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Protein

Multidrug resistance-associated protein 1

Gene

ABCC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei653ATP 11
Binding sitei713ATP 11

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi678 – 685ATP 18
Nucleotide bindingi1327 – 1334ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: UniProtKB
  • ATPase activity, coupled to transmembrane movement of substances Source: Reactome
  • ATPase-coupled anion transmembrane transporter activity Source: Reactome
  • ATP binding Source: ProtInc
  • cobalamin-transporting ATPase activity Source: Reactome
  • glutathione S-conjugate-exporting ATPase activity Source: GO_Central
  • glutathione transmembrane transporter activity Source: GO_Central
  • phospholipid-translocating ATPase activity Source: BHF-UCL
  • sphingolipid-translocating ATPase activity Source: BHF-UCL
  • transporter activity Source: ProtInc
  • xenobiotic transmembrane transporting ATPase activity Source: GO_Central

GO - Biological processi

  • cell chemotaxis Source: BHF-UCL
  • cobalamin metabolic process Source: Reactome
  • drug transmembrane transport Source: GO_Central
  • glutathione transmembrane transport Source: GO_Central
  • leukotriene metabolic process Source: Reactome
  • phospholipid translocation Source: BHF-UCL
  • response to drug Source: ProtInc
  • sphingolipid translocation Source: BHF-UCL
  • transmembrane transport Source: Reactome
  • xenobiotic transport Source: GO_Central

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000103222-MONOMER
ReactomeiR-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-HSA-382556 ABC-family proteins mediated transport
SIGNORiP33527

Protein family/group databases

TCDBi3.A.1.208.8 the atp-binding cassette (abc) superfamily

Chemistry databases

SwissLipidsiSLP:000000404

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 1
Alternative name(s):
ATP-binding cassette sub-family C member 1
Leukotriene C(4) transporter
Short name:
LTC4 transporter
Gene namesi
Name:ABCC1
Synonyms:MRP, MRP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000103222.18
HGNCiHGNC:51 ABCC1
MIMi158343 gene
neXtProtiNX_P33527

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularAdd BLAST33
Transmembranei34 – 54Helical; Name=1Add BLAST21
Topological domaini55 – 74CytoplasmicAdd BLAST20
Transmembranei75 – 95Helical; Name=2Add BLAST21
Topological domaini96 – 100Extracellular5
Transmembranei101 – 121Helical; Name=3Add BLAST21
Topological domaini122 – 133CytoplasmicAdd BLAST12
Transmembranei134 – 154Helical; Name=4Add BLAST21
Topological domaini155 – 172ExtracellularAdd BLAST18
Transmembranei173 – 193Helical; Name=5Add BLAST21
Topological domaini194 – 316CytoplasmicAdd BLAST123
Transmembranei317 – 337Helical; Name=6Add BLAST21
Topological domaini338 – 363ExtracellularAdd BLAST26
Transmembranei364 – 384Helical; Name=7Add BLAST21
Topological domaini385 – 440CytoplasmicAdd BLAST56
Transmembranei441 – 461Helical; Name=8Add BLAST21
Topological domaini462 – 464Extracellular3
Transmembranei465 – 485Helical; Name=9Add BLAST21
Topological domaini486 – 547CytoplasmicAdd BLAST62
Transmembranei548 – 568Helical; Name=10Add BLAST21
Topological domaini569 – 590ExtracellularAdd BLAST22
Transmembranei591 – 611Helical; Name=11Add BLAST21
Topological domaini612 – 967CytoplasmicAdd BLAST356
Transmembranei968 – 988Helical; Name=12Add BLAST21
Topological domaini989 – 1025ExtracellularAdd BLAST37
Transmembranei1026 – 1046Helical; Name=13Add BLAST21
Topological domaini1047 – 1089CytoplasmicAdd BLAST43
Transmembranei1090 – 1110Helical; Name=14Add BLAST21
Topological domaini1111Extracellular1
Transmembranei1112 – 1132Helical; Name=15Add BLAST21
Topological domaini1133 – 1203CytoplasmicAdd BLAST71
Transmembranei1204 – 1224Helical; Name=16Add BLAST21
Topological domaini1225 – 1226Extracellular2
Transmembranei1227 – 1247Helical; Name=17Add BLAST21
Topological domaini1248 – 1531CytoplasmicAdd BLAST284

