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Entry version 185 (07 Apr 2021)
Sequence version 1 (01 Feb 1994)
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Protein

Transcription factor tau 131 kDa subunit

Gene

TFC4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes. TFC4 is the TFIIIB-assembling subunit of TFIIIC and essential for viability.2 Publications

Miscellaneous

Present with 876 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-SCE-76066, RNA Polymerase III Transcription Initiation From Type 2 Promoter

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription factor tau 131 kDa subunit
Alternative name(s):
TFIIIC 131 kDa subunit
Transcription factor C subunit 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TFC4
Synonyms:PCF1
Ordered Locus Names:YGR047C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VII

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000003279, TFC4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YGR047C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi148E → K in PCF1-17; increases RNA polymerase III gene transcription. 1 Publication1
Mutagenesisi162F → L in PCF1-12; increases RNA polymerase III gene transcription. 1 Publication1
Mutagenesisi162F → S in PCF1-139; increases RNA polymerase III gene transcription. 1 Publication1
Mutagenesisi164A → V in PCF1-19; increases RNA polymerase III gene transcription. 1 Publication1
Mutagenesisi167T → I in PCF1-2; increases RNA polymerase III gene transcription due to an increase in the recruitment of BRF1 to TFIIIC-DNA. No effect on affinity of TFIIIC for DNA. 1 Publication1
Mutagenesisi172Y → C in PCF1-11; increases RNA polymerase III gene transcription. 1
Mutagenesisi188A → T in PCF1-23; increases RNA polymerase III gene transcription. 1 Publication1
Mutagenesisi190H → Y in PCF1-1; affects the rate of recruitment of TFIIIB to the template. Increases the amount of transcriptionally active TFIIIB. Increases RNA polymerase III gene transcription. Increases the binding affinity for BRF1, but does not affect the binding affinity for BDP1 in the TFIIIC-dependent assembly of TFIIIB. Overcomes autoinhibition of BRF1 binding. 4 Publications1
Mutagenesisi192N → L in PCF1-138; increases RNA polymerase III gene transcription. 1 Publication1
Mutagenesisi199W → R in PCF1-15; increases RNA polymerase III gene transcription. 1 Publication1
Mutagenesisi469L → K: RNA polymerase III defective. Defect in the recruitment of BRF1 into TFIIIB-TFIIIC-DNA complexes and diminished direct interaction between TFC4 and BRF1. Decreased binding affinity for BDP1 incorporation into TFIIIB-TFIIIC-DNA complexes and inhibited binary interaction between BDP1 and TFC4. 1 Publication1
Mutagenesisi472E → K: RNA polymerase III defective. 1 Publication1
Mutagenesisi504V → K: RNA polymerase III defective. 1 Publication1
Mutagenesisi541S → I: RNA polymerase III defective. 1 Publication1
Mutagenesisi542L → G: RNA polymerase III defective. 1 Publication1
Mutagenesisi728R → E in PCF1-8; increases RNA polymerase III transcription. 1 Publication1
Mutagenesisi728R → G in PCF1-7; increases RNA polymerase III transcription. 1 Publication1
Mutagenesisi728R → H in PCF1-4; increases RNA polymerase III transcription ninefold over wild-type. Increases the amount of transcriptionally active TFIIIB. 1 Publication1
Mutagenesisi728R → K in PCF1-3; increases RNA polymerase III transcription two- to threefold over wild-type. Increases the amount of transcriptionally active TFIIIB. 1 Publication1
Mutagenesisi728R → M in PCF1-5; increases RNA polymerase III transcription. 1 Publication1
Mutagenesisi728R → V in PCF1-6; increases RNA polymerase III transcription. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001063641 – 1025Transcription factor tau 131 kDa subunitAdd BLAST1025

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei311PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P33339

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P33339

PRoteomics IDEntifications database

More...
PRIDEi
P33339

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P33339

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the TFIIIC complex composed of TFC1, TFC3, TFC4, TFC6, TFC7 and TFC8. The subunits are organized in two globular domains, tauA and tauB, connected by a proteolysis-sensitive and flexible linker.

