UniProtKB - P33535 (OPRM_RAT)
Mu-type opioid receptor
Oprm1
Functioni
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation. Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling. Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. Involved in neurogenesis.
12 PublicationsGO - Molecular functioni
- beta-endorphin receptor activity Source: RGD
- filamin binding Source: RGD
- G-protein alpha-subunit binding Source: UniProtKB
- G-protein beta-subunit binding Source: RGD
- G protein-coupled opioid receptor activity Source: RGD
- G protein-coupled receptor activity Source: RGD
- morphine receptor activity Source: RGD
- neuropeptide binding Source: GO_Central
- peptide binding Source: GO_Central
- protein C-terminus binding Source: RGD
- protein domain specific binding Source: RGD
- voltage-gated calcium channel activity Source: UniProtKB
GO - Biological processi
- acute inflammatory response to antigenic stimulus Source: RGD
- adenylate cyclase-activating dopamine receptor signaling pathway Source: RGD
- adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway Source: GO_Central
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: RGD
- adenylate cyclase-inhibiting opioid receptor signaling pathway Source: RGD
- behavioral response to ethanol Source: RGD
- eating behavior Source: RGD
- estrous cycle Source: RGD
- excitatory postsynaptic potential Source: RGD
- G protein-coupled opioid receptor signaling pathway Source: RGD
- G protein-coupled receptor signaling pathway Source: RGD
- immune response Source: RGD
- locomotory behavior Source: RGD
- negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: RGD
- negative regulation of cAMP-mediated signaling Source: UniProtKB
- negative regulation of cytosolic calcium ion concentration Source: UniProtKB
- negative regulation of nitric oxide biosynthetic process Source: UniProtKB
- negative regulation of Wnt protein secretion Source: UniProtKB
- neuropeptide signaling pathway Source: GO_Central
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: UniProtKB
- positive regulation of appetite Source: RGD
- positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
- positive regulation of neurogenesis Source: UniProtKB
- regulation of cellular response to stress Source: RGD
- regulation of NMDA receptor activity Source: UniProtKB
- regulation of sensory perception of pain Source: RGD
- response to cocaine Source: RGD
- response to ethanol Source: RGD
- response to food Source: RGD
- response to growth factor Source: RGD
- response to lipopolysaccharide Source: RGD
- response to morphine Source: RGD
- response to radiation Source: RGD
- sensory perception of pain Source: UniProtKB
- wound healing Source: RGD
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-RNO-111885, Opioid Signalling R-RNO-202040, G-protein activation R-RNO-375276, Peptide ligand-binding receptors R-RNO-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Mu-type opioid receptorShort name: M-OR-1 Short name: MOR-1 Alternative name(s): Opioid receptor B |
Gene namesi | Name:Oprm1 Synonyms:Ror-b |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3234, Oprm1 |
Subcellular locationi
Endosome
- Endosome By similarity
Plasma membrane
- Cell membrane 2 Publications; Multi-pass membrane protein By similarity
Other locations
- axon By similarity
- Perikaryon By similarity
- dendrite By similarity
Note: Is rapidly internalized after agonist binding.By similarity
Endosome
- endosome Source: UniProtKB
Plasma Membrane
- dendrite membrane Source: RGD
- integral component of plasma membrane Source: GO_Central
- integral component of postsynaptic membrane Source: SynGO
- integral component of presynaptic membrane Source: SynGO
