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Protein

Multidrug resistance-associated protein 1

Gene

ABCC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei653ATP 11
Binding sitei713ATP 11

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi678 – 685ATP 18
Nucleotide bindingi1327 – 1334ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATPase activity Source: UniProtKB
  • ATPase activity, coupled to transmembrane movement of substances Source: GO_Central
  • ATPase-coupled anion transmembrane transporter activity Source: Reactome
  • ATP binding Source: ProtInc
  • cobalamin-transporting ATPase activity Source: Reactome
  • glutathione transmembrane transporter activity Source: GO_Central
  • phospholipid-translocating ATPase activity Source: BHF-UCL
  • sphingolipid-translocating ATPase activity Source: BHF-UCL
  • transporter activity Source: ProtInc
  • xenobiotic transmembrane transporting ATPase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:ENSG00000103222-MONOMER

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-HSA-382556 ABC-family proteins mediated transport

SIGNOR Signaling Network Open Resource

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SIGNORi
P33527

Protein family/group databases

Transport Classification Database

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TCDBi
3.A.1.208.8 the atp-binding cassette (abc) superfamily

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000404

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multidrug resistance-associated protein 1
Alternative name(s):
ATP-binding cassette sub-family C member 1
Leukotriene C(4) transporter
Short name:
LTC4 transporter
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCC1
Synonyms:MRP, MRP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000103222.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:51 ABCC1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
158343 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P33527

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 33ExtracellularAdd BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei34 – 54Helical; Name=1Add BLAST21
Topological domaini55 – 74CytoplasmicAdd BLAST20
Transmembranei75 – 95Helical; Name=2Add BLAST21
Topological domaini96 – 100Extracellular5
Transmembranei101 – 121Helical; Name=3Add BLAST21
Topological domaini122 – 133CytoplasmicAdd BLAST12
Transmembranei134 – 154Helical; Name=4Add BLAST21
Topological domaini155 – 172ExtracellularAdd BLAST18
Transmembranei173 – 193Helical; Name=5Add BLAST21
Topological domaini194 – 316CytoplasmicAdd BLAST123
Transmembranei317 – 337Helical; Name=6Add BLAST21
Topological domaini338 – 363ExtracellularAdd BLAST26
Transmembranei364 – 384Helical; Name=7Add BLAST21
Topological domaini385 – 440CytoplasmicAdd BLAST56
Transmembranei441 – 461Helical; Name=8Add BLAST21
Topological domaini462 – 464Extracellular3
Transmembranei465 – 485Helical; Name=9Add BLAST21
Topological domaini486 – 547CytoplasmicAdd BLAST62
Transmembranei548 – 568Helical; Name=10Add BLAST21
Topological domaini569 – 590ExtracellularAdd BLAST22
Transmembranei591 – 611Helical; Name=11Add BLAST21
Topological domaini612 – 967CytoplasmicAdd BLAST356
Transmembranei968 – 988Helical; Name=12Add BLAST21
Topological domaini989 – 1025ExtracellularAdd BLAST37
Transmembranei1026 – 1046Helical; Name=13Add BLAST21
Topological domaini1047 – 1089CytoplasmicAdd BLAST43
Transmembranei1090 – 1110Helical; Name=14Add BLAST21
Topological domaini1111Extracellular1
Transmembranei1112 – 1132Helical; Name=15Add BLAST21
Topological domaini1133 – 1203CytoplasmicAdd BLAST71
Transmembranei1204 – 1224Helical; Name=16Add BLAST21
Topological domaini1225 – 1226Extracellular2
Transmembranei1227 – 1247Helical; Name=17Add BLAST21
Topological domaini1248 – 1531CytoplasmicAdd BLAST284

