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Entry version 70 (12 Aug 2020)
Sequence version 1 (01 Feb 1994)
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Protein

Major viral transcription factor ICP4 homolog

Gene

IE

Organism
Suid herpesvirus 1 (strain Kaplan) (SuHV-1) (Pseudorabies virus (strain Kaplan))
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This IE protein is a multifunctional protein capable of migrating to the nucleus, binding to DNA, trans-activating other viral genes, and autoregulating its own synthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Major viral transcription factor ICP4 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IE
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSuid herpesvirus 1 (strain Kaplan) (SuHV-1) (Pseudorabies virus (strain Kaplan))
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri33703 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesDuplodnaviriaHeunggongviraePeploviricotaHerviviricetesHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiSus scrofa (Pig) [TaxID: 9823]

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001158221 – 1446Major viral transcription factor ICP4 homologAdd BLAST1446

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

A long stretch of serine residues may be a major site of phosphorylation.

Keywords - PTMi

Phosphoprotein

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Keywords - Developmental stagei

Early protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P33479

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi347 – 354Poly-Ser8
Compositional biasi379 – 397Poly-SerAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the herpesviridae ICP4 family.Curated

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005205, Herpes_ICP4_C
IPR005206, Herpes_ICP4_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03585, Herpes_ICP4_C, 2 hits
PF03584, Herpes_ICP4_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P33479-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADDLFDFIE TEGNFSQLLA AAAAAEEEGI ASGPDGGSQG SRRRGSSGED
60 70 80 90 100
LLFGPGGLFS DDAAEAEAAV LAAAAGATRP PRPPSAQQQQ QPRRGSGEIV
110 120 130 140 150
VLDDEDEEED EPGSPAAGSP GRALHQGSEH GHLVLGPRSR AGSGPRPPTP
160 170 180 190 200
AALAAAEAGA PGGPGRSSPS AASPASSSGS PGPSAAPRRW SPARGDPVGE
210 220 230 240 250
PGPAARPRTP APPAQPAAVA AAPARRGPAS PASPAAGPVS APGGGGAPSA
260 270 280 290 300
GGDRGRHHHQ HREPLLDEPA AARRLDPRPL GARSPVSSNP NSNSNSTTTV
310 320 330 340 350
AVETVARGPE KDEDGLGLAG DGGAPPQRQP RRRRAGEGAL RRGRGFSSSS
360 370 380 390 400
SSGSDSDLSP ARSPSAPRAP AAAARRSASS SSSSSSSSSS SSSSSSSEGE
410 420 430 440 450
EDEGVRPGAP LARAGPPPSP PAPAAAPRPS ASSASSSAAA SPAPAPEPAR
460 470 480 490 500
PPRRKRRSTN NHLSLMADGP PPTDGPLLTP LGEPWPGSDP PADGRVRYGG
510 520 530 540 550
AGDSREGLWD EDDVRQAAAR YRAAAGPVPV FIPEMGDSRK QHEALVRLIY
560 570 580 590 600
SGAAGEAMSW LQNPRMQAPD QRFNQFCQRR VHAPHGHGSF ITGSVTPPLP
610 620 630 640 650
HIGDAMAAQD PLWALPHAVS AVAMSRRYDR TQKTFILQSL RRAYADMAYP
660 670 680 690 700
GRAADPRAGE ATVEALCARV RAAFAAAQPG RVPRELADAC VLACRGVLER
710 720 730 740 750
LLPCPLRLPA PARAPAALGP ACLEEVTAAL LALRDAIPGA GPAERRQAAD
760 770 780 790 800
SVALVARTVA PLVRYSVDGA RAREAAWTYA AALFAPANVA AARLAEAAAR
810 820 830 840 850
PGPAEPAPGL PPLWPEQPGL VVPAPAPAAA GAPSGLPGSG PSSPASTKSS
860 870 880 890 900
SSTKSSSSTK SGLSGSSGYA SSPAAGPDPA PERRKKKRRA PGARRPGDGE
910 920 930 940 950
EDEGLSGAAL RGDGHGHRDD EEDRGPRRKR RSLGLGPAPD PAPALLSSSS
960 970 980 990 1000
SSSEDDRLRR PLGPMPEHPA PDGGFRRVPA GETHTPRPSE AALAAYCPPE
1010 1020 1030 1040 1050
VARALVDQEV FPELWRPALT FDPAALAHIA ARRGAPLRRR AAWMRQIADP
1060 1070 1080 1090 1100
EDVRVVVLYD PLPHEELCAE PAEGAPRPAW DPRRGGLSAL LAAFAHRLCT
1110 1120 1130 1140 1150
PDSHAWAGNW TGRPDIGRLN AQGVLLLSAR DLGFAGAVEY LCSRLGAARR
1160 1170 1180 1190 1200
RLIVLDTIED WPADGPAVGD YHVYVRVRLD PAAQCAVRWP GCRELRAAVL
1210 1220 1230 1240 1250
DSSSIVGPAC FARVEASFAR LHPGAEPLRL CRQDNVRYTV STRAGPRTPV
1260 1270 1280 1290 1300
PLPPRAYRQR VLPTVDGCKD MARQRSALGL GDPDFDAGAA FGHRAANRWG
1310 1320 1330 1340 1350
LGAPLRPVFV SCGRRGLAEL RGPEGLPAEL RAFCAAALLE PDAEAAPLVL
1360 1370 1380 1390 1400
TPGAVAAAGA PPAVLWDFAP FETSVRAAAG GAVETHRPAG ASGAGAGPGE
1410 1420 1430 1440
DGDSVEIVGV RGGDGRPRGP LGPIKVEAIS DDEEAEDAGN PYLLLR
Length:1,446
Mass (Da):148,642
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i81F43A3DE3DDA068
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M34651 Genomic DNA Translation: AAA47470.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A45344

NCBI Reference Sequences

More...
RefSeqi
YP_068382.1, NC_006151.1
YP_068393.1, NC_006151.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2952493
2952540

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:2952493
vg:2952540

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34651 Genomic DNA Translation: AAA47470.1
PIRiA45344
RefSeqiYP_068382.1, NC_006151.1
YP_068393.1, NC_006151.1

3D structure databases

SMRiP33479
ModBaseiSearch...

Genome annotation databases

GeneIDi2952493
2952540
KEGGivg:2952493
vg:2952540

Family and domain databases

InterProiView protein in InterPro
IPR005205, Herpes_ICP4_C
IPR005206, Herpes_ICP4_N
PfamiView protein in Pfam
PF03585, Herpes_ICP4_C, 2 hits
PF03584, Herpes_ICP4_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiICP4_SUHVK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P33479
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: August 12, 2020
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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