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UniProtKB - P33316 (DUT_HUMAN)

Entry version 216 (29 Sep 2021)
Sequence version 4 (21 Sep 2011)
Previous versions | rss
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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

Gene

DUT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

3 Publications

Miscellaneous

Each trimer binds three substrate molecules. The ligands are bound between subunits, and for each substrate molecule, residues from adjacent subunits contribute to the binding interactions.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Phosphorylation is necessary for activity.

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kM is identical for both isoform 2 and isoform 3.1 Publication
  1. KM=2.5 µM for dUTP1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: dUMP biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes dUMP from dCTP (dUTP route).2 Publications This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei198dUTP; via amide nitrogen and carbonyl oxygenCombined sources1 Publication1 Publication1
Binding sitei241dUTPCombined sources1 Publication1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMagnesium

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS05235-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.6.1.23, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P33316

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-499943, Interconversion of nucleotide di- and triphosphates [P33316-2]

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P33316

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00610;UER00666

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial1 Publication (EC:3.6.1.233 Publications)
Short name:
dUTPase1 Publication
Alternative name(s):
dUTP pyrophosphatase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DUT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3078, DUT

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601266, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P33316

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000128951

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi99S → A: Loss of phosphorylation. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		1854

Open Targets

More...OpenTargetsi		ENSG00000128951

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA151

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P33316, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5203

Drug and drug target database

More...DrugBanki		DB04685, 1-{(2S,5S)-4-FLUORO-5-[(TRITYLOXY)METHYL]TETRAHYDROFURAN-2-YL}PYRIMIDINE-2,4(1H,3H)-DIONE
DB03413, Deoxyuridine-5'-Diphosphate

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DUT

Domain mapping of disease mutations (DMDM)

More...DMDMi		347595814

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 69MitochondrionCombined sources2 PublicationsAdd BLAST69
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000739270 – 252Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrialAdd BLAST183
Isoform 2 (identifier: P33316-2)
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei88PhosphoserineCombined sources1
Modified residuei99PhosphoserineCombined sources1
Isoform 2 (identifier: P33316-2)
Modified residuei11PhosphoserineCombined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Nuclear isoform 2 is phosphorylated in vivo on Ser-11, a reaction that can be catalyzed in vitro by CDC2. Phosphorylation in mature T-cells occurs in a cell cycle-dependent manner. Isoform 3 is not phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-64
CPTAC-65

Encyclopedia of Proteome Dynamics

More...EPDi		P33316

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P33316

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P33316

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P33316

PeptideAtlas

More...PeptideAtlasi		P33316

PRoteomics IDEntifications database

More...PRIDEi		P33316

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54908 [P33316-3]
54909 [P33316-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P33316-2 [P33316-2]
P33316-3 [P33316-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P33316, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P33316

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P33316

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P33316

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P33316

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in a variety of tissues. Isoform 3 expression is constitutive, while isoform 2 expression correlates with the onset of DNA replication (at protein level). Isoform 2 degradation coincides with the cessation of nuclear DNA replication (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000128951, Expressed in liver and 260 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P33316, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P33316, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000128951, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108187, 102 interactors

Protein interaction database and analysis system

More...IntActi		P33316, 35 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000370376

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P33316

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P33316, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1252
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P33316

Small Angle Scattering Biological Data Bank

More...SASBDBi		P33316

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P33316

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P33316

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni78 – 104DisorderedSequence analysisAdd BLAST27
Regioni173 – 175dUTP bindingCombined sources1 Publication1 Publication3
Regioni187 – 193dUTP bindingCombined sources1 Publication1 Publication7
Regioni246 – 247dUTP bindingCombined sources1 Publication1 Publication2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dUTPase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3370, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000018390

Database of Orthologous Groups

More...OrthoDBi		1495752at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P33316

TreeFam database of animal gene trees

More...TreeFami		TF105416

Family and domain databases

Conserved Domains Database

More...CDDi		cd07557, trimeric_dUTPase, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.70.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029054, dUTPase-like
IPR036157, dUTPase-like_sf
IPR008181, dUTPase_1
IPR033704, dUTPase_trimeric

The PANTHER Classification System

More...PANTHERi		PTHR11241, PTHR11241, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00692, dUTPase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51283, SSF51283, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00576, dut, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: P33316-3) [UniParc]FASTAAdd to basket
Also known as: DUT-M

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTPLCPRPAL CYHFLTSLLR SAMQNARGAR QRAEAAVLSG PGPPLGRAAQ 
        60         70         80         90        100
HGIPRPLSSA GRLSQGCRGA STVGAAGWKG ELPKAGGSPA PGPETPAISP 
       110        120        130        140        150
SKRARPAEVG GMQLRFARLS EHATAPTRGS ARAAGYDLYS AYDYTIPPME 
       160        170        180        190        200
KAVVKTDIQI ALPSGCYGRV APRSGLAAKH FIDVGAGVID EDYRGNVGVV 
       210        220        230        240        250
LFNFGKEKFE VKKGDRIAQL ICERIFYPEI EEVQALDDTE RGSGGFGSTG 

