Delta-type opioid receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• enkephalin receptor activity Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.2

    "Molecular cloning and expression of a delta-opioid receptor from rat brain."
    Abood M.E., Noel M.A., Farnsworth J.S., Tao Q.
    J. Neurosci. Res. 37:714-719(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
• G protein-coupled receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• neuropeptide binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• opioid receptor activity Source: RGDInferred from sequence orthologyⁱ
  • "Quantitative autoradiographic mapping of opioid receptors in the brain of delta-opioid receptor gene knockout mice."
    Goody R.J., Oakley S.M., Filliol D., Kieffer B.L., Kitchen I.
    Brain Res. 945:9-19(2002) [PubMed] [Europe PMC] [Abstract]
  • "Cys-27 variant of human delta-opioid receptor modulates maturation and cell surface delivery of Phe-27 variant via heteromerization."
    Leskela T.T., Lackman J.J., Vierimaa M.M., Kobayashi H., Bouvier M., Petaja-Repo U.E.
    J. Biol. Chem. 287:5008-5020(2012) [PubMed] [Europe PMC] [Abstract]
  • "Cloning and functional comparison of kappa and delta opioid receptors from mouse brain."
    Yasuda K., Raynor K., Kong H., Breder C.D., Takeda J., Reisine T., Bell G.I.
    Proc. Natl. Acad. Sci. U.S.A. 90:6736-6740(1993) [PubMed] [Europe PMC] [Abstract]
  • "Differences among mouse strains in the regulation by mu, delta 1 and delta 2 opioid receptors of striatal adenylyl cyclases activated by dopamine D1 or adenosine A2a receptors."
    Noble F., Cox B.M.
    Brain Res. 716:107-117(1996) [PubMed] [Europe PMC] [Abstract]
• peptide binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• receptor serine/threonine kinase binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Identification of a signaling cascade that maintains constitutive delta-opioid receptor incompetence in peripheral sensory neurons."
    Brackley A.D., Sarrami S., Gomez R., Guerrero K.A., Jeske N.A.
    J. Biol. Chem. 292:8762-8772(2017) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Differences among mouse strains in the regulation by mu, delta 1 and delta 2 opioid receptors of striatal adenylyl cyclases activated by dopamine D1 or adenosine A2a receptors."
    Noble F., Cox B.M.
    Brain Res. 716:107-117(1996) [PubMed] [Europe PMC] [Abstract]
• adult locomotory behavior Source: RGDInferred from sequence orthologyⁱ
  • "Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses."
    Filliol D., Ghozland S., Chluba J., Martin M., Matthes H.W., Simonin F., Befort K., Gaveriaux-Ruff C., Dierich A., LeMeur M., Valverde O., Maldonado R., Kieffer B.L.
    Nat. Genet. 25:195-200(2000) [PubMed] [Europe PMC] [Abstract]
• cellular response to growth factor stimulus Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Characterization of a delta opioid receptor in rat pheochromocytoma cells."
    Abood M.E., Tao Q.
    J. Pharmacol. Exp. Ther. 274:1566-1573(1995) [PubMed] [Europe PMC] [Abstract]
• cellular response to hypoxia Source: RGDInferred from sequence orthologyⁱ
  • "delta-Opioid receptor activation reduces alpha-synuclein overexpression and oligomer formation induced by MPP(+) and/or hypoxia."
    Chen T., Li J., Chao D., Sandhu H.K., Liao X., Zhao J., Wen G., Xia Y.
    Exp. Neurol. 255:127-136(2014) [PubMed] [Europe PMC] [Abstract]
• cellular response to toxic substance Source: RGDInferred from sequence orthologyⁱ
  • "delta-Opioid receptor activation reduces alpha-synuclein overexpression and oligomer formation induced by MPP(+) and/or hypoxia."
    Chen T., Li J., Chao D., Sandhu H.K., Liao X., Zhao J., Wen G., Xia Y.
    Exp. Neurol. 255:127-136(2014) [PubMed] [Europe PMC] [Abstract]
• eating behavior Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "NPY-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats."
    Israel Y., Kandov Y., Khaimova E., Kest A., Lewis S.R., Pasternak G.W., Pan Y.X., Rossi G.C., Bodnar R.J.
    Peptides 26:1167-1175(2005) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription."
    Kang J., Shi Y., Xiang B., Qu B., Su W., Zhu M., Zhang M., Bao G., Wang F., Zhang X., Yang R., Fan F., Chen X., Pei G., Ma L.
    Cell 123:833-847(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: RGDInferred from sequence orthologyⁱ
  • "delta-Opioid receptor activation reduces alpha-synuclein overexpression and oligomer formation induced by MPP(+) and/or hypoxia."
    Chen T., Li J., Chao D., Sandhu H.K., Liao X., Zhao J., Wen G., Xia Y.
