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Protein

Cyclin-dependent kinases regulatory subunit 2

Gene

CKS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinases regulatory subunit 2
Short name:
CKS-2
Gene namesi
Name:CKS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000123975.4
HGNCiHGNC:2000 CKS2
MIMi116901 gene
neXtProtiNX_P33552

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi1164
OpenTargetsiENSG00000123975
PharmGKBiPA26536

Polymorphism and mutation databases

BioMutaiCKS2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002062371 – 79Cyclin-dependent kinases regulatory subunit 2Add BLAST79

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP33552
PaxDbiP33552
PeptideAtlasiP33552
PRIDEiP33552
ProteomicsDBi54921
TopDownProteomicsiP33552

PTM databases

iPTMnetiP33552
PhosphoSitePlusiP33552

Expressioni

Gene expression databases

BgeeiENSG00000123975 Expressed in 189 organ(s), highest expression level in right testis
CleanExiHS_CKS2
GenevisibleiP33552 HS

Organism-specific databases

HPAiHPA003424
HPA030762

Interactioni

Subunit structurei

Forms a homohexamer that can probably bind six kinase subunits.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107583, 37 interactors
IntActiP33552, 12 interactors
MINTiP33552
STRINGi9606.ENSP00000364976

Structurei

Secondary structure

179
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP33552
SMRiP33552
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP33552

Family & Domainsi

Sequence similaritiesi

Belongs to the CKS family.Curated

Phylogenomic databases

eggNOGiKOG3484 Eukaryota
ENOG4111UAN LUCA
GeneTreeiENSGT00390000011006
HOVERGENiHBG003626
InParanoidiP33552
KOiK02219
OMAiKHVPKSH
OrthoDBiEOG091G18GQ
PhylomeDBiP33552
TreeFamiTF101142

Family and domain databases

Gene3Di3.30.170.10, 1 hit
InterProiView protein in InterPro
IPR000789 Cyclin-dep_kinase_reg-sub
IPR036858 Cyclin-dep_kinase_reg-sub_sf
PfamiView protein in Pfam
PF01111 CKS, 1 hit
PRINTSiPR00296 CYCLINKINASE
SMARTiView protein in SMART
SM01084 CKS, 1 hit
SUPFAMiSSF55637 SSF55637, 1 hit
PROSITEiView protein in PROSITE
PS00944 CKS_1, 1 hit
PS00945 CKS_2, 1 hit

Sequencei

Sequence statusi: Complete.

P33552-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHKQIYYSD KYFDEHYEYR HVMLPRELSK QVPKTHLMSE EEWRRLGVQQ
60 70
SLGWVHYMIH EPEPHILLFR RPLPKDQQK
Length:79
Mass (Da):9,860
Last modified:February 1, 1994 - v1
Checksum:i811B5927691EEC5C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20R → L in CAG28558 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54942 mRNA Translation: CAA38703.1
AF506708 Genomic DNA Translation: AAM22232.1
BT006630 mRNA Translation: AAP35276.1
CR407630 mRNA Translation: CAG28558.1
CR542118 mRNA Translation: CAG46915.1
AL160054 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62762.1
BC006458 mRNA Translation: AAH06458.1
CCDSiCCDS6682.1
PIRiB36670
RefSeqiNP_001818.1, NM_001827.2
UniGeneiHs.83758

Genome annotation databases

EnsembliENST00000314355; ENSP00000364976; ENSG00000123975
GeneIDi1164
KEGGihsa:1164
UCSCiuc004aqh.3 human

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54942 mRNA Translation: CAA38703.1
AF506708 Genomic DNA Translation: AAM22232.1
BT006630 mRNA Translation: AAP35276.1
CR407630 mRNA Translation: CAG28558.1
CR542118 mRNA Translation: CAG46915.1
AL160054 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62762.1
BC006458 mRNA Translation: AAH06458.1
CCDSiCCDS6682.1
PIRiB36670
RefSeqiNP_001818.1, NM_001827.2
UniGeneiHs.83758

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CKSX-ray2.10A/B/C1-79[»]
4Y72X-ray2.30C1-79[»]
4YC3X-ray2.70C1-79[»]
5HQ0X-ray2.30C1-79[»]
5LQFX-ray2.06C/F1-79[»]
ProteinModelPortaliP33552
SMRiP33552
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107583, 37 interactors
IntActiP33552, 12 interactors
MINTiP33552
STRINGi9606.ENSP00000364976

PTM databases

iPTMnetiP33552
PhosphoSitePlusiP33552

Polymorphism and mutation databases

BioMutaiCKS2

Proteomic databases

EPDiP33552
PaxDbiP33552
PeptideAtlasiP33552
PRIDEiP33552
ProteomicsDBi54921
TopDownProteomicsiP33552

Protocols and materials databases

DNASUi1164
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314355; ENSP00000364976; ENSG00000123975
GeneIDi1164
KEGGihsa:1164
UCSCiuc004aqh.3 human

Organism-specific databases

CTDi1164
DisGeNETi1164
EuPathDBiHostDB:ENSG00000123975.4
GeneCardsiCKS2
HGNCiHGNC:2000 CKS2
HPAiHPA003424
HPA030762
MIMi116901 gene
neXtProtiNX_P33552
OpenTargetsiENSG00000123975
PharmGKBiPA26536
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3484 Eukaryota
ENOG4111UAN LUCA
GeneTreeiENSGT00390000011006
HOVERGENiHBG003626
InParanoidiP33552
KOiK02219
OMAiKHVPKSH
OrthoDBiEOG091G18GQ
PhylomeDBiP33552
TreeFamiTF101142

Miscellaneous databases

EvolutionaryTraceiP33552
GeneWikiiCKS2
GenomeRNAii1164
PROiPR:P33552
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123975 Expressed in 189 organ(s), highest expression level in right testis
CleanExiHS_CKS2
GenevisibleiP33552 HS

Family and domain databases

Gene3Di3.30.170.10, 1 hit
InterProiView protein in InterPro
IPR000789 Cyclin-dep_kinase_reg-sub
IPR036858 Cyclin-dep_kinase_reg-sub_sf
PfamiView protein in Pfam
PF01111 CKS, 1 hit
PRINTSiPR00296 CYCLINKINASE
SMARTiView protein in SMART
SM01084 CKS, 1 hit
SUPFAMiSSF55637 SSF55637, 1 hit
PROSITEiView protein in PROSITE
PS00944 CKS_1, 1 hit
PS00945 CKS_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCKS2_HUMAN
AccessioniPrimary (citable) accession number: P33552
Secondary accession number(s): Q6FGI9, Q6LET5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 7, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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