Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Non-structural protein V

Gene

P/V

Organism
Mumps virus (strain SBL) (MuV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays an essential role in the inhibition of host immune response. Prevents the establishment of cellular antiviral state by blocking interferon-alpha/beta (IFN-alpha/beta) production and signaling pathway. Interacts with host IFIH1/MDA5 and DHX58/LGP2 to inhibit the transduction pathway involved in the activation of IFN-beta promoter, thus protecting the virus against cell antiviral state. Blocks the type I and II interferon signaling pathways by interacting with host STAT1, STAT2 and STAT3, and mediating their ubiquitination and subsequent proteasomal degradation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi170Zinc 1By similarity1
Metal bindingi189Zinc 1By similarity1
Metal bindingi193Zinc 2By similarity1
Metal bindingi205Zinc 2By similarity1
Metal bindingi207Zinc 2By similarity1
Metal bindingi210Zinc 2By similarity1
Metal bindingi214Zinc 1By similarity1
Metal bindingi217Zinc 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host MDA5 by virus, Inhibition of host RLR pathway by virus, Inhibition of host STAT1 by virus, Inhibition of host STAT2 by virus, Interferon antiviral system evasion, Viral immunoevasion
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein V
Alternative name(s):
Non-structural protein NS1
Gene namesi
Name:P/V
OrganismiMumps virus (strain SBL) (MuV)
Taxonomic identifieri33729 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeRubulavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001428211 – 224Non-structural protein VAdd BLAST224

Interactioni

Subunit structurei

Interacts with host IFIH1/MDA5 and DHX58/LGP2. Forms with host DDB1, CUL4A, STAT1, STAT2 and STAT3 the mumps virus V-dependent complex (VDC) (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP33483
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paramyxoviruses V protein family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR024279 Paramyx_V_Zn-bd
PfamiView protein in Pfam
PF13008 zf-Paramyx-P, 1 hit

Sequencei

Sequence statusi: Complete.

P33483-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDQFIKQDET GDLIETGMNV ANHFLSAPIQ GTNSLSKASI IPGVAPVLIG
60 70 80 90 100
NPEQKNIQHP TASHQGSKSK GSGSGVRSII VPPSEAGNGG TQDPEPLFAQ
110 120 130 140 150
TGQGGIVTTV YQDPTIQPTG SSRSVELAKI GKERMINRFV EKPRISTPVT
160 170 180 190 200
EFKRGAGSGC SRPDNPRGGH RREWSLSWVQ GEVRVFEWCN PICSPITAAA
210 220
RFHSCKCGNC PAKCDQCERD YGPP
Length:224
Mass (Da):24,011
Last modified:February 1, 1994 - v1
Checksum:iE7162A8617D14713
GO

RNA editingi

Edited at position 155.1 Publication
Partially edited. RNA editing at this position consists of an insertion of two guanine nucleotides. The sequence displayed here is the V protein, derived from the unedited RNA. The edited RNA gives rise to the P protein (AC P60166).

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00663 Genomic RNA Translation: BAA00559.1
PIRiJQ0597

Keywords - Coding sequence diversityi

RNA editing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00663 Genomic RNA Translation: BAA00559.1
PIRiJQ0597

3D structure databases

ProteinModelPortaliP33483
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR024279 Paramyx_V_Zn-bd
PfamiView protein in Pfam
PF13008 zf-Paramyx-P, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiV_MUMPS
AccessioniPrimary (citable) accession number: P33483
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 2, 2016
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again