We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - P33552 (CKS2_HUMAN)
Protein
Cyclin-dependent kinases regulatory subunit 2
Gene
CKS2
Organism
Homo sapiens (Human)
Status
Functioni
Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
GO - Molecular functioni
- chromatin binding Source: Ensembl
- cyclin-dependent protein serine/threonine kinase activator activity Source: GO_Central
- histone binding Source: GO_Central
- protein kinase binding Source: GO_Central
- ubiquitin binding Source: GO_Central
GO - Biological processi
- cell division Source: UniProtKB-KW
- cell population proliferation Source: Ensembl
- meiosis I Source: Ensembl
- mitotic cell cycle phase transition Source: Ensembl
- regulation of mitotic cell cycle Source: GO_Central
- regulation of transcription by RNA polymerase II Source: Ensembl
Keywordsi
Biological process | Cell cycle, Cell division |
Enzyme and pathway databases
PathwayCommonsi | P33552 |
SignaLinki | P33552 |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-dependent kinases regulatory subunit 2Short name: CKS-2 |
Gene namesi | Name:CKS2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2000, CKS2 |
MIMi | 116901, gene |
neXtProti | NX_P33552 |
VEuPathDBi | HostDB:ENSG00000123975 |
Subcellular locationi
Other locations
- cyclin-dependent protein kinase holoenzyme complex Source: GO_Central
- SCF ubiquitin ligase complex Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 1164 |
OpenTargetsi | ENSG00000123975 |
PharmGKBi | PA26536 |
Miscellaneous databases
Pharosi | P33552, Tbio |
Genetic variation databases
BioMutai | CKS2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000206237 | 1 – 79 | Cyclin-dependent kinases regulatory subunit 2Add BLAST | 79 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 4 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | P33552 |
jPOSTi | P33552 |
MassIVEi | P33552 |
PaxDbi | P33552 |
PeptideAtlasi | P33552 |
PRIDEi | P33552 |
ProteomicsDBi | 54921 |
TopDownProteomicsi | P33552 |
PTM databases
iPTMneti | P33552 |
PhosphoSitePlusi | P33552 |
Expressioni
Gene expression databases
Bgeei | ENSG00000123975, Expressed in ventricular zone and 201 other tissues |
Genevisiblei | P33552, HS |
Organism-specific databases
HPAi | ENSG00000123975, Tissue enhanced (bone marrow, testis) |
Interactioni
Subunit structurei
Forms a homohexamer that can probably bind six kinase subunits.
Binary interactionsi
P33552
With | #Exp. | IntAct |
---|---|---|
CDK3 [Q00526] | 4 | EBI-711840,EBI-1245761 |
GO - Molecular functioni
- histone binding Source: GO_Central
- protein kinase binding Source: GO_Central
- ubiquitin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 107583, 45 interactors |
IntActi | P33552, 28 interactors |
MINTi | P33552 |
STRINGi | 9606.ENSP00000364976 |
Miscellaneous databases
RNActi | P33552, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P33552 |
SMRi | P33552 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P33552 |
Family & Domainsi
Sequence similaritiesi
Belongs to the CKS family.Curated
Phylogenomic databases
eggNOGi | KOG3484, Eukaryota |
GeneTreei | ENSGT00950000182971 |
HOGENOMi | CLU_140546_2_0_1 |
InParanoidi | P33552 |
OMAi | CIQNCER |
OrthoDBi | 1377855at2759 |
PhylomeDBi | P33552 |
TreeFami | TF101142 |
Family and domain databases
Gene3Di | 3.30.170.10, 1 hit |
InterProi | View protein in InterPro IPR000789, Cyclin-dep_kinase_reg-sub IPR036858, Cyclin-dep_kinase_reg-sub_sf |
Pfami | View protein in Pfam PF01111, CKS, 1 hit |
PRINTSi | PR00296, CYCLINKINASE |
SMARTi | View protein in SMART SM01084, CKS, 1 hit |
SUPFAMi | SSF55637, SSF55637, 1 hit |
PROSITEi | View protein in PROSITE PS00944, CKS_1, 1 hit PS00945, CKS_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P33552-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAHKQIYYSD KYFDEHYEYR HVMLPRELSK QVPKTHLMSE EEWRRLGVQQ
60 70
SLGWVHYMIH EPEPHILLFR RPLPKDQQK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 20 | R → L in CAG28558 (Ref. 4) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X54942 mRNA Translation: CAA38703.1 AF506708 Genomic DNA Translation: AAM22232.1 BT006630 mRNA Translation: AAP35276.1 CR407630 mRNA Translation: CAG28558.1 CR542118 mRNA Translation: CAG46915.1 AL160054 Genomic DNA No translation available. CH471089 Genomic DNA Translation: EAW62762.1 BC006458 mRNA Translation: AAH06458.1 |
