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UniProtKB - P33570 (TKT2_ECOLI)

Entry version 159 (12 Aug 2020)
Sequence version 1 (01 Feb 1994)
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Protein

Transketolase 2

Gene

tktB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate, producing xylulose-5-phosphate and ribose-5-phosphate. Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei25SubstrateBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei25Important for catalytic activityBy similarity1
Binding sitei65Thiamine pyrophosphateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi154MagnesiumBy similarity1
Binding sitei155Thiamine pyrophosphate; via amide nitrogenBy similarity1
Metal bindingi184MagnesiumBy similarity1
Binding sitei184Thiamine pyrophosphateBy similarity1
Metal bindingi186Magnesium; via carbonyl oxygenBy similarity1
Binding sitei260SubstrateBy similarity1
Binding sitei260Thiamine pyrophosphateBy similarity1
Sitei260Important for catalytic activityBy similarity1
Binding sitei357SubstrateBy similarity1
Binding sitei384SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei410Proton donorBy similarity1
Binding sitei436Thiamine pyrophosphateBy similarity1
Binding sitei460SubstrateBy similarity1
Binding sitei468SubstrateBy similarity1
Binding sitei519SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi113 – 115Thiamine pyrophosphateBy similarity3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • transketolase activity Source: EcoliWiki
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
LigandCalcium, Magnesium, Metal-binding, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:TRANSKETOII-MONOMER
ECOL316407:JW2449-MONOMER
MetaCyc:TRANSKETOII-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.2.1.1, 2026

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transketolase 2 (EC:2.2.1.1)
Short name:
TK 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tktB
Ordered Locus Names:b2465, JW2449
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Complete GO annotation on QuickGO ...

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001918571 – 667Transketolase 2Add BLAST667

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei342N6-acetyllysine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P33570

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P33570

PRoteomics IDEntifications database

More...PRIDEi		P33570

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P33570

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4262216, 19 interactors

Database of interacting proteins

More...DIPi		DIP-10999N

Protein interaction database and analysis system

More...IntActi		P33570, 6 interactors

STRING: functional protein association networks

More...STRINGi		511145.b2465

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P33570

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the transketolase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG0021, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009227_0_0_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P33570

KEGG Orthology (KO)

More...KOi		K00615

Database for complete collections of gene phylogenies

More...PhylomeDBi		P33570

Family and domain databases

Conserved Domains Database

More...CDDi		cd02012, TPP_TK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.920, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029061, THDP-binding
IPR009014, Transketo_C/PFOR_II
IPR005475, Transketolase-like_Pyr-bd
IPR005478, Transketolase_bac-like
IPR020826, Transketolase_BS
IPR033248, Transketolase_C
IPR033247, Transketolase_fam
IPR005474, Transketolase_N

The PANTHER Classification System

More...PANTHERi		PTHR43522, PTHR43522, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02779, Transket_pyr, 1 hit
PF02780, Transketolase_C, 1 hit
PF00456, Transketolase_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00861, Transket_pyr, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52518, SSF52518, 2 hits
SSF52922, SSF52922, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00232, tktlase_bact, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00801, TRANSKETOLASE_1, 1 hit
PS00802, TRANSKETOLASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P33570-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRKDLANAI RALSMDAVQK ANSGHPGAPM GMADIAEVLW NDFLKHNPTD 
        60         70         80         90        100
PTWYDRDRFI LSNGHASMLL YSLLHLTGYD LPLEELKNFR QLHSKTPGHP 
       110        120        130        140        150
EIGYTPGVET TTGPLGQGLA NAVGLAIAER TLAAQFNQPD HEIVDHFTYV 
       160        170        180        190        200
FMGDGCLMEG ISHEVCSLAG TLGLGKLIGF YDHNGISIDG ETEGWFTDDT 
       210        220        230        240        250
AKRFEAYHWH VIHEIDGHDP QAVKEAILEA QSVKDKPSLI ICRTVIGFGS 
       260        270        280        290        300
PNKAGKEEAH GAPLGEEEVA LARQKLGWHH PPFEIPKEIY HAWDAREKGE 
       310        320        330        340        350
KAQQSWNEKF AAYKKAHPQL AEEFTRRMSG GLPKDWEKTT QKYINELQAN 
       360        370        380        390        400
PAKIATRKAS QNTLNAYGPM LPELLGGSAD LAPSNLTIWK GSVSLKEDPA 
       410        420        430        440        450
GNYIHYGVRE FGMTAIANGI AHHGGFVPYT ATFLMFVEYA RNAARMAALM 
       460        470        480        490        500
KARQIMVYTH DSIGLGEDGP THQAVEQLAS LRLTPNFSTW RPCDQVEAAV 
       510        520        530        540        550
GWKLAVERHN GPTALILSRQ NLAQVERTPD QVKEIARGGY VLKDSGGKPD 
       560        570        580        590        600
IILIATGSEM EITLQAAEKL AGEGRNVRVV SLPSTDIFDA QDEEYRESVL 
       610        620        630        640        650
PSNVAARVAV EAGIADYWYK YVGLKGAIVG MTGYGESAPA DKLFPFFGFT 
       660 
AENIVAKAHK VLGVKGA
Length:667
Mass (Da):73,043
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i451D748B13ED51E5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D12473 Genomic DNA Translation: BAA02039.1
U00096 Genomic DNA Translation: AAC75518.1
AP009048 Genomic DNA Translation: BAA16340.1

