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Protein

Glycine betaine uptake system ATP-binding protein YehX

Gene

yehX

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of an ABC transporter complex involved in low-affinity glycine betaine uptake. Probably responsible for energy coupling to the transport system.1 Publication

Caution

Was originally thought to be part of an osmoprotectant uptake system (PubMed:15251200). However, it was shown later that the complex does not mediate osmotic stress protection (PubMed:26325238).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi34 – 41ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • amino acid transport Source: UniProtKB-KW
  • glycine betaine transport Source: EcoCyc

Keywordsi

Molecular functionHydrolase
Biological processAmino-acid transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:YEHX-MONOMER
MetaCyc:YEHX-MONOMER

Protein family/group databases

TCDBi3.A.1.12.15 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine betaine uptake system ATP-binding protein YehXCurated (EC:3.6.3.-Curated)
Gene namesi
Name:yehX
Ordered Locus Names:b2129, JW2117
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12010 yehX

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000931671 – 308Glycine betaine uptake system ATP-binding protein YehXAdd BLAST308

Proteomic databases

PaxDbiP33360
PRIDEiP33360

Expressioni

Inductioni

Expression is sigma S-dependent. Induced by both osmotic shock and entry into stationary phase.1 Publication

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (YehX), two transmembrane proteins (YehW and YehY) and a solute-binding protein (YehZ).Curated

Protein-protein interaction databases

BioGridi4260448, 33 interactors
DIPiDIP-11912N
IntActiP33360, 8 interactors
STRINGi316385.ECDH10B_2285

Structurei

3D structure databases

ProteinModelPortaliP33360
SMRiP33360
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 235ABC transporterPROSITE-ProRule annotationAdd BLAST234

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated

Phylogenomic databases

eggNOGiENOG4108IJ8 Bacteria
COG1125 LUCA
InParanoidiP33360
KOiK05847
OMAiALAEMIW
PhylomeDBiP33360

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

P33360-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIEFSHVSKL FGAQKAVNDL NLNFQEGSFS VLIGTSGSGK STTLKMINRL
60 70 80 90 100
VEHDSGEIRF AGEEIRSLPV LELRRRMGYA IQSIGLFPHW SVAQNIATVP
110 120 130 140 150
QLQKWSRARI DDRIDELMAL LGLESNLRER YPHQLSGGQQ QRVGVARALA
160 170 180 190 200
ADPQVLLMDE PFGALDPVTR GALQQEMTRI HRLLGRTIVL VTHDIDEALR
210 220 230 240 250
LAEHLVLMDH GEVVQQGNPL TMLTRPANDF VRQFFGRSEL GVRLLSLRSV
260 270 280 290 300
ADYVRREERA DGEALAEEMT LRDALSLFVA RGCEVLPVVN MQGQPCGTLH

FQDLLVEA
Length:308
Mass (Da):34,425
Last modified:February 1, 1994 - v1
Checksum:i037C7C84E4EFB690
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00007 Genomic DNA Translation: AAA60492.1
U00096 Genomic DNA Translation: AAC75190.1
AP009048 Genomic DNA Translation: BAE76606.1
PIRiH64980
RefSeqiNP_416633.1, NC_000913.3
WP_000569315.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75190; AAC75190; b2129
BAE76606; BAE76606; BAE76606
GeneIDi946659
KEGGiecj:JW2117
eco:b2129
PATRICifig|1411691.4.peg.115

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00007 Genomic DNA Translation: AAA60492.1
U00096 Genomic DNA Translation: AAC75190.1
AP009048 Genomic DNA Translation: BAE76606.1
PIRiH64980
RefSeqiNP_416633.1, NC_000913.3
WP_000569315.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP33360
SMRiP33360
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260448, 33 interactors
DIPiDIP-11912N
IntActiP33360, 8 interactors
STRINGi316385.ECDH10B_2285

Protein family/group databases

TCDBi3.A.1.12.15 the atp-binding cassette (abc) superfamily

Proteomic databases

PaxDbiP33360
PRIDEiP33360

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75190; AAC75190; b2129
BAE76606; BAE76606; BAE76606
GeneIDi946659
KEGGiecj:JW2117
eco:b2129
PATRICifig|1411691.4.peg.115

Organism-specific databases

EchoBASEiEB1948
EcoGeneiEG12010 yehX

Phylogenomic databases

eggNOGiENOG4108IJ8 Bacteria
COG1125 LUCA
InParanoidiP33360
KOiK05847
OMAiALAEMIW
PhylomeDBiP33360

Enzyme and pathway databases

BioCyciEcoCyc:YEHX-MONOMER
MetaCyc:YEHX-MONOMER

Miscellaneous databases

PROiPR:P33360

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiYEHX_ECOLI
AccessioniPrimary (citable) accession number: P33360
Secondary accession number(s): Q2MAV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 28, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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