yehX

Functionⁱ

Part of an ABC transporter complex involved in low-affinity glycine betaine uptake. Probably responsible for energy coupling to the transport system.1 Publication

Caution

Was originally thought to be part of an osmoprotectant uptake system (PubMed:15251200). However, it was shown later that the complex does not mediate osmotic stress protection (PubMed:26325238).2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	34 – 41	ATPPROSITE-ProRule annotation		8

GO - Molecular functionⁱ

ATPase activity Source: InterPro
ATP binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

amino acid transport Source: UniProtKB-KW
glycine betaine transport
Source: EcoCyc
Inferred from direct assayⁱ
- 26325238

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Amino-acid transport, Transport
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	EcoCyc:YEHX-MONOMER MetaCyc:YEHX-MONOMER

BioCycⁱ

EcoCyc:YEHX-MONOMER
MetaCyc:YEHX-MONOMER

Protein family/group databases

TCDBⁱ	3.A.1.12.15 the atp-binding cassette (abc) superfamily

TCDBⁱ

3.A.1.12.15 the atp-binding cassette (abc) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glycine betaine uptake system ATP-binding protein YehXCurated (EC:3.6.3.-Curated)
Gene namesⁱ	Name:yehX Ordered Locus Names:b2129, JW2117
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG12010 yehX

EcoGeneⁱ

EG12010 yehX

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000093167	1 – 308	Glycine betaine uptake system ATP-binding protein YehXAdd BLAST		308

Proteomic databases

PaxDbⁱ	P33360
PRIDEⁱ	P33360

Expressionⁱ

Inductionⁱ

Expression is sigma S-dependent. Induced by both osmotic shock and entry into stationary phase.1 Publication

Interactionⁱ

Subunit structureⁱ

The complex is composed of two ATP-binding proteins (YehX), two transmembrane proteins (YehW and YehY) and a solute-binding protein (YehZ).Curated

Protein-protein interaction databases

BioGridⁱ	4260448, 33 interactors
Database of interacting proteins More...DIPⁱ	DIP-11912N
IntActⁱ	P33360, 8 interactors
STRINGⁱ	316385.ECDH10B_2285

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P33360
SMRⁱ	P33360
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	2 – 235	ABC transporterPROSITE-ProRule annotationAdd BLAST		234

Sequence similaritiesⁱ

Belongs to the ABC transporter superfamily.Curated

Phylogenomic databases

eggNOGⁱ	ENOG4108IJ8 Bacteria COG1125 LUCA
InParanoidⁱ	P33360
KEGG Orthology (KO) More...KOⁱ	K05847
OMAⁱ	ALAEMIW
PhylomeDBⁱ	P33360

Family and domain databases

InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR003439 ABC_transporter-like IPR017871 ABC_transporter_CS IPR027417 P-loop_NTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00005 ABC_tran, 1 hit
SMARTⁱ	View protein in SMART SM00382 AAA, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00211 ABC_TRANSPORTER_1, 1 hit PS50893 ABC_TRANSPORTER_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P33360-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MIEFSHVSKL FGAQKAVNDL NLNFQEGSFS VLIGTSGSGK STTLKMINRL 
        60         70         80         90        100
VEHDSGEIRF AGEEIRSLPV LELRRRMGYA IQSIGLFPHW SVAQNIATVP 
       110        120        130        140        150
QLQKWSRARI DDRIDELMAL LGLESNLRER YPHQLSGGQQ QRVGVARALA 
       160        170        180        190        200
ADPQVLLMDE PFGALDPVTR GALQQEMTRI HRLLGRTIVL VTHDIDEALR 
       210        220        230        240        250
LAEHLVLMDH GEVVQQGNPL TMLTRPANDF VRQFFGRSEL GVRLLSLRSV 
       260        270        280        290        300
ADYVRREERA DGEALAEEMT LRDALSLFVA RGCEVLPVVN MQGQPCGTLH 