KN
Length:252
Mass (Da):26,563
Last modified:September 21, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8E2EBC9ED5B0FAD2
GO
Isoform 2 (identifier: P33316-2) [UniParc]FASTAAdd to basket
Also known as: DUT-N

The sequence of this isoform differs from the canonical sequence as follows:
     1-93: MTPLCPRPAL...KAGGSPAPGP → MPCSE

Note: Major isoform.Curated
Show »
Length:164
Mass (Da):17,748
Checksum:iE75BC583BF8C7245
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YNW5H0YNW5_HUMAN
Deoxyuridine 5'-triphosphate nucleo...
DUT
167Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKC5H0YKC5_HUMAN
Deoxyuridine 5'-triphosphate nucleo...
DUT
221Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGL3A0A0C4DGL3_HUMAN
Deoxyuridine 5'-triphosphate nucleo...
DUT hCG_41784
141Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMP1H0YMP1_HUMAN
Deoxyuridine 5'-triphosphate nucleo...
DUT
107Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMM5H0YMM5_HUMAN
Deoxyuridine 5'-triphosphate nucleo...
DUT
133Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKI0H0YKI0_HUMAN
Deoxyuridine 5'-triphosphate nucleo...
DUT
226Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNJ9H0YNJ9_HUMAN
Deoxyuridine 5'-triphosphate nucleo...
DUT
143Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB71393 differs from that shown. Reason: Frameshift.Curated
The sequence AAB93866 differs from that shown. Reason: Frameshift.Curated
The sequence AAB94642 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti175G → S in BAF84204 (PubMed:14702039).Curated1
Sequence conflicti182I → T in BAG60677 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022314100P → S1 PublicationCorresponds to variant dbSNP:rs28381104EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0013241 – 93MTPLC…PAPGP → MPCSE in isoform 2. 6 PublicationsAdd BLAST93

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U31930 mRNA Translation: AAC50418.1
U62891 mRNA Translation: AAC51123.1
AF018432 AF018431 Genomic DNA Translation: AAB71393.1 Frameshift.
AF018432 AF018431 Genomic DNA Translation: AAB71394.1
U90223 mRNA Translation: AAB94642.1 Frameshift.
U90224 Genomic DNA Translation: AAB93866.1 Frameshift.
U90224 Genomic DNA Translation: AAB93867.1
AB049113 mRNA Translation: BAB13724.1
AY935242 Genomic DNA Translation: AAX14045.1
AK291515 mRNA Translation: BAF84204.1
AK312122 mRNA Translation: BAG35058.1
CR541720 mRNA Translation: CAG46521.1
CR541781 mRNA Translation: CAG46580.1
CH471082 Genomic DNA Translation: EAW77350.1
AK298464 mRNA Translation: BAG60677.1
BC033645 mRNA Translation: AAH33645.1
BC070339 mRNA Translation: AAH70339.1
BC110377 mRNA Translation: AAI10378.1
M89913 mRNA Translation: AAA58444.1
L11877 mRNA Translation: AAA36801.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32231.1 [P33316-3]
CCDS45255.1 [P33316-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A46256
G02777

NCBI Reference Sequences

More...RefSeqi		NP_001020419.1, NM_001025248.1 [P33316-3]
NP_001020420.1, NM_001025249.1
NP_001317215.1, NM_001330286.1
NP_001939.1, NM_001948.3 [P33316-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000331200; ENSP00000370376; ENSG00000128951 [P33316-3]
ENST00000455976; ENSP00000405160; ENSG00000128951 [P33316-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1854