Other locations
- axon Source: UniProtKB
- cytoplasm Source: RGD
- dendrite Source: RGD
- dendrite cytoplasm Source: RGD
- focal adhesion Source: RGD
- membrane Source: RGD
- membrane raft Source: RGD
- neuron projection Source: GO_Central
- perikaryon Source: RGD
- spine apparatus Source: SynGO
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 66 | ExtracellularBy similarityAdd BLAST | 66 | |
Transmembranei | 67 – 91 | Helical; Name=1By similarityAdd BLAST | 25 | |
Topological domaini | 92 – 104 | CytoplasmicBy similarityAdd BLAST | 13 | |
Transmembranei | 105 – 129 | Helical; Name=2By similarityAdd BLAST | 25 | |
Topological domaini | 130 – 140 | ExtracellularBy similarityAdd BLAST | 11 | |
Transmembranei | 141 – 163 | Helical; Name=3By similarityAdd BLAST | 23 | |
Topological domaini | 164 – 183 | CytoplasmicBy similarityAdd BLAST | 20 | |
Transmembranei | 184 – 205 | Helical; Name=4By similarityAdd BLAST | 22 | |
Topological domaini | 206 – 228 | ExtracellularBy similarityAdd BLAST | 23 | |
Transmembranei | 229 – 253 | Helical; Name=5By similarityAdd BLAST | 25 | |
Topological domaini | 254 – 277 | CytoplasmicBy similarityAdd BLAST | 24 | |
Transmembranei | 278 – 304 | Helical; Name=6By similarityAdd BLAST | 27 | |
Topological domaini | 305 – 312 | ExtracellularBy similarity | 8 | |
Transmembranei | 313 – 336 | Helical; Name=7By similarityAdd BLAST | 24 | |
Topological domaini | 337 – 398 | CytoplasmicBy similarityAdd BLAST | 62 |
Keywords - Cellular componenti
Cell membrane, Cell projection, Endosome, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 91 | Y → A: Abolishes agonist-induced G-protein-independent receptor internalization; when associated with A-96, A-166 and A-336. 1 Publication | 1 | |
Mutagenesisi | 96 | Y → A: Abolishes agonist-induced G-protein-independent receptor internalization; when associated with A-91, A-166 and A-336. 1 Publication | 1 | |
Mutagenesisi | 114 | D → A or N: Impairs agonist affinity, agonist-induced inhibition of adenylate cyclase and coupling to G-proteins. 2 Publications | 1 | |
Mutagenesisi | 114 | D → E: No effect on inhibition of adenylate cyclase. 2 Publications | 1 | |
Mutagenesisi | 147 | D → A: No effect on constitutive activation. Impairs agonist affinity and agonist-induced inhibition of adenylate cyclase. 2 Publications | 1 | |
Mutagenesisi | 147 | D → E: Impairs agonist affinity and increases agonist-induced inhibition of adenylate cyclase. 2 Publications | 1 | |
Mutagenesisi | 147 | D → N: No effect on constitutive activation. 2 Publications | 1 | |
Mutagenesisi | 164 | D → E: Reduces basal activity. 1 Publication | 1 | |
Mutagenesisi | 164 | D → H, M, Q or Y: Constitutive active. 1 Publication | 1 | |
Mutagenesisi | 166 | Y → A: Abolishes agonist-induced G-protein-independent receptor internalization; when associated with A-91, A-96 and A-336. 2 Publications | 1 | |
Mutagenesisi | 166 | Y → F: Decrease in phosphorylation, no decrease in G-protein binding. 2 Publications | 1 | |
Mutagenesisi | 180 | T → A: Impairs ARRB2- and GRK3-mediated receptor desensitization. 1 Publication | 1 | |
Mutagenesisi | 275 | L → E: No effect on constitutive activation. Some constitutive activity; when associated with K-279. 1 Publication | 1 | |
Mutagenesisi | 279 | T → D: Receptor inactivation. 2 Publications | 1 | |
Mutagenesisi | 279 | T → K: Constitutive active. Some constitutive activity; when associated with E-275. 2 Publications | 1 | |
Mutagenesisi | 297 | H → A: Impairs agonist affinity and increases agonist-induced inhibition of adenylate cyclase. 1 Publication | 1 | |
Mutagenesisi | 336 | Y → A: Abolishes agonist-induced G-protein-independent receptor internalization; when associated with A-91, A-96 and A-166. 1 Publication | 1 | |
