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Protein

Cadherin-related tumor suppressor

Gene

ft

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in regulation of planar cell polarity in the compound eye where it is required for correct specification of the R3 and R4 photoreceptor cells by regulating Fz activity in the R3/R4 precursor cells (PubMed:11893338). This is likely to occur through creation of an ft gradient so that the equatorial R3/R4 precursor cell has a higher level of ft function than its polar neighbor (PubMed:15548581). Also required for planar cell polarity of wing hairs (PubMed:12540853, PubMed:15240556). Mediates heterophilic cell adhesion in vitro and is required to stabilize ds on the cell surface (PubMed:15240556). Involved in regulation of eye imaginal disk size (PubMed:23667559). Upstream component of the Hippo pathway where it is likely to act as a cell surface receptor involved in regulation of tissue size and is required for the localization and stability of ex (PubMed:16996265). Probably acts as a cell surface receptor for ds (PubMed:20434335).7 Publications
Ft-mito: Regulates mitochondrial electron transport chain integrity and promotes oxidative phosphorylation.1 Publication

Miscellaneous

The name 'fat' originates from weak mutant alleles that exhibit a broadening of the abdomen.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cadherin binding Source: FlyBase
  • calcium ion binding Source: FlyBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processCell adhesion
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-350379 Homo-/heterophilic binding of transmembrane components
R-DME-390023 Subcellular localisation of D
R-DME-451850 Positive regulation of FT and DS

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cadherin-related tumor suppressor
Alternative name(s):
Protein fat
Cleaved into the following chain:
Ft-mito1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ftImported
ORF Names:CG3352Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0001075 ft

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini36 – 4583ExtracellularSequence analysisAdd BLAST4548
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4584 – 4609HelicalSequence analysisAdd BLAST26
Topological domaini4610 – 5147CytoplasmicSequence analysisAdd BLAST538

Keywords - Cellular componenti

Cell membrane, Membrane, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Severe overgrown imaginal disk derivatives and pupal death (PubMed:16996265). Overall larval growth is reduced (PubMed:25215488). Cells are round, swollen and have abnormal mitochondrial cristae due to defects in assembly of the mitochondrial electron chain complexes I and V (CI and CV) (PubMed:25215488). Loss of CI activity results in a switch to aerobic glycosis which increases lactate levels (PubMed:25215488). RNAi-mediated knockdown results in dorsal-ventral inversions in ommatidia planar cell polarity (PubMed:25215488).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi273S → A or D: Blocks ability of fj to enhance binding to ds. 1 Publication1
Mutagenesisi4854T → I in ft61; strong overgrowth of eye imaginal disks. Binding to Fbxl7 is not affected. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000434022? – 5147Ft-mito1 Publication
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000000401536 – 5147Cadherin-related tumor suppressorAdd BLAST5112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi239N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi257N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi276N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi280N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi402N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi461N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi605N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi631N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1155N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1367N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1458N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1751N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1831N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1880N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2080N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2171N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2247N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2290N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2437N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2581N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2799N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2920N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2946N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2967N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3303N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3386N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3389N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3525N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3852N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3865N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3905N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi3954 ↔ 3966By similarity
Disulfide bondi3960 ↔ 3999By similarity
Disulfide bondi4001 ↔ 4010By similarity
Disulfide bondi4017 ↔ 4028By similarity
Disulfide bondi4022 ↔ 4037By similarity
Disulfide bondi4039 ↔ 4048By similarity
Disulfide bondi4056 ↔ 4067By similarity
Disulfide bondi4061 ↔ 4078By similarity
Disulfide bondi4080 ↔ 4089By similarity
Disulfide bondi4096 ↔ 4107By similarity
Disulfide bondi4101 ↔ 4116By similarity
Disulfide bondi4118 ↔ 4127By similarity
Disulfide bondi4294 ↔ 4320By similarity
Glycosylationi4306N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4325 ↔ 4341By similarity
Disulfide bondi4334 ↔ 4350By similarity
Disulfide bondi4352 ↔ 4361By similarity
Glycosylationi4414N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4471N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4487N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4536 ↔ 4569By similarity
Glycosylationi4539N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4550N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei4843Phosphoserine1 Publication1
Modified residuei5054Phosphoserine1 Publication1
Modified residuei5061Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by fj on Ser/Thr of cadherin domains (PubMed:18635802). Phosphorylation by fj enhances binding to ds (PubMed:20434335). Phosphorylated in the cytoplasmic domain in a dco-dependent manner which is promoted by ds (PubMed:19574458).3 Publications
Proteolytically cleaved to yield stably associated N- and C-terminal fragments (PubMed:19574458). The C-terminal fragment is processed further to release a 68 kDa mitochondrial fragment, Ft-mito (PubMed:25215488).2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P33450

