Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Importin alpha re-exporter

Gene

CSE1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Export receptor for importin alpha (SRP1). Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm.4 Publications

Miscellaneous

Present with 23500 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • nuclear export signal receptor activity Source: SGD
  • Ran GTPase binding Source: InterPro

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • positive regulation of protein export from nucleus Source: UniProtKB
  • protein export from nucleus Source: SGD
  • protein import into nucleus Source: GO_Central

Keywordsi

Biological processCell cycle, Cell division, Mitosis, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30711-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Importin alpha re-exporter
Alternative name(s):
Chromosome segregation protein CSE1
Gene namesi
Name:CSE1
Ordered Locus Names:YGL238W
ORF Names:HRC135
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL238W
SGDiS000003207 CSE1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001172931 – 960Importin alpha re-exporterAdd BLAST960

Proteomic databases

MaxQBiP33307
PaxDbiP33307
PRIDEiP33307

PTM databases

iPTMnetiP33307

Interactioni

Subunit structurei

Binds with high affinity to SRP1 only in the presence of RanGTP. The complex is dissociated by the RanGTP-binding protein YRB1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SRP1Q028212EBI-5168,EBI-1797

GO - Molecular functioni

Protein-protein interaction databases

BioGridi33001, 243 interactors
DIPiDIP-1131N
IntActiP33307, 22 interactors
MINTiP33307
STRINGi4932.YGL238W

Structurei

Secondary structure

1960
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP33307
SMRiP33307
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP33307

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 33HEAT 1Add BLAST33
Domaini23 – 96Importin N-terminalPROSITE-ProRule annotationAdd BLAST74
Repeati34 – 73HEAT 2Add BLAST40
Repeati74 – 120HEAT 3Add BLAST47
Repeati121 – 157HEAT 4Add BLAST37
Repeati158 – 220HEAT 5Add BLAST63
Repeati221 – 278HEAT 6Add BLAST58
Repeati279 – 323HEAT 7Add BLAST45
Repeati324 – 392HEAT 8Add BLAST69
Repeati393 – 445HEAT 9Add BLAST53
Repeati446 – 489HEAT 10Add BLAST44
Repeati490 – 528HEAT 11Add BLAST39
Repeati529 – 586HEAT 12Add BLAST58
Repeati587 – 630HEAT 13Add BLAST44
Repeati631 – 674HEAT 14Add BLAST44
Repeati675 – 716HEAT 15Add BLAST42
Repeati717 – 751HEAT 16Add BLAST35
Repeati752 – 794HEAT 17Add BLAST43
Repeati795 – 826HEAT 18Add BLAST32
Repeati827 – 928HEAT 19; with insertAdd BLAST102
Repeati929 – 960HEAT 20Add BLAST32

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi366 – 381Nuclear localization signalSequence analysisAdd BLAST16

Sequence similaritiesi

Belongs to the XPO2/CSE1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00550000074884
HOGENOMiHOG000201317
InParanoidiP33307
KOiK18423
OMAiFMPYVFQ
OrthoDBiEOG092C0P3I

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR005043 CAS_CSE1_C
IPR013713 Cse1
IPR001494 Importin-beta_N
PfamiView protein in Pfam
PF03378 CAS_CSE1, 1 hit
PF08506 Cse1, 1 hit
PF03810 IBN_N, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

Sequencei

Sequence statusi: Complete.