Interacts with TFC1, TFC3, TFC6, TFIIIB subunits BRF1 and BDP1, and with RNA polymerase III subunit RPC10.

7 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
33294, 136 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1656, Transcription factor TFIIIC complex

Database of interacting proteins

More...
DIPi
DIP-230N

Protein interaction database and analysis system

More...
IntActi
P33339, 16 interactors

Molecular INTeraction database

More...
MINTi
P33339

STRING: functional protein association networks

More...
STRINGi
4932.YGR047C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P33339, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11025
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P33339

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati128 – 161TPR 1Add BLAST34
Repeati162 – 195TPR 2Add BLAST34
Repeati196 – 229TPR 3Add BLAST34
Repeati230 – 263TPR 4Add BLAST34
Repeati264 – 297TPR 5Add BLAST34
Repeati432 – 465TPR 6Add BLAST34
Repeati467 – 501TPR 7Add BLAST35
Repeati502 – 535TPR 8Add BLAST34
Repeati536 – 569TPR 9Add BLAST34
Repeati875 – 908TPR 10Add BLAST34
Repeati959 – 992TPR 11Add BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni128 – 569Sufficient to bind BDP1Add BLAST442

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2076, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016929

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002391_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P33339

Identification of Orthologs from Complete Genome Data

More...
OMAi
RICMEII

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039340, Tfc4/TFIIIC-102/Sfc4
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR23082, PTHR23082, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13174, TPR_6, 1 hit
PF13181, TPR_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028, TPR, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005, TPR, 6 hits
PS50293, TPR_REGION, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P33339-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAGKLKKEQ QNQSAERESA DTGKVNDEDE EHLYGNIDDY KHLIQDEEYD
60 70 80 90 100
DEDVPHDLQL SEDEYNSERD SSLLAEFSDY GEISEDDEED FMNAIREASN
110 120 130 140 150
FKVKKKKKND KGKSYGRQRK ERVLDPEVAQ LLSQANEAFV RNDLQVAERL
160 170 180 190 200
FNEVIKKDAR NFAAYETLGD IYQLQGRLND CCNSWFLAAH LNASDWEFWK
210 220 230 240 250
IVAILSADLD HVRQAIYCFS RVISLNPMEW ESIYRRSMLY KKTGQLARAL
260 270 280 290 300
DGFQRLYMYN PYDANILREL AILYVDYDRI EDSIELYMKV FNANVERREA
310 320 330 340 350
ILAALENALD SSDEESAAEG EDADEKEPLE QDEDRQMFPD INWKKIDAKY
360 370 380 390 400
KCIPFDWSSL NILAELFLKL AVSEVDGIKT IKKCARWIQR RESQTFWDHV
410 420 430 440 450
PDDSEFDNRR FKNSTFDSLL AAEKEKSYNI PIDIRVRLGL LRLNTDNLVE
460 470 480 490 500
ALNHFQCLYD ETFSDVADLY FEAATALTRA EKYKEAIDFF TPLLSLEEWR
510 520 530 540 550
TTDVFKPLAR CYKEIESYET AKEFYELAIK SEPDDLDIRV SLAEVYYRLN
560 570 580 590 600
DPETFKHMLV DVVEMRKHQV DETLHRISNE KSSNDTSDIS SKPLLEDSKF
610 620 630 640 650
RTFRKKKRTP YDAERERIER ERRITAKVVD KYEKMKKFEL NSGLNEAKQA
660 670 680 690 700
SIWINTVSEL VDIFSSVKNF FMKSRSRKFV GILRRTKKFN TELDFQIERL
710 720 730 740 750
SKLAEGDSVF EGPLMEERVT LTSATELRGL SYEQWFELFM ELSLVIAKYQ
760 770 780 790 800
SVEDGLSVVE TAQEVNVFFQ DPERVKMMKF VKLAIVLQMD DEEELAENLR
810 820 830 840 850
GLLNQFQFNR KVLQVFMYSL CRGPSSLNIL SSTIQQKFFL RQLKAFDSCR
860 870 880 890 900
YNTEVNGQAS ITNKEVYNPN KKSSPYLYYI YAVLLYSSRG FLSALQYLTR
910 920 930 940 950
LEEDIPDDPM VNLLMGLSHI HRAMQRLTAQ RHFQIFHGLR YLYRYHKIRK
960 970 980 990 1000
SLYTDLEKQE ADYNLGRAFH LIGLVSIAIE YYNRVLENYD DGKLKKHAAY
1010 1020
NSIIIYQQSG NVELADHLME KYLSI
Length:1,025
Mass (Da):120,229
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i12DE18304AAF4862
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti280I → T in strain: SK1. 1 Publication1
Natural varianti635M → V in strain: SK1. 1 Publication1
Natural varianti1025I → V in strain: SK1. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L12722 Genomic DNA Translation: AAA35145.1
DQ115391 Genomic DNA Translation: AAZ22462.1
Z72832 Genomic DNA Translation: CAA97046.1
Z72833 Genomic DNA Translation: CAA97048.1
BK006941 Genomic DNA Translation: DAA08145.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A47453