PRoteomics IDEntifications database

More...
PRIDEi
P33450

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P33450

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0001075 Expressed in 39 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P33450 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P33450 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with Fbxl7 (PubMed:25107277). Ft-mito interacts with NADH dehydrogenase subunit ND-24 and with ATP synthase subunit ATPsynC (PubMed:25215488).2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
59824, 75 interactors

Database of interacting proteins

More...
DIPi
DIP-21094N

Protein interaction database and analysis system

More...
IntActi
P33450, 52 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0077167

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P33450

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P33450

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 156Cadherin 1PROSITE-ProRule annotationAdd BLAST121
Domaini157 – 270Cadherin 2PROSITE-ProRule annotationAdd BLAST114
Domaini271 – 382Cadherin 3PROSITE-ProRule annotationAdd BLAST112
Domaini383 – 494Cadherin 4PROSITE-ProRule annotationAdd BLAST112
Domaini495 – 599Cadherin 5PROSITE-ProRule annotationAdd BLAST105
Domaini600 – 708Cadherin 6PROSITE-ProRule annotationAdd BLAST109
Domaini709 – 820Cadherin 7PROSITE-ProRule annotationAdd BLAST112
Domaini821 – 942Cadherin 8PROSITE-ProRule annotationAdd BLAST122
Domaini943 – 1049Cadherin 9PROSITE-ProRule annotationAdd BLAST107
Domaini1050 – 1153Cadherin 10PROSITE-ProRule annotationAdd BLAST104
Domaini1154 – 1278Cadherin 11PROSITE-ProRule annotationAdd BLAST125
Domaini1279 – 1384Cadherin 12PROSITE-ProRule annotationAdd BLAST106
Domaini1385 – 1489Cadherin 13PROSITE-ProRule annotationAdd BLAST105
Domaini1490 – 1601Cadherin 14PROSITE-ProRule annotationAdd BLAST112
Domaini1602 – 1713Cadherin 15PROSITE-ProRule annotationAdd BLAST112
Domaini1714 – 1823Cadherin 16PROSITE-ProRule annotationAdd BLAST110
Domaini1824 – 1922Cadherin 17PROSITE-ProRule annotationAdd BLAST99
Domaini1923 – 2027Cadherin 18PROSITE-ProRule annotationAdd BLAST105
Domaini2028 – 2167Cadherin 19PROSITE-ProRule annotationAdd BLAST140
Domaini2168 – 2278Cadherin 20PROSITE-ProRule annotationAdd BLAST111
Domaini2279 – 2385Cadherin 21PROSITE-ProRule annotationAdd BLAST107
Domaini2386 – 2491Cadherin 22PROSITE-ProRule annotationAdd BLAST106
Domaini2492 – 2596Cadherin 23PROSITE-ProRule annotationAdd BLAST105
Domaini2597 – 2703Cadherin 24PROSITE-ProRule annotationAdd BLAST107
Domaini2704 – 2810Cadherin 25PROSITE-ProRule annotationAdd BLAST107
Domaini2811 – 2913Cadherin 26PROSITE-ProRule annotationAdd BLAST103
Domaini2914 – 3013Cadherin 27PROSITE-ProRule annotationAdd BLAST100
Domaini3014 – 3124Cadherin 28PROSITE-ProRule annotationAdd BLAST111
Domaini3125 – 3229Cadherin 29PROSITE-ProRule annotationAdd BLAST105
Domaini3230 – 3334Cadherin 30PROSITE-ProRule annotationAdd BLAST105
Domaini3335 – 3439Cadherin 31PROSITE-ProRule annotationAdd BLAST105
Domaini3440 – 3545Cadherin 32PROSITE-ProRule annotationAdd BLAST106
Domaini3546 – 3651Cadherin 33PROSITE-ProRule annotationAdd BLAST106
Domaini3652 – 3756Cadherin 34PROSITE-ProRule annotationAdd BLAST105
Domaini3950 – 4011EGF-like 1PROSITE-ProRule annotationAdd BLAST62
Domaini4013 – 4049EGF-like 2PROSITE-ProRule annotationAdd BLAST37
Domaini4052 – 4090EGF-like 3PROSITE-ProRule annotationAdd BLAST39
Domaini4092 – 4128EGF-like 4PROSITE-ProRule annotationAdd BLAST37
Domaini4129 – 4320Laminin G-like 1PROSITE-ProRule annotationAdd BLAST192
Domaini4321 – 4362EGF-like 5PROSITE-ProRule annotationAdd BLAST42
Domaini4402 – 4569Laminin G-like 2PROSITE-ProRule annotationAdd BLAST168