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi580Q → A: No effect. 1 Publication1
Mutagenesisi581T → A: No effect. 1 Publication1
Mutagenesisi585S → A: No effect. 1 Publication1
Mutagenesisi597N → A: Increases resistance to vincristine and decreases resistance to VP-16. 1 Publication1
Mutagenesisi604S → A: Increases estradiol glucuronide transport. 1 Publication1
Mutagenesisi605S → A: Decreases resistance to vincristine, VP-16 and doxorubicin. 1 Publication1
Mutagenesisi792D → A: Only partially affects protein maturation; impairs leukotriene C4 transport. 1 Publication1
Mutagenesisi792D → L: Impairs protein maturation and leukotriene C4 transport. 1 Publication1
Mutagenesisi793D → L: No effect on protein maturation and leukotriene C4 transport. 1 Publication1
Mutagenesisi1046R → D: Slightly impairs leukotriene C4 and estradiol glucuronide transport. 1 Publication1
Mutagenesisi1084D → R: Impairs leukotriene C4 and estradiol glucuronide transport. 1 Publication1
Mutagenesisi1089E → A, L, N or Q: Decreases resistance to anthracyclines. 1 Publication1
Mutagenesisi1089E → D: No effect. 1 Publication1
Mutagenesisi1089E → K: Abolishes resistance to anthracyclines. 1 Publication1
Mutagenesisi1131R → E: Slightly impairs leukotriene C4 and estradiol glucuronide transport. 1 Publication1
Mutagenesisi1138R → E or K: Strongly reduced transport of leukotriene C4, estradiol glucuronide and of glutathione. 1 Publication1
Mutagenesisi1141K → E: Reduced transport of leukotriene C4 and of glutathione. 1 Publication1
Mutagenesisi1141K → R: Reduced transport of glutathione. 1 Publication1
Mutagenesisi1142R → E or K: Reduced transport of leukotriene C4, estradiol glucuronide and of glutathione. 1 Publication1
Mutagenesisi1246W → A, F or Y: Impairs estradiol glucuronide transport. 1 Publication1
Mutagenesisi1246W → C: Impairs estradiol glucuronide transport; loss of resistance to alkaloid vincristine, cationic anthracyclines, epipodophyllotoxin VP-16, but not potassium antimony tartrate; partial loss of resistance to sodium arsenite. 1 Publication1
Mutagenesisi1333K → L: Impairs leukotriene C4 transport. 1 Publication1
Mutagenesisi1454 – 1455DE → LL: Impairs leukotriene C4 transport. 1 Publication2

Organism-specific databases

DisGeNETi4363
OpenTargetsiENSG00000103222
PharmGKBiPA244

Chemistry databases

ChEMBLiCHEMBL3004
DrugBankiDB05812 Abiraterone
DB00345 Aminohippuric acid
DB00701 Amprenavir
DB01072 Atazanavir
DB01076 Atorvastatin
DB04851 Biricodar dicitrate
DB02659 Cholic Acid
DB01394 Colchicine
DB00286 Conjugated Equine Estrogens
DB00091 Cyclosporine
DB00970 Dactinomycin
DB00694 Daunorubicin
DB00586 Diclofenac
DB01248 Docetaxel
DB00997 Doxorubicin
DB00445 Epirubicin
DB00773 Etoposide
DB00693 Fluorescein
DB01645 Genistein
DB00143 Glutathione
DB01016 Glyburide
DB00365 Grepafloxacin
DB01050 Ibuprofen
DB01177 Idarubicin
DB00224 Indinavir
DB00328 Indomethacin
DB00762 Irinotecan
DB00602 Ivermectin
DB00709 Lamivudine
DB00563 Methotrexate
DB00834 Mifepristone
DB01204 Mitoxantrone
DB02375 Myricetin
DB03467 Naringenin
DB01165 Ofloxacin
DB01229 Paclitaxel
DB01174 Phenobarbital
DB01032 Probenecid
DB00396 Progesterone
DB04216 Quercetin
DB03825 Rhodamine 6G
DB01045 Rifampicin
DB00503 Ritonavir
DB01098 Rosuvastatin
DB01232 Saquinavir
DB06335 Saxagliptin
DB01138 Sulfinpyrazone
DB04348 Taurocholic Acid
DB09161 Technetium Tc-99m sestamibi
DB05294 Vandetanib
DB08881 Vemurafenib
DB00661 Verapamil
DB00570 Vinblastine
DB00541 Vincristine
DB00399 Zoledronic acid
GuidetoPHARMACOLOGYi779

