CKS2

Functionⁱ

Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

GO - Molecular functionⁱ

chromatin binding Source: Ensembl
cyclin-dependent protein serine/threonine kinase activator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
histone binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein kinase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ubiquitin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell division Source: UniProtKB-KW
cell proliferation Source: Ensembl
meiosis I Source: Ensembl
mitotic cell cycle phase transition Source: Ensembl
positive regulation of cyclin-dependent protein serine/threonine kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of mitotic cell cycle
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of transcription by RNA polymerase II Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Cell division

Biological process

Cell cycle, Cell division

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cyclin-dependent kinases regulatory subunit 2 Short name: CKS-2
Gene namesⁱ	Name:CKS2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000123975.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2000 CKS2
MIMⁱ	116901 gene
neXtProtⁱ	NX_P33552

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1164
Open Targets More...OpenTargetsⁱ	ENSG00000123975
PharmGKBⁱ	PA26536

Polymorphism and mutation databases

BioMutaⁱ	CKS2

BioMutaⁱ

CKS2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000206237	1 – 79	Cyclin-dependent kinases regulatory subunit 2Add BLAST		79

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	4	N6-acetyllysineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	P33552
PaxDbⁱ	P33552
PeptideAtlas More...PeptideAtlasⁱ	P33552
PRIDEⁱ	P33552
ProteomicsDBⁱ	54921
TopDownProteomicsⁱ	P33552

PTM databases

iPTMnetⁱ	P33552
PhosphoSitePlusⁱ	P33552

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000123975 Expressed in 189 organ(s), highest expression level in right testis
CleanExⁱ	HS_CKS2
Genevisibleⁱ	P33552 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA003424 HPA030762

HPAⁱ

HPA003424
HPA030762

Interactionⁱ

Subunit structureⁱ

Forms a homohexamer that can probably bind six kinase subunits.

GO - Molecular functionⁱ

histone binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein kinase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ubiquitin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107583, 37 interactors
IntActⁱ	P33552, 12 interactors
Molecular INTeraction database More...MINTⁱ	P33552
STRINGⁱ	9606.ENSP00000364976

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	15 – 23	Combined sources	9
Helixⁱ	26 – 29	Combined sources	4
Beta strandⁱ	34 – 36	Combined sources	3
Helixⁱ	40 – 45	Combined sources	6
Beta strandⁱ	55 – 59	Combined sources	5
Beta strandⁱ	66 – 72	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	P33552
SMRⁱ	P33552
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P33552

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the CKS family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3484 Eukaryota ENOG4111UAN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011006
HOVERGENⁱ	HBG003626
InParanoidⁱ	P33552
KEGG Orthology (KO) More...KOⁱ	K02219
OMAⁱ	KHVPKSH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G18GQ
PhylomeDBⁱ	P33552
TreeFamⁱ	TF101142

Family and domain databases

Gene3Dⁱ	3.30.170.10, 1 hit
InterProⁱ	View protein in InterPro IPR000789 Cyclin-dep_kinase_reg-sub IPR036858 Cyclin-dep_kinase_reg-sub_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01111 CKS, 1 hit
PRINTSⁱ	PR00296 CYCLINKINASE
SMARTⁱ	View protein in SMART SM01084 CKS, 1 hit
SUPFAMⁱ	SSF55637 SSF55637, 1 hit
PROSITEⁱ	View protein in PROSITE PS00944 CKS_1, 1 hit PS00945 CKS_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P33552-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAHKQIYYSD KYFDEHYEYR HVMLPRELSK QVPKTHLMSE EEWRRLGVQQ 
        60         70 
SLGWVHYMIH EPEPHILLFR RPLPKDQQK

Length:79

Mass (Da):9,860

Last modified:February 1, 1994 - v1

Checksum:ⁱ811B5927691EEC5C

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	20	R → L in CAG28558 (Ref. 4) Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X54942 mRNA Translation: CAA38703.1 AF506708 Genomic DNA Translation: AAM22232.1 BT006630 mRNA Translation: AAP35276.1 CR407630 mRNA Translation: CAG28558.1 CR542118 mRNA Translation: CAG46915.1 AL160054 Genomic DNA No translation available. CH471089 Genomic DNA Translation: EAW62762.1 BC006458 mRNA Translation: AAH06458.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6682.1
PIRⁱ	B36670
NCBI Reference Sequences More...RefSeqⁱ	NP_001818.1, NM_001827.2
UniGeneⁱ	Hs.83758

Genome annotation databases

Ensemblⁱ	ENST00000314355; ENSP00000364976; ENSG00000123975
GeneIDⁱ	1164
KEGGⁱ	hsa:1164
UCSC genome browser More...UCSCⁱ	uc004aqh.3 human

Protein	Similar proteins		Species	Score	Length	Source
P33552	Cyclin-dependent kinases regulatory subunit 2		BOVIN		79	UniRef100_P33552
Cyclin-dependent kinases regulatory subunit		SAIBB		59
Cyclin-dependent kinases regulatory subunit (Fragment)		MACFA		60
Cyclin-dependent kinases regulatory subunit		CALJA		79
Cyclin-dependent kinases regulatory subunit		PANTR		79
+31

