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UniProtKB - P33316 (DUT_HUMAN)

Entry version 215 (02 Jun 2021)
Sequence version 4 (21 Sep 2011)
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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

Gene

DUT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

3 Publications

Miscellaneous

Each trimer binds three substrate molecules. The ligands are bound between subunits, and for each substrate molecule, residues from adjacent subunits contribute to the binding interactions.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Phosphorylation is necessary for activity.

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kM is identical for both isoform 2 and isoform 3.1 Publication
  1. KM=2.5 µM for dUTP1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: dUMP biosynthesis

    This protein is involved in step 2 of the subpathway that synthesizes dUMP from dCTP (dUTP route).2 Publications This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei198dUTP; via amide nitrogen and carbonyl oxygenCombined sources1 Publication1 Publication1
    Binding sitei241dUTPCombined sources1 Publication1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase
    Biological processNucleotide metabolism
    LigandMagnesium

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...    BioCyci    		MetaCyc:HS05235-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...    BRENDAi    		3.6.1.23, 2681

    Pathway Commons web resource for biological pathway data

    More...    PathwayCommonsi    		P33316

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-499943, Interconversion of nucleotide di- and triphosphates [P33316-2]

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		P33316

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...    UniPathwayi    		UPA00610;UER00666

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial1 Publication (EC:3.6.1.233 Publications)
    Short name:
    dUTPase1 Publication
    Alternative name(s):
    dUTP pyrophosphatase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:DUT
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

    Organism-specific databases

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:3078, DUT

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		601266, gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_P33316

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...    VEuPathDBi    		HostDB:ENSG00000128951.13

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Mitochondrion, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi99S → A: Loss of phosphorylation. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		1854

    Open Targets

    More...    OpenTargetsi    		ENSG00000128951

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA151

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		P33316, Tchem

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL5203

    Drug and drug target database

    More...    DrugBanki    		DB04685, 1-{(2S,5S)-4-FLUORO-5-[(TRITYLOXY)METHYL]TETRAHYDROFURAN-2-YL}PYRIMIDINE-2,4(1H,3H)-DIONE
    DB03413, Deoxyuridine-5'-Diphosphate

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		DUT

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		347595814

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 69MitochondrionCombined sources2 PublicationsAdd BLAST69
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000739270 – 252Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrialAdd BLAST183
    Isoform 2 (identifier: P33316-2)
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei88PhosphoserineCombined sources1
    Modified residuei99PhosphoserineCombined sources1
    Isoform 2 (identifier: P33316-2)
    Modified residuei11PhosphoserineCombined sources1 Publication1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Nuclear isoform 2 is phosphorylated in vivo on Ser-11, a reaction that can be catalyzed in vitro by CDC2. Phosphorylation in mature T-cells occurs in a cell cycle-dependent manner. Isoform 3 is not phosphorylated.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    The CPTAC Assay portal

    More...    CPTACi    		CPTAC-64
    CPTAC-65

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		P33316

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		P33316

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		P33316

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		P33316

    PeptideAtlas

    More...    PeptideAtlasi    		P33316

    PRoteomics IDEntifications database

    More...    PRIDEi    		P33316

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		54908 [P33316-3]
    54909 [P33316-2]

    Consortium for Top Down Proteomics

    More...    TopDownProteomicsi    		P33316-2 [P33316-2]
    P33316-3 [P33316-3]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		P33316

    MetOSite database of methionine sulfoxide sites

    More...    MetOSitei    		P33316

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		P33316

    SwissPalm database of S-palmitoylation events

    More...    SwissPalmi    		P33316

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Found in a variety of tissues. Isoform 3 expression is constitutive, while isoform 2 expression correlates with the onset of DNA replication (at protein level). Isoform 2 degradation coincides with the cessation of nuclear DNA replication (at protein level).1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000128951, Expressed in liver and 260 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		P33316, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		P33316, HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000128951, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homotrimer.

