTELAHGSM LTLEITSGVV
510 520 530 540 550
AVVGILLAAW LWLGKRTLVT SIANSAPGRL LGTWWYNAWG FDWLYDKVFV
560 570 580 590 600
KPFLGIAWLL KRDPLNSMMN IPAVLSRFAG KGLLLSENGY LRWYVASMSI
610
GAVVVLALLM VLR
Length:613
Mass (Da):66,438
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B768F6D4F2668A1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti39G → A in CAA48371 (PubMed:7690854).Curated1
Sequence conflicti47 – 58FIGVD…ANGEQ → LSALISSLTASK in CAA48371 (PubMed:7690854).CuratedAdd BLAST12
Sequence conflicti182A → R in CAA48371 (PubMed:7690854).Curated1
Sequence conflicti208F → L in CAA48371 (PubMed:7690854).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X68301 Genomic DNA Translation: CAA48371.1
U00096 Genomic DNA Translation: AAC75338.1
AP009048 Genomic DNA Translation: BAA16106.1

Protein sequence database of the Protein Information Resource

More...
PIRi
D64999

NCBI Reference Sequences

More...
RefSeqi
NP_416781.1, NC_000913.3
WP_001056643.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC75338; AAC75338; b2278
BAA16106; BAA16106; BAA16106

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
945540

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW2273
eco:b2278

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.4458

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68301 Genomic DNA Translation: CAA48371.1
U00096 Genomic DNA Translation: AAC75338.1
AP009048 Genomic DNA Translation: BAA16106.1
PIRiD64999
RefSeqiNP_416781.1, NC_000913.3
WP_001056643.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP33607
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260888, 94 interactors
ComplexPortaliCPX-243 Respiratory chain complex I
DIPiDIP-10388N
IntActiP33607, 1 interactor
STRINGi316385.ECDH10B_2440

Protein family/group databases

TCDBi3.D.1.1.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

Proteomic databases

PaxDbiP33607
PRIDEiP33607

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75338; AAC75338; b2278
BAA16106; BAA16106; BAA16106
GeneIDi945540
KEGGiecj:JW2273
eco:b2278
PATRICifig|1411691.4.peg.4458

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB2016
EcoGeneiEG12092 nuoL

Phylogenomic databases

eggNOGiENOG4105D65 Bacteria
COG1009 LUCA
HOGENOMiHOG000100570
InParanoidiP33607
KOiK00341
PhylomeDBiP33607

Enzyme and pathway databases

BioCyciEcoCyc:NUOL-MONOMER
MetaCyc:NUOL-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P33607

Family and domain databases

InterProiView protein in InterPro
IPR003945 NADHpl_OxRdtase_5
IPR018393 NADHpl_OxRdtase_5_subgr
IPR001750 ND/Mrp_mem
IPR001516 Proton_antipo_N
PfamiView protein in Pfam
PF00361 Proton_antipo_M, 1 hit
PF00662 Proton_antipo_N, 1 hit
PRINTSiPR01435 NPOXDRDTASE5
TIGRFAMsiTIGR01974 NDH_I_L, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUOL_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P33607
Secondary accession number(s): P78254
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 1, 1997
Last modified: December 5, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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