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Protein

Lysozyme

Gene

lysA

Organism
Lactococcus phage mv1 (Lactococcus delbrueckii bacteriophage mv1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Helps to release the mature phage particles from the cell wall by breaking down the peptidoglycan.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei8PROSITE-ProRule annotation1
Active sitei99PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH25 Glycoside Hydrolase Family 25

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme (EC:3.2.1.17)
Alternative name(s):
Endolysin
MV1 lysin
Muramidase
Gene namesi
Name:lysA
OrganismiLactococcus phage mv1 (Lactococcus delbrueckii bacteriophage mv1)
Taxonomic identifieri33769 [NCBI]
Taxonomic lineageiVirusesunclassified bacterial viruses
Virus hostiLactobacillus delbrueckii [TaxID: 1584]

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002082621 – 202LysozymeAdd BLAST202

Proteomic databases

PRIDEiP33486

Structurei

3D structure databases

ProteinModelPortaliP33486
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 25 family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR002053 Glyco_hydro_25
IPR008270 Glyco_hydro_25_AS
IPR018077 Glyco_hydro_fam25_subgr
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF01183 Glyco_hydro_25, 1 hit
SMARTiView protein in SMART
SM00641 Glyco_25, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00953 GLYCOSYL_HYDROL_F25, 1 hit

Sequencei

Sequence statusi: Complete.

P33486-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTKTYGVDVA VYQPIDLAAY HKAGASFAIV KLTEGVDYVN RRGPSRWTAP
60 70 80 90 100
GLTTSTLMPT ISRSFGSSVS RAKKEAAYFL KEAKKQDISK KRMLWLDWEA
110 120 130 140 150
GSGNVVTGSK SSNTAAILDF MDAIKAAGWR PGLYSGASLM RTAIDTKQVV
160 170 180 190 200
KKYGTCLWVA SYPTMAAVST ADFGYFRQWT GSPSGSLPVT AWPGRRRERC

SG
Length:202
Mass (Da):21,985
Last modified:May 30, 2000 - v3
Checksum:iF40F125D936D6E8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60167 Genomic DNA Translation: AAA32264.1
PIRiJQ0789 MUBPM1

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60167 Genomic DNA Translation: AAA32264.1
PIRiJQ0789 MUBPM1

3D structure databases

ProteinModelPortaliP33486
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH25 Glycoside Hydrolase Family 25

Proteomic databases

PRIDEiP33486

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR002053 Glyco_hydro_25
IPR008270 Glyco_hydro_25_AS
IPR018077 Glyco_hydro_fam25_subgr
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF01183 Glyco_hydro_25, 1 hit
SMARTiView protein in SMART
SM00641 Glyco_25, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00953 GLYCOSYL_HYDROL_F25, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLYS_BPMV1
AccessioniPrimary (citable) accession number: P33486
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 30, 2000
Last modified: May 10, 2017
This is version 77 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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Main funding by: National Institutes of Health

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