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Entry version 156 (08 May 2019)
Sequence version 2 (01 Feb 1995)
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Protein

Urea active transporter

Gene

DUR3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for active transport of urea.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-31036-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.21.6.1 the solute:sodium symporter (sss) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Urea active transporter
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DUR3
Ordered Locus Names:YHL016C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VIII

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YHL016C

Saccharomyces Genome Database

More...
SGDi
S000001008 DUR3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Topological domaini36 – 85ExtracellularSequence analysisAdd BLAST50
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 130CytoplasmicSequence analysisAdd BLAST24
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Topological domaini152 – 166ExtracellularSequence analysisAdd BLAST15
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 189CytoplasmicSequence analysis2
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 253ExtracellularSequence analysisAdd BLAST43
Transmembranei254 – 274HelicalSequence analysisAdd BLAST21
Topological domaini275 – 295CytoplasmicSequence analysisAdd BLAST21
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Topological domaini317 – 343ExtracellularSequence analysisAdd BLAST27
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Topological domaini365 – 403CytoplasmicSequence analysisAdd BLAST39
Transmembranei404 – 424HelicalSequence analysisAdd BLAST21
Topological domaini425ExtracellularSequence analysis1
Transmembranei426 – 446HelicalSequence analysisAdd BLAST21
Topological domaini447 – 454CytoplasmicSequence analysis8
Transmembranei455 – 475HelicalSequence analysisAdd BLAST21
Topological domaini476 – 496ExtracellularSequence analysisAdd BLAST21
Transmembranei497 – 517HelicalSequence analysisAdd BLAST21
Topological domaini518 – 618CytoplasmicSequence analysisAdd BLAST101
Transmembranei619 – 639HelicalSequence analysisAdd BLAST21
Topological domaini640 – 650ExtracellularSequence analysisAdd BLAST11
Transmembranei651 – 671HelicalSequence analysisAdd BLAST21
Topological domaini672 – 735CytoplasmicSequence analysisAdd BLAST64

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001053971 – 735Urea active transporterAdd BLAST735

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P33413

PRoteomics IDEntifications database

More...
PRIDEi
P33413

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P33413

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By allophanate or its non-metabolized analog oxalurate. Sensitive to nitrogen catabolite repression.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May polymerize.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
36407, 44 interactors

Protein interaction database and analysis system

More...
IntActi
P33413, 17 interactors

Molecular INTeraction database

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MINTi
P33413

STRING: functional protein association networks

More...
STRINGi
4932.YHL016C

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000106394

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P33413

KEGG Orthology (KO)

More...
KOi
K20989

Identification of Orthologs from Complete Genome Data

More...
OMAi
WALKRYQ

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1730.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031155 DUR
IPR038377 Na/Glc_symporter_sf
IPR001734 Na/solute_symporter

The PANTHER Classification System

More...
PANTHERi
PTHR46154:SF4 PTHR46154:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00474 SSF, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00813 sss, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50283 NA_SOLUT_SYMP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P33413-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGEFKPPLPQ GAGYAIVLGL GAVFAGMMVL TTYLLKRYQK EIITAEEFTT
60 70 80 90 100
AGRSVKTGLV AAAVVSSWIW CSTLLTSSTK EYADGIFGGY AYAAGACFQI
110 120 130 140 150
IAFAILAIKT KQMAPNAHTY LELVRTRYGK IGHGCYLFYA IATNILVTSM
160 170 180 190 200
LLTSGSAVFS DLTGMNTIAS CFLLPVGVVV YTLFGGIKAT FLTDYMHTCV
210 220 230 240 250
IIIIVLVFAF KVYATSDVLG SPGKVYDLVR EAAKRHPVDG NYQGEYMTMT
260 270 280 290 300
SKSAGILLII NLIGNFGTVF LDNGYWNKAI SASPAASLKA YAIGGLAWFA
310 320 330 340 350
VPSLISLTMG LACLAVETSP NFPTYPDPLT SFQANSGLVL PAAAIAIMGK
360 370 380 390 400
GGAVASLLMI FMAVTSAMSA ELIAVSSVFT YDIYREYIDP RASGKKLIYT
410 420 430 440 450
SHVACIFFGL AMSGFSVGLY YGGISMGYIY EMMGIIISSA VLPVVLTLCS
460 470 480 490 500
KDMNLVAAVV SPILGTGLAI MSWLVCTKSL YKELTVDTTF MDYPMLTGNL
510 520 530 540 550
VALLSPAIFI PILTYVFKPQ NFDWEKMKDI TRVDETAELV QADPDIQLYD
560 570 580 590 600
AEANDKEQEE ETNSLVSDSE KNDVRVNNEK LIEPNLGVVI SNAIFQEDDT
610 620 630 640 650
QLQNELDEEQ RELARGLKIA YFLCVFFALA FLVVWPMPMY GSKYIFSKKF
660 670 680 690 700
FTGWVVVMII WLFFSAFAVC IYPLWEGRHG IYTTLRGLYW DLSGQTYKLR
710 720 730
EWQNSNPQDL HVVTSQISAR AHRQSSHFGQ VDEII
Length:735
Mass (Da):80,617
Last modified:February 1, 1995 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD1252DB838BF5CF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti58 – 63GLVAAA → RLSGCS in AAA34582 (PubMed:8335627).Curated6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L19875 Genomic DNA Translation: AAA34582.1
U11582 Genomic DNA Translation: AAB65069.1
AY693170 Genomic DNA Translation: AAT93189.1
BK006934 Genomic DNA Translation: DAA06669.1

Protein sequence database of the Protein Information Resource

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PIRi
S46830

NCBI Reference Sequences

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RefSeqi
NP_011847.1, NM_001179096.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YHL016C_mRNA; YHL016C_mRNA; YHL016C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
856370

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YHL016C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19875 Genomic DNA Translation: AAA34582.1
U11582 Genomic DNA Translation: AAB65069.1
AY693170 Genomic DNA Translation: AAT93189.1
BK006934 Genomic DNA Translation: DAA06669.1
PIRiS46830
RefSeqiNP_011847.1, NM_001179096.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi36407, 44 interactors
IntActiP33413, 17 interactors
MINTiP33413
STRINGi4932.YHL016C

Protein family/group databases

TCDBi2.A.21.6.1 the solute:sodium symporter (sss) family

PTM databases

iPTMnetiP33413

Proteomic databases

PaxDbiP33413
PRIDEiP33413

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHL016C_mRNA; YHL016C_mRNA; YHL016C
GeneIDi856370
KEGGisce:YHL016C

Organism-specific databases

EuPathDBiFungiDB:YHL016C
SGDiS000001008 DUR3

Phylogenomic databases

HOGENOMiHOG000106394
InParanoidiP33413
KOiK20989
OMAiWALKRYQ

Enzyme and pathway databases

BioCyciYEAST:G3O-31036-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P33413

Family and domain databases

Gene3Di1.20.1730.10, 1 hit
InterProiView protein in InterPro
IPR031155 DUR
IPR038377 Na/Glc_symporter_sf
IPR001734 Na/solute_symporter
PANTHERiPTHR46154:SF4 PTHR46154:SF4, 1 hit
PfamiView protein in Pfam
PF00474 SSF, 1 hit
TIGRFAMsiTIGR00813 sss, 1 hit
PROSITEiView protein in PROSITE
PS50283 NA_SOLUT_SYMP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDUR3_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P33413
Secondary accession number(s): D3DKP5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1995
Last modified: May 8, 2019
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names
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