Polymorphism and mutation databases

BioMutaiABCC1
DMDMi296439301

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933511 – 1531Multidrug resistance-associated protein 1Add BLAST1531

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi19N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi23N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei277PhosphotyrosineBy similarity1
Modified residuei289PhosphoserineBy similarity1
Modified residuei503N6-succinyllysineBy similarity1
Modified residuei905PhosphoserineCombined sources1
Modified residuei915PhosphoserineCombined sources1
Modified residuei930PhosphoserineCombined sources1
Glycosylationi1006N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP33527
MaxQBiP33527
PaxDbiP33527
PeptideAtlasiP33527
PRIDEiP33527
ProteomicsDBi54912
54913 [P33527-2]
54914 [P33527-3]
54915 [P33527-4]
54916 [P33527-5]
54917 [P33527-6]
54918 [P33527-7]
54919 [P33527-8]
54920 [P33527-9]

PTM databases

iPTMnetiP33527
PhosphoSitePlusiP33527
SwissPalmiP33527

Expressioni

Tissue specificityi

Lung, testis and peripheral blood mononuclear cells.

Gene expression databases

BgeeiENSG00000103222
CleanExiHS_ABCC1
ExpressionAtlasiP33527 baseline and differential
GenevisibleiP33527 HS

Organism-specific databases

HPAiHPA002380

Interactioni

Protein-protein interaction databases

BioGridi110503, 57 interactors
IntActiP33527, 14 interactors
MINTiP33527
STRINGi9606.ENSP00000382342

Chemistry databases

BindingDBiP33527

Structurei

Secondary structure

11531
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi644 – 653Combined sources10
Beta strandi660 – 668Combined sources9
Beta strandi673 – 677Combined sources5
Helixi684 – 691Combined sources8
Beta strandi695 – 704Combined sources10
Beta strandi708 – 711Combined sources4
Beta strandi719 – 721Combined sources3
Helixi722 – 727Combined sources6
Helixi736 – 743Combined sources8
Helixi747 – 750Combined sources4
Helixi756 – 758Combined sources3
Beta strandi759 – 762Combined sources4
Helixi770 – 784Combined sources15
Beta strandi787 – 793Combined sources7
Turni794 – 797Combined sources4
Helixi800 – 809Combined sources10
Turni816 – 819Combined sources4
Beta strandi820 – 825Combined sources6
Helixi832 – 834Combined sources3
Beta strandi835 – 842Combined sources8
Beta strandi845 – 850Combined sources6
Helixi852 – 858Combined sources7
Helixi861 – 868Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CBZX-ray1.50A642-871[»]
4C3ZX-ray2.10A628-881[»]
ProteinModelPortaliP33527
SMRiP33527
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP33527

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini325 – 608ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST284
Domaini644 – 868ABC transporter 1PROSITE-ProRule annotationAdd BLAST225
Domaini975 – 1256ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST282
Domaini1293 – 1527ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00880000137856
HOVERGENiHBG108314
InParanoidiP33527
KOiK05665
OMAiENEWRVD
OrthoDBiEOG091G00IN
PhylomeDBiP33527
TreeFamiTF105199

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR005292 Multidrug-R_assoc
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
TIGRFAMsiTIGR00957 MRP_assoc_pro, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: P33527-1) [UniParc]FASTAAdd to basket
Also known as: Allexons

