Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA repair protein XRS2

Gene

XRS2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

During meiosis is involved in homologous recombination and during vegetative growth it is necessary for DNA repair. It probably regulates the 5'-3' exonuclease degradation of double strand breaks either at the initiation stage or a later stage.

Miscellaneous

Present with 358 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repair, Meiosis

Enzyme and pathway databases

BioCyciYEAST:G3O-29919-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein XRS2
Gene namesi
Name:XRS2
Ordered Locus Names:YDR369C
ORF Names:D9481.13
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

SGDiS000002777 XRS2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000660501 – 854DNA repair protein XRS2Add BLAST854

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei349PhosphoserineCombined sources1
Modified residuei533PhosphoserineCombined sources1
Modified residuei534PhosphoserineCombined sources1
Modified residuei553PhosphoserineCombined sources1
Modified residuei555PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP33301
PaxDbiP33301
PRIDEiP33301

PTM databases

iPTMnetiP33301

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi32428, 367 interactors
ComplexPortaliCPX-1872 MRE11-RAD50-XRS2 meiotic recombination initiation complex
DIPiDIP-2420N
IntActiP33301, 17 interactors
MINTiP33301
STRINGi4932.YDR369C

Structurei

3D structure databases

ProteinModelPortaliP33301
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi836 – 843Poly-Asp8

Phylogenomic databases

InParanoidiP33301
KOiK10868
OMAiFEWINEV
OrthoDBiEOG092C0KCP

Family and domain databases

CDDicd00060 FHA, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR008984 SMAD_FHA_dom_sf
PfamiView protein in Pfam
PF00498 FHA, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit

Sequencei

Sequence statusi: Complete.

P33301-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWVVRYQNTL EDGSISFISC CLQAFKTYSI GRSSKNPLII KNDKSISRQH
60 70 80 90 100
ITFKWEINNS SDLKHSSLCL VNKGKLTSLN KKFMKVGETF TINASDVLKS
110 120 130 140 150
TIIELGTTPI RIEFEWINEV WNIPPHLTQF RTMLSEYGIS TEISINDIPA
160 170 180 190 200
NLMISDYPKS EDNSIRELYA LVSTIPMKKS RFLMELCNTL LPTSKTNLKF
210 220 230 240 250
DEMWNDMISN PEYNVFDFDP NILLSKFMRL NNIRVLTTIK SEPRLSSLLR
260 270 280 290 300
TFNINLFAFD NIDSLYKYVD SLEASTEYLI LTTTDKKENG KILCTIKTML
310 320 330 340 350
TSIIDGTLSA VINMKGASSR TLDNGKFDQI SEGMSTILKT SRAPEVEASP
360 370 380 390 400
VVSKKRKLNR RRVLPLDSLD FFAGGLSTKT LSENRSLTDA KRLNCGAESK
410 420 430 440 450
TVISSPNIAE ADEKHAPFLQ NALKPTEDIG KKSGHSSPGA IIVSSPNLGT
460 470 480 490 500
VNTSEDSLDK SLQSHKLPQP SLPEVAGIGS QTISSNSADY ETAAVNSMDD
510 520 530 540 550
AEVTKNFRVN HHQNIEQPSK NIRKLSNYSR EISSPLQENC KSPVKELSIK
560 570 580 590 600
EKSGTPHAFV EAIQETKNRE VKRVKSTIVE LKDEELSEEA INQLKNLAIV
610 620 630 640 650
EPSNNLLRKS FDSEGNKTSR TTEKWENSLM EPEWHKRKNF KTFVKVRPKS
660 670 680 690 700
KAHKEEGKNN TQSSDFIRNA AFLITRNYVP LKKYSKKDTT TKWGTEENED
710 720 730 740 750
MFALTEMERF GSNTFMSDNI NSNTIQKRSQ ALNRFTNEDS SNEGEEDSFS
760 770 780 790 800
FSRCSGTAAS VQPLKNKIFI TDEDDLGDID DKSDRLNHRE NNRNLFVVKE
810 820 830 840 850
MNLRPNLSEE CSKQSRHSRS ATSRSRGSFG ASNNGDGDDD DDDGPKFTFK

RRKG
Length:854
Mass (Da):96,365
Last modified:February 1, 1994 - v1
Checksum:i833DAD6D20F6693E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22856 Genomic DNA Translation: AAA35220.1
U28373 Genomic DNA Translation: AAB64805.1
X80642 Genomic DNA Translation: CAA56687.1
BK006938 Genomic DNA Translation: DAA12210.1
PIRiS61164
RefSeqiNP_010657.3, NM_001180677.3

Genome annotation databases

EnsemblFungiiYDR369C; YDR369C; YDR369C
GeneIDi851975
KEGGisce:YDR369C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22856 Genomic DNA Translation: AAA35220.1
U28373 Genomic DNA Translation: AAB64805.1
X80642 Genomic DNA Translation: CAA56687.1
BK006938 Genomic DNA Translation: DAA12210.1
PIRiS61164
RefSeqiNP_010657.3, NM_001180677.3

3D structure databases

ProteinModelPortaliP33301
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32428, 367 interactors
ComplexPortaliCPX-1872 MRE11-RAD50-XRS2 meiotic recombination initiation complex
DIPiDIP-2420N
IntActiP33301, 17 interactors
MINTiP33301
STRINGi4932.YDR369C

PTM databases

iPTMnetiP33301

Proteomic databases

MaxQBiP33301
PaxDbiP33301
PRIDEiP33301

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR369C; YDR369C; YDR369C
GeneIDi851975
KEGGisce:YDR369C

Organism-specific databases

SGDiS000002777 XRS2

Phylogenomic databases

InParanoidiP33301
KOiK10868
OMAiFEWINEV
OrthoDBiEOG092C0KCP

Enzyme and pathway databases

BioCyciYEAST:G3O-29919-MONOMER

Miscellaneous databases

PROiPR:P33301

Family and domain databases

CDDicd00060 FHA, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR008984 SMAD_FHA_dom_sf
PfamiView protein in Pfam
PF00498 FHA, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiXRS2_YEAST
AccessioniPrimary (citable) accession number: P33301
Secondary accession number(s): D6VT00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 7, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again