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Entry version 142 (17 Jun 2020)
Sequence version 2 (01 Feb 1995)
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Protein

Protein BCK2

Gene

BCK2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dosage dependent suppressor of PKC1 deletion and MPK1 deletion. Involved in cell lysis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
YEAST:G3O-30328-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein BCK2
Alternative name(s):
Bypass of kinase C protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BCK2
Synonyms:CTR7
Ordered Locus Names:YER167W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YER167W

Saccharomyces Genome Database

More...
SGDi
S000000969 BCK2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000648831 – 851Protein BCK2Add BLAST851

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei334PhosphoserineCombined sources1
Modified residuei757PhosphoserineCombined sources1
Modified residuei761PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P33306

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P33306

PRoteomics IDEntifications database

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PRIDEi
P33306

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P33306

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
36920, 246 interactors

Database of interacting proteins

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DIPi
DIP-6406N

Protein interaction database and analysis system

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IntActi
P33306, 14 interactors

Molecular INTeraction database

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MINTi
P33306

STRING: functional protein association networks

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STRINGi
4932.YER167W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P33306 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_016939_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P33306

Identification of Orthologs from Complete Genome Data

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OMAi
HIEDIVE

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P33306-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKNSHHHRS SSVNSTKSRS TESTNKWKIP HYYRRSASGS TQASPDRNSS
60 70 80 90 100
TGSCSTPVLP TMNVMSSPKK VLLEDPRDNH TKAKKSSRKK SGEMVFVNYT
110 120 130 140 150
VQDTANENDT DLQTQPVSVP APKAKLKKKS SKRRMLKIFG SSKNEHIEDI
160 170 180 190 200
VEEQPMVLQM DSESKPLSGT PISESGIDAS SLTTKRSYNS FLKHNRLNGK
210 220 230 240 250
TPFSGNLSFP SLNMMGNTTD LPIDNNDFCS EKEVVPKSTH DPSLAKPPSR
260 270 280 290 300
FTESETNSTP NLSSIPLMNT KNTRLKYNKV APQSSDRQKS QESGLYHSTE
310 320 330 340 350
SFNFKDQNYS NNKSSLSLNS DLSTPHFAKH SPDSPRTSRS FNCGDSQSKV
360 370 380 390 400
KLPEENDASI AFSKMFTRKR ANTGGSTCSL ASPTIAQTIQ QSNIKVNKLP
410 420 430 440 450
TQRTTSVGSL SSMSNRYSPI RVASPGRARS ATRGSSLYRL SRDLNSLPSV
460 470 480 490 500
TDLPEMDSTT PVNEIFLDGQ PQHKSGSVKG GHRKKQESIS DAQRIQHSNS
510 520 530 540 550
YITTPSSSLV TPPYYMTGYT LPSSASASST PNVLETHNMN FVPSTSTVTS
560 570 580 590 600
YRPSSNFSSF DKEYSNENDA SGEFSAFNTP MENIPALKGI PRSTLEENEE
610 620 630 640 650
EDVLVQDIPN TAHFQRRDIM GMDTHRKDDS LDFNSLMPHG STTSSSIVDS
660 670 680 690 700
VMTNSISTTT SNATGNYFQD QDKYTLVNTG LGLSDANLDH FIRSQWKHAS
710 720 730 740 750
RSESNNNTGN RVSYSGSTPN NVDTTKTNLQ VYTEFDFENP ESFFHEQSKL
760 770 780 790 800
LGEMGHSNNN SNSAINMNEP KSADTYIGNI SPDTSATVSL GDLMGSNVSN
810 820 830 840 850
NSERNFYDGH TFVPQYQANS SVENSNNQNA APIANNDIDN NLQSFYFDNS

N
Length:851
Mass (Da):93,738
Last modified:February 1, 1995 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9F824F2701FC452D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4 – 5NS → HC in AAA34452 (PubMed:8395014).Curated2
Sequence conflicti100T → A in AAA34452 (PubMed:8395014).Curated1
Sequence conflicti167L → F in AAA34452 (PubMed:8395014).Curated1
Sequence conflicti812F → C in AAA34452 (PubMed:8395014).Curated1
Sequence conflicti827N → K in AAA34452 (PubMed:8395014).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L10242 Genomic DNA Translation: AAA34452.1
U18922 Genomic DNA Translation: AAB64694.1
BK006939 Genomic DNA Translation: DAA07829.1

Protein sequence database of the Protein Information Resource

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PIRi
S50670

NCBI Reference Sequences

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RefSeqi
NP_011094.3, NM_001179057.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YER167W_mRNA; YER167W; YER167W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
856914

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YER167W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10242 Genomic DNA Translation: AAA34452.1
U18922 Genomic DNA Translation: AAB64694.1
BK006939 Genomic DNA Translation: DAA07829.1
PIRiS50670
RefSeqiNP_011094.3, NM_001179057.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi36920, 246 interactors
DIPiDIP-6406N
IntActiP33306, 14 interactors
MINTiP33306
STRINGi4932.YER167W

PTM databases

iPTMnetiP33306

Proteomic databases

MaxQBiP33306
PaxDbiP33306
PRIDEiP33306

Genome annotation databases

EnsemblFungiiYER167W_mRNA; YER167W; YER167W
GeneIDi856914
KEGGisce:YER167W

Organism-specific databases

EuPathDBiFungiDB:YER167W
SGDiS000000969 BCK2

Phylogenomic databases

HOGENOMiCLU_016939_0_0_1
InParanoidiP33306
OMAiHIEDIVE

Enzyme and pathway databases

BioCyciYEAST:G3O-30328-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P33306
RNActiP33306 protein

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBCK2_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P33306
Secondary accession number(s): D3DM75
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1995
Last modified: June 17, 2020
This is version 142 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names
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