Mutagenesisi | 346 | C → A: No change in palmitoylation. No change in palmitoylation; when associated with A-351. 1 Publication | 1 | |
Mutagenesisi | 351 | C → A: No change in palmitoylation; when associated with A-346. 1 Publication | 1 | |
Mutagenesisi | 363 | S → A: Abolishes basal phosphorylation; when associated with A-370. Abolishes basal and agonist-induced phosphorylation; when associated with A-370 and A-375. Accelerates agonist-induced receptor internalization. 2 Publications | 1 | |
Mutagenesisi | 370 | T → A: Abolishes basal phosphorylation; when associated with A-363. Abolishes basal and agonist-induced phosphorylation; when associated with A-363 and A-375. Accelerates agonist-induced receptor internalization. 2 Publications | 1 | |
Mutagenesisi | 375 | S → A: Reduces agonist-induced receptor internalization. Abolishes morphine-induced phosphorylation. Restores agonist-specific PRKCE activity. Abolishes basal and agonist-induced phosphorylation; when associated with A-363 and A-370. 3 Publications | 1 | |
Mutagenesisi | 394 | T → A: Impairs phosphorylation and abolishes agonist-mediated acute receptor desensitization. 2 Publications | 1 |
Chemistry databases
ChEMBLi | CHEMBL270 |
DrugCentrali | P33535 |
GuidetoPHARMACOLOGYi | 319 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069978 | 1 – 398 | Mu-type opioid receptorAdd BLAST | 398 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 9 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 31 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 38 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 46 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 53 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 140 ↔ 217 | PROSITE-ProRule annotation | ||
Modified residuei | 166 | Phosphotyrosine1 Publication | 1 | |
Lipidationi | 351 | S-palmitoyl cysteineSequence analysis | 1 | |
Modified residuei | 363 | Phosphoserine1 Publication | 1 | |
Modified residuei | 370 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 375 | Phosphoserine1 Publication | 1 | |
Modified residuei | 394 | Phosphothreonine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | P33535 |
PTM databases
GlyGeni | P33535, 5 sites |
iPTMneti | P33535 |
PhosphoSitePlusi | P33535 |
SwissPalmi | P33535 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSRNOG00000018191, Expressed in brain and 9 other tissues |
ExpressionAtlasi | P33535, baseline and differential |
Genevisiblei | P33535, RN |
Interactioni
Subunit structurei
Forms homooligomers and heterooligomers with other GPCRs, such as OPRD1, OPRK1, OPRL1, NPFFR2, ADRA2A, SSTR2, CNR1 and CCR5 (probably in dimeric forms) (PubMed:10842167, PubMed:11896051, PubMed:14645661, PubMed:14729105, PubMed:17384143, PubMed:16682964).
Interacts with heterotrimeric G proteins; interaction with a heterotrimeric complex containing GNAI1, GNB1 and GNG2 stabilizes the active conformation of the receptor and increases its affinity for endomorphin-2, the synthetic opioid peptide DAMGO and for morphinan agonists (By similarity).
Interacts with PPL; the interaction disrupts agonist-mediated G-protein activation.
Interacts (via C-terminus) with DNAJB4 (via C-terminus).
Interacts with calmodulin; the interaction inhibits the constitutive activity of OPRM1; it abolishes basal and attenuates agonist-stimulated G-protein coupling (By similarity).
Interacts with FLNA, PLD2, RANBP9 and WLS and GPM6A (PubMed:12519790, PubMed:17548356).
Interacts with RTP4 (By similarity).
Interacts with SYP and GNAS (PubMed:15857684, PubMed:17005904).
Interacts with RGS9, RGS17, RGS20, RGS4, PPP1R9B and HINT1 (By similarity).
