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UniProtKB - P33327 (DHE2_YEAST)
Protein
NAD-specific glutamate dehydrogenase
Gene
GDH2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
NAD+-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.
Miscellaneous
Present with 7400 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
- EC:1.4.1.2
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 626 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- glutamate dehydrogenase (NAD+) activity Source: SGD
GO - Biological processi
- glutamate catabolic process Source: GO_Central
- glutamate catabolic process to 2-oxoglutarate Source: InterPro
- nitrogen compound metabolic process Source: SGD
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Enzyme and pathway databases
BRENDAi | 1.4.1.2, 984 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:GDH2 Ordered Locus Names:YDL215C ORF Names:D0892 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000002374, GDH2 |
VEuPathDBi | FungiDB:YDL215C |
Pathology & Biotechi
Disruption phenotypei
Leads to rapamycin resistance when grown on glutamate as the sole nitrogen source.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000182733 | 1 – 1092 | NAD-specific glutamate dehydrogenaseAdd BLAST | 1092 |
Post-translational modificationi
Phosphorylated by a complex containing the NNK1 kinase.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P33327 |
PaxDbi | P33327 |
PRIDEi | P33327 |
PTM databases
iPTMneti | P33327 |
Interactioni
Subunit structurei
Homotetramer.
Interacts with NNK1.
1 PublicationBinary interactionsi
P33327
With | #Exp. | IntAct |
---|---|---|
NNK1 [P36003] | 3 | EBI-5815,EBI-9796 |
Protein-protein interaction databases
BioGRIDi | 31830, 147 interactors |
DIPi | DIP-1689N |
IntActi | P33327, 19 interactors |
MINTi | P33327 |
STRINGi | 4932.YDL215C |
Miscellaneous databases
RNActi | P33327, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.Curated
Phylogenomic databases
eggNOGi | KOG2250, Eukaryota |
GeneTreei | ENSGT00390000000854 |
HOGENOMi | CLU_005220_0_0_1 |
InParanoidi | P33327 |
OMAi | LYCLPQN |
Family and domain databases
InterProi | View protein in InterPro IPR046346, Aminiacid_DH-like_N_sf IPR033524, Glu/Leu/Phe/Val_DH_AS IPR006096, Glu/Leu/Phe/Val_DH_C IPR036291, NAD(P)-bd_dom_sf IPR016210, NAD-GDH_euk |
Pfami | View protein in Pfam PF00208, ELFV_dehydrog, 1 hit |
PIRSFi | PIRSF000184, GDH_NAD, 1 hit |
SMARTi | View protein in SMART SM00839, ELFV_dehydrog, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit SSF53223, SSF53223, 1 hit |
PROSITEi | View protein in PROSITE PS00074, GLFV_DEHYDROGENASE, 1 hit |
i Sequence
Sequence statusi: Complete.
P33327-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLFDNKNRGA LNSLNTPDIA SLSISSMSDY HVFDFPGKDL QREEVIDLLD
60 70 80 90 100
QQGFIPDDLI EQEVDWFYNS LGIDDLFFSR ESPQLISNII HSLYASKLDF
110 120 130 140 150
FAKSKFNGIQ PRLFSIKNKI ITNDNHAIFM ESNTGVSISD SQQKNFKFAS
160 170 180 190 200
DAVGNDTLEH GKDTIKKNRI EMDDSCPPYE LDSEIDDLFL DNKSQKNCRL
210 220 230 240 250
VSFWAPESEL KLTFVYESVY PNDDPAGVDI SSQDLLKGDI ESISDKTMYK
260 270 280 290 300
VSSNENKKLY GLLLKLVKER EGPVIKTTRS VENKDEIRLL VAYKRFTTKR
310 320 330 340 350
YYSALNSLFH YYKLKPSKFY LESFNVKDDD IIIFSVYLNE NQQLEDVLLH
360 370 380 390 400
DVEAALKQVE REASLLYAIP NNSFHEVYQR RQFSPKEAIY AHIGAIFINH
410 420 430 440 450
FVNRLGSDYQ NLLSQITIKR NDTTLLEIVE NLKRKLRNET LTQQTIINIM
460 470 480 490 500
SKHYTIISKL YKNFAQIHYY HNSTKDMEKT LSFQRLEKVE PFKNDQEFEA