FQDLLVEA

Length:308

Mass (Da):34,425

Last modified:February 1, 1994 - v1

Checksum:ⁱ037C7C84E4EFB690

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U00007 Genomic DNA Translation: AAA60492.1 U00096 Genomic DNA Translation: AAC75190.1 AP009048 Genomic DNA Translation: BAE76606.1
PIRⁱ	H64980
NCBI Reference Sequences More...RefSeqⁱ	NP_416633.1, NC_000913.3 WP_000569315.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC75190; AAC75190; b2129 BAE76606; BAE76606; BAE76606
GeneIDⁱ	946659
KEGGⁱ	ecj:JW2117 eco:b2129
PATRICⁱ	fig\|1411691.4.peg.115

Protein	Similar proteins		Species	Score	Length	Source
P33360	ATP-binding protein		Escherichia coli O145 str. RM9872		308	UniRef100_P33360
ABC transporter related protein		ECOLX		308
ATP-binding protein		SHIBO		308
Uncharacterized protein		Escherichia coli UMNK88		308
Osmoprotectant ABC transporter ATP-binding subunit YehX		Escherichia coli O145:H28 str. RM12581		308
+9

Protein	Similar proteins		Species	Score	Length	Source
P33360	ATP-binding protein		Escherichia coli O145 str. RM9872		308	UniRef90_P33360
ABC transporter related protein		ECOLX		308
ATP-binding protein		SHIBO		308
Uncharacterized protein		Escherichia coli UMNK88		308
Osmoprotectant ABC transporter ATP-binding subunit YehX		Escherichia coli O145:H28 str. RM12581		308
+230

Protein	Similar proteins		Species	Score	Length	Source
P33360	ATP-binding protein		Escherichia coli O145 str. RM9872		308	UniRef50_P33360
ABC transporter related protein		ECOLX		308
ATP-binding protein		SHIBO		308
Uncharacterized protein		Escherichia coli UMNK88		308
Osmoprotectant ABC transporter ATP-binding subunit YehX		Escherichia coli O145:H28 str. RM12581		308
+529

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U00007 Genomic DNA Translation: AAA60492.1 U00096 Genomic DNA Translation: AAC75190.1 AP009048 Genomic DNA Translation: BAE76606.1
PIRⁱ	H64980
RefSeqⁱ	NP_416633.1, NC_000913.3 WP_000569315.1, NZ_LN832404.1

3D structure databases

ProteinModelPortalⁱ	P33360
SMRⁱ	P33360
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4260448, 33 interactors
DIPⁱ	DIP-11912N
IntActⁱ	P33360, 8 interactors
STRINGⁱ	316385.ECDH10B_2285

Protein family/group databases

TCDBⁱ	3.A.1.12.15 the atp-binding cassette (abc) superfamily

TCDBⁱ

3.A.1.12.15 the atp-binding cassette (abc) superfamily

Proteomic databases

PaxDbⁱ	P33360
PRIDEⁱ	P33360

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC75190; AAC75190; b2129 BAE76606; BAE76606; BAE76606
GeneIDⁱ	946659
KEGGⁱ	ecj:JW2117 eco:b2129
PATRICⁱ	fig\|1411691.4.peg.115

Organism-specific databases

EchoBASEⁱ	EB1948
EcoGeneⁱ	EG12010 yehX

Phylogenomic databases

eggNOGⁱ	ENOG4108IJ8 Bacteria COG1125 LUCA
InParanoidⁱ	P33360
KOⁱ	K05847
OMAⁱ	ALAEMIW
PhylomeDBⁱ	P33360

Enzyme and pathway databases

BioCycⁱ	EcoCyc:YEHX-MONOMER MetaCyc:YEHX-MONOMER

BioCycⁱ

EcoCyc:YEHX-MONOMER
MetaCyc:YEHX-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P33360

PROⁱ

PR:P33360

Family and domain databases

InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR003439 ABC_transporter-like IPR017871 ABC_transporter_CS IPR027417 P-loop_NTPase
Pfamⁱ	View protein in Pfam PF00005 ABC_tran, 1 hit
SMARTⁱ	View protein in SMART SM00382 AAA, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00211 ABC_TRANSPORTER_1, 1 hit PS50893 ABC_TRANSPORTER_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	YEHX_ECOLI
Accessionⁱ	P33360Primary (citable) accession number: P33360 Secondary accession number(s): Q2MAV0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
	Last sequence update:	February 1, 1994
	Last modified:	March 28, 2018
	This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P33360 (YEHX_ECOLI)

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Glycine betaine uptake system ATP-binding protein YehX

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