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UniProtKB - P33363 (BGLX_ECOLI)

Entry version 151 (02 Dec 2020)
Sequence version 2 (01 Feb 1995)
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Protein

Periplasmic beta-glucosidase

Gene

bglX

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose. EC:3.2.1.21

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei287By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • glucan catabolic process Source: GO_Central
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:EG12013-MONOMER
MetaCyc:EG12013-MONOMER

Protein family/group databases

Carbohydrate-Active enZymes

More...CAZyi		GH3, Glycoside Hydrolase Family 3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Periplasmic beta-glucosidase (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase
Cellobiase
Gentiobiase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:bglX
Synonyms:yohA
Ordered Locus Names:b2132, JW2120
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Periplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001178121 – 765Periplasmic beta-glucosidaseAdd BLAST745

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P33363

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P33363

PRoteomics IDEntifications database

More...PRIDEi		P33363

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4260451, 32 interactors

Database of interacting proteins

More...DIPi		DIP-9218N

Protein interaction database and analysis system

More...IntActi		P33363, 16 interactors

STRING: functional protein association networks

More...STRINGi		511145.b2132

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P33363

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG1472, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004542_5_1_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P33363

Database for complete collections of gene phylogenies

More...PhylomeDBi		P33363

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 1 hit
3.20.20.300, 1 hit
3.40.50.1700, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026891, Fn3-like
IPR019800, Glyco_hydro_3_AS
IPR002772, Glyco_hydro_3_C
IPR036881, Glyco_hydro_3_C_sf
IPR001764, Glyco_hydro_3_N
IPR036962, Glyco_hydro_3_N_sf
IPR017853, Glycoside_hydrolase_SF
IPR013783, Ig-like_fold

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14310, Fn3-like, 1 hit
PF00933, Glyco_hydro_3, 1 hit
PF01915, Glyco_hydro_3_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00133, GLHYDRLASE3

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01217, Fn3_like, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51445, SSF51445, 1 hit
SSF52279, SSF52279, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00775, GLYCOSYL_HYDROL_F3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P33363-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKWLCSVGIA VSLALQPALA DDLFGNHPLT PEARDAFVTE LLKKMTVDEK 
        60         70         80         90        100
IGQLRLISVG PDNPKEAIRE MIKDGQVGAI FNTVTRQDIR AMQDQVMELS 
       110        120        130        140        150
RLKIPLFFAY DVLHGQRTVF PISLGLASSF NLDAVKTVGR VSAYEAADDG 
       160        170        180        190        200
LNMTWAPMVD VSRDPRWGRA SEGFGEDTYL TSTMGKTMVE AMQGKSPADR 
       210        220        230        240        250
YSVMTSVKHF AAYGAVEGGK EYNTVDMSPQ RLFNDYMPPY KAGLDAGSGA 
       260        270        280        290        300
VMVALNSLNG TPATSDSWLL KDVLRDQWGF KGITVSDHGA IKELIKHGTA 
       310        320        330        340        350
ADPEDAVRVA LKSGINMSMS DEYYSKYLPG LIKSGKVTMA ELDDAARHVL 
       360        370        380        390        400
NVKYDMGLFN DPYSHLGPKE SDPVDTNAES RLHRKEAREV ARESLVLLKN 
       410        420        430        440        450
RLETLPLKKS ATIAVVGPLA DSKRDVMGSW SAAGVADQSV TVLTGIKNAV 
       460        470        480        490        500
GENGKVLYAK GANVTSDKGI IDFLNQYEEA VKVDPRSPQE MIDEAVQTAK 
       510        520        530        540        550
QSDVVVAVVG EAQGMAHEAS SRTDITIPQS QRDLIAALKA TGKPLVLVLM 
       560        570        580        590        600
NGRPLALVKE DQQADAILET WFAGTEGGNA IADVLFGDYN PSGKLPMSFP 
       610        620        630        640        650
RSVGQIPVYY SHLNTGRPYN ADKPNKYTSR YFDEANGALY PFGYGLSYTT 
       660        670        680        690        700
FTVSDVKLSA PTMKRDGKVT ASVQVTNTGK REGATVVQMY LQDVTASMSR 
       710        720        730        740        750
PVKQLKGFEK ITLKPGETQT VSFPIDIEAL KFWNQQMKYD AEPGKFNVFI 
       760 
GTDSARVKKG EFELL
Length:765
Mass (Da):83,460
Last modified:February 1, 1995 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0E89B0AB42B8F8F3
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA60495 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U15049 Genomic DNA Translation: AAB38487.1
U00007 Genomic DNA Translation: AAA60495.1 Different initiation.
U00096 Genomic DNA Translation: AAC75193.1
AP009048 Genomic DNA Translation: BAE76609.1

Protein sequence database of the Protein Information Resource

More...PIRi		C64981

NCBI Reference Sequences

More...RefSeqi		NP_416636.1, NC_000913.3
WP_000871504.1, NZ_SSZK01000011.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC75193; AAC75193; b2132
BAE76609; BAE76609; BAE76609

Database of genes from NCBI RefSeq genomes

More...GeneIDi		946682

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW2120
eco:b2132

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|511145.12.peg.2212

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15049 Genomic DNA Translation: AAB38487.1
U00007 Genomic DNA Translation: AAA60495.1 Different initiation.
U00096 Genomic DNA Translation: AAC75193.1
AP009048 Genomic DNA Translation: BAE76609.1
PIRiC64981
RefSeqiNP_416636.1, NC_000913.3
WP_000871504.1, NZ_SSZK01000011.1

3D structure databases

SMRiP33363
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4260451, 32 interactors
DIPiDIP-9218N
IntActiP33363, 16 interactors
STRINGi511145.b2132

Protein family/group databases

CAZyiGH3, Glycoside Hydrolase Family 3

Proteomic databases

jPOSTiP33363
PaxDbiP33363
PRIDEiP33363

Genome annotation databases

EnsemblBacteriaiAAC75193; AAC75193; b2132
BAE76609; BAE76609; BAE76609
GeneIDi946682
KEGGiecj:JW2120
eco:b2132
PATRICifig|511145.12.peg.2212

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB1951

Phylogenomic databases

eggNOGiCOG1472, Bacteria
HOGENOMiCLU_004542_5_1_6
InParanoidiP33363
PhylomeDBiP33363

Enzyme and pathway databases

BioCyciEcoCyc:EG12013-MONOMER
MetaCyc:EG12013-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P33363

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.20.20.300, 1 hit
3.40.50.1700, 1 hit
InterProiView protein in InterPro
IPR026891, Fn3-like
IPR019800, Glyco_hydro_3_AS
IPR002772, Glyco_hydro_3_C
IPR036881, Glyco_hydro_3_C_sf
IPR001764, Glyco_hydro_3_N
IPR036962, Glyco_hydro_3_N_sf
IPR017853, Glycoside_hydrolase_SF
IPR013783, Ig-like_fold
PfamiView protein in Pfam
PF14310, Fn3-like, 1 hit
PF00933, Glyco_hydro_3, 1 hit
PF01915, Glyco_hydro_3_C, 1 hit
PRINTSiPR00133, GLHYDRLASE3
SMARTiView protein in SMART
SM01217, Fn3_like, 1 hit
SUPFAMiSSF51445, SSF51445, 1 hit
SSF52279, SSF52279, 1 hit
PROSITEiView protein in PROSITE
PS00775, GLYCOSYL_HYDROL_F3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBGLX_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P33363
Secondary accession number(s): Q2MAU7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1995
Last modified: December 2, 2020
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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