    2 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		108187, 102 interactors

    Protein interaction database and analysis system

    More...    IntActi    		P33316, 34 interactors

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000370376

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		P33316

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		P33316, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1252
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Biological Magnetic Resonance Data Bank

    More...    BMRBi    		P33316

    Small Angle Scattering Biological Data Bank

    More...    SASBDBi    		P33316

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		P33316

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...    EvolutionaryTracei    		P33316

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni78 – 104DisorderedSequence analysisAdd BLAST27
    Regioni173 – 175dUTP bindingCombined sources1 Publication1 Publication3
    Regioni187 – 193dUTP bindingCombined sources1 Publication1 Publication7
    Regioni246 – 247dUTP bindingCombined sources1 Publication1 Publication2

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the dUTPase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG3370, Eukaryota

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00390000018390

    Database of Orthologous Groups

    More...    OrthoDBi    		1495752at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		P33316

    TreeFam database of animal gene trees

    More...    TreeFami    		TF105416

    Family and domain databases

    Conserved Domains Database

    More...    CDDi    		cd07557, trimeric_dUTPase, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		2.70.40.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR029054, dUTPase-like
    IPR036157, dUTPase-like_sf
    IPR008181, dUTPase_1
    IPR033704, dUTPase_trimeric

    The PANTHER Classification System

    More...    PANTHERi    		PTHR11241, PTHR11241, 1 hit

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF00692, dUTPase, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF51283, SSF51283, 1 hit

    TIGRFAMs; a protein family database

    More...    TIGRFAMsi    		TIGR00576, dut, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 3 (identifier: P33316-3) [UniParc]FASTAAdd to basket
    Also known as: DUT-M

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MTPLCPRPAL CYHFLTSLLR SAMQNARGAR QRAEAAVLSG PGPPLGRAAQ 
            60         70         80         90        100
    HGIPRPLSSA GRLSQGCRGA STVGAAGWKG ELPKAGGSPA PGPETPAISP 
           110        120        130        140        150
    SKRARPAEVG GMQLRFARLS EHATAPTRGS ARAAGYDLYS AYDYTIPPME 
           160        170        180        190        200
    KAVVKTDIQI ALPSGCYGRV APRSGLAAKH FIDVGAGVID EDYRGNVGVV 
           210        220        230        240        250
    LFNFGKEKFE VKKGDRIAQL ICERIFYPEI EEVQALDDTE RGSGGFGSTG 

    KN
    Length:252
    Mass (Da):26,563
    Last modified:September 21, 2011 - v4
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8E2EBC9ED5B0FAD2
    GO
    Isoform 2 (identifier: P33316-2) [UniParc]FASTAAdd to basket
    Also known as: DUT-N

    The sequence of this isoform differs from the canonical sequence as follows:
         1-93: MTPLCPRPAL...KAGGSPAPGP → MPCSE

    Note: Major isoform.Curated
    Show »
    Length:164
    Mass (Da):17,748
    Checksum:iE75BC583BF8C7245
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    H0YNW5H0YNW5_HUMAN
    Deoxyuridine 5'-triphosphate nucleo...
    DUT
    		167Annotation score:

    Annotation score:3 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YKC5H0YKC5_HUMAN
    Deoxyuridine 5'-triphosphate nucleo...
    DUT
    		221Annotation score:

    Annotation score:3 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A0C4DGL3A0A0C4DGL3_HUMAN
    Deoxyuridine 5'-triphosphate nucleo...
    DUT hCG_41784
    		141Annotation score:

    Annotation score:3 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YMP1H0YMP1_HUMAN
    Deoxyuridine 5'-triphosphate nucleo...
    DUT
    		107Annotation score:

    Annotation score:3 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YMM5H0YMM5_HUMAN
    Deoxyuridine 5'-triphosphate nucleo...
    DUT
    		133Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YKI0H0YKI0_HUMAN
    Deoxyuridine 5'-triphosphate nucleo...
    DUT
    		226Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YNJ9H0YNJ9_HUMAN
    Deoxyuridine 5'-triphosphate nucleo...
    DUT
    		143Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAB71393 differs from that shown. Reason: Frameshift.Curated
    The sequence AAB93866 differs from that shown. Reason: Frameshift.Curated
    The sequence AAB94642 differs from that shown. Reason: Frameshift.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti175G → S in BAF84204 (PubMed:14702039).Curated1
    Sequence conflicti182I → T in BAG60677 (PubMed:14702039).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022314100P → S1 PublicationCorresponds to variant dbSNP:rs28381104EnsemblClinVar.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0013241 – 93MTPLC…PAPGP → MPCSE in isoform 2. 6 PublicationsAdd BLAST93