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni4744 – 4771Essential for stability of mitochondrial electron chain complexes I and V, and promotes interaction with ND-241 PublicationAdd BLAST28

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The extracellular domain is required for correct subcellular localization and for cell adhesion.1 Publication
The intracellular domain is sufficient for viability, growth control and planar cell polarity.1 Publication

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1219 Eukaryota
ENOG410XPEI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155719

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000107041

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P33450

KEGG Orthology (KO)

More...
KOi
K16669

Identification of Orthologs from Complete Genome Data

More...
OMAi
NNQYVNP

Database of Orthologous Groups

More...
OrthoDBi
EOG091G000B

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P33450

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 33 hits
PF00008 EGF, 2 hits
PF00054 Laminin_G_1, 1 hit
PF02210 Laminin_G_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 34 hits
SM00181 EGF, 5 hits
SM00179 EGF_CA, 3 hits
SM00282 LamG, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 34 hits
SSF49899 SSF49899, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 22 hits
PS50268 CADHERIN_2, 34 hits
PS00022 EGF_1, 4 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 4 hits
PS50025 LAM_G_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P33450-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERLLLLFFL LLAGRESLCQ TGDTKLELLA PRGRSYATTY EQYAAFPRRR
60 70 80 90 100
SSSSSPSGEM QSRAVDTSAD FEVLEGQPRG TTVGFIPTKP KFSYRFNEPP
110 120 130 140 150
REFTLDPVTG EVKTNVVLDR EGMRDHYDLV VLSSQPTYPI EVRIKVLDVN
160 170 180 190 200
DNSPEFPEPS IAISFSESAT SGTRLLLDAA TDADVGENGV TDQYEIVAGN
210 220 230 240 250
VDNKFRLVTT ANPSGDTSYL HLETTGNLDR ESRGSYQLNI SARDGGSPPR
260 270 280 290 300
FGYLQVNVTI LDVNDNPPIF DHSDYNVSLN ETALPGTPVV TVMASDNDLG
310 320 330 340 350
DNSKITYYLA ETEHQFTVNP ETGVISTTER VNCPQQTNVK SSASQKSCVF
360 370 380 390 400
TVFARDHGSP RQDGRTYVTV NLLDTNDHDP IISFRFFPDG GKVATVDENA
410 420 430 440 450
VNGTVVAAVA VKDSDSGLNG RTSVRIVSGN ELGHFRLEEA ADLHIVRVNG
460 470 480 490 500