By similarity11 PublicationsBinary interactionsi
P33535
With | #Exp. | IntAct |
---|---|---|
Gpm6a [Q812E9] | 7 | EBI-4392569,EBI-6113756 |
Pld2 [P70498] | 3 | EBI-4392569,EBI-6140589 |
Syp [P07825] | 8 | EBI-4392569,EBI-976085 |
Wls [Q6P689] | 2 | EBI-4392569,EBI-6113235 |
GO - Molecular functioni
- filamin binding Source: RGD
- G-protein alpha-subunit binding Source: UniProtKB
- G-protein beta-subunit binding Source: RGD
- protein C-terminus binding Source: RGD
- protein domain specific binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 247631, 5 interactors |
CORUMi | P33535 |
IntActi | P33535, 6 interactors |
STRINGi | 10116.ENSRNOP00000051290 |
Chemistry databases
BindingDBi | P33535 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 361 – 385 | DisorderedSequence analysisAdd BLAST | 25 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 332 – 336 | NPxxY; plays a role in stabilizing the activated conformation of the receptorBy similarity | 5 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000158236 |
InParanoidi | P33535 |
OMAi | CTDPFTH |
OrthoDBi | 1011272at2759 |
TreeFami | TF315737 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000105, Mu_opioid_rcpt IPR001418, Opioid_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00537, MUOPIOIDR PR00384, OPIOIDR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
s (8+)i Sequence
Sequence statusi: Complete.
This entry describes 8 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 8 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDSSTGPGNT SDCSDPLAQA SCSPAPGSWL NLSHVDGNQS DPCGLNRTGL
60 70 80 90 100
GGNDSLCPQT GSPSMVTAIT IMALYSIVCV VGLFGNFLVM YVIVRYTKMK
110 120 130 140 150
TATNIYIFNL ALADALATST LPFQSVNYLM GTWPFGTILC KIVISIDYYN
160 170 180 190 200
MFTSIFTLCT MSVDRYIAVC HPVKALDFRT PRNAKIVNVC NWILSSAIGL
210 220 230 240 250
PVMFMATTKY RQGSIDCTLT FSHPTWYWEN LLKICVFIFA FIMPVLIITV
260 270 280 290 300
CYGLMILRLK SVRMLSGSKE KDRNLRRITR MVLVVVAVFI VCWTPIHIYV
310 320 330 340 350
IIKALITIPE TTFQTVSWHF CIALGYTNSC LNPVLYAFLD ENFKRCFREF
360 370 380 390
CIPTSSTIEQ QNSTRVRQNT REHPSTANTV DRTNHQLENL EAETAPLP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A125U2D0 | A0A125U2D0_RAT | Mu-type opioid receptor | Oprm1 | 222 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 237 | F → G in AAA79180 (PubMed:8189219).Curated | 1 | |
Sequence conflicti | 238 | I → V in AAQ77386 (Ref. 7) Curated | 1 | |
Sequence conflicti | 245 | V → I in AAA41630 (PubMed:8393525).Curated | 1 | |
Sequence conflicti | 245 | V → I in AAA70049 (Ref. 4) Curated | 1 | |
Sequence conflicti | 245 | V → I in S77863 (PubMed:7733926).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041828 | 387 – 398 | LENLE…TAPLP → VCAF in isoform 2. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_041829 | 387 – 398 | LENLE…TAPLP → GAEL in isoform 3. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_041830 | 387 – 398 | LENLE…TAPLP → KIVLF in isoform 4. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_041831 | 387 – 398 | LENLE…TAPLP → EPQSVET in isoform 5. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_041832 | 387 – 398 | LENLE…TAPLP → PALAVSVAQIFTGYPSPTHG EKPCKSYRDRPRPCGRTWSL KSRAESNVEHFHCGAALIYN NVNFI in isoform 6. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_041833 | 387 – 398 | LENLE…TAPLP → PALAVSVAQIFTGYPSPTHG EKPCKSYRDRPRPCGRTWSL KSRAESNVEHFHCGAALIYN NELKIGPVSWLQMPAHVLVR PW in isoform 7. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_041834 | 387 – 398 | LENLE…TAPLP → T in isoform 8. 1 PublicationAdd BLAST | 12 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D16349 mRNA Translation: BAA03852.1 L20684 mRNA Translation: AAA41643.1 L13069 mRNA Translation: AAA41630.1 U02083 mRNA Translation: AAA70049.1 L22455 mRNA Translation: AAA16075.1 U35424 mRNA Translation: AAA79180.1 AY309003 mRNA Translation: AAQ77387.1 Frameshift. AY309004 mRNA Translation: AAQ77388.1 AY225402 mRNA Translation: AAP44725.1 AY225403 mRNA Translation: AAP44726.1 AY309000 mRNA Translation: AAQ77384.1 AY309002 mRNA Translation: AAQ77386.1 S77863 mRNA No translation available. S75669 mRNA Translation: AAB33530.2 |
