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Entry version 71 (05 Jun 2019)
Sequence version 1 (01 Feb 1994)
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Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Uukuniemi virus (strain S23) (Uuk)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processViral RNA replication
LigandNucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-directed RNA polymerase L (EC:2.7.7.48)
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiUukuniemi virus (strain S23) (Uuk)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri487099 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaNegarnaviricotaPolyploviricotinaEllioviricetesBunyaviralesPhenuiviridaePhlebovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
Ixodes ricinus (Common tick) (Acarus ricinus) [TaxID: 34613]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008595 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002220281 – 2103RNA-directed RNA polymerase LAdd BLAST2103

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P33453

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini978 – 1175RdRp catalyticPROSITE-ProRule annotationAdd BLAST198

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the phlebovirus RNA polymerase family.Curated

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022531 DUF3770
IPR029124 L_protein_N
IPR007099 RNA-dir_pol_NSvirus
IPR014385 RNA-dir_pol_phlebovirus
IPR007322 RNA_pol_bunyavir

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04196 Bunya_RdRp, 1 hit
PF12603 DUF3770, 1 hit
PF15518 L_protein_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000826 L_PhleboV, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50525 RDRP_SSRNA_NEG_SEG, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P33453-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLAICSRTI RQQGLNCPPA VTFTSSHMRP PIPSFLLWTE GSDVLMDFDL
60 70 80 90 100
DTIPAGSVTG SSIGPKFKIK TQAASSFVHD FTFAHWCDAS DMPLRDHFPL
110 120 130 140 150
VNDTFDHWTP DFISQRLDGS KVVVEFTTNR SDQEQSLISA FNTKVGKYEV
160 170 180 190 200
ALHNRSTTSS ILFGVVVVSE TTVVTNLNLN QQEVDELCFR FLVARAVHLE
210 220 230 240 250
MTTKMIIPEY DDEDEDKRSR EVKAAFHSVQ PDWNVTEANF APFSRRMFSN
260 270 280 290 300
FAQMEPDKEY LAHIILDSLK QAQADLDGNH YLNESLTEQA RLDRNREESL
310 320 330 340 350
NMVKDFERDF NNAAQRSAWS HKSTVPFPGV IPKVSGDTTS LSRLVELPVI
360 370 380 390 400
TGGSDATIRA WRSAYGSVSN GTVERCDEDV ERERRAALCS LTVEELEESK
410 420 430 440 450
ALRMKYHRCK IDNGMMDKLD LAMQGVEAKE FKNHPSIIKK RSKSKKTFPL
460 470 480 490 500
TADTRDIDLF LHHDDLMFNN EHSQTPPAAM IEAVKAGADA QSLHGLDKSA
510 520 530 540 550
NPWYASALWF LGLPIGLWLF MCTCIGVELS ISLKQHCGRQ KFIIKKLRFF
560 570 580 590 600
DIFLLIKPTN SGSHVFYSIA FPESAILGKL HRSQCFKGLQ FEDGWFWTEF
610 620 630 640 650
SSFKMSKLTN VVKCLSTGFN LFWFWRDYYE VPFWAGNEKD FQTGKQRANK
660 670 680 690 700
MFKFCLLMLL EDKARTEEIA TLSRYVMMEG FVSPPCIPKP QKMIEKLPNL
710 720 730 740 750
ARTKFQVWLI SRMLQTIIRV SDYPFKITAG HKSANWTGMF NWVTGEPIES
760 770 780 790 800
TQKLISLFYL GYLKNKEESP ERNASIGMYK KILEYEDKHP GRYTYLGLGD
810 820 830 840 850
PPSDDTRFHE YSISLLKHLC IHAEHDLRRN WGESFKAMIS RDIVDAIASL
860 870 880 890 900
DLERLATLKA SSNFNEEWYQ KRGDGKTYHR SKVLEKVSKY VKKSSSHVHH
910 920 930 940 950
IMEECLRKVE SQGCMHVCLF KKPQHGGLRE IYVLGFEERV VQLVIETIAR