VLDREEIGKY NLTVVAMDQG TPARTTTAHL IIDVNDVNDH EPVFEKSEYS
510 520 530 540 550
AVLSELAPTG SFVASITATD EDTGVNAQVH YDILSGNELK WFSMDPLTGL
560 570 580 590 600
IVTTGPLDRE IRDTVELSIS ARDGGPNPKF AYTQLKVIIL DENDEAPQFS
610 620 630 640 650
QREQNVTLGE DAPPQTIVAL MTATDHDQGT NGSVTFALAP SVERLYPLQF
660 670 680 690 700
ALDALTGQLT TRRPLDREKM SQYEISVIAR DQGAPTPQSA TATVWLNVAD
710 720 730 740 750
VNDNDPQFYP RHYIYSLADD DDDIKLKKEV EKERILLHVT ASDKDDGDNA
760 770 780 790 800
LIEYRLESGG EGLFQLDARS GAISLRGDAP ASMHWKPHYK LLVSARDAGQ
810 820 830 840 850
RRSQQDAIVE IVLKSKLEML ECGQAQAGGY EFQMVEDHEQ QRNSQPNREV
860 870 880 890 900
GIVQVKSTNG KANSHIEYDI IQGDRAQNFR IDTRSGRITT ARPLDREEQA
910 920 930 940 950
NYRLTILASS SSSSSAAASS VSYGQCIVNI AIIDLNDNAP VFALDRESEP
960 970 980 990 1000
TISLPENAAV GQEIYLSRVR DRDAGVNSRI SYSLTNNPNQ QFRIGPVTGV
1010 1020 1030 1040 1050
LYLQRPIRAE PGSLIHVELM ATDAGSPPLS SKLSLSVLIA DVNDHTPVFD
1060 1070 1080 1090 1100
HTSYETSLPE TTKVNTRFFA LAATDIDLGD NGRISYEIIE GNTERMFGVF
1110 1120 1130 1140 1150
PDGYLFVRAP LDREERDYYA LTVSCRDAGQ PSRSSVVPVV IHVIDENDNA
1160 1170 1180 1190 1200
PQFTNSTFTF SIPENAPADT FVGKLTAVDR DIGRNAELSF TLSSQTQDFT
1210 1220 1230 1240 1250
IDTRNGFIKT LRPFDREALV KVSRNAEASG EDGSLRGSMA GNYMLLEATV
1260 1270 1280 1290 1300
SDNGIPRLQD KVKVKVIVTD VNDNAPEFLR APYHVTISEG ASEGTHITHV
1310 1320 1330 1340 1350
FTQDADEGLN GDVYYSLAKG NEAGQFNLDS ATGQLSLGRR LDRESQEIHH
1360 1370 1380 1390 1400
LIVVAKDAAL KHPLSSNASI TIVVLDENDN APEFTQSSSE VSVLETSPTG
1410 1420 1430 1440 1450
TELMRFRASD ADQGVNSQVV FSISAGNRRD TFHIDSITGS LYLHKPLDYE
1460 1470 1480 1490 1500
DITSYTLNIT ASDCGTPSLS TTVLYNVLVV DDNDNPPIFP STAIVRQIKE
1510 1520 1530 1540 1550
GIPLKTPIVT VTADDPDSGL NGKVSYAISK QEPQLPQGRH FGINTETGVI
1560 1570 1580 1590 1600
HTLREIDRES IDTFRLTVVA TDRAQPSERQ LSTEKLVTVI VEDINDNAPV
1610 1620 1630 1640 1650
FVSMNAAILP PKFSTSKGSS TAVMQVHAKD ADSSSNGLVT YEIVSGPQEL
1660 1670 1680 1690 1700
FKLQRNTGII TFTPGPQFKQ EVRYQLTLKS TDEAVQSERR SSEVYITIIT
1710 1720 1730 1740 1750
PGSGGSESSV PQFEQRSKLS GSVYENEPIG TSILTVTAHL ASAEIEYFVT
1760 1770 1780 1790 1800
NVTATGSRGQ VDRLFDIDAK LGILSTAAEL DREAGPEEYE VEVYAIALGG
1810 1820 1830 1840 1850
QPRTSRTKVR VTVLDKNDSP PQFLDTPFVY NVSEDLQIGH TISTLRAHDP
1860 1870 1880 1890 1900
DTLGSVTFLL MDGHDGKFLL EPSTGKLILN DTLDRETKSK YELRIRVSDG
1910 1920 1930 1940 1950
VQYTEAYATI QVSDTNDNPP LFEDTVYSFD IPENAQRGYQ VGQIVARDAD
1960 1970 1980 1990 2000
LGQNAQLSYG VVSDWANDVF SLNPQTGMLT LTARLDYEEV QHYILIVQAQ
2010 2020 2030 2040 2050
DNGQPSLSTT ITVYCNVLDL NDNAPIFDPM SYSSEVFENV PIATEVVTVS
2060 2070 2080 2090 2100
AKDIDSGNNG LIEYSITAGD VDSEFGIDSN GTIRTRRNLD REHRSTYTLT
2110 2120 2130 2140 2150
VTARDCADEF ASFSELEETQ LKLKYRSPRK YQQTRQEFLA HQKQQRLSST
2160 2170 2180 2190 2200
VKVTILIKDV NDEVPVFISA NETAIMENVA INTVVIAVKA VDNDEGRNGY
2210 2220 2230 2240 2250
IDYLMKEARD EDMGQSDPLP FSLNPTDGQL RVVDALDREL RSSYLLNITA
2260 2270 2280 2290 2300
RDRGEPPQST ESQLLIRILD ENDNSPVFDP KQYSASVAEN ASIGAMVLQV
2310 2320 2330 2340 2350
SATDVDEGAN GRIRYSIVLG DQNHDFSISE DTGVVRVAKN LNYERLSRYS
2360 2370 2380 2390 2400
LTVRAEDCAL ENPAGDTAEL TINILDINDN RPTFLDSPYL ARVMENTVPP
2410 2420 2430 2440 2450
NGGYVLTVNA YDADTPPLNS QVRYFLKEGD SDLFRINASS GDIALLKPLD
2460 2470 2480 2490 2500
REQQSEYTLT LVAMDTGSPP LTGTGIVRVE VQDINDNDPV FELQSYHATV
2510 2520 2530 2540 2550
RENLPSGTHV LTPRATDKDE GLNAKLRFNL LGEHMHRFHI DSETGEISTA
2560 2570 2580 2590 2600
TTLDREETSV YHLTLMAQDS SITEPRASSV NLTISVSDVN DNIPKFDSTT
2610 2620 2630 2640 2650
YNVAVPERIS KGEFVFGARA LDLDDGENAV VHYTISGRDQ HYFDINTKTG
2660 2670 2680 2690 2700
VVSTKLELKT KTKSHDDLTY TIVISAMDQG EQSLSSKAEL TVILRPPELF
2710 2720 2730 2740 2750
PTFAYMANSH FAMSEDVRPG KMITKVSATS PKKGLVGKIR YAIAGGIMGD
2760 2770 2780 2790 2800
SLRVDPNSGL LSVGQDGLDY ELTHLYEIWI EAADGDTPSL RSVTLITLNV
2810 2820 2830 2840 2850
TDANDNAPVM EQLIYNAEVL EEESPPQLIA VVKASDRDSG DNGNVIYRLQ
2860 2870 2880 2890 2900
NDFDGTFEIT ESGEIYTRMR LDREEIGDYA FVVEAVDQGV PHMTGTASVL
2910 2920 2930 2940 2950
LHLLDKNDNP PKFTRLFSLN VTENAEIGSF VIRVTSSDLD LGANANASYS
2960 2970 2980 2990 3000
FSENPGEKFR IEPQSGNITV AGHLDREQQD EYILKVVASD GAWRAETPIT
3010 3020 3030 3040 3050
ITIQDQNDNA PEFEHSFYSF SFPELQQSIA LVGQIIATDR DKQGPNSVIS
3060 3070 3080 3090 3100
YSLQQPSPMF SIDPATGEVF SKKAVRFKHS QYVRSPENMY ALTVLATDNG
3110 3120 3130 3140 3150
KPPLYSECLV NINIVDAHNN PPKFEQAEYL APLPQDAVRG QRIVRVHAND
3160 3170 3180 3190 3200
KQDLGTNEMD YSLMTFNLSS IFSVGRHDGW ITLVKPIQVP PNTRYELVVR
3210 3220 3230 3240 3250
ATDRGVPPQS DETRVVIVVT GENMDTPRFS VNSYQVIVPE NEPVGSTILT
3260 3270 3280 3290 3300
VGATDDDTGP NGMLRYSISG GNERQDFSVD ERTGGIVIQQ QLDYDLIQEY
3310 3320 3330 3340 3350
HLNITVQDLG YHPLSSVAML TIILTDVNDN PPVFNHKEYH CYIPENKPVG
3360 3370 3380 3390 3400
TFVFQAHAAD KDSPKNAIIH YAFLPSGPDR HFFIMNQSNG TISSAVSFDY
3410 3420 3430 3440 3450
EERRIYTLQI KAKNPDSSME SYANLYVHVL GVNEFYPQFL QPVFHFDVSE
3460 3470 3480 3490 3500
TSAVGTRVGA VQATDKDSGE DGRVYYLLVG SSNDKGFRID TNTGLIYVAR
3510 3520 3530 3540 3550
HLDRETQNRV VLTVMAKNYG SIRGNDTDEA QVIISIQDGN DPPEFIKHYY
3560 3570 3580 3590 3600
TSTISEAAPV GTKVTTVKAI DKDVRTQNNQ FSYSIINGNL KQSFKIDVQT
3610 3620 3630 3640 3650
GEISTASRLD REETSTYNLV IGAIDTGLPP QTGSATVHIE LEDVNDNGPT
3660 3670 3680 3690 3700
FTPEGLNGYI SENEPAGTSI MTLIASDPDL PRNGGPFTYQ LIGGKHKSWL
3710 3720 3730 3740 3750
SVDRNSGVVR STTSFDREMT PILEAIIEVE DSGKPKQKSQ HLLTITVLDQ
3760 3770 3780 3790 3800
NDNPSTTRSL HIAVSLFNGD LPSNVKLADV RPNDIDIVGD YRCRLQKNPA
3810 3820 3830 3840 3850
QSQLQLAIPR ACDLITTSHT TPIASVFSYT GNDGKHGDVS SKVSVAFQSF
3860 3870 3880 3890 3900
NNETLANSVS IMVRNMTAYH FLANHYRPIL EMIKSRMSNE DEVILYSLLE
3910 3920 3930 3940 3950
GGSGNSTNLQ LLMAVRLAKT SYQQPKYLIE RLREKRSAFS ELLQKEVIVG
3960 3970 3980 3990 4000
YEPCSEPDVC ENGGVCSATM RLLDAHSFVI QDSPALVLSG PRVVHDYSCQ
4010 4020 4030 4040 4050
CTSGFSGEQC SRRQDPCLPN PCHSQVQCRR LGSDFQCMCP ANRDGKHCEK
4060 4070 4080 4090 4100
ERSDVCYSKP CRNGGSCQRS PDGSSYFCLC RPGFRGNQCE SVSDSCRPNP
4110 4120 4130 4140 4150
CLHGGLCVSL KPGYKCNCTP GRYGRHCERF SYGFQPLSYM TFPALDVTTN
4160 4170 4180 4190 4200
DISIVFATTK PNSLLLYNYG MQSGGRSDFL AIELVHGRAY FSSGGARTAI
4210 4220 4230 4240 4250
STVIAGRNLA DGGWHKVTAT RNGRVMSLSV AKCADSGDVC TECLPGDSSC
4260 4270 4280 4290 4300
YADEVGPVGT LNFNKQPLMI GGLSSADPIL ERPGQVHSDD LVGCLHSVHI
4310 4320 4330 4340 4350
GGRALNLSLP LQQKGILAGC NRQACQPALA AERCGGFAGQ CIDRWSSSLC
4360 4370 4380 4390 4400
QCGGHLQSPD CSDSLEPITL GEGAFVEFRI SEIYRRMQLL DNLYNSKSAW
4410 4420 4430 4440 4450
LDNQQMRERR AVSNFSTASQ IYEAPKMLSM LFRTYKDQGQ ILYAATNQMF
4460 4470 4480 4490 4500
TSLSLREGRL VYYSKQHLTI NMTVQETSTL NDGKWHNVSL FSESRSLRLI
4510 4520 4530 4540 4550
VDGRQVGDEL DIAGVHDFLD PYLTILNVGG EAFVGCLANV TVNNELQPLN
4560 4570 4580 4590 4600
GSGSIFPEVR YHGKIESGCR GDIGQDAAQV ADPLSIGFTL VIVFFVILVV
4610 4620 4630 4640 4650
AILGSYVIYR FRGKQEKIGS LSCGVPGFKI KHPGGPVTQS QVDHVLVRNL
4660 4670 4680 4690 4700
HPSEAPSPPV GAGDHMRPPV GSHHLVGPEL LTKKFKEPTA EMPQPQQQQQ
4710 4720 4730 4740 4750
RPQRPDIIER ESPLIREDHH LPIPPLHPLP LEHASSVDMG SEYPEHYDLE
4760 4770 4780 4790 4800
NASSIAPSDI DIVYHYKGYR EAAGLRKYKA SVPPVSAYTH HKHQNSGSQQ
4810 4820 4830 4840 4850
QQQQHRHTAP FVTRNQGGQP PPPPTSASRT HQSTPLARLS PSSELSSQQP
4860 4870 4880 4890 4900
RILTLHDISG KPLQSALLAT TSSSGGVGKD VHSNSERSLN SPVMSQLSGQ
4910 4920 4930 4940 4950
SSSASRQKPG VPQQQAQQTS MGLTAEEIER LNGRPRTCSL ISTLDAVSSS
4960 4970 4980 4990 5000
SEAPRVSSSA LHMSLGGDVD AHSSTSTDES GNDSFTCSEI EYDNNSLSGD
5010 5020 5030 5040 5050
GKYSTSKSLL DGRSPVSRAL SGGETSRNPP TTVVKTPPIP PHAYDGFESS
5060 5070 5080 5090 5100
FRGSLSTLVA SDDDIANHLS GIYRKANGAA SPSATTLGWE YLLNWGPSYE
5110 5120 5130 5140
NLMGVFKDIA ELPDTNGPSQ QQQQQTQVVS TLRMPSSNGP AAPEEYV
Length:5,147
Mass (Da):564,791
Last modified:February 21, 2001 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6A5A4743FC7E07D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti676S → P in AAA28530 (PubMed:1959133).Curated1
Sequence conflicti718A → T in AAA28530 (PubMed:1959133).Curated1
Sequence conflicti889T → S in AAA28530 (PubMed:1959133).Curated1
Sequence conflicti1298T → M in AAA28530 (PubMed:1959133).Curated1
Sequence conflicti1338G → A in AAA28530 (PubMed:1959133).Curated1
Sequence conflicti1366S → T in AAA28530 (PubMed:1959133).Curated1
Sequence conflicti1408A → G in AAA28530 (PubMed:1959133).Curated1
Sequence conflicti1755T → V in AAA28530 (PubMed:1959133).Curated1
Sequence conflicti2168I → V in AAA28530 (PubMed:1959133).Curated1
Sequence conflicti2266I → V in AAA28530 (PubMed:1959133).Curated1
Sequence conflicti2665H → T in AAA28530 (PubMed:1959133).Curated1
Sequence conflicti2712A → T in AAA28530 (PubMed:1959133).Curated1
Sequence conflicti2816N → T in AAA28530 (PubMed:1959133).Curated1
Sequence conflicti2893M → L in AAA28530 (PubMed:1959133).Curated1
Sequence conflicti3359A → T in AAA28530 (PubMed:1959133).Curated1
Sequence conflicti3674I → M in AAA28530 (PubMed:1959133).Curated1
Sequence conflicti3722I → V in AAA28530 (PubMed:1959133).Curated1
Sequence conflicti3869Y → N in AAA28530 (PubMed:1959133).Curated1
Sequence conflicti4187G → D in AAA28530 (PubMed:1959133).Curated1
Sequence conflicti4309L → S in AAA28530 (PubMed:1959133).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti1229S → G. 1
Natural varianti1233G → S. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M80537 Genomic DNA Translation: AAA28530.1
AE014134 Genomic DNA Translation: AAF51036.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A41087 IJFFTM

NCBI Reference Sequences

More...
RefSeqi
NP_477497.1, NM_058149.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Dm.293

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0077478; FBpp0077167; FBgn0001075

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
33627

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG3352

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80537 Genomic DNA Translation: AAA28530.1
AE014134 Genomic DNA Translation: AAF51036.1
PIRiA41087 IJFFTM
RefSeqiNP_477497.1, NM_058149.4
UniGeneiDm.293

3D structure databases

ProteinModelPortaliP33450
SMRiP33450
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi59824, 75 interactors
DIPiDIP-21094N
IntActiP33450, 52 interactors
STRINGi7227.FBpp0077167

PTM databases

iPTMnetiP33450

Proteomic databases

PaxDbiP33450
PRIDEiP33450

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0077478; FBpp0077167; FBgn0001075
GeneIDi33627
KEGGidme:Dmel_CG3352

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
33627
FlyBaseiFBgn0001075 ft

Phylogenomic databases

eggNOGiKOG1219 Eukaryota
ENOG410XPEI LUCA
GeneTreeiENSGT00940000155719
HOGENOMiHOG000107041
InParanoidiP33450
KOiK16669
OMAiNNQYVNP
OrthoDBiEOG091G000B
PhylomeDBiP33450

Enzyme and pathway databases

ReactomeiR-DME-350379 Homo-/heterophilic binding of transmembrane components
R-DME-390023 Subcellular localisation of D
R-DME-451850 Positive regulation of FT and DS

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
33627

Protein Ontology

More...
PROi
PR:P33450

Gene expression databases

BgeeiFBgn0001075 Expressed in 39 organ(s), highest expression level in embryo
ExpressionAtlasiP33450 baseline and differential
GenevisibleiP33450 DM

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00028 Cadherin, 33 hits
PF00008 EGF, 2 hits
PF00054 Laminin_G_1, 1 hit
PF02210 Laminin_G_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 34 hits
SM00181 EGF, 5 hits
SM00179 EGF_CA, 3 hits
SM00282 LamG, 2 hits
SUPFAMiSSF49313 SSF49313, 34 hits
SSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 22 hits
PS50268 CADHERIN_2, 34 hits
PS00022 EGF_1, 4 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 4 hits
PS50025 LAM_G_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFAT_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P33450
Secondary accession number(s): Q9VQX5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 21, 2001
Last modified: December 5, 2018
This is version 172 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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