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi580Q → A: No effect. 1 Publication1
Mutagenesisi581T → A: No effect. 1 Publication1
Mutagenesisi585S → A: No effect. 1 Publication1
Mutagenesisi597N → A: Increases resistance to vincristine and decreases resistance to VP-16. 1 Publication1
Mutagenesisi604S → A: Increases estradiol glucuronide transport. 1 Publication1
Mutagenesisi605S → A: Decreases resistance to vincristine, VP-16 and doxorubicin. 1 Publication1
Mutagenesisi792D → A: Only partially affects protein maturation; impairs leukotriene C4 transport. 1 Publication1
Mutagenesisi792D → L: Impairs protein maturation and leukotriene C4 transport. 1 Publication1
Mutagenesisi793D → L: No effect on protein maturation and leukotriene C4 transport. 1 Publication1
Mutagenesisi1046R → D: Slightly impairs leukotriene C4 and estradiol glucuronide transport. 1 Publication1
Mutagenesisi1084D → R: Impairs leukotriene C4 and estradiol glucuronide transport. 1 Publication1
Mutagenesisi1089E → A, L, N or Q: Decreases resistance to anthracyclines. 1 Publication1
Mutagenesisi1089E → D: No effect. 1 Publication1
Mutagenesisi1089E → K: Abolishes resistance to anthracyclines. 1 Publication1
Mutagenesisi1131R → E: Slightly impairs leukotriene C4 and estradiol glucuronide transport. 1 Publication1
Mutagenesisi1138R → E or K: Strongly reduced transport of leukotriene C4, estradiol glucuronide and of glutathione. 1 Publication1
Mutagenesisi1141K → E: Reduced transport of leukotriene C4 and of glutathione. 1 Publication1
Mutagenesisi1141K → R: Reduced transport of glutathione. 1 Publication1
Mutagenesisi1142R → E or K: Reduced transport of leukotriene C4, estradiol glucuronide and of glutathione. 1 Publication1
Mutagenesisi1246W → A, F or Y: Impairs estradiol glucuronide transport. 1 Publication1
Mutagenesisi1246W → C: Impairs estradiol glucuronide transport; loss of resistance to alkaloid vincristine, cationic anthracyclines, epipodophyllotoxin VP-16, but not potassium antimony tartrate; partial loss of resistance to sodium arsenite. 1 Publication1
Mutagenesisi1333K → L: Impairs leukotriene C4 transport. 1 Publication1
Mutagenesisi1454 – 1455DE → LL: Impairs leukotriene C4 transport. 1 Publication2

Organism-specific databases

DisGeNET

More...
DisGeNETi
4363

Open Targets

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OpenTargetsi
ENSG00000103222

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA244

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3004

Drug and drug target database

More...
DrugBanki
DB05812 Abiraterone
DB00345 Aminohippuric acid
DB00701 Amprenavir
DB01072 Atazanavir
DB01076 Atorvastatin
DB04851 Biricodar dicitrate
DB02659 Cholic Acid
DB01394 Colchicine
DB00286 Conjugated Equine Estrogens
DB00091 Cyclosporine
DB00970 Dactinomycin
DB00694 Daunorubicin
DB00586 Diclofenac
DB01248 Docetaxel
DB00997 Doxorubicin
DB00445 Epirubicin
DB00773 Etoposide
DB00693 Fluorescein
DB01645 Genistein
DB00143 Glutathione
DB01016 Glyburide
DB00365 Grepafloxacin
DB01050 Ibuprofen
DB01177 Idarubicin
DB00224 Indinavir
DB00328 Indomethacin
DB00762 Irinotecan
DB00602 Ivermectin
DB00709 Lamivudine
DB00563 Methotrexate
DB00834 Mifepristone
DB01204 Mitoxantrone
DB02375 Myricetin
DB03467 Naringenin
DB01165 Ofloxacin
DB01229 Paclitaxel
DB01174 Phenobarbital
DB01032 Probenecid
DB00396 Progesterone
DB04216 Quercetin
DB03825 Rhodamine 6G
DB01045 Rifampicin
DB00503 Ritonavir
DB01098 Rosuvastatin
DB01232 Saquinavir
DB06335 Saxagliptin
DB01138 Sulfinpyrazone
DB04348 Taurocholic Acid
DB09161 Technetium Tc-99m sestamibi
DB05294 Vandetanib
DB08881 Vemurafenib
DB00661 Verapamil
DB00570 Vinblastine
DB00541 Vincristine
DB00399 Zoledronic acid

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
779

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ABCC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439301

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000933511 – 1531Multidrug resistance-associated protein 1Add BLAST1531

