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Entry version 167 (17 Jun 2020)
Sequence version 1 (01 Feb 1994)
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Protein

DNA repair protein XRS2

Gene

XRS2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

During meiosis is involved in homologous recombination and during vegetative growth it is necessary for DNA repair. It probably regulates the 5'-3' exonuclease degradation of double strand breaks either at the initiation stage or a later stage.

Miscellaneous

Present with 358 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repair, Meiosis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-29919-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA repair protein XRS2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:XRS2
Ordered Locus Names:YDR369C
ORF Names:D9481.13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YDR369C

Saccharomyces Genome Database

More...
SGDi
S000002777 XRS2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000660501 – 854DNA repair protein XRS2Add BLAST854

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei349PhosphoserineCombined sources1
Modified residