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UniProtKB - P33535 (OPRM_RAT)

Protein

Mu-type opioid receptor

Gene

Oprm1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation. Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling. Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. Involved in neurogenesis.12 Publications

GO - Molecular functioni

  • beta-endorphin receptor activity Source: GO_Central
  • filamin binding Source: RGD
  • G-protein alpha-subunit binding Source: UniProtKB
  • G-protein beta-subunit binding Source: RGD
  • G protein-coupled receptor activity Source: RGD
  • morphine receptor activity Source: RGD
  • neuropeptide binding Source: GO_Central
  • protein C-terminus binding Source: RGD
  • protein domain specific binding Source: RGD
  • voltage-gated calcium channel activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-111885 Opioid Signalling
R-RNO-202040 G-protein activation
R-RNO-375276 Peptide ligand-binding receptors
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Mu-type opioid receptor
Short name:
M-OR-1
Short name:
MOR-1
Alternative name(s):
Opioid receptor B
Gene namesi
Name:Oprm1
Synonyms:Ror-b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3234 Oprm1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 66ExtracellularBy similarityAdd BLAST66
Transmembranei67 – 91Helical; Name=1By similarityAdd BLAST25
Topological domaini92 – 104CytoplasmicBy similarityAdd BLAST13
Transmembranei105 – 129Helical; Name=2By similarityAdd BLAST25
Topological domaini130 – 140ExtracellularBy similarityAdd BLAST11
Transmembranei141 – 163Helical; Name=3By similarityAdd BLAST23
Topological domaini164 – 183CytoplasmicBy similarityAdd BLAST20
Transmembranei184 – 205Helical; Name=4By similarityAdd BLAST22
Topological domaini206 – 228ExtracellularBy similarityAdd BLAST23
Transmembranei229 – 253Helical; Name=5By similarityAdd BLAST25
Topological domaini254 – 277CytoplasmicBy similarityAdd BLAST24
Transmembranei278 – 304Helical; Name=6By similarityAdd BLAST27
Topological domaini305 – 312ExtracellularBy similarity8
Transmembranei313 – 336Helical; Name=7By similarityAdd BLAST24
Topological domaini337 – 398CytoplasmicBy similarityAdd BLAST62

Keywords - Cellular componenti

Cell membrane, Cell projection, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi91Y → A: Abolishes agonist-induced G-protein-independent receptor internalization; when associated with A-96, A-166 and A-336. 1 Publication1
Mutagenesisi96Y → A: Abolishes agonist-induced G-protein-independent receptor internalization; when associated with A-91, A-166 and A-336. 1 Publication1
Mutagenesisi114D → A or N: Impairs agonist affinity, agonist-induced inhibition of adenylate cyclase and coupling to G-proteins. 2 Publications1
Mutagenesisi114D → E: No effect on inhibition of adenylate cyclase. 2 Publications1
Mutagenesisi147D → A: No effect on constitutive activation. Impairs agonist affinity and agonist-induced inhibition of adenylate cyclase. 2 Publications1
Mutagenesisi147D → E: Impairs agonist affinity and increases agonist-induced inhibition of adenylate cyclase. 2 Publications1
Mutagenesisi147D → N: No effect on constitutive activation. 2 Publications1
Mutagenesisi164D → E: Reduces basal activity. 1 Publication1
Mutagenesisi164D → H, M, Q or Y: Constitutive active. 1 Publication1
Mutagenesisi166Y → A: Abolishes agonist-induced G-protein-independent receptor internalization; when associated with A-91, A-96 and A-336. 2 Publications1
Mutagenesisi166Y → F: Decrease in phosphorylation, no decrease in G-protein binding. 2 Publications1
Mutagenesisi180T → A: Impairs ARRB2- and GRK3-mediated receptor desensitization. 1 Publication1
Mutagenesisi275L → E: No effect on constitutive activation. Some constitutive activity; when associated with K-279. 1 Publication1
Mutagenesisi279T → D: Receptor inactivation. 2 Publications1
Mutagenesisi279T → K: Constitutive active. Some constitutive activity; when associated with E-275. 2 Publications1
Mutagenesisi297H → A: Impairs agonist affinity and increases agonist-induced inhibition of adenylate cyclase. 1 Publication1
Mutagenesisi336Y → A: Abolishes agonist-induced G-protein-independent receptor internalization; when associated with A-91, A-96 and A-166. 1 Publication1
Mutagenesisi346C → A: No change in palmitoylation. No change in palmitoylation; when associated with A-351. 1 Publication1
Mutagenesisi351C → A: No change in palmitoylation; when associated with A-346. 1 Publication1
Mutagenesisi363S → A: Abolishes basal phosphorylation; when associated with A-370. Abolishes basal and agonist-induced phosphorylation; when associated with A-370 and A-375. Accelerates agonist-induced receptor internalization. 2 Publications1
Mutagenesisi370T → A: Abolishes basal phosphorylation; when associated with A-363. Abolishes basal and agonist-induced phosphorylation; when associated with A-363 and A-375. Accelerates agonist-induced receptor internalization. 2 Publications1
Mutagenesisi375S → A: Reduces agonist-induced receptor internalization. Abolishes morphine-induced phosphorylation. Restores agonist-specific PRKCE activity. Abolishes basal and agonist-induced phosphorylation; when associated with A-363 and A-370. 3 Publications1
Mutagenesisi394T → A: Impairs phosphorylation and abolishes agonist-mediated acute receptor desensitization. 2 Publications1

Chemistry databases

ChEMBLiCHEMBL270
GuidetoPHARMACOLOGYi319

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699781 – 398Mu-type opioid receptorAdd BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi140 ↔ 217PROSITE-ProRule annotation
Modified residuei166Phosphotyrosine1 Publication1
Lipidationi351S-palmitoyl cysteineSequence analysis1
Modified residuei363Phosphoserine1 Publication1
Modified residuei370Phosphothreonine1 Publication1
Modified residuei375Phosphoserine1 Publication1
Modified residuei394Phosphothreonine1 Publication1

Post-translational modificationi

Phosphorylated. Differentially phosphorylated in basal and agonist-induced conditions. Agonist-mediated phosphorylation modulates receptor internalization. Phosphorylated by GRK2 in a agonist-dependent manner. Phosphorylation at Tyr-166 requires receptor activation, is dependent on non-receptor protein tyrosine kinase Src and results in a decrease in agonist efficacy by reducing G-protein coupling efficiency. Phosphorylated on tyrosine residues; the phosphorylation is involved in agonist-induced G-protein-independent receptor down-regulation. Phosphorylation at Ser-375 is involved in G-protein-dependent but not beta-arrestin-dependent activation of the ERK pathway.5 Publications
Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP33535
PRIDEiP33535

PTM databases

iPTMnetiP33535
PhosphoSitePlusiP33535
SwissPalmiP33535

Expressioni

Tissue specificityi

Brain. Is expressed in the cerebral cortex, caudate putamen, nucleus accumbens, septal nuclei, thalamus, hippocampus, and habenula. Not detected in cerebellum.

Gene expression databases

BgeeiENSRNOG00000018191 Expressed in 1 organ(s), highest expression level in brain
ExpressionAtlasiP33535 baseline and differential
GenevisibleiP33535 RN

Interactioni

Subunit structurei

Forms homooligomers and heterooligomers with other GPCRs, such as OPRD1, OPRK1, OPRL1, NPFFR2, ADRA2A, SSTR2, CNR1 and CCR5 (probably in dimeric forms) (PubMed:10842167, PubMed:11896051, PubMed:14645661, PubMed:14729105, PubMed:17384143, PubMed:16682964). Interacts with heterotrimeric G proteins; interaction with a heterotrimeric complex containing GNAI1, GNB1 and GNG2 stabilizes the active conformation of the receptor and increases its affinity for endomorphin-2, the synthetic opioid peptide DAMGO and for morphinan agonists (By similarity). Interacts with PPL; the interaction disrupts agonist-mediated G-protein activation. Interacts (via C-terminus) with DNAJB4 (via C-terminus). Interacts with calmodulin; the interaction inhibits the constitutive activity of OPRM1; it abolishes basal and attenuates agonist-stimulated G-protein coupling (By similarity). Interacts with FLNA, PLD2, RANBP9 and WLS and GPM6A (PubMed:12519790, PubMed:17548356). Interacts with RTP4 (By similarity). Interacts with SYP and GNAS (PubMed:15857684, PubMed:17005904). Interacts with RGS9, RGS17, RGS20, RGS4, PPP1R9B and HINT1 (By similarity).By similarity11 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

