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UniProtKB - P33418 (XPOT_YEAST)

Entry version 164 (25 May 2022)
Sequence version 1 (01 Feb 1994)
Previous versions | rss
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Protein

Exportin-T

Gene

LOS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Preferentially interacts with tRNAs with mature 5'- and 3'-termini and does not distinguish between intron-containing and spliced tRNAs. In the nucleus binds to tRNA and to the Ran-GTPases GSP1 or GSP2 in their active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP cause release of the tRNA from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

13 Publications

Miscellaneous

Present with 3490 molecules/cell in log phase SD medium.1 Publication

Caution

Has been originally identified as involved in pre-tRNA splicing since its deletion accumulates pre-tRNAs (PubMed:7363329, PubMed:3031485). However, further studies have shown that it is actually a nuclear pore protein involved in transport of pre-tRNAs and mature tRNAs (PubMed:9774653).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • tRNA export from nucleus Source: SGD
  • tRNA re-export from nucleus Source: SGD
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding, tRNA-binding
Biological processTransport

Protein family/group databases

Transport Classification Database

More...TCDBi		9.A.50.1.1, the nuclear t-rna exporter (trna-e) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exportin-T
Alternative name(s):
Exportin(tRNA)
Karyopherin-beta
tRNA exportin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOS1
Ordered Locus Names:YKL205W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XI

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000001688, LOS1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YKL205W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Leads to the accumulation of pre-tRNAs.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000844601 – 1100Exportin-TAdd BLAST1100

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P33418

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P33418

PRoteomics IDEntifications database

More...PRIDEi		P33418

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P33418

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CEX1, GSP1, GSP2, NSP1, NUP2 and UTP8.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		33918, 174 interactors

Database of interacting proteins

More...DIPi		DIP-760N

Protein interaction database and analysis system

More...IntActi		P33418, 8 interactors

Molecular INTeraction database

More...MINTi		P33418

STRING: functional protein association networks

More...STRINGi		4932.YKL205W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P33418, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P33418

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P33418

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the exportin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2021, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000007890

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004414_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P33418

Identification of Orthologs from Complete Genome Data

More...OMAi		RFSPLCW

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR013598, Exportin-1/Importin-b-like
IPR045546, Exportin-T_C
IPR040017, XPOT