NCBI Reference Sequences

More...
RefSeqi
NP_011561.3, NM_001181176.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YGR047C_mRNA; YGR047C; YGR047C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852938

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YGR047C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12722 Genomic DNA Translation: AAA35145.1
DQ115391 Genomic DNA Translation: AAZ22462.1
Z72832 Genomic DNA Translation: CAA97046.1
Z72833 Genomic DNA Translation: CAA97048.1
BK006941 Genomic DNA Translation: DAA08145.1
PIRiA47453
RefSeqiNP_011561.3, NM_001181176.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5AEMX-ray3.40A123-566[»]
5AIOX-ray3.15A123-566[»]
6YJ6electron microscopy3.10A1-1025[»]
SMRiP33339
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi33294, 136 interactors
ComplexPortaliCPX-1656, Transcription factor TFIIIC complex
DIPiDIP-230N
IntActiP33339, 16 interactors
MINTiP33339
STRINGi4932.YGR047C

PTM databases

iPTMnetiP33339

Proteomic databases

MaxQBiP33339
PaxDbiP33339
PRIDEiP33339

Genome annotation databases

EnsemblFungiiYGR047C_mRNA; YGR047C; YGR047C
GeneIDi852938
KEGGisce:YGR047C

Organism-specific databases

SGDiS000003279, TFC4
VEuPathDBiFungiDB:YGR047C

Phylogenomic databases

eggNOGiKOG2076, Eukaryota
GeneTreeiENSGT00390000016929
HOGENOMiCLU_002391_0_1_1
InParanoidiP33339
OMAiRICMEII

Enzyme and pathway databases

ReactomeiR-SCE-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-SCE-76066, RNA Polymerase III Transcription Initiation From Type 2 Promoter

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P33339
RNActiP33339, protein

Family and domain databases

Gene3Di1.25.40.10, 4 hits
InterProiView protein in InterPro
IPR039340, Tfc4/TFIIIC-102/Sfc4
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
PANTHERiPTHR23082, PTHR23082, 1 hit
PfamiView protein in Pfam
PF13174, TPR_6, 1 hit
PF13181, TPR_8, 1 hit
SMARTiView protein in SMART
SM00028, TPR, 8 hits
SUPFAMiSSF48452, SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005, TPR, 6 hits
PS50293, TPR_REGION, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTFC4_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P33339
Secondary accession number(s): D6VUI4, Q45U37
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 7, 2021
This is version 185 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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