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		U31930 mRNA Translation: AAC50418.1
    U62891 mRNA Translation: AAC51123.1
    AF018432 AF018431 Genomic DNA Translation: AAB71393.1 Frameshift.
    AF018432 AF018431 Genomic DNA Translation: AAB71394.1
    U90223 mRNA Translation: AAB94642.1 Frameshift.
    U90224 Genomic DNA Translation: AAB93866.1 Frameshift.
    U90224 Genomic DNA Translation: AAB93867.1
    AB049113 mRNA Translation: BAB13724.1
    AY935242 Genomic DNA Translation: AAX14045.1
    AK291515 mRNA Translation: BAF84204.1
    AK312122 mRNA Translation: BAG35058.1
    CR541720 mRNA Translation: CAG46521.1
    CR541781 mRNA Translation: CAG46580.1
    CH471082 Genomic DNA Translation: EAW77350.1
    AK298464 mRNA Translation: BAG60677.1
    BC033645 mRNA Translation: AAH33645.1
    BC070339 mRNA Translation: AAH70339.1
    BC110377 mRNA Translation: AAI10378.1
    M89913 mRNA Translation: AAA58444.1
    L11877 mRNA Translation: AAA36801.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS32231.1 [P33316-3]
    CCDS45255.1 [P33316-2]

    Protein sequence database of the Protein Information Resource

    More...    PIRi    		A46256
    G02777

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001020419.1, NM_001025248.1 [P33316-3]
    NP_001020420.1, NM_001025249.1
    NP_001317215.1, NM_001330286.1
    NP_001939.1, NM_001948.3 [P33316-2]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000331200; ENSP00000370376; ENSG00000128951 [P33316-3]
    ENST00000455976; ENSP00000405160; ENSG00000128951 [P33316-2]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		1854

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:1854

    UCSC genome browser

    More...    UCSCi    		uc001zws.4, human [P33316-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		U31930 mRNA Translation: AAC50418.1
    U62891 mRNA Translation: AAC51123.1
    AF018432 AF018431 Genomic DNA Translation: AAB71393.1 Frameshift.
    AF018432 AF018431 Genomic DNA Translation: AAB71394.1
    U90223 mRNA Translation: AAB94642.1 Frameshift.
    U90224 Genomic DNA Translation: AAB93866.1 Frameshift.
    U90224 Genomic DNA Translation: AAB93867.1
    AB049113 mRNA Translation: BAB13724.1
    AY935242 Genomic DNA Translation: AAX14045.1
    AK291515 mRNA Translation: BAF84204.1
    AK312122 mRNA Translation: BAG35058.1
    CR541720 mRNA Translation: CAG46521.1
    CR541781 mRNA Translation: CAG46580.1
    CH471082 Genomic DNA Translation: EAW77350.1
    AK298464 mRNA Translation: BAG60677.1
    BC033645 mRNA Translation: AAH33645.1
    BC070339 mRNA Translation: AAH70339.1
    BC110377 mRNA Translation: AAI10378.1
    M89913 mRNA Translation: AAA58444.1
    L11877 mRNA Translation: AAA36801.1
    CCDSiCCDS32231.1 [P33316-3]
    CCDS45255.1 [P33316-2]
    PIRiA46256
    G02777
    RefSeqiNP_001020419.1, NM_001025248.1 [P33316-3]
    NP_001020420.1, NM_001025249.1
    NP_001317215.1, NM_001330286.1
    NP_001939.1, NM_001948.3 [P33316-2]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1Q5HX-ray2.00A/B/C112-252[»]
    1Q5UX-ray2.00X/Y/Z112-252[»]
    2HQUX-ray2.20A/B/C94-252[»]
    3ARAX-ray1.70A/B/C94-252[»]
    3ARNX-ray1.80A/B/C94-252[»]
    3EHWX-ray1.80A/B/C/X/Y/Z94-252[»]
    4MZ5X-ray2.10A/C97-109[»]
    4MZ6X-ray1.88A/C97-109[»]
    5H4JX-ray1.80A94-252[»]
    BMRBiP33316
    SASBDBiP33316
    SMRiP33316
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi108187, 102 interactors
    IntActiP33316, 34 interactors
    STRINGi9606.ENSP00000370376