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALRGFCSAD GSDPLWDWNV TWNTSNPDFT KCFQNTVLVW VPCFYLWACF
60 70 80 90 100
PFYFLYLSRH DRGYIQMTPL NKTKTALGFL LWIVCWADLF YSFWERSRGI
110 120 130 140 150
FLAPVFLVSP TLLGITMLLA TFLIQLERRK GVQSSGIMLT FWLVALVCAL
160 170 180 190 200
AILRSKIMTA LKEDAQVDLF RDITFYVYFS LLLIQLVLSC FSDRSPLFSE
210 220 230 240 250
TIHDPNPCPE SSASFLSRIT FWWITGLIVR GYRQPLEGSD LWSLNKEDTS
260 270 280 290 300
EQVVPVLVKN WKKECAKTRK QPVKVVYSSK DPAQPKESSK VDANEEVEAL
310 320 330 340 350
IVKSPQKEWN PSLFKVLYKT FGPYFLMSFF FKAIHDLMMF SGPQILKLLI
360 370 380 390 400
KFVNDTKAPD WQGYFYTVLL FVTACLQTLV LHQYFHICFV SGMRIKTAVI
410 420 430 440 450
GAVYRKALVI TNSARKSSTV GEIVNLMSVD AQRFMDLATY INMIWSAPLQ
460 470 480 490 500
VILALYLLWL NLGPSVLAGV AVMVLMVPVN AVMAMKTKTY QVAHMKSKDN
510 520 530 540 550
RIKLMNEILN GIKVLKLYAW ELAFKDKVLA IRQEELKVLK KSAYLSAVGT
560 570 580 590 600
FTWVCTPFLV ALCTFAVYVT IDENNILDAQ TAFVSLALFN ILRFPLNILP
610 620 630 640 650
MVISSIVQAS VSLKRLRIFL SHEELEPDSI ERRPVKDGGG TNSITVRNAT
660 670 680 690 700
FTWARSDPPT LNGITFSIPE GALVAVVGQV GCGKSSLLSA LLAEMDKVEG
710 720 730 740 750
HVAIKGSVAY VPQQAWIQND SLRENILFGC QLEEPYYRSV IQACALLPDL
760 770 780 790 800
EILPSGDRTE IGEKGVNLSG GQKQRVSLAR AVYSNADIYL FDDPLSAVDA
810 820 830 840 850
HVGKHIFENV IGPKGMLKNK TRILVTHSMS YLPQVDVIIV MSGGKISEMG
860 870 880 890 900
SYQELLARDG AFAEFLRTYA STEQEQDAEE NGVTGVSGPG KEAKQMENGM
910 920 930 940 950
LVTDSAGKQL QRQLSSSSSY SGDISRHHNS TAELQKAEAK KEETWKLMEA
960 970 980 990 1000
DKAQTGQVKL SVYWDYMKAI GLFISFLSIF LFMCNHVSAL ASNYWLSLWT
1010 1020 1030 1040 1050
DDPIVNGTQE HTKVRLSVYG ALGISQGIAV FGYSMAVSIG GILASRCLHV
1060 1070 1080 1090 1100
DLLHSILRSP MSFFERTPSG NLVNRFSKEL DTVDSMIPEV IKMFMGSLFN
1110 1120 1130 1140 1150
VIGACIVILL ATPIAAIIIP PLGLIYFFVQ RFYVASSRQL KRLESVSRSP
1160 1170 1180 1190 1200
VYSHFNETLL GVSVIRAFEE QERFIHQSDL KVDENQKAYY PSIVANRWLA
1210 1220 1230 1240 1250
VRLECVGNCI VLFAALFAVI SRHSLSAGLV GLSVSYSLQV TTYLNWLVRM
1260 1270 1280 1290 1300
SSEMETNIVA VERLKEYSET EKEAPWQIQE TAPPSSWPQV GRVEFRNYCL
1310 1320 1330 1340 1350
RYREDLDFVL RHINVTINGG EKVGIVGRTG AGKSSLTLGL FRINESAEGE
1360 1370 1380 1390 1400
IIIDGINIAK IGLHDLRFKI TIIPQDPVLF SGSLRMNLDP FSQYSDEEVW
1410 1420 1430 1440 1450
TSLELAHLKD FVSALPDKLD HECAEGGENL SVGQRQLVCL ARALLRKTKI
1460 1470 1480 1490 1500
LVLDEATAAV DLETDDLIQS TIRTQFEDCT VLTIAHRLNT IMDYTRVIVL
1510 1520 1530
DKGEIQEYGA PSDLLQQRGL FYSMAKDAGL V
Length:1,531
Mass (Da):171,591
Last modified:May 18, 2010 - v3
Checksum:i46A7CB643B9478C4
GO
Isoform 2 (identifier: P33527-2) [UniParc]FASTAAdd to basket
Also known as: Delexon-17