CORUMiP33535
IntActiP33535, 6 interactors
STRINGi10116.ENSRNOP00000051290

Chemistry databases

BindingDBiP33535

Structurei

3D structure databases

ProteinModelPortaliP33535
SMRiP33535
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi332 – 336NPxxY; plays a role in stabilizing the activated conformation of the receptorBy similarity5

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118797
HOGENOMiHOG000230486
HOVERGENiHBG106919
InParanoidiP33535
KOiK04215
OMAiPAWYWEN
TreeFamiTF315737

Family and domain databases

CDDicd15090 7tmA_Mu_opioid_R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000105 Mu_opioid_rcpt
IPR001418 Opioid_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00537 MUOPIOIDR
PR00384 OPIOIDR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (8+)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P33535-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSSTGPGNT SDCSDPLAQA SCSPAPGSWL NLSHVDGNQS DPCGLNRTGL 
        60         70         80         90        100
GGNDSLCPQT GSPSMVTAIT IMALYSIVCV VGLFGNFLVM YVIVRYTKMK 
       110        120        130        140        150
TATNIYIFNL ALADALATST LPFQSVNYLM GTWPFGTILC KIVISIDYYN 
       160        170        180        190        200
MFTSIFTLCT MSVDRYIAVC HPVKALDFRT PRNAKIVNVC NWILSSAIGL 
       210        220        230        240        250
PVMFMATTKY RQGSIDCTLT FSHPTWYWEN LLKICVFIFA FIMPVLIITV 
       260        270        280        290        300
CYGLMILRLK SVRMLSGSKE KDRNLRRITR MVLVVVAVFI VCWTPIHIYV 
       310        320        330        340        350
IIKALITIPE TTFQTVSWHF CIALGYTNSC LNPVLYAFLD ENFKRCFREF 
       360        370        380        390 
CIPTSSTIEQ QNSTRVRQNT REHPSTANTV DRTNHQLENL EAETAPLP
Length:398
Mass (Da):44,494
Last modified:February 1, 1994 - v1
Checksum:i9C916DE7C1C33743
GO
Isoform 2 (identifier: P33535-2) [UniParc]FASTAAdd to basket
Also known as: MOR1A

The sequence of this isoform differs from the canonical sequence as follows:
     387-398: LENLEAETAPLP → VCAF

Show »
Length:390
Mass (Da):43,636
Checksum:i1880D1C9918035A4
GO
Isoform 3 (identifier: P33535-3) [UniParc]FASTAAdd to basket
Also known as: MOR1R

The sequence of this isoform differs from the canonical sequence as follows:
     387-398: LENLEAETAPLP → GAEL

Show »
Length:390
Mass (Da):43,586
Checksum:i166612B3218035A4
GO
Isoform 4 (identifier: P33535-4) [UniParc]FASTAAdd to basket
Also known as: MOR1B

The sequence of this isoform differs from the canonical sequence as follows:
     387-398: LENLEAETAPLP → KIVLF

Show »
Length:391
Mass (Da):43,816
Checksum:i81767FCF38618035
GO
Isoform 5 (identifier: P33535-5) [UniParc]FASTAAdd to basket
Also known as: MOR1B2

The sequence of this isoform differs from the canonical sequence as follows:
     387-398: LENLEAETAPLP → EPQSVET

Show »
Length:393
Mass (Da):43,986
Checksum:iA9819A64EBC80041
GO
Isoform 6 (identifier: P33535-6) [UniParc]FASTAAdd to basket
Also known as: MOR1C1

The sequence of this isoform differs from the canonical sequence as follows:
     387-398: LENLEAETAPLP → PALAVSVAQI...ALIYNNVNFI

Show »
Length:451
Mass (Da):50,445
Checksum:iF1130789E14DF1F7
GO
Isoform 7 (identifier: P33535-7) [UniParc]FASTAAdd to basket
Also known as: MOR-1C2

The sequence of this isoform differs from the canonical sequence as follows:
     387-398: LENLEAETAPLP → PALAVSVAQI...MPAHVLVRPW

Show »
Length:468
Mass (Da):52,410
Checksum:i55F763EE13B2B6D1
GO
Isoform 8 (identifier: P33535-8) [UniParc]FASTAAdd to basket
Also known as: rMOR-1D

The sequence of this isoform differs from the canonical sequence as follows:
     387-398: LENLEAETAPLP → T

Show »
Length:387
Mass (Da):43,317
Checksum:iBAF18035A454EB66
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A125U2D0A0A125U2D0_RAT
Mu-type opioid receptor
Oprm1
222Annotation score:

Sequence cautioni

The sequence AAQ77387 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti237F → G in AAA79180 (PubMed:8189219).Curated1
Sequence conflicti238I → V in AAQ77386 (Ref. 7) Curated1
Sequence conflicti245V → I in AAA41630 (PubMed:8393525).Curated1
Sequence conflicti245V → I in AAA70049 (Ref. 4) Curated1
Sequence conflicti245V → I in S77863 (PubMed:7733926).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041828387 – 398LENLE…TAPLP → VCAF in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_041829387 – 398LENLE…TAPLP → GAEL in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_041830387 – 398LENLE…TAPLP → KIVLF in isoform 4. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_041831387 – 398LENLE…TAPLP → EPQSVET in isoform 5. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_041832387 – 398LENLE…TAPLP → PALAVSVAQIFTGYPSPTHG EKPCKSYRDRPRPCGRTWSL KSRAESNVEHFHCGAALIYN NVNFI in isoform 6. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_041833387 – 398LENLE…TAPLP → PALAVSVAQIFTGYPSPTHG EKPCKSYRDRPRPCGRTWSL KSRAESNVEHFHCGAALIYN NELKIGPVSWLQMPAHVLVR PW in isoform 7. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_041834387 – 398LENLE…TAPLP → T in isoform 8. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16349 mRNA Translation: BAA03852.1
L20684 mRNA Translation: AAA41643.1
L13069 mRNA Translation: AAA41630.1
U02083 mRNA Translation: AAA70049.1
L22455 mRNA Translation: AAA16075.1
U35424 mRNA Translation: AAA79180.1
AY309003 mRNA Translation: AAQ77387.1 Frameshift.
AY309004 mRNA Translation: AAQ77388.1
AY225402 mRNA Translation: AAP44725.1
AY225403 mRNA Translation: AAP44726.1
AY309000 mRNA Translation: AAQ77384.1
AY309002 mRNA Translation: AAQ77386.1
S77863 mRNA No translation available.
S75669 mRNA Translation: AAB33530.2
PIRiI56504
I56517
S69010
RefSeqiNP_001033686.1, NM_001038597.2 [P33535-2]
NP_001033688.2, NM_001038599.2 [P33535-5]
NP_001033689.1, NM_001038600.2 [P33535-6]
NP_001033690.1, NM_001038601.2 [P33535-7]
NP_001291664.1, NM_001304735.1 [P33535-1]
NP_001291666.1, NM_001304737.1 [P33535-1]
NP_001291667.1, NM_001304738.1 [P33535-1]
NP_001291669.1, NM_001304740.1 [P33535-1]
NP_037203.1, NM_013071.2 [P33535-1]
UniGeneiRn.10118