P33307-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDLETVAKF LAESVIASTA KTSERNLRQL ETQDGFGLTL LHVIASTNLP
60 70 80 90 100
LSTRLAGALF FKNFIKRKWV DENGNHLLPA NNVELIKKEI VPLMISLPNN
110 120 130 140 150
LQVQIGEAIS SIADSDFPDR WPTLLSDLAS RLSNDDMVTN KGVLTVAHSI
160 170 180 190 200
FKRWRPLFRS DELFLEIKLV LDVFTAPFLN LLKTVDEQIT ANENNKASLN
210 220 230 240 250
ILFDVLLVLI KLYYDFNCQD IPEFFEDNIQ VGMGIFHKYL SYSNPLLEDP
260 270 280 290 300
DETEHASVLI KVKSSIQELV QLYTTRYEDV FGPMINEFIQ ITWNLLTSIS
310 320 330 340 350
NQPKYDILVS KSLSFLTAVT RIPKYFEIFN NESAMNNITE QIILPNVTLR
360 370 380 390 400
EEDVELFEDD PIEYIRRDLE GSDTDTRRRA CTDFLKELKE KNEVLVTNIF
410 420 430 440 450
LAHMKGFVDQ YMSDPSKNWK FKDLYIYLFT ALAINGNITN AGVSSTNNLL
460 470 480 490 500
NVVDFFTKEI APDLTSNNIP HIILRVDAIK YIYTFRNQLT KAQLIELMPI
510 520 530 540 550
LATFLQTDEY VVYTYAAITI EKILTIRESN TSPAFIFHKE DISNSTEILL
560 570 580 590 600
KNLIALILKH GSSPEKLAEN EFLMRSIFRV LQTSEDSIQP LFPQLLAQFI
610 620 630 640 650
EIVTIMAKNP SNPRFTHYTF ESIGAILNYT QRQNLPLLVD SMMPTFLTVF
660 670 680 690 700
SEDIQEFIPY VFQIIAFVVE QSATIPESIK PLAQPLLAPN VWELKGNIPA
710 720 730 740 750
VTRLLKSFIK TDSSIFPDLV PVLGIFQRLI ASKAYEVHGF DLLEHIMLLI
760 770 780 790 800
DMNRLRPYIK QIAVLLLQRL QNSKTERYVK KLTVFFGLIS NKLGSDFLIH
810 820 830 840 850
FIDEVQDGLF QQIWGNFIIT TLPTIGNLLD RKIALIGVLN MVINGQFFQS
860 870 880 890 900
KYPTLISSTM NSIIETASSQ SIANLKNDYV DLDNLEEIST FGSHFSKLVS
910 920 930 940 950
ISEKPFDPLP EIDVNNGVRL YVAEALNKYN AISGNTFLNT ILPQLTQENQ
960
VKLNQLLVGN
Length:960
Mass (Da):109,356
Last modified:October 1, 1996 - v2
Checksum:i0A32D221DFC2C483
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti515Y → D in AAA34531 (PubMed:8336709).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14838 Genomic DNA Translation: AAA34531.1
Z72761 Genomic DNA Translation: CAA96957.1
Z49149 Genomic DNA Translation: CAA89018.1
BK006941 Genomic DNA Translation: DAA07880.1
PIRiA48083
RefSeqiNP_011276.1, NM_001181104.1

Genome annotation databases

EnsemblFungiiYGL238W; YGL238W; YGL238W
GeneIDi852612
KEGGisce:YGL238W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14838 Genomic DNA Translation: AAA34531.1
Z72761 Genomic DNA Translation: CAA96957.1
Z49149 Genomic DNA Translation: CAA89018.1
BK006941 Genomic DNA Translation: DAA07880.1
PIRiA48083
RefSeqiNP_011276.1, NM_001181104.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WA5X-ray2.00C1-960[»]
1Z3HX-ray3.10A/B1-960[»]
ProteinModelPortaliP33307
SMRiP33307
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33001, 243 interactors
DIPiDIP-1131N
IntActiP33307, 22 interactors
MINTiP33307
STRINGi4932.YGL238W

PTM databases

iPTMnetiP33307

Proteomic databases

MaxQBiP33307
PaxDbiP33307
PRIDEiP33307

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL238W; YGL238W; YGL238W
GeneIDi852612
KEGGisce:YGL238W

Organism-specific databases

EuPathDBiFungiDB:YGL238W
SGDiS000003207 CSE1

Phylogenomic databases

GeneTreeiENSGT00550000074884
HOGENOMiHOG000201317
InParanoidiP33307
KOiK18423
OMAiFMPYVFQ
OrthoDBiEOG092C0P3I

Enzyme and pathway databases

BioCyciYEAST:G3O-30711-MONOMER

Miscellaneous databases

EvolutionaryTraceiP33307
PROiPR:P33307

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR005043 CAS_CSE1_C
IPR013713 Cse1
IPR001494 Importin-beta_N
PfamiView protein in Pfam
PF03378 CAS_CSE1, 1 hit
PF08506 Cse1, 1 hit
PF03810 IBN_N, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCSE1_YEAST
AccessioniPrimary (citable) accession number: P33307
Secondary accession number(s): D6VV96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 1, 1996
Last modified: September 12, 2018
This is version 176 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again