The sequence of this isoform differs from the canonical sequence as follows:
     706-764: Missing.

Show »
Length:1,472
Mass (Da):164,971
Checksum:i143FA6CB7F3123EF
GO
Isoform 3 (identifier: P33527-3) [UniParc]FASTAAdd to basket
Also known as: Delexon-18

The sequence of this isoform differs from the canonical sequence as follows:
     765-820: Missing.

Show »
Length:1,475
Mass (Da):165,569
Checksum:iF49C1B33B976D008
GO
Isoform 4 (identifier: P33527-4) [UniParc]FASTAAdd to basket
Also known as: Delexon-30

The sequence of this isoform differs from the canonical sequence as follows:
     1431-1495: Missing.

Show »
Length:1,466
Mass (Da):164,304
Checksum:i314A53D4242BAF1B
GO
Isoform 5 (identifier: P33527-5) [UniParc]FASTAAdd to basket
Also known as: Delexon-17-18

The sequence of this isoform differs from the canonical sequence as follows:
     706-764: Missing.
     765-820: Missing.

Show »
Length:1,416
Mass (Da):158,949
Checksum:i6CAB8926692A0377
GO
Isoform 6 (identifier: P33527-6) [UniParc]FASTAAdd to basket
Also known as: Delexon-17-30

The sequence of this isoform differs from the canonical sequence as follows:
     706-764: Missing.
     1431-1495: Missing.

Show »
Length:1,407
Mass (Da):157,683
Checksum:iE76D558115609C22
GO
Isoform 7 (identifier: P33527-7) [UniParc]FASTAAdd to basket
Also known as: Delexon-18-30

The sequence of this isoform differs from the canonical sequence as follows:
     765-820: Missing.
     1431-1495: Missing.

Show »
Length:1,410
Mass (Da):158,282
Checksum:i6AAC80E7E87AD25D
GO
Isoform 8 (identifier: P33527-8) [UniParc]FASTAAdd to basket
Also known as: Delexon-17-18-30

The sequence of this isoform differs from the canonical sequence as follows:
     706-764: Missing.
     765-820: Missing.
     1431-1495: Missing.

Show »
Length:1,351
Mass (Da):151,661
Checksum:iB3FD697CE71EBB51
GO
Isoform 9 (identifier: P33527-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     882-882: G → GSTVMDEEEAG

Note: No experimental confirmation available.
Show »
Length:1,541
Mass (Da):172,640
Checksum:i5AE3F0E657F948F8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01331743C → S1 PublicationCorresponds to variant dbSNP:rs41395947Ensembl.1
Natural variantiVAR_01331873T → I1 PublicationCorresponds to variant dbSNP:rs41494447Ensembl.1
Natural variantiVAR_013319117M → T3 Publications1
Natural variantiVAR_013320433R → S2 PublicationsCorresponds to variant dbSNP:rs60782127EnsemblClinVar.1
Natural variantiVAR_011488633R → Q1 PublicationCorresponds to variant dbSNP:rs112282109Ensembl.1
Natural variantiVAR_011489671G → V No effect on leukotriene C4 and estradiol glucuronide transport. 4 PublicationsCorresponds to variant dbSNP:rs45511401Ensembl.1
Natural variantiVAR_013321723R → Q2 PublicationsCorresponds to variant dbSNP:rs4148356EnsemblClinVar.1
Natural variantiVAR_055384861A → T1 PublicationCorresponds to variant dbSNP:rs45517537Ensembl.1
Natural variantiVAR_0553851047C → S1 PublicationCorresponds to variant dbSNP:rs13337489Ensembl.1
Natural variantiVAR_0133221058R → Q1 PublicationCorresponds to variant dbSNP:rs41410450Ensembl.1
Natural variantiVAR_0553861146V → I1 PublicationCorresponds to variant dbSNP:rs28706727Ensembl.1
Natural variantiVAR_0133231512S → L1 PublicationCorresponds to variant dbSNP:rs369410659Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000037706 – 764Missing in isoform 2, isoform 5, isoform 6 and isoform 8. CuratedAdd BLAST59
Alternative sequenceiVSP_000038765 – 820Missing in isoform 3, isoform 5, isoform 7 and isoform 8. CuratedAdd BLAST56
Alternative sequenceiVSP_017014882G → GSTVMDEEEAG in isoform 9. 1 Publication1
Alternative sequenceiVSP_0000391431 – 1495Missing in isoform 4, isoform 6, isoform 7 and isoform 8. CuratedAdd BLAST65

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05628 mRNA Translation: AAB46616.1
AF022853
, AF022827, AF022828, AF022829, AF022831, AF022833, AF022835, AF022837, AF022839, AF022841, AF022850, AF022849, AF022848, AF022847, AF022846, AF022845, AF022844, AF022843, AF022842, AF022852, AF022851, AF022840, AF022838, AF022836, AF022834, AF022832, AF022826, AF022825, AF022824, AF022830 Genomic DNA Translation: AAB83979.1
AF022853
, AF022824, AF022825, AF022826, AF022828, AF022830, AF022832, AF022834, AF022836, AF022838, AF022848, AF022847, AF022846, AF022845, AF022844, AF022843, AF022842, AF022841, AF022839, AF022852, AF022851, AF022850, AF022849, AF022837, AF022835, AF022833, AF022831, AF022829, AF022827 Genomic DNA Translation: AAB83980.1
AF022853
, AF022824, AF022825, AF022826, AF022827, AF022829, AF022831, AF022833, AF022835, AF022837, AF022847, AF022846, AF022845, AF022844, AF022843, AF022842, AF022841, AF022840, AF022838, AF022852, AF022851, AF022850, AF022849, AF022848, AF022836, AF022834, AF022832, AF022830, AF022828 Genomic DNA Translation: AAB83981.1
AF022853
, AF022824, AF022825, AF022826, AF022827, AF022828, AF022829, AF022830, AF022831, AF022832, AF022833, AF022834, AF022835, AF022836, AF022837, AF022838, AF022839, AF022840, AF022841, AF022842, AF022843, AF022844, AF022845, AF022846, AF022847, AF022848, AF022849, AF022850, AF022851 Genomic DNA Translation: AAB83983.1
EF419769 Genomic DNA Translation: ABN79590.1
AC025778 Genomic DNA No translation available.
AC130651 Genomic DNA No translation available.
AC136624 Genomic DNA No translation available.
AB209120 mRNA Translation: BAD92357.1
U91318 Genomic DNA Translation: AAC15784.1
AC003026 Genomic DNA Translation: AAC05808.1
CCDSiCCDS42122.1 [P33527-1]
PIRiA44231 DVHUAR
RefSeqiNP_004987.2, NM_004996.3 [P33527-1]
UniGeneiHs.391464

Genome annotation databases

EnsembliENST00000399410; ENSP00000382342; ENSG00000103222 [P33527-1]
ENST00000621144; ENSP00000483316; ENSG00000278183 [P33527-1]
GeneIDi4363
KEGGihsa:4363
UCSCiuc010bvi.4 human [P33527-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMRP1_HUMAN
AccessioniPrimary (citable) accession number: P33527
Secondary accession number(s): A3RJX2
, C9JPJ4, O14819, O43333, P78419, Q59GI9, Q9UQ97, Q9UQ99, Q9UQA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 193 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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