UniProtKB - P33596 (RECX_ECOLI)
Protein
Regulatory protein RecX
Gene
recX
Organism
Escherichia coli (strain K12)
Status
Functioni
Modulates RecA activity through direct physical interaction. Can inhibit both RecA recombinase and coprotease activities. May have a regulatory role during the SOS response. Inhibits DNA strand exchange in vitro.1 Publication
GO - Molecular functioni
- enzyme binding Source: EcoCyc
GO - Biological processi
- cellular response to DNA damage stimulus Source: EcoCyc
- DNA repair Source: UniProtKB-KW
- negative regulation of catalytic activity Source: EcoCyc
- regulation of DNA repair Source: UniProtKB-UniRule
- SOS response Source: EcoCyc
Keywordsi
Biological process | DNA damage, DNA repair, SOS response |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12080-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Regulatory protein RecXAlternative name(s): Protein OraA |
Gene namesi | Name:recX Synonyms:oraA Ordered Locus Names:b2698, JW2668 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm Curated
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000162429 | 1 – 166 | Regulatory protein RecXAdd BLAST | 166 |
Proteomic databases
jPOSTi | P33596 |
PaxDbi | P33596 |
PRIDEi | P33596 |
Expressioni
Inductioni
By DNA damage, via LexA, as part of the SOS response.
Interactioni
Binary interactionsi
P33596
With | #Exp. | IntAct |
---|---|---|
fldA [P61949] | 3 | EBI-1129990,EBI-550021 |
GO - Molecular functioni
- enzyme binding Source: EcoCyc
Protein-protein interaction databases
BioGRIDi | 4259217, 129 interactors 851504, 1 interactor |
DIPi | DIP-10410N |
IntActi | P33596, 5 interactors |
STRINGi | 511145.b2698 |
Family & Domainsi
Sequence similaritiesi
Belongs to the RecX family.Curated
Phylogenomic databases
eggNOGi | COG2137, Bacteria |
HOGENOMi | CLU_066607_3_2_6 |
InParanoidi | P33596 |
PhylomeDBi | P33596 |
Family and domain databases
Gene3Di | 1.10.10.10, 3 hits |
HAMAPi | MF_01114, RecX, 1 hit |
InterProi | View protein in InterPro IPR003783, Regulatory_RecX IPR036388, WH-like_DNA-bd_sf |
PANTHERi | PTHR33602, PTHR33602, 1 hit |
Pfami | View protein in Pfam PF02631, RecX, 1 hit |
i Sequence
Sequence statusi: Complete.
P33596-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTESTSRRPA YARLLDRAVR ILAVRDHSEQ ELRRKLAAPI MGKNGPEEID
60 70 80 90 100
ATAEDYERVI AWCHEHGYLD DSRFVARFIA SRSRKGYGPA RIRQELNQKG
110 120 130 140 150
ISREATEKAM RECDIDWCAL ARDQATRKYG EPLPTVFSEK VKIQRFLLYR
160
GYLMEDIQEI WRNFAD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 19 | V → L in AAA19106 (PubMed:7512687).Curated | 1 | |
Sequence conflicti | 120 | L → P in AAA19106 (PubMed:7512687).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L25853 Unassigned DNA Translation: AAA19106.1 U00096 Genomic DNA Translation: AAC75740.1 AP009048 Genomic DNA Translation: BAA16560.1 |
PIRi | F65049 |
RefSeqi | NP_417178.1, NC_000913.3 WP_000140508.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC75740; AAC75740; b2698 BAA16560; BAA16560; BAA16560 |
GeneIDi | 57728645 947172 |
KEGGi | ecj:JW2668 eco:b2698 |
PATRICi | fig|1411691.4.peg.4044 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L25853 Unassigned DNA Translation: AAA19106.1 U00096 Genomic DNA Translation: AAC75740.1 AP009048 Genomic DNA Translation: BAA16560.1 |
PIRi | F65049 |
RefSeqi | NP_417178.1, NC_000913.3 WP_000140508.1, NZ_LN832404.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2A7Z | model | - | A | 1-166 | [»] | |
SMRi | P33596 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4259217, 129 interactors 851504, 1 interactor |
DIPi | DIP-10410N |
IntActi | P33596, 5 interactors |
STRINGi | 511145.b2698 |
Proteomic databases
jPOSTi | P33596 |
PaxDbi | P33596 |
PRIDEi | P33596 |
Genome annotation databases
EnsemblBacteriai | AAC75740; AAC75740; b2698 BAA16560; BAA16560; BAA16560 |
GeneIDi | 57728645 947172 |
KEGGi | ecj:JW2668 eco:b2698 |
PATRICi | fig|1411691.4.peg.4044 |
Organism-specific databases
EchoBASEi | EB2005 |
Phylogenomic databases
eggNOGi | COG2137, Bacteria |
HOGENOMi | CLU_066607_3_2_6 |
InParanoidi | P33596 |
PhylomeDBi | P33596 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12080-MONOMER |
Miscellaneous databases
PROi | PR:P33596 |
Family and domain databases
Gene3Di | 1.10.10.10, 3 hits |
HAMAPi | MF_01114, RecX, 1 hit |
InterProi | View protein in InterPro IPR003783, Regulatory_RecX IPR036388, WH-like_DNA-bd_sf |
PANTHERi | PTHR33602, PTHR33602, 1 hit |
Pfami | View protein in Pfam PF02631, RecX, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RECX_ECOLI | |
Accessioni | P33596Primary (citable) accession number: P33596 Secondary accession number(s): P77798 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 10, 2021 | |
This is version 139 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families