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Protein

ATP-dependent permease MDL1, mitochondrial

Gene

MDL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates export of peptides with molecular masses of 2100 to 600 daltons generated upon proteolysis of mitochondrial inner membrane proteins.1 Publication

Miscellaneous

Present with 1040 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi467 – 474ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: SGD
  • ATP binding Source: UniProtKB-KW
  • oligopeptide-transporting ATPase activity Source: SGD

GO - Biological processi

  • oligopeptide export from mitochondrion Source: SGD

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32311-MONOMER
ReactomeiR-SCE-1369007 Mitochondrial ABC transporters
R-SCE-382556 ABC-family proteins mediated transport
R-SCE-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Protein family/group databases

TCDBi3.A.1.212.1 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent permease MDL1, mitochondrial
Alternative name(s):
ABC transporter MDL1
Multidrug resistance-like protein 1
Gene namesi
Name:MDL1
Ordered Locus Names:YLR188W
ORF Names:L9470.3
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR188W
SGDiS000004178 MDL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei103 – 123HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei156 – 176HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei242 – 262HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei337 – 357HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei372 – 392HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi467G → V: Decreased release of long peptides from mitochondria. 1 Publication1
Mutagenesisi575S → N: Decreased release of long peptides from mitochondria. 1 Publication1
Mutagenesisi598D → A: Decreased release of long peptides from mitochondria. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 100MitochondrionSequence analysisAdd BLAST100
ChainiPRO_0000045330101 – 695ATP-dependent permease MDL1, mitochondrialAdd BLAST595

Proteomic databases

MaxQBiP33310
PaxDbiP33310
PRIDEiP33310

Interactioni

Protein-protein interaction databases

BioGridi31458, 125 interactors
STRINGi4932.YLR188W

Structurei

3D structure databases

ProteinModelPortaliP33310
SMRiP33310
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini103 – 398ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST296
Domaini432 – 673ABC transporterPROSITE-ProRule annotationAdd BLAST242

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074497
InParanoidiP33310
KOiK02021
OMAiMLIDPIS
OrthoDBiEOG092C3H79

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030279 Mdl1/Mdl2
IPR027417 P-loop_NTPase
PANTHERiPTHR43394:SF2 PTHR43394:SF2, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33310-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVRMIRLCK GPKLLRSQFA SASALYSTKS LFKPPMYQKA EINLIIPHRK
60 70 80 90 100
HFLLRSIRLQ SDIAQGKKST KPTLKLSNAN SKSSGFKDIK RLFVLSKPES
110 120 130 140 150
KYIGLALLLI LISSSVSMAV PSVIGKLLDL ASESDGEDEE GSKSNKLYGF
160 170 180 190 200
TKKQFFTALG AVFIIGAVAN ASRIIILKVT GERLVARLRT RTMKAALDQD
210 220 230 240 250
ATFLDTNRVG DLISRLSSDA SIVAKSVTQN VSDGTRAIIQ GFVGFGMMSF
260 270 280 290 300
LSWKLTCVMM ILAPPLGAMA LIYGRKIRNL SRQLQTSVGG LTKVAEEQLN
310 320 330 340 350
ATRTIQAYGG EKNEVRRYAK EVRNVFHIGL KEAVTSGLFF GSTGLVGNTA
360 370 380 390 400
MLSLLLVGTS MIQSGSMTVG ELSSFMMYAV YTGSSLFGLS SFYSELMKGA
410 420 430 440 450
GAAARVFELN DRKPLIRPTI GKDPVSLAQK PIVFKNVSFT YPTRPKHQIF
460 470 480 490 500
KDLNITIKPG EHVCAVGPSG SGKSTIASLL LRYYDVNSGS IEFGDEDIRN
510 520 530 540 550
FNLRKYRRLI GYVQQEPLLF NGTILDNILY CIPPEIAEQD DRIRRAIGKA
560 570 580 590 600
NCTKFLANFP DGLQTMVGAR GAQLSGGQKQ RIALARAFLL DPAVLILDEA
610 620 630 640 650
TSALDSQSEE IVAKNLQRRV ERGFTTISIA HRLSTIKHST RVIVLGKHGS
660 670 680 690
VVETGSFRDL IAIPNSELNA LLAEQQDEEG KGGVIDLDNS VAREV
Length:695
Mass (Da):75,950
Last modified:February 1, 1996 - v2
Checksum:i3175B17FBD779BBE
GO

Sequence cautioni

The sequence AAA20681 differs from that shown. Reason: Frameshift at positions 417 and 433.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22A → G in AAA20681 (PubMed:7912468).Curated1
Sequence conflicti150F → L in AAA20681 (PubMed:7912468).Curated1
Sequence conflicti267 – 268GA → WP in AAA20681 (PubMed:7912468).Curated2
Sequence conflicti313 – 314NE → KQ in AAA20681 (PubMed:7912468).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16958 Genomic DNA Translation: AAA20681.1 Frameshift.
U17246 Genomic DNA Translation: AAB67455.1
BK006945 Genomic DNA Translation: DAA09507.1
PIRiS51433
RefSeqiNP_013289.1, NM_001182075.1

Genome annotation databases

EnsemblFungiiYLR188W; YLR188W; YLR188W
GeneIDi850885
KEGGisce:YLR188W

Similar proteinsi

Entry informationi

Entry nameiMDL1_YEAST
AccessioniPrimary (citable) accession number: P33310
Secondary accession number(s): D6VYJ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1996
Last modified: June 20, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

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