Genome annotation databases

EnsembliENSRNOT00000024682; ENSRNOP00000024682; ENSRNOG00000018191 [P33535-6]
ENSRNOT00000079628; ENSRNOP00000072626; ENSRNOG00000018191 [P33535-8]
ENSRNOT00000083308; ENSRNOP00000074079; ENSRNOG00000018191 [P33535-1]
ENSRNOT00000092034; ENSRNOP00000068988; ENSRNOG00000018191 [P33535-7]
GeneIDi25601
KEGGirno:25601

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16349 mRNA Translation: BAA03852.1
L20684 mRNA Translation: AAA41643.1
L13069 mRNA Translation: AAA41630.1
U02083 mRNA Translation: AAA70049.1
L22455 mRNA Translation: AAA16075.1
U35424 mRNA Translation: AAA79180.1
AY309003 mRNA Translation: AAQ77387.1 Frameshift.
AY309004 mRNA Translation: AAQ77388.1
AY225402 mRNA Translation: AAP44725.1
AY225403 mRNA Translation: AAP44726.1
AY309000 mRNA Translation: AAQ77384.1
AY309002 mRNA Translation: AAQ77386.1
S77863 mRNA No translation available.
S75669 mRNA Translation: AAB33530.2
PIRiI56504
I56517
S69010
RefSeqiNP_001033686.1, NM_001038597.2 [P33535-2]
NP_001033688.2, NM_001038599.2 [P33535-5]
NP_001033689.1, NM_001038600.2 [P33535-6]
NP_001033690.1, NM_001038601.2 [P33535-7]
NP_001291664.1, NM_001304735.1 [P33535-1]
NP_001291666.1, NM_001304737.1 [P33535-1]
NP_001291667.1, NM_001304738.1 [P33535-1]
NP_001291669.1, NM_001304740.1 [P33535-1]
NP_037203.1, NM_013071.2 [P33535-1]
UniGeneiRn.10118

3D structure databases

ProteinModelPortaliP33535
SMRiP33535
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiP33535
IntActiP33535, 6 interactors
STRINGi10116.ENSRNOP00000051290

Chemistry databases

BindingDBiP33535
ChEMBLiCHEMBL270
GuidetoPHARMACOLOGYi319

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP33535
PhosphoSitePlusiP33535
SwissPalmiP33535

Proteomic databases

PaxDbiP33535
PRIDEiP33535

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024682; ENSRNOP00000024682; ENSRNOG00000018191 [P33535-6]
ENSRNOT00000079628; ENSRNOP00000072626; ENSRNOG00000018191 [P33535-8]
ENSRNOT00000083308; ENSRNOP00000074079; ENSRNOG00000018191 [P33535-1]
ENSRNOT00000092034; ENSRNOP00000068988; ENSRNOG00000018191 [P33535-7]
GeneIDi25601
KEGGirno:25601

Organism-specific databases

CTDi4988
RGDi3234 Oprm1

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118797
HOGENOMiHOG000230486
HOVERGENiHBG106919
InParanoidiP33535
KOiK04215
OMAiPAWYWEN
TreeFamiTF315737

Enzyme and pathway databases

ReactomeiR-RNO-111885 Opioid Signalling
R-RNO-202040 G-protein activation
R-RNO-375276 Peptide ligand-binding receptors
R-RNO-418594 G alpha (i) signalling events

Miscellaneous databases

PROiPR:P33535

Gene expression databases

BgeeiENSRNOG00000018191 Expressed in 1 organ(s), highest expression level in brain
ExpressionAtlasiP33535 baseline and differential
GenevisibleiP33535 RN

Family and domain databases

CDDicd15090 7tmA_Mu_opioid_R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000105 Mu_opioid_rcpt
IPR001418 Opioid_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00537 MUOPIOIDR
PR00384 OPIOIDR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOPRM_RAT
AccessioniPrimary (citable) accession number: P33535
Secondary accession number(s): Q2TV20
, Q2TV21, Q4VWM5, Q4VWM7, Q4VWX7, Q4VWX8, Q62846, Q64064, Q64120
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 7, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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