Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

La protein homolog

Gene

LHP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone that binds nascent RNA polymerase III transcripts, stabilizing these RNAs against exonucleases. Required for the 3' endonucleolytic cleavage that matures tRNA precursors and for efficient folding of certain pre-tRNAs. Cooperaes with GCD14 in the maturation of a subset of RNA polymerase III transcripts. Functions also in the assembly of certain RNA polymerase II-transcribed RNAs into RNPs. Binds and stabilizes newly synthesized U6 snRNA as well as precursors of U3 snRNA from degradation. Facilitates efficient Sm protein binding, thus assisting formation of the U4/U6 snRNP. Required fot Ty3 normal transposition frequency.16 Publications

GO - Molecular functioni

  • RNA binding Source: SGD
  • tRNA binding Source: SGD

GO - Biological processi

  • tRNA processing Source: SGD

Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29469-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
La protein homolog
Alternative name(s):
La autoantigen homolog
La ribonucleoprotein
Gene namesi
Name:LHP1
Synonyms:LAH1, YLA1
Ordered Locus Names:YDL051W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL051W
SGDiS000002209 LHP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi15S → A: Prevents phosphorylation; when associated with A-19 and A-235. 1 Publication1
Mutagenesisi19S → A: Prevents phosphorylation; when associated with A-15 and A-235. 1 Publication1
Mutagenesisi235S → A: Prevents phosphorylation; when associated with A-15 and A-19. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002076082 – 275La protein homologAdd BLAST274

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei15PhosphoserineCombined sources1 Publication1
Modified residuei19PhosphoserineCombined sources1 Publication1
Modified residuei104Omega-N-methylarginine1 Publication1
Modified residuei230PhosphoserineCombined sources1
Modified residuei233PhosphoserineCombined sources1
Modified residuei235PhosphoserineCombined sources1 Publication1

Post-translational modificationi

Phosphorylation is not required for the roles tRNA and snRNP biogenesis.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

MaxQBiP33399
PaxDbiP33399
PRIDEiP33399

PTM databases

iPTMnetiP33399

Interactioni

Subunit structurei

Interacts with SXM1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PRP40P332032EBI-10046,EBI-701

Protein-protein interaction databases

BioGridi32008, 145 interactors
DIPiDIP-6444N
IntActiP33399, 21 interactors
MINTiP33399
STRINGi4932.YDL051W

Structurei

3D structure databases

ProteinModelPortaliP33399
SMRiP33399
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 112HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST90
Domaini123 – 216RRMPROSITE-ProRule annotationAdd BLAST94

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi240 – 256Nuclear localization signalSequence analysisAdd BLAST17

Phylogenomic databases

GeneTreeiENSGT00830000128323
InParanoidiP33399
KOiK11090
OMAiNDGWVEL
OrthoDBiEOG092C4I3J

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR006630 La_HTH
IPR002344 Lupus_La
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF05383 La, 1 hit
PF00076 RRM_1, 1 hit
PRINTSiPR00302 LUPUSLA
SMARTiView protein in SMART
SM00715 LA, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50961 HTH_LA, 1 hit
PS50102 RRM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33399-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEKPQQEEQ EKPQSRRNSF AVIEFTPEVL DRCLKQVEFY FSEFNFPYDR
60 70 80 90 100
FLRTTAEKND GWVPISTIAT FNRMKKYRPV DKVIEALRSS EILEVSADGE
110 120 130 140 150
NVKRRVPLDL TAARNARIEQ NQRTLAVMNF PHEDVEASQI PELQENLEAF
160 170 180 190 200
FKKLGEINQV RLRRDHRNKK FNGTVLVEFK TIPECEAFLK SYSNDDESNE
210 220 230 240 250
ILSYEGKKLS VLTKKQFDLQ REASKSKNFS GRSRSFNGHK KKNLPKFPKN
260 270
KKKNGKEESK EDSSAIADDD EEHKE
Length:275
Mass (Da):32,104
Last modified:October 1, 1994 - v2
Checksum:i43CDB2E6C740978D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33023 Genomic DNA Translation: AAA21777.1
Z74099 Genomic DNA Translation: CAA98612.1
AY558373 Genomic DNA Translation: AAS56699.1
L13282 Unassigned DNA Translation: AAA16515.1
X80801 Genomic DNA Translation: CAA56782.1
BK006938 Genomic DNA Translation: DAA11805.1
PIRiB48600
RefSeqiNP_010232.1, NM_001180110.1

Genome annotation databases

EnsemblFungiiYDL051W; YDL051W; YDL051W
GeneIDi851509
KEGGisce:YDL051W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33023 Genomic DNA Translation: AAA21777.1
Z74099 Genomic DNA Translation: CAA98612.1
AY558373 Genomic DNA Translation: AAS56699.1
L13282 Unassigned DNA Translation: AAA16515.1
X80801 Genomic DNA Translation: CAA56782.1
BK006938 Genomic DNA Translation: DAA11805.1
PIRiB48600
RefSeqiNP_010232.1, NM_001180110.1

3D structure databases

ProteinModelPortaliP33399
SMRiP33399
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32008, 145 interactors
DIPiDIP-6444N
IntActiP33399, 21 interactors
MINTiP33399
STRINGi4932.YDL051W

PTM databases

iPTMnetiP33399

Proteomic databases

MaxQBiP33399
PaxDbiP33399
PRIDEiP33399

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDL051W; YDL051W; YDL051W
GeneIDi851509
KEGGisce:YDL051W

Organism-specific databases

EuPathDBiFungiDB:YDL051W
SGDiS000002209 LHP1

Phylogenomic databases

GeneTreeiENSGT00830000128323
InParanoidiP33399
KOiK11090
OMAiNDGWVEL
OrthoDBiEOG092C4I3J

Enzyme and pathway databases

BioCyciYEAST:G3O-29469-MONOMER

Miscellaneous databases

PROiPR:P33399

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR006630 La_HTH
IPR002344 Lupus_La
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF05383 La, 1 hit
PF00076 RRM_1, 1 hit
PRINTSiPR00302 LUPUSLA
SMARTiView protein in SMART
SM00715 LA, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50961 HTH_LA, 1 hit
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLHP1_YEAST
AccessioniPrimary (citable) accession number: P33399
Secondary accession number(s): D6VRU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 1, 1994
Last modified: September 12, 2018
This is version 176 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again