960 970 980 990 1000
QICKRFKSET LTNPKQKLAI PETHGLRAVK TCGIHHETVA TSDDAAKWNQ
1010 1020 1030 1040 1050
CHHVTKFALM LCHFTDPLFH GFIIRGCSMF MKKRIMIDQS LIDIIDSHTT
1060 1070 1080 1090 1100
LETSDAYLQK IHRGYHGSLD DQPRWISRGG AFVQTETGMM QGILHYTSSL
1110 1120 1130 1140 1150
LHTLLQEWLR TFSQRFIRTR VSVDQRPDVL VDVLQSSDDS GMMISFPSTD
1160 1170 1180 1190 1200
KGATGKYRYL SALIFKYKKV IGKYLGIYSS VKSTNNTLHL LEFNSEFFFH
1210 1220 1230 1240 1250
INHNRPLLRW ITACDTISEQ ESLASRQEEM YNNLTSVLEG GGSFSLVSFC
1260 1270 1280 1290 1300
QFGQLLLHYT LLGMTVSPLF LEYIKLVSEI KDPSLGYFLM DHPFGSGLSG
1310 1320 1330 1340 1350
FKYNVWVAVQ NSILGSRYRS LLEAIQNSDS AAPKKTLDTT TSGTFVQSTI
1360 1370 1380 1390 1400
IRFGDRKKWQ RLVDRLNLPE DWLDVIDKNP EIVYRRPRDG FEVSLRIAEK
1410 1420 1430 1440 1450
VHSPGVSNSL SKGNCIIRVI SSSVYILSRS ILSDGLAWLY DEEEEVKRPL
1460 1470 1480 1490 1500
LYKVMNQPEL DLHSRLTPAQ LSTLFPMMAE FEKLQTHLRS YMKIEGEFIS
1510 1520 1530 1540 1550
KKKVITQTRV NILETERFLR ARPEDLIADK WFGFTRTRMT PRTFKEEWEN
1560 1570 1580 1590 1600
LTSVFPWLTG NPSETLELSP FQHHVQLRNF FSRLDLKGRD IRIIGAPIKK
1610 1620 1630 1640 1650
SSGVSNVSTA IRDNFFPRFV LTHIPDEAAM ERIEAAGILK HALFLTVTGP
1660 1670 1680 1690 1700
YTDQSKLDMC RDFITSSEPI TLKPNHGKTR TNVLSLFQDY FSKRGPDIIF
1710 1720 1730 1740 1750
NRIQMANCGV IGGFTSPQKP KEVDGKIVYT GDGVWRGIVD GFQIQLVITY
1760 1770 1780 1790 1800
MPKQKSNELK SITVNSDRCI SALSSFCQSW CKEMGVFNTE DFSKTQRFSK
1810 1820 1830 1840 1850
ASFFMHKFKI SGSKQTLGAP IFIVSEKIFR PICWDPSKLE FRVRGNTLNL
1860 1870 1880 1890 1900
TYKEVNPGAG QRMFNILSYT VKDTDVSDEN AFKLMSLSPR HKFHGREPST
1910 1920 1930 1940 1950
SWICMRALPI STIDKLLERI LNRERISGSI DNERLAECFK NVMESTLRRK
1960 1970 1980 1990 2000
GVFLSEFSRA TQKMLDGLSR DMLDFFAEAG LNDDLLLEEE PWLSGLDTFM
2010 2020 2030 2040 2050
LDDEAYLEEY NLGPFGVFSV EQEMNTKYYH HLLLDSLVED VIQKLSLDGL
2060 2070 2080 2090 2100
RKLFQEEEAP LEYKKEVIRL LNILQRDASQ IKWKSRDLLS ENMGLDVDDD

MFG
Length:2,103
Mass (Da):241,041
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB0EA708451B0B6BD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D10759 Genomic RNA Translation: BAA01590.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JQ1621

NCBI Reference Sequences

More...
RefSeqi
NP_941973.1, NC_005214.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2943071

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:2943071

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10759 Genomic RNA Translation: BAA01590.1
PIRiJQ1621
RefSeqiNP_941973.1, NC_005214.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiP33453

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2943071
KEGGivg:2943071

Family and domain databases

InterProiView protein in InterPro
IPR022531 DUF3770
IPR029124 L_protein_N
IPR007099 RNA-dir_pol_NSvirus
IPR014385 RNA-dir_pol_phlebovirus
IPR007322 RNA_pol_bunyavir
PfamiView protein in Pfam
PF04196 Bunya_RdRp, 1 hit
PF12603 DUF3770, 1 hit
PF15518 L_protein_N, 1 hit
PIRSFiPIRSF000826 L_PhleboV, 1 hit
PROSITEiView protein in PROSITE
PS50525 RDRP_SSRNA_NEG_SEG, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiL_UUKS
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P33453
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 5, 2019
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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