CCDSi | CCDS6682.1 |
PIRi | B36670 |
RefSeqi | NP_001818.1, NM_001827.2 |
Genome annotation databases
Ensembli | ENST00000314355.7; ENSP00000364976.3; ENSG00000123975.5 |
GeneIDi | 1164 |
KEGGi | hsa:1164 |
MANE-Selecti | ENST00000314355.7; ENSP00000364976.3; NM_001827.3; NP_001818.1 |
UCSCi | uc004aqh.3, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X54942 mRNA Translation: CAA38703.1 AF506708 Genomic DNA Translation: AAM22232.1 BT006630 mRNA Translation: AAP35276.1 CR407630 mRNA Translation: CAG28558.1 CR542118 mRNA Translation: CAG46915.1 AL160054 Genomic DNA No translation available. CH471089 Genomic DNA Translation: EAW62762.1 BC006458 mRNA Translation: AAH06458.1 |
CCDSi | CCDS6682.1 |
PIRi | B36670 |
RefSeqi | NP_001818.1, NM_001827.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1CKS | X-ray | 2.10 | A/B/C | 1-79 | [»] | |
4Y72 | X-ray | 2.30 | C | 1-79 | [»] | |
4YC3 | X-ray | 2.70 | C | 1-79 | [»] | |
5HQ0 | X-ray | 2.30 | C | 1-79 | [»] | |
5LQF | X-ray | 2.06 | C/F | 1-79 | [»] | |
6GU2 | X-ray | 2.00 | C | 1-79 | [»] | |
6GU3 | X-ray | 2.65 | C | 1-79 | [»] | |
6GU4 | X-ray | 2.73 | C | 1-79 | [»] | |
6GU6 | X-ray | 2.33 | B | 1-79 | [»] | |
6GU7 | X-ray | 2.75 | B/D/F/H | 1-79 | [»] | |
AlphaFoldDBi | P33552 | |||||
SMRi | P33552 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107583, 45 interactors |
IntActi | P33552, 28 interactors |
MINTi | P33552 |
STRINGi | 9606.ENSP00000364976 |
PTM databases
iPTMneti | P33552 |
PhosphoSitePlusi | P33552 |
Genetic variation databases
BioMutai | CKS2 |
Proteomic databases
EPDi | P33552 |
jPOSTi | P33552 |
MassIVEi | P33552 |
PaxDbi | P33552 |
PeptideAtlasi | P33552 |
PRIDEi | P33552 |
ProteomicsDBi | 54921 |
TopDownProteomicsi | P33552 |
Protocols and materials databases
Antibodypediai | 27992, 254 antibodies from 33 providers |
DNASUi | 1164 |
Genome annotation databases
Ensembli | ENST00000314355.7; ENSP00000364976.3; ENSG00000123975.5 |
GeneIDi | 1164 |
KEGGi | hsa:1164 |
MANE-Selecti | ENST00000314355.7; ENSP00000364976.3; NM_001827.3; NP_001818.1 |
UCSCi | uc004aqh.3, human |
Organism-specific databases
CTDi | 1164 |
DisGeNETi | 1164 |
GeneCardsi | CKS2 |
HGNCi | HGNC:2000, CKS2 |
HPAi | ENSG00000123975, Tissue enhanced (bone marrow, testis) |
MIMi | 116901, gene |
neXtProti | NX_P33552 |
OpenTargetsi | ENSG00000123975 |
PharmGKBi | PA26536 |
VEuPathDBi | HostDB:ENSG00000123975 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3484, Eukaryota |
GeneTreei | ENSGT00950000182971 |
HOGENOMi | CLU_140546_2_0_1 |
InParanoidi | P33552 |
OMAi | CIQNCER |
OrthoDBi | 1377855at2759 |
PhylomeDBi | P33552 |
TreeFami | TF101142 |
Enzyme and pathway databases
PathwayCommonsi | P33552 |
SignaLinki | P33552 |
Miscellaneous databases
BioGRID-ORCSi | 1164, 123 hits in 1083 CRISPR screens |
ChiTaRSi | CKS2, human |
EvolutionaryTracei | P33552 |
GeneWikii | CKS2 |
GenomeRNAii | 1164 |
Pharosi | P33552, Tbio |
PROi | PR:P33552 |
RNActi | P33552, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000123975, Expressed in ventricular zone and 201 other tissues |
Genevisiblei | P33552, HS |
Family and domain databases
Gene3Di | 3.30.170.10, 1 hit |
InterProi | View protein in InterPro IPR000789, Cyclin-dep_kinase_reg-sub IPR036858, Cyclin-dep_kinase_reg-sub_sf |
Pfami | View protein in Pfam PF01111, CKS, 1 hit |
PRINTSi | PR00296, CYCLINKINASE |
SMARTi | View protein in SMART SM01084, CKS, 1 hit |
SUPFAMi | SSF55637, SSF55637, 1 hit |
PROSITEi | View protein in PROSITE PS00944, CKS_1, 1 hit PS00945, CKS_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CKS2_HUMAN | |
Accessioni | P33552Primary (citable) accession number: P33552 Secondary accession number(s): Q6FGI9, Q6LET5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | February 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 187 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families