    Exp. Neurol. 255:127-136(2014) [PubMed] [Europe PMC] [Abstract]
• negative regulation of protein-containing complex assembly Source: RGDInferred from sequence orthologyⁱ
  • "delta-Opioid receptor activation reduces alpha-synuclein overexpression and oligomer formation induced by MPP(+) and/or hypoxia."
    Chen T., Li J., Chao D., Sandhu H.K., Liao X., Zhao J., Wen G., Xia Y.
    Exp. Neurol. 255:127-136(2014) [PubMed] [Europe PMC] [Abstract]
• neuropeptide signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Cloning and functional comparison of kappa and delta opioid receptors from mouse brain."
    Yasuda K., Raynor K., Kong H., Breder C.D., Takeda J., Reisine T., Bell G.I.
    Proc. Natl. Acad. Sci. U.S.A. 90:6736-6740(1993) [PubMed] [Europe PMC] [Abstract]
• opioid receptor signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Delta-opioid receptors expressed by Jurkat T cells enhance IL-2 secretion by increasing AP-1 complexes and activity of the NF-AT/AP-1-binding promoter element."
    Hedin K.E., Bell M.P., Kalli K.R., Huntoon C.J., Sharp B.M., McKean D.J.
    J. Immunol. 159:5431-5440(1997) [PubMed] [Europe PMC] [Abstract]
• phospholipase C-activating G protein-coupled receptor signaling pathway Source: UniProtKBInferred from direct assayⁱ
  • "Differential coupling of mu-, delta-, and kappa-opioid receptors to G alpha16-mediated stimulation of phospholipase C."
    Lee J.W., Joshi S., Chan J.S., Wong Y.H.
    J. Neurochem. 70:2203-2211(1998) [PubMed] [Europe PMC] [Abstract]
• positive regulation of peptidyl-serine phosphorylation Source: RGDInferred from sequence orthologyⁱ
  • "delta-Opioid receptor activation reduces alpha-synuclein overexpression and oligomer formation induced by MPP(+) and/or hypoxia."
    Chen T., Li J., Chao D., Sandhu H.K., Liao X., Zhao J., Wen G., Xia Y.
    Exp. Neurol. 255:127-136(2014) [PubMed] [Europe PMC] [Abstract]
• regulation of calcium ion transport Source: RGDInferred from mutant phenotypeⁱ
  • "delta opioid receptor modulation of several voltage-dependent Ca(2+) currents in rat sensory neurons."
    Acosta C.G., Lopez H.S.
    J. Neurosci. 19:8337-8348(1999) [PubMed] [Europe PMC] [Abstract]
• regulation of mitochondrial membrane potential Source: RGDInferred from sequence orthologyⁱ
  • "delta-Opioid receptor activation reduces alpha-synuclein overexpression and oligomer formation induced by MPP(+) and/or hypoxia."
    Chen T., Li J., Chao D., Sandhu H.K., Liao X., Zhao J., Wen G., Xia Y.
    Exp. Neurol. 255:127-136(2014) [PubMed] [Europe PMC] [Abstract]
• regulation of sensory perception of pain Source: RGDInferred from direct assayⁱ
  • "kappa -opioid receptor agonists modulate visceral nociception at a novel, peripheral site of action."
    Joshi S.K., Su X., Porreca F., Gebhart G.F.
    J. Neurosci. 20:5874-5879(2000) [PubMed] [Europe PMC] [Abstract]
  • "Spinal pharmacology of antinociception produced by microinjection of mu or delta opioid receptor agonists in the ventromedial medulla of the rat."
    Hurley R.W., Banfor P., Hammond D.L.
    Neuroscience 118:789-796(2003) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• receptor serine/threonine kinase binding Source: RGDInferred from physical interactionⁱ
  • "Identification of a signaling cascade that maintains constitutive delta-opioid receptor incompetence in peripheral sensory neurons."
    Brackley A.D., Sarrami S., Gomez R., Guerrero K.A., Jeske N.A.
    J. Biol. Chem. 292:8762-8772(2017) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MEPVPSARAE LQFSLLANVS DTFPSAFPSA SANASGSPGA RSASSLALAI 
        60         70         80         90        100
AITALYSAVC AVGLLGNVLV MFGIVRYTKL KTATNIYIFN LALADALATS 
       110        120        130        140        150
TLPFQSAKYL METWPFGELL CKAVLSIDYY NMFTSIFTLT MMSVDRYIAV 
       160        170        180        190        200
CHPVKALDFR TPAKAKLINI CIWVLASGVG VPIMVMAVTQ PRDGAVVCTL 
       210        220        230        240        250
QFPSPSWYWD TVTKICVFLF AFVVPILIIT VCYGLMLLRL RSVRLLSGSK 
       260        270        280        290        300
EKDRSLRRIT RMVLVVVGAF VVCWAPIHIF VIVWTLVDIN RRDPLVVAAL 
       310        320        330        340        350
HLCIALGYAN SSLNPVLYAF LDENFKRCFR QLCRAPCGGQ EPGSLRRPRQ 
       360        370 
ATARERVTAC TPSDGPGGGA AA                               

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries