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Protein

Exportin-T

Gene

LOS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Preferentially interacts with tRNAs with mature 5'- and 3'-termini and does not distinguish between intron-containing and spliced tRNAs. In the nucleus binds to tRNA and to the Ran-GTPases GSP1 or GSP2 in their active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP cause release of the tRNA from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.16 Publications

Miscellaneous

Present with 3490 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • Ran GTPase binding Source: SGD
  • tRNA binding Source: GO_Central

GO - Biological processi

  • tRNA export from nucleus Source: SGD
  • tRNA processing Source: UniProtKB-KW
  • tRNA re-export from nucleus Source: SGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding, tRNA-binding
Biological processTransport, tRNA processing

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
YEAST:G3O-31964-MONOMER

Protein family/group databases

Transport Classification Database

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TCDBi
9.A.50.1.1 the nuclear t-rna exporter (t-exporter) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exportin-T
Alternative name(s):
Exportin(tRNA)
Karyopherin-beta
tRNA exportin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOS1
Ordered Locus Names:YKL205W
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XI

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000001688 LOS1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000844601 – 1100Exportin-TAdd BLAST1100

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P33418

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P33418

PRoteomics IDEntifications database

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PRIDEi
P33418

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CEX1, GSP1, GSP2, NSP1, NUP2 and UTP8.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CEX1Q124532EBI-10188,EBI-31271

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
33918, 167 interactors

Database of interacting proteins

More...
DIPi
DIP-760N

Protein interaction database and analysis system

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IntActi
P33418, 8 interactors

Molecular INTeraction database

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MINTi
P33418

STRING: functional protein association networks

More...
STRINGi
4932.YKL205W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P33418

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the exportin family.Curated

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00390000007890

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000111186

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P33418

KEGG Orthology (KO)

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KOi
K14288

Identification of Orthologs from Complete Genome Data

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OMAi
WVSWIDI

Database of Orthologous Groups

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OrthoDBi
EOG092C0BAM

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013598 Exportin-1/Importin-b-like
IPR040017 XPOT

The PANTHER Classification System

More...
PANTHERi
PTHR15952 PTHR15952, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08389 Xpo1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P33418-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLERIQQLVN AVNDPRSDVA TKRQAIELLN GIKSSENALE IFISLVINEN
60 70 80 90 100
SNDLLKFYGL STLIELMTEG VNANPNGLNL VKFEITKWLK FQVLGNKQTK
110 120 130 140 150
LPDFLMNKIS EVLTTLFMLM YSDCNGNQWN SFFDDLMSLF QVDSAISNTS
160 170 180 190 200
PSTDGNILLG LEFFNKLCLM INSEIADQSF IRSKESQLKN NNIKDWMRDN
210 220 230 240 250
DIMKLSNVWF QCLKLDEQIV SQCPGLINST LDCIGSFISW IDINLIIDAN
260 270 280 290 300
NYYLQLIYKF LNLKETKISC YNCILAIISK KMKPMDKLAF LNMINLTNEL
310 320 330 340 350
TYYHQAISMN PQIITFDNLE VWESLTKLIT SFGIEFTIII EQVNDDQKLD
360 370 380 390 400
TLYKQSVISN VDSILLEKII PILLEFMNNE FDSITAKTFP FWSNYLAFLK
410 420 430 440 450
KYKASSPNFV PLHKDFLDNF QQICFKRMKF SDDEVTQDDF EEFNETVRFK
460 470 480 490 500
LKNFQEIIVV IDPSLFLNNI SQEISANLMN CKNESWQIFE LTIYQIFNLS
510 520 530 540 550
ECTKNNYFGL NKNEIMTSQP SLTLVRFLNE LLMMKDFLLA IDNEQIQILF
560 570 580 590 600
MELIVKNYNF IFSTSANTAN ATDDDEKYLL ILNIFMSSFA MFNKRENVRL
610 620 630 640 650
RSWYLFTRFL KLTRINLKKI LFANKNLVNE ITNKISPLLH IKVTSINAQG
660 670 680 690 700
TDDNDTIFDN QLYIFEGIGF IITLNNSSQE LTAATANTPI DYDILDQILT
710 720 730 740 750
PLFTQLEGCI TQGASPVVIL ECHHILMAIG TLARGLHIGL VPENQVNNMV
760 770 780 790 800
VNKKLINDSL IHKFSNIAEV ILVTFSFFNK FENIRDASRF TFARLIPILS
810 820 830 840 850
NKILPFINKL IELILSSTDL KSWEMIDFLG FLSQLIHMFH TDTDCYQLFN
860 870 880 890 900
QLLTPLINKV HSIIEEIDEQ HDQQSSSNKP IDTAVTATSV NKNIVVTDSY
910 920 930 940 950
RDKILLKKAY CTFLQSFTNN SVTSILLSDI NRAILPVILN DLVTYTPQEI
960 970 980 990 1000
QETSMMKVSL NVLCNFIKCF GNGTCLDNDD INKDPNLKID GLNEYFIMKC
1010 1020 1030 1040 1050
VPIIFEIPFN PIYKFNIKEG NFKTMAYDLA RLLRELFIVS SNPTTNENEC
1060 1070 1080 1090 1100
VKYLTQIYLP QIQLPQELTI QLVNMLTTMG QKQFEKWFVD NFISVLKQGQ
Length:1,100
Mass (Da):126,820
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i01A91E5FAC78FEDB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L13941 Unassigned DNA Translation: AAC37342.1
Z28205 Genomic DNA Translation: CAA82050.1
BK006944 Genomic DNA Translation: DAA08964.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S38043

NCBI Reference Sequences

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RefSeqi
NP_012717.1, NM_001179770.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YKL205W_mRNA; YKL205W_mRNA; YKL205W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
853630

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YKL205W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13941 Unassigned DNA Translation: AAC37342.1
Z28205 Genomic DNA Translation: CAA82050.1
BK006944 Genomic DNA Translation: DAA08964.1
PIRiS38043
RefSeqiNP_012717.1, NM_001179770.1

3D structure databases

ProteinModelPortaliP33418
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33918, 167 interactors
DIPiDIP-760N
IntActiP33418, 8 interactors
MINTiP33418
STRINGi4932.YKL205W

Protein family/group databases

TCDBi9.A.50.1.1 the nuclear t-rna exporter (t-exporter) family

Proteomic databases

MaxQBiP33418
PaxDbiP33418
PRIDEiP33418

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL205W_mRNA; YKL205W_mRNA; YKL205W
GeneIDi853630
KEGGisce:YKL205W

Organism-specific databases

SGDiS000001688 LOS1

Phylogenomic databases

GeneTreeiENSGT00390000007890
HOGENOMiHOG000111186
InParanoidiP33418
KOiK14288
OMAiWVSWIDI
OrthoDBiEOG092C0BAM

Enzyme and pathway databases

BioCyciYEAST:G3O-31964-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P33418

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013598 Exportin-1/Importin-b-like
IPR040017 XPOT
PANTHERiPTHR15952 PTHR15952, 1 hit
PfamiView protein in Pfam
PF08389 Xpo1, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXPOT_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P33418
Secondary accession number(s): D6VWZ8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: December 5, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names
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