    Chemistry databases

    BindingDBiP33316
    ChEMBLiCHEMBL5203
    DrugBankiDB04685, 1-{(2S,5S)-4-FLUORO-5-[(TRITYLOXY)METHYL]TETRAHYDROFURAN-2-YL}PYRIMIDINE-2,4(1H,3H)-DIONE
    DB03413, Deoxyuridine-5'-Diphosphate

    PTM databases

    iPTMnetiP33316
    MetOSiteiP33316
    PhosphoSitePlusiP33316
    SwissPalmiP33316

    Genetic variation databases

    BioMutaiDUT
    DMDMi347595814

    Proteomic databases

    CPTACiCPTAC-64
    CPTAC-65
    EPDiP33316
    jPOSTiP33316
    MassIVEiP33316
    PaxDbiP33316
    PeptideAtlasiP33316
    PRIDEiP33316
    ProteomicsDBi54908 [P33316-3]
    54909 [P33316-2]
    TopDownProteomicsiP33316-2 [P33316-2]
    P33316-3 [P33316-3]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		24524, 379 antibodies

    The DNASU plasmid repository

    More...    DNASUi    		1854

    Genome annotation databases

    EnsembliENST00000331200; ENSP00000370376; ENSG00000128951 [P33316-3]
    ENST00000455976; ENSP00000405160; ENSG00000128951 [P33316-2]
    GeneIDi1854
    KEGGihsa:1854
    UCSCiuc001zws.4, human [P33316-3]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		1854
    DisGeNETi1854

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		DUT
    HGNCiHGNC:3078, DUT
    HPAiENSG00000128951, Low tissue specificity
    MIMi601266, gene
    neXtProtiNX_P33316
    OpenTargetsiENSG00000128951
    PharmGKBiPA151
    VEuPathDBiHostDB:ENSG00000128951.13

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG3370, Eukaryota
    GeneTreeiENSGT00390000018390
    OrthoDBi1495752at2759
    PhylomeDBiP33316
    TreeFamiTF105416

    Enzyme and pathway databases

    UniPathwayiUPA00610;UER00666
    BioCyciMetaCyc:HS05235-MONOMER
    BRENDAi3.6.1.23, 2681
    PathwayCommonsiP33316
    ReactomeiR-HSA-499943, Interconversion of nucleotide di- and triphosphates [P33316-2]
    SABIO-RKiP33316

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		1854, 785 hits in 1014 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		DUT, human
    EvolutionaryTraceiP33316

    The Gene Wiki collection of pages on human genes and proteins

    More...    GeneWikii    		DUT_(gene)

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		1854
    PharosiP33316, Tchem

    Protein Ontology

    More...    PROi    		PR:P33316
    RNActiP33316, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000128951, Expressed in liver and 260 other tissues
    ExpressionAtlasiP33316, baseline and differential
    GenevisibleiP33316, HS

    Family and domain databases

    CDDicd07557, trimeric_dUTPase, 1 hit
    Gene3Di2.70.40.10, 1 hit
    InterProiView protein in InterPro
    IPR029054, dUTPase-like
    IPR036157, dUTPase-like_sf
    IPR008181, dUTPase_1
    IPR033704, dUTPase_trimeric
    PANTHERiPTHR11241, PTHR11241, 1 hit
    PfamiView protein in Pfam
    PF00692, dUTPase, 1 hit
    SUPFAMiSSF51283, SSF51283, 1 hit
    TIGRFAMsiTIGR00576, dut, 1 hit

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDUT_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P33316
    Secondary accession number(s): A8K650
    , B4DPR5, O14785, Q16708, Q16860, Q6FHN1, Q6NSA3, Q96Q81
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: September 21, 2011
    Last modified: June 2, 2021
    This is version 215 of the entry and version 4 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with genetic variants
      List of human entries with genetic variants
    3. Human variants curated from literature reports
      Index of human variants curated from literature reports
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families
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