The PANTHER Classification System

More...PANTHERi		PTHR15952, PTHR15952, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF19282, Exportin-T, 2 hits
PF08389, Xpo1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P33418-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLERIQQLVN AVNDPRSDVA TKRQAIELLN GIKSSENALE IFISLVINEN 
        60         70         80         90        100
SNDLLKFYGL STLIELMTEG VNANPNGLNL VKFEITKWLK FQVLGNKQTK 
       110        120        130        140        150
LPDFLMNKIS EVLTTLFMLM YSDCNGNQWN SFFDDLMSLF QVDSAISNTS 
       160        170        180        190        200
PSTDGNILLG LEFFNKLCLM INSEIADQSF IRSKESQLKN NNIKDWMRDN 
       210        220        230        240        250
DIMKLSNVWF QCLKLDEQIV SQCPGLINST LDCIGSFISW IDINLIIDAN 
       260        270        280        290        300
NYYLQLIYKF LNLKETKISC YNCILAIISK KMKPMDKLAF LNMINLTNEL 
       310        320        330        340        350
TYYHQAISMN PQIITFDNLE VWESLTKLIT SFGIEFTIII EQVNDDQKLD 
       360        370        380        390        400
TLYKQSVISN VDSILLEKII PILLEFMNNE FDSITAKTFP FWSNYLAFLK 
       410        420        430        440        450
KYKASSPNFV PLHKDFLDNF QQICFKRMKF SDDEVTQDDF EEFNETVRFK 
       460        470        480        490        500
LKNFQEIIVV IDPSLFLNNI SQEISANLMN CKNESWQIFE LTIYQIFNLS 
       510        520        530        540        550
ECTKNNYFGL NKNEIMTSQP SLTLVRFLNE LLMMKDFLLA IDNEQIQILF 
       560        570        580        590        600
MELIVKNYNF IFSTSANTAN ATDDDEKYLL ILNIFMSSFA MFNKRENVRL 
       610        620        630        640        650
RSWYLFTRFL KLTRINLKKI LFANKNLVNE ITNKISPLLH IKVTSINAQG 
       660        670        680        690        700
TDDNDTIFDN QLYIFEGIGF IITLNNSSQE LTAATANTPI DYDILDQILT 
       710        720        730        740        750
PLFTQLEGCI TQGASPVVIL ECHHILMAIG TLARGLHIGL VPENQVNNMV 
       760        770        780        790        800
VNKKLINDSL IHKFSNIAEV ILVTFSFFNK FENIRDASRF TFARLIPILS 
       810        820        830        840        850
NKILPFINKL IELILSSTDL KSWEMIDFLG FLSQLIHMFH TDTDCYQLFN 
       860        870        880        890        900
QLLTPLINKV HSIIEEIDEQ HDQQSSSNKP IDTAVTATSV NKNIVVTDSY 
       910        920        930        940        950
RDKILLKKAY CTFLQSFTNN SVTSILLSDI NRAILPVILN DLVTYTPQEI 
       960        970        980        990       1000
QETSMMKVSL NVLCNFIKCF GNGTCLDNDD INKDPNLKID GLNEYFIMKC 
      1010       1020       1030       1040       1050
VPIIFEIPFN PIYKFNIKEG NFKTMAYDLA RLLRELFIVS SNPTTNENEC 
      1060       1070       1080       1090       1100
VKYLTQIYLP QIQLPQELTI QLVNMLTTMG QKQFEKWFVD NFISVLKQGQ
Length:1,100
Mass (Da):126,820
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i01A91E5FAC78FEDB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L13941 Unassigned DNA Translation: AAC37342.1
Z28205 Genomic DNA Translation: CAA82050.1
BK006944 Genomic DNA Translation: DAA08964.1

Protein sequence database of the Protein Information Resource

More...PIRi		S38043

NCBI Reference Sequences

More...RefSeqi		NP_012717.1, NM_001179770.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YKL205W_mRNA; YKL205W; YKL205W

Database of genes from NCBI RefSeq genomes

More...GeneIDi		853630

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YKL205W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13941 Unassigned DNA Translation: AAC37342.1
Z28205 Genomic DNA Translation: CAA82050.1
BK006944 Genomic DNA Translation: DAA08964.1
PIRiS38043
RefSeqiNP_012717.1, NM_001179770.1

3D structure databases

AlphaFoldDBiP33418
SMRiP33418
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi33918, 174 interactors
DIPiDIP-760N
IntActiP33418, 8 interactors
MINTiP33418
STRINGi4932.YKL205W

Protein family/group databases

TCDBi9.A.50.1.1, the nuclear t-rna exporter (trna-e) family

PTM databases

iPTMnetiP33418

Proteomic databases

MaxQBiP33418
PaxDbiP33418
PRIDEiP33418

Genome annotation databases

EnsemblFungiiYKL205W_mRNA; YKL205W; YKL205W
GeneIDi853630
KEGGisce:YKL205W

Organism-specific databases

SGDiS000001688, LOS1
VEuPathDBiFungiDB:YKL205W

Phylogenomic databases

eggNOGiKOG2021, Eukaryota
GeneTreeiENSGT00390000007890
HOGENOMiCLU_004414_0_1_1
InParanoidiP33418
OMAiRFSPLCW

Miscellaneous databases

Protein Ontology

More...PROi		PR:P33418
RNActiP33418, protein

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR013598, Exportin-1/Importin-b-like
IPR045546, Exportin-T_C
IPR040017, XPOT
PANTHERiPTHR15952, PTHR15952, 1 hit
PfamiView protein in Pfam
PF19282, Exportin-T, 2 hits
PF08389, Xpo1, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXPOT_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P33418
Secondary accession number(s): D6VWZ8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 25, 2022
This is version 164 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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