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1854

UCSC genome browser

More...UCSCi		uc001zws.4, human [P33316-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31930 mRNA Translation: AAC50418.1
U62891 mRNA Translation: AAC51123.1
AF018432 AF018431 Genomic DNA Translation: AAB71393.1 Frameshift.
AF018432 AF018431 Genomic DNA Translation: AAB71394.1
U90223 mRNA Translation: AAB94642.1 Frameshift.
U90224 Genomic DNA Translation: AAB93866.1 Frameshift.
U90224 Genomic DNA Translation: AAB93867.1
AB049113 mRNA Translation: BAB13724.1
AY935242 Genomic DNA Translation: AAX14045.1
AK291515 mRNA Translation: BAF84204.1
AK312122 mRNA Translation: BAG35058.1
CR541720 mRNA Translation: CAG46521.1
CR541781 mRNA Translation: CAG46580.1
CH471082 Genomic DNA Translation: EAW77350.1
AK298464 mRNA Translation: BAG60677.1
BC033645 mRNA Translation: AAH33645.1
BC070339 mRNA Translation: AAH70339.1
BC110377 mRNA Translation: AAI10378.1
M89913 mRNA Translation: AAA58444.1
L11877 mRNA Translation: AAA36801.1
CCDSiCCDS32231.1 [P33316-3]
CCDS45255.1 [P33316-2]
PIRiA46256
G02777
RefSeqiNP_001020419.1, NM_001025248.1 [P33316-3]
NP_001020420.1, NM_001025249.1
NP_001317215.1, NM_001330286.1
NP_001939.1, NM_001948.3 [P33316-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q5HX-ray2.00A/B/C112-252[»]
1Q5UX-ray2.00X/Y/Z112-252[»]
2HQUX-ray2.20A/B/C94-252[»]
3ARAX-ray1.70A/B/C94-252[»]
3ARNX-ray1.80A/B/C94-252[»]
3EHWX-ray1.80A/B/C/X/Y/Z94-252[»]
4MZ5X-ray2.10A/C97-109[»]
4MZ6X-ray1.88A/C97-109[»]
5H4JX-ray1.80A94-252[»]
BMRBiP33316
SASBDBiP33316
SMRiP33316
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108187, 102 interactors
IntActiP33316, 35 interactors
STRINGi9606.ENSP00000370376

Chemistry databases

BindingDBiP33316
ChEMBLiCHEMBL5203
DrugBankiDB04685, 1-{(2S,5S)-4-FLUORO-5-[(TRITYLOXY)METHYL]TETRAHYDROFURAN-2-YL}PYRIMIDINE-2,4(1H,3H)-DIONE
DB03413, Deoxyuridine-5'-Diphosphate

PTM databases

GlyGeniP33316, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP33316
MetOSiteiP33316
PhosphoSitePlusiP33316
SwissPalmiP33316

Genetic variation databases

BioMutaiDUT
DMDMi347595814

Proteomic databases

CPTACiCPTAC-64
CPTAC-65
EPDiP33316
jPOSTiP33316
MassIVEiP33316
PaxDbiP33316
PeptideAtlasiP33316
PRIDEiP33316
ProteomicsDBi54908 [P33316-3]
54909 [P33316-2]
TopDownProteomicsiP33316-2 [P33316-2]
P33316-3 [P33316-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24524, 381 antibodies

The DNASU plasmid repository

More...DNASUi		1854

Genome annotation databases

EnsembliENST00000331200; ENSP00000370376; ENSG00000128951 [P33316-3]
ENST00000455976; ENSP00000405160; ENSG00000128951 [P33316-2]
GeneIDi1854
KEGGihsa:1854
UCSCiuc001zws.4, human [P33316-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1854
DisGeNETi1854

GeneCards: human genes, protein and diseases

More...GeneCardsi		DUT
HGNCiHGNC:3078, DUT
HPAiENSG00000128951, Low tissue specificity
MIMi601266, gene
neXtProtiNX_P33316
OpenTargetsiENSG00000128951
PharmGKBiPA151
VEuPathDBiHostDB:ENSG00000128951

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3370, Eukaryota
GeneTreeiENSGT00390000018390
OrthoDBi1495752at2759
PhylomeDBiP33316
TreeFamiTF105416

Enzyme and pathway databases

UniPathwayiUPA00610;UER00666
BioCyciMetaCyc:HS05235-MONOMER
BRENDAi3.6.1.23, 2681
PathwayCommonsiP33316
ReactomeiR-HSA-499943, Interconversion of nucleotide di- and triphosphates [P33316-2]
SABIO-RKiP33316

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1854, 789 hits in 1038 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DUT, human
EvolutionaryTraceiP33316

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		DUT_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1854
PharosiP33316, Tchem

Protein Ontology

More...PROi		PR:P33316
RNActiP33316, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000128951, Expressed in liver and 260 other tissues
ExpressionAtlasiP33316, baseline and differential
GenevisibleiP33316, HS

Family and domain databases

CDDicd07557, trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
InterProiView protein in InterPro
IPR029054, dUTPase-like
IPR036157, dUTPase-like_sf
IPR008181, dUTPase_1
IPR033704, dUTPase_trimeric
PANTHERiPTHR11241, PTHR11241, 1 hit
PfamiView protein in Pfam
PF00692, dUTPase, 1 hit
SUPFAMiSSF51283, SSF51283, 1 hit
TIGRFAMsiTIGR00576, dut, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDUT_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P33316
Secondary accession number(s): A8K650
, B4DPR5, O14785, Q16708, Q16860, Q6FHN1, Q6NSA3, Q96Q81
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: September 21, 2011
Last modified: September 29, 2021
This is version 216 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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