Protein	Similar proteins		Species	Score	Length	Source
P33552	Cyclin-dependent kinases regulatory subunit 2		BOVIN		79	UniRef90_P33552
Cyclin-dependent kinases regulatory subunit		SAIBB		59
Cyclin-dependent kinases regulatory subunit (Fragment)		MACFA		60
Cyclin-dependent kinases regulatory subunit		CALJA		79
Cyclin-dependent kinases regulatory subunit		PANTR		79
+31

Protein	Similar proteins		Species	Score	Length	Source
P33552	Cyclin-dependent kinases regulatory subunit 2		BOVIN		79	UniRef50_P33552
Cyclin-dependent kinases regulatory subunit		SAIBB		59
Cyclin-dependent kinases regulatory subunit (Fragment)		MACFA		60
Cyclin-dependent kinases regulatory subunit		CALJA		79
Cyclin-dependent kinases regulatory subunit		PANTR		79
+32

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X54942 mRNA Translation: CAA38703.1 AF506708 Genomic DNA Translation: AAM22232.1 BT006630 mRNA Translation: AAP35276.1 CR407630 mRNA Translation: CAG28558.1 CR542118 mRNA Translation: CAG46915.1 AL160054 Genomic DNA No translation available. CH471089 Genomic DNA Translation: EAW62762.1 BC006458 mRNA Translation: AAH06458.1
CCDSⁱ	CCDS6682.1
PIRⁱ	B36670
RefSeqⁱ	NP_001818.1, NM_001827.2
UniGeneⁱ	Hs.83758

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1CKS	X-ray	2.10	A/B/C	1-79	[»]
	4Y72	X-ray	2.30	C	1-79	[»]
	4YC3	X-ray	2.70	C	1-79	[»]
	5HQ0	X-ray	2.30	C	1-79	[»]
	5LQF	X-ray	2.06	C/F	1-79	[»]
ProteinModelPortalⁱ	P33552
SMRⁱ	P33552
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107583, 37 interactors
IntActⁱ	P33552, 12 interactors
MINTⁱ	P33552
STRINGⁱ	9606.ENSP00000364976

PTM databases

iPTMnetⁱ	P33552
PhosphoSitePlusⁱ	P33552

Polymorphism and mutation databases

BioMutaⁱ	CKS2

BioMutaⁱ

CKS2

Proteomic databases

EPDⁱ	P33552
PaxDbⁱ	P33552
PeptideAtlasⁱ	P33552
PRIDEⁱ	P33552
ProteomicsDBⁱ	54921
TopDownProteomicsⁱ	P33552

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1164
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000314355; ENSP00000364976; ENSG00000123975
GeneIDⁱ	1164
KEGGⁱ	hsa:1164
UCSCⁱ	uc004aqh.3 human

Organism-specific databases

CTDⁱ	1164
DisGeNETⁱ	1164
EuPathDBⁱ	HostDB:ENSG00000123975.4
GeneCardsⁱ	CKS2
HGNCⁱ	HGNC:2000 CKS2
HPAⁱ	HPA003424 HPA030762
MIMⁱ	116901 gene
neXtProtⁱ	NX_P33552
OpenTargetsⁱ	ENSG00000123975
PharmGKBⁱ	PA26536
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3484 Eukaryota ENOG4111UAN LUCA
GeneTreeⁱ	ENSGT00390000011006
HOVERGENⁱ	HBG003626
InParanoidⁱ	P33552
KOⁱ	K02219
OMAⁱ	KHVPKSH
OrthoDBⁱ	EOG091G18GQ
PhylomeDBⁱ	P33552
TreeFamⁱ	TF101142

Miscellaneous databases

EvolutionaryTraceⁱ	P33552
GeneWikiⁱ	CKS2
GenomeRNAiⁱ	1164
Protein Ontology More...PROⁱ	PR:P33552
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000123975 Expressed in 189 organ(s), highest expression level in right testis
CleanExⁱ	HS_CKS2
Genevisibleⁱ	P33552 HS

Family and domain databases

Gene3Dⁱ	3.30.170.10, 1 hit
InterProⁱ	View protein in InterPro IPR000789 Cyclin-dep_kinase_reg-sub IPR036858 Cyclin-dep_kinase_reg-sub_sf
Pfamⁱ	View protein in Pfam PF01111 CKS, 1 hit
PRINTSⁱ	PR00296 CYCLINKINASE
SMARTⁱ	View protein in SMART SM01084 CKS, 1 hit
SUPFAMⁱ	SSF55637 SSF55637, 1 hit
PROSITEⁱ	View protein in PROSITE PS00944 CKS_1, 1 hit PS00945 CKS_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CKS2_HUMAN
Accessionⁱ	P33552Primary (citable) accession number: P33552 Secondary accession number(s): Q6FGI9, Q6LET5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
	Last sequence update:	February 1, 1994
	Last modified:	November 7, 2018
	This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - P33552 (CKS2_HUMAN)

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Cyclin-dependent kinases regulatory subunit 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