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi19N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi23N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei277PhosphotyrosineBy similarity1
Modified residuei289PhosphoserineBy similarity1
Modified residuei503N6-succinyllysineBy similarity1
Modified residuei905PhosphoserineCombined sources1
Modified residuei915PhosphoserineCombined sources1
Modified residuei930PhosphoserineCombined sources1
Glycosylationi1006N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P33527

MaxQB - The MaxQuant DataBase

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MaxQBi
P33527

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P33527

PeptideAtlas

More...
PeptideAtlasi
P33527

PRoteomics IDEntifications database

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PRIDEi
P33527

ProteomicsDB human proteome resource

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ProteomicsDBi
54912
54913 [P33527-2]
54914 [P33527-3]
54915 [P33527-4]
54916 [P33527-5]
54917 [P33527-6]
54918 [P33527-7]
54919 [P33527-8]
54920 [P33527-9]

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1523

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P33527

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P33527

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P33527

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Lung, testis and peripheral blood mononuclear cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000103222 Expressed in 230 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_ABCC1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P33527 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P33527 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA002380

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110503, 58 interactors

Protein interaction database and analysis system

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IntActi
P33527, 15 interactors

Molecular INTeraction database

More...
MINTi
P33527

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000382342

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P33527

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11531
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P33527

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P33527

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P33527

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini325 – 608ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST284
Domaini644 – 868ABC transporter 1PROSITE-ProRule annotationAdd BLAST225
Domaini975 – 1256ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST282
Domaini1293 – 1527ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0054 Eukaryota
COG1132 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160271

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108314

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P33527

KEGG Orthology (KO)

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KOi
K05665

Identification of Orthologs from Complete Genome Data

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OMAi
NEWRVDA

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00IN

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P33527

TreeFam database of animal gene trees

More...
TreeFami
TF105199

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR005292 Multidrug-R_assoc
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00957 MRP_assoc_pro, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 9 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms.

This entry has 9 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P33527-1) [UniParc]FASTAAdd to basket
Also known as: Allexons