Protein sequence database of the Protein Information Resource

More...PIRi		A48660

NCBI Reference Sequences

More...RefSeqi		NP_416960.1, NC_000913.3
WP_000087280.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC75518; AAC75518; b2465
BAA16340; BAA16340; BAA16340

Database of genes from NCBI RefSeq genomes

More...GeneIDi		945865

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW2449
eco:b2465

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|511145.12.peg.2559

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12473 Genomic DNA Translation: BAA02039.1
U00096 Genomic DNA Translation: AAC75518.1
AP009048 Genomic DNA Translation: BAA16340.1
PIRiA48660
RefSeqiNP_416960.1, NC_000913.3
WP_000087280.1, NZ_LN832404.1

3D structure databases

SMRiP33570
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4262216, 19 interactors
DIPiDIP-10999N
IntActiP33570, 6 interactors
STRINGi511145.b2465

PTM databases

iPTMnetiP33570

Proteomic databases

jPOSTiP33570
PaxDbiP33570
PRIDEiP33570

Genome annotation databases

EnsemblBacteriaiAAC75518; AAC75518; b2465
BAA16340; BAA16340; BAA16340
GeneIDi945865
KEGGiecj:JW2449
eco:b2465
PATRICifig|511145.12.peg.2559

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB2024

Phylogenomic databases

eggNOGiCOG0021, Bacteria
HOGENOMiCLU_009227_0_0_6
InParanoidiP33570
KOiK00615
PhylomeDBiP33570

Enzyme and pathway databases

BioCyciEcoCyc:TRANSKETOII-MONOMER
ECOL316407:JW2449-MONOMER
MetaCyc:TRANSKETOII-MONOMER
BRENDAi2.2.1.1, 2026

Miscellaneous databases

Protein Ontology

More...PROi		PR:P33570

Family and domain databases

CDDicd02012, TPP_TK, 1 hit
Gene3Di3.40.50.920, 1 hit
InterProiView protein in InterPro
IPR029061, THDP-binding
IPR009014, Transketo_C/PFOR_II
IPR005475, Transketolase-like_Pyr-bd
IPR005478, Transketolase_bac-like
IPR020826, Transketolase_BS
IPR033248, Transketolase_C
IPR033247, Transketolase_fam
IPR005474, Transketolase_N
PANTHERiPTHR43522, PTHR43522, 1 hit
PfamiView protein in Pfam
PF02779, Transket_pyr, 1 hit
PF02780, Transketolase_C, 1 hit
PF00456, Transketolase_N, 1 hit
SMARTiView protein in SMART
SM00861, Transket_pyr, 1 hit
SUPFAMiSSF52518, SSF52518, 2 hits
SSF52922, SSF52922, 1 hit
TIGRFAMsiTIGR00232, tktlase_bact, 1 hit
PROSITEiView protein in PROSITE
PS00801, TRANSKETOLASE_1, 1 hit
PS00802, TRANSKETOLASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTKT2_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P33570
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: August 12, 2020
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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