PIRi | I56504 I56517 S69010 |
RefSeqi | NP_001033686.1, NM_001038597.2 [P33535-2] NP_001033688.2, NM_001038599.2 [P33535-5] NP_001033689.1, NM_001038600.2 [P33535-6] NP_001033690.1, NM_001038601.2 [P33535-7] NP_001291664.1, NM_001304735.1 [P33535-1] NP_001291666.1, NM_001304737.1 [P33535-1] NP_001291667.1, NM_001304738.1 [P33535-1] NP_001291669.1, NM_001304740.1 [P33535-1] NP_037203.1, NM_013071.2 [P33535-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D16349 mRNA Translation: BAA03852.1 L20684 mRNA Translation: AAA41643.1 L13069 mRNA Translation: AAA41630.1 U02083 mRNA Translation: AAA70049.1 L22455 mRNA Translation: AAA16075.1 U35424 mRNA Translation: AAA79180.1 AY309003 mRNA Translation: AAQ77387.1 Frameshift. AY309004 mRNA Translation: AAQ77388.1 AY225402 mRNA Translation: AAP44725.1 AY225403 mRNA Translation: AAP44726.1 AY309000 mRNA Translation: AAQ77384.1 AY309002 mRNA Translation: AAQ77386.1 S77863 mRNA No translation available. S75669 mRNA Translation: AAB33530.2 |
PIRi | I56504 I56517 S69010 |
RefSeqi | NP_001033686.1, NM_001038597.2 [P33535-2] NP_001033688.2, NM_001038599.2 [P33535-5] NP_001033689.1, NM_001038600.2 [P33535-6] NP_001033690.1, NM_001038601.2 [P33535-7] NP_001291664.1, NM_001304735.1 [P33535-1] NP_001291666.1, NM_001304737.1 [P33535-1] NP_001291667.1, NM_001304738.1 [P33535-1] NP_001291669.1, NM_001304740.1 [P33535-1] NP_037203.1, NM_013071.2 [P33535-1] |
3D structure databases
SMRi | P33535 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 247631, 5 interactors |
CORUMi | P33535 |
IntActi | P33535, 6 interactors |
STRINGi | 10116.ENSRNOP00000051290 |
Chemistry databases
BindingDBi | P33535 |
ChEMBLi | CHEMBL270 |
DrugCentrali | P33535 |
GuidetoPHARMACOLOGYi | 319 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P33535, 5 sites |
iPTMneti | P33535 |
PhosphoSitePlusi | P33535 |
SwissPalmi | P33535 |
Proteomic databases
PaxDbi | P33535 |
Genome annotation databases
Organism-specific databases
CTDi | 4988 |
RGDi | 3234, Oprm1 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000158236 |
InParanoidi | P33535 |
OMAi | CTDPFTH |
OrthoDBi | 1011272at2759 |
TreeFami | TF315737 |
Enzyme and pathway databases
Reactomei | R-RNO-111885, Opioid Signalling R-RNO-202040, G-protein activation R-RNO-375276, Peptide ligand-binding receptors R-RNO-418594, G alpha (i) signalling events |
Miscellaneous databases
PROi | PR:P33535 |
Gene expression databases
Bgeei | ENSRNOG00000018191, Expressed in brain and 9 other tissues |
ExpressionAtlasi | P33535, baseline and differential |
Genevisiblei | P33535, RN |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000105, Mu_opioid_rcpt IPR001418, Opioid_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00537, MUOPIOIDR PR00384, OPIOIDR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | OPRM_RAT | |
Accessioni | P33535Primary (citable) accession number: P33535 Secondary accession number(s): Q2TV20 Q64120 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | February 1, 1994 | |
Last modified: | September 29, 2021 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families