510 520 530 540 550
YLNKFIPNDS PDLLILKTLN IFNKSILKTN FFITRKVAIS FRLDPSLVMT
560 570 580 590 600
KFEYPETPYG IFFVVGNTFK GFHIRFRDIA RGGIRIVCSR NQDIYDLNSK
610 620 630 640 650
NVIDENYQLA STQQRKNKDI PEGGSKGVIL LNPGLVEHDQ TFVAFSQYVD
660 670 680 690 700
AMIDILINDP LKENYVNLLP KEEILFFGPD EGTAGFVDWA TNHARVRNCP
710 720 730 740 750
WWKSFLTGKS PSLGGIPHDE YGMTSLGVRA YVNKIYETLN LTNSTVYKFQ
760 770 780 790 800
TGGPDGDLGS NEILLSSPNE CYLAILDGSG VLCDPKGLDK DELCRLAHER
810 820 830 840 850
KMISDFDTSK LSNNGFFVSV DAMDIMLPNG TIVANGTTFR NTFHTQIFKF
860 870 880 890 900
VDHVDIFVPC GGRPNSITLN NLHYFVDEKT GKCKIPYIVE GANLFITQPA
910 920 930 940 950
KNALEEHGCI LFKDASANKG GVTSSSMEVL ASLALNDNDF VHKFIGDVSG
960 970 980 990 1000
ERSALYKSYV VEVQSRIQKN AELEFGQLWN LNQLNGTHIS EISNQLSFTI
1010 1020 1030 1040 1050
NKLNDDLVAS QELWLNDLKL RNYLLLDKII PKILIDVAGP QSVLENIPES
1060 1070 1080 1090
YLKVLLSSYL SSTFVYQNGI DVNIGKFLEF IGGLKREAEA SA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S66436 Genomic DNA Translation: AAB20327.1 X99000 Genomic DNA Translation: CAA67475.1 Z74263 Genomic DNA Translation: CAA98793.1 X72015 Genomic DNA Translation: CAA50894.1 BK006938 Genomic DNA Translation: DAA11649.1 |
PIRi | S37676 |
RefSeqi | NP_010066.1, NM_001180275.1 |
Genome annotation databases
EnsemblFungii | YDL215C_mRNA; YDL215C; YDL215C |
GeneIDi | 851311 |
KEGGi | sce:YDL215C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S66436 Genomic DNA Translation: AAB20327.1 X99000 Genomic DNA Translation: CAA67475.1 Z74263 Genomic DNA Translation: CAA98793.1 X72015 Genomic DNA Translation: CAA50894.1 BK006938 Genomic DNA Translation: DAA11649.1 |
PIRi | S37676 |
RefSeqi | NP_010066.1, NM_001180275.1 |
3D structure databases
AlphaFoldDBi | P33327 |
SMRi | P33327 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 31830, 147 interactors |
DIPi | DIP-1689N |
IntActi | P33327, 19 interactors |
MINTi | P33327 |
STRINGi | 4932.YDL215C |
PTM databases
iPTMneti | P33327 |
Proteomic databases
MaxQBi | P33327 |
PaxDbi | P33327 |
PRIDEi | P33327 |
Genome annotation databases
EnsemblFungii | YDL215C_mRNA; YDL215C; YDL215C |
GeneIDi | 851311 |
KEGGi | sce:YDL215C |
Organism-specific databases
SGDi | S000002374, GDH2 |
VEuPathDBi | FungiDB:YDL215C |
Phylogenomic databases
eggNOGi | KOG2250, Eukaryota |
GeneTreei | ENSGT00390000000854 |
HOGENOMi | CLU_005220_0_0_1 |
InParanoidi | P33327 |
OMAi | LYCLPQN |
Enzyme and pathway databases
BRENDAi | 1.4.1.2, 984 |
Miscellaneous databases
PROi | PR:P33327 |
RNActi | P33327, protein |
Family and domain databases
InterProi | View protein in InterPro IPR046346, Aminiacid_DH-like_N_sf IPR033524, Glu/Leu/Phe/Val_DH_AS IPR006096, Glu/Leu/Phe/Val_DH_C IPR036291, NAD(P)-bd_dom_sf IPR016210, NAD-GDH_euk |
Pfami | View protein in Pfam PF00208, ELFV_dehydrog, 1 hit |
PIRSFi | PIRSF000184, GDH_NAD, 1 hit |
SMARTi | View protein in SMART SM00839, ELFV_dehydrog, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit SSF53223, SSF53223, 1 hit |
PROSITEi | View protein in PROSITE PS00074, GLFV_DEHYDROGENASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DHE2_YEAST | |
Accessioni | P33327Primary (citable) accession number: P33327 Secondary accession number(s): D6VRD9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | February 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IV
Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names - SIMILARITY comments
Index of protein domains and families