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALRGFCSAD GSDPLWDWNV TWNTSNPDFT KCFQNTVLVW VPCFYLWACF
60 70 80 90 100
PFYFLYLSRH DRGYIQMTPL NKTKTALGFL LWIVCWADLF YSFWERSRGI
110 120 130 140 150
FLAPVFLVSP TLLGITMLLA TFLIQLERRK GVQSSGIMLT FWLVALVCAL
160 170 180 190 200
AILRSKIMTA LKEDAQVDLF RDITFYVYFS LLLIQLVLSC FSDRSPLFSE
210 220 230 240 250
TIHDPNPCPE SSASFLSRIT FWWITGLIVR GYRQPLEGSD LWSLNKEDTS
260 270 280 290 300
EQVVPVLVKN WKKECAKTRK QPVKVVYSSK DPAQPKESSK VDANEEVEAL
310 320 330 340 350
IVKSPQKEWN PSLFKVLYKT FGPYFLMSFF FKAIHDLMMF SGPQILKLLI
360 370 380 390 400
KFVNDTKAPD WQGYFYTVLL FVTACLQTLV LHQYFHICFV SGMRIKTAVI
410 420 430 440 450
GAVYRKALVI TNSARKSSTV GEIVNLMSVD AQRFMDLATY INMIWSAPLQ
460 470 480 490 500
VILALYLLWL NLGPSVLAGV AVMVLMVPVN AVMAMKTKTY QVAHMKSKDN
510 520 530 540 550
RIKLMNEILN GIKVLKLYAW ELAFKDKVLA IRQEELKVLK KSAYLSAVGT
560 570 580 590 600
FTWVCTPFLV ALCTFAVYVT IDENNILDAQ TAFVSLALFN ILRFPLNILP
610 620 630 640 650
MVISSIVQAS VSLKRLRIFL SHEELEPDSI ERRPVKDGGG TNSITVRNAT
660 670 680 690 700
FTWARSDPPT LNGITFSIPE GALVAVVGQV GCGKSSLLSA LLAEMDKVEG
710 720 730 740 750
HVAIKGSVAY VPQQAWIQND SLRENILFGC QLEEPYYRSV IQACALLPDL
760 770 780 790 800
EILPSGDRTE IGEKGVNLSG GQKQRVSLAR AVYSNADIYL FDDPLSAVDA
810 820 830 840 850
HVGKHIFENV IGPKGMLKNK TRILVTHSMS YLPQVDVIIV MSGGKISEMG
860 870 880 890 900
SYQELLARDG AFAEFLRTYA STEQEQDAEE NGVTGVSGPG KEAKQMENGM
910 920 930 940 950
LVTDSAGKQL QRQLSSSSSY SGDISRHHNS TAELQKAEAK KEETWKLMEA
960 970 980 990 1000
DKAQTGQVKL SVYWDYMKAI GLFISFLSIF LFMCNHVSAL ASNYWLSLWT
1010 1020 1030 1040 1050
DDPIVNGTQE HTKVRLSVYG ALGISQGIAV FGYSMAVSIG GILASRCLHV
1060 1070 1080 1090 1100
DLLHSILRSP MSFFERTPSG NLVNRFSKEL DTVDSMIPEV IKMFMGSLFN
1110 1120 1130 1140 1150
VIGACIVILL ATPIAAIIIP PLGLIYFFVQ RFYVASSRQL KRLESVSRSP
1160 1170 1180 1190 1200
VYSHFNETLL GVSVIRAFEE QERFIHQSDL KVDENQKAYY PSIVANRWLA
1210 1220 1230 1240 1250
VRLECVGNCI VLFAALFAVI SRHSLSAGLV GLSVSYSLQV TTYLNWLVRM
1260 1270 1280 1290 1300
SSEMETNIVA VERLKEYSET EKEAPWQIQE TAPPSSWPQV GRVEFRNYCL
1310 1320 1330 1340 1350
RYREDLDFVL RHINVTINGG EKVGIVGRTG AGKSSLTLGL FRINESAEGE
1360 1370 1380 1390 1400
IIIDGINIAK IGLHDLRFKI TIIPQDPVLF SGSLRMNLDP FSQYSDEEVW
1410 1420 1430 1440 1450
TSLELAHLKD FVSALPDKLD HECAEGGENL SVGQRQLVCL ARALLRKTKI
1460 1470 1480 1490 1500
LVLDEATAAV DLETDDLIQS TIRTQFEDCT VLTIAHRLNT IMDYTRVIVL
1510 1520 1530
DKGEIQEYGA PSDLLQQRGL FYSMAKDAGL V
Length:1,531
Mass (Da):171,591
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i46A7CB643B9478C4
GO
Isoform 2 (identifier: P33527-2) [UniParc]FASTAAdd to basket
Also known as: Delexon-17

The sequence of this isoform differs from the canonical sequence as follows:
     706-764: Missing.

Show »
Length:1,472
Mass (Da):164,971
Checksum:i143FA6CB7F3123EF
GO
Isoform 3 (identifier: P33527-3) [UniParc]FASTAAdd to basket
Also known as: Delexon-18

The sequence of this isoform differs from the canonical sequence as follows:
     765-820: Missing.

Show »
Length:1,475
Mass (Da):165,569
Checksum:iF49C1B33B976D008
GO
Isoform 4 (identifier: P33527-4) [UniParc]FASTAAdd to basket
Also known as: Delexon-30

The sequence of this isoform differs from the canonical sequence as follows:
     1431-1495: Missing.

Show »
Length:1,466
Mass (Da):164,304
Checksum:i314A53D4242BAF1B
GO
Isoform 5 (identifier: P33527-5) [UniParc]FASTAAdd to basket
Also known as: Delexon-17-18

The sequence of this isoform differs from the canonical sequence as follows:
     706-764: Missing.
     765-820: Missing.

Show »
Length:1,416
Mass (Da):158,949
Checksum:i6CAB8926692A0377
GO
Isoform 6 (identifier: P33527-6) [UniParc]FASTAAdd to basket
Also known as: Delexon-17-30

The sequence of this isoform differs from the canonical sequence as follows:
     706-764: Missing.
     1431-1495: Missing.

Show »
Length:1,407
Mass (Da):157,683
Checksum:iE76D558115609C22
GO
Isoform 7 (identifier: P33527-7) [UniParc]FASTAAdd to basket
Also known as: Delexon-18-30

The sequence of this isoform differs from the canonical sequence as follows:
     765-820: Missing.
     1431-1495: Missing.

Show »
Length:1,410
Mass (Da):158,282
Checksum:i6AAC80E7E87AD25D
GO
Isoform 8 (identifier: P33527-8) [UniParc]FASTAAdd to basket
Also known as: Delexon-17-18-30

The sequence of this isoform differs from the canonical sequence as follows:
     706-764: Missing.
     765-820: Missing.
     1431-1495: Missing.

Show »
Length:1,351
Mass (Da):151,661
Checksum:iB3FD697CE71EBB51
GO
Isoform 9 (identifier: P33527-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     882-882: G → GSTVMDEEEAG

Note: No experimental confirmation available.
Show »
Length:1,541
Mass (Da):172,640
Checksum:i5AE3F0E657F948F8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L4X2I3L4X2_HUMAN
Multidrug resistance-associated pro...
ABCC1
1,440Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MS99A0A0A0MS99_HUMAN
Multidrug resistance-associated pro...
ABCC1
1,215Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2H9I3L2H9_HUMAN
Multidrug resistance-associated pro...
ABCC1
22Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01331743C → S1 PublicationCorresponds to variant dbSNP:rs41395947Ensembl.1
Natural variantiVAR_01331873T → I1 PublicationCorresponds to variant dbSNP:rs41494447Ensembl.1
Natural variantiVAR_013319117M → T3 Publications1
Natural variantiVAR_013320433R → S2 PublicationsCorresponds to variant dbSNP:rs60782127EnsemblClinVar.1
Natural variantiVAR_011488633R → Q1 PublicationCorresponds to variant dbSNP:rs112282109Ensembl.1
Natural variantiVAR_011489671G → V No effect on leukotriene C4 and estradiol glucuronide transport. 4 PublicationsCorresponds to variant dbSNP:rs45511401Ensembl.1
Natural variantiVAR_013321723R → Q2 PublicationsCorresponds to variant dbSNP:rs4148356EnsemblClinVar.1
Natural variantiVAR_055384861A → T1 PublicationCorresponds to variant dbSNP:rs45517537Ensembl.1
Natural variantiVAR_0553851047C → S1 PublicationCorresponds to variant dbSNP:rs13337489Ensembl.1
Natural variantiVAR_0133221058R → Q1 PublicationCorresponds to variant dbSNP:rs41410450Ensembl.1
Natural variantiVAR_0553861146V → I1 PublicationCorresponds to variant dbSNP:rs28706727Ensembl.1
Natural variantiVAR_0133231512S → L1 PublicationCorresponds to variant dbSNP:rs369410659Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000037706 – 764Missing in isoform 2, isoform 5, isoform 6 and isoform 8. CuratedAdd BLAST59
Alternative sequenceiVSP_000038765 – 820Missing in isoform 3, isoform 5, isoform 7 and isoform 8. CuratedAdd BLAST56
Alternative sequenceiVSP_017014882G → GSTVMDEEEAG in isoform 9. 1 Publication1
Alternative sequenceiVSP_0000391431 – 1495Missing in isoform 4, isoform 6, isoform 7 and isoform 8. CuratedAdd BLAST65

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L05628 mRNA Translation: AAB46616.1
AF022853
, AF022827, AF022828, AF022829, AF022831, AF022833, AF022835, AF022837, AF022839, AF022841, AF022850, AF022849, AF022848, AF022847, AF022846, AF022845, AF022844, AF022843, AF022842, AF022852, AF022851, AF022840, AF022838, AF022836, AF022834, AF022832, AF022826, AF022825, AF022824, AF022830 Genomic DNA Translation: AAB83979.1
AF022853
, AF022824, AF022825, AF022826, AF022828, AF022830, AF022832, AF022834, AF022836, AF022838, AF022848, AF022847, AF022846, AF022845, AF022844, AF022843, AF022842, AF022841, AF022839, AF022852, AF022851, AF022850, AF022849, AF022837, AF022835, AF022833, AF022831, AF022829, AF022827 Genomic DNA Translation: AAB83980.1
AF022853
, AF022824, AF022825, AF022826, AF022827, AF022829, AF022831, AF022833, AF022835, AF022837, AF022847, AF022846, AF022845, AF022844, AF022843, AF022842, AF022841, AF022840, AF022838, AF022852, AF022851, AF022850, AF022849, AF022848, AF022836, AF022834, AF022832, AF022830, AF022828 Genomic DNA Translation: AAB83981.1
AF022853
, AF022824, AF022825, AF022826, AF022827, AF022828, AF022829, AF022830, AF022831, AF022832, AF022833, AF022834, AF022835, AF022836, AF022837, AF022838, AF022839, AF022840, AF022841, AF022842, AF022843, AF022844, AF022845, AF022846, AF022847, AF022848, AF022849, AF022850, AF022851 Genomic DNA Translation: AAB83983.1
EF419769 Genomic DNA Translation: ABN79590.1
AC025778 Genomic DNA No translation available.
AC130651 Genomic DNA No translation available.
AC136624 Genomic DNA No translation available.
AB209120 mRNA Translation: BAD92357.1
U91318 Genomic DNA Translation: AAC15784.1
AC003026 Genomic DNA Translation: AAC05808.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42122.1 [P33527-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A44231 DVHUAR

NCBI Reference Sequences

More...
RefSeqi
NP_004987.2, NM_004996.3 [P33527-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.391464

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000399410; ENSP00000382342; ENSG00000103222 [P33527-1]
ENST00000621144; ENSP00000483316; ENSG00000278183 [P33527-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4363

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4363

UCSC genome browser

More...
UCSCi
uc010bvi.4 human [P33527-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs
ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05628 mRNA Translation: AAB46616.1
AF022853
, AF022827, AF022828, AF022829, AF022831, AF022833, AF022835, AF022837, AF022839, AF022841, AF022850, AF022849, AF022848, AF022847, AF022846, AF022845, AF022844, AF022843, AF022842, AF022852, AF022851, AF022840, AF022838, AF022836, AF022834, AF022832, AF022826, AF022825, AF022824, AF022830 Genomic DNA Translation: AAB83979.1
AF022853
, AF022824, AF022825, AF022826, AF022828, AF022830, AF022832, AF022834, AF022836, AF022838, AF022848, AF022847, AF022846, AF022845, AF022844, AF022843, AF022842, AF022841, AF022839, AF022852, AF022851, AF022850, AF022849, AF022837, AF022835, AF022833, AF022831, AF022829, AF022827 Genomic DNA Translation: AAB83980.1
AF022853
, AF022824, AF022825, AF022826, AF022827, AF022829, AF022831, AF022833, AF022835, AF022837, AF022847, AF022846, AF022845, AF022844, AF022843, AF022842, AF022841, AF022840, AF022838, AF022852, AF022851, AF022850, AF022849, AF022848, AF022836, AF022834, AF022832, AF022830, AF022828 Genomic DNA Translation: AAB83981.1
AF022853
, AF022824, AF022825, AF022826, AF022827, AF022828, AF022829, AF022830, AF022831, AF022832, AF022833, AF022834, AF022835, AF022836, AF022837, AF022838, AF022839, AF022840, AF022841, AF022842, AF022843, AF022844, AF022845, AF022846, AF022847, AF022848, AF022849, AF022850, AF022851 Genomic DNA Translation: AAB83983.1
EF419769 Genomic DNA Translation: ABN79590.1
AC025778 Genomic DNA No translation available.
AC130651 Genomic DNA No translation available.
AC136624 Genomic DNA No translation available.
AB209120 mRNA Translation: BAD92357.1
U91318 Genomic DNA Translation: AAC15784.1
AC003026 Genomic DNA Translation: AAC05808.1
CCDSiCCDS42122.1 [P33527-1]
PIRiA44231 DVHUAR
RefSeqiNP_004987.2, NM_004996.3 [P33527-1]
UniGeneiHs.391464

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CBZX-ray1.50A642-871[»]
4C3ZX-ray2.10A628-881[»]
ProteinModelPortaliP33527
SMRiP33527
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110503, 58 interactors
IntActiP33527, 15 interactors
MINTiP33527
STRINGi9606.ENSP00000382342

Chemistry databases

BindingDBiP33527
ChEMBLiCHEMBL3004
DrugBankiDB05812 Abiraterone
DB00345 Aminohippuric acid
DB00701 Amprenavir
DB01072 Atazanavir
DB01076 Atorvastatin
DB04851 Biricodar dicitrate
DB02659 Cholic Acid
DB01394 Colchicine
DB00286 Conjugated Equine Estrogens
DB00091 Cyclosporine
DB00970 Dactinomycin
DB00694 Daunorubicin
DB00586 Diclofenac
DB01248 Docetaxel
DB00997 Doxorubicin
DB00445 Epirubicin
DB00773 Etoposide
DB00693 Fluorescein
DB01645 Genistein
DB00143 Glutathione
DB01016 Glyburide
DB00365 Grepafloxacin
DB01050 Ibuprofen
DB01177 Idarubicin
DB00224 Indinavir
DB00328 Indomethacin
DB00762 Irinotecan
DB00602 Ivermectin
DB00709 Lamivudine
DB00563 Methotrexate
DB00834 Mifepristone
DB01204 Mitoxantrone
DB02375 Myricetin
DB03467 Naringenin
DB01165 Ofloxacin
DB01229 Paclitaxel
DB01174 Phenobarbital
DB01032 Probenecid
DB00396 Progesterone
DB04216 Quercetin
DB03825 Rhodamine 6G
DB01045 Rifampicin
DB00503 Ritonavir
DB01098 Rosuvastatin
DB01232 Saquinavir
DB06335 Saxagliptin
DB01138 Sulfinpyrazone
DB04348 Taurocholic Acid
DB09161 Technetium Tc-99m sestamibi
DB05294 Vandetanib
DB08881 Vemurafenib
DB00661 Verapamil
DB00570 Vinblastine
DB00541 Vincristine
DB00399 Zoledronic acid
GuidetoPHARMACOLOGYi779
SwissLipidsiSLP:000000404

Protein family/group databases

TCDBi3.A.1.208.8 the atp-binding cassette (abc) superfamily

PTM databases

GlyConnecti1523
iPTMnetiP33527
PhosphoSitePlusiP33527
SwissPalmiP33527

Polymorphism and mutation databases

BioMutaiABCC1
DMDMi296439301

Proteomic databases

EPDiP33527
MaxQBiP33527
PaxDbiP33527
PeptideAtlasiP33527
PRIDEiP33527
ProteomicsDBi54912
54913 [P33527-2]
54914 [P33527-3]
54915 [P33527-4]
54916 [P33527-5]
54917 [P33527-6]
54918 [P33527-7]
54919 [P33527-8]
54920 [P33527-9]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399410; ENSP00000382342; ENSG00000103222 [P33527-1]
ENST00000621144; ENSP00000483316; ENSG00000278183 [P33527-1]
GeneIDi4363
KEGGihsa:4363
UCSCiuc010bvi.4 human [P33527-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4363
DisGeNETi4363
EuPathDBiHostDB:ENSG00000103222.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ABCC1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0134370
HGNCiHGNC:51 ABCC1
HPAiHPA002380
MIMi158343 gene
neXtProtiNX_P33527
OpenTargetsiENSG00000103222
PharmGKBiPA244

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00940000160271
HOVERGENiHBG108314
InParanoidiP33527
KOiK05665
OMAiNEWRVDA
OrthoDBiEOG091G00IN
PhylomeDBiP33527
TreeFamiTF105199

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000103222-MONOMER
ReactomeiR-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-HSA-382556 ABC-family proteins mediated transport
SIGNORiP33527

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ABCC1 human
EvolutionaryTraceiP33527

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ABCC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4363

Protein Ontology

More...
PROi
PR:P33527

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000103222 Expressed in 230 organ(s), highest expression level in testis
CleanExiHS_ABCC1
ExpressionAtlasiP33527 baseline and differential
GenevisibleiP33527 HS

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR005292 Multidrug-R_assoc
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
TIGRFAMsiTIGR00957 MRP_assoc_pro, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P33527
Secondary accession number(s): A3RJX2
, C9JPJ4, O14819, O43333, P78419, Q59GI9, Q9UQ97, Q9UQ99, Q9UQA0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 18, 2010
Last modified: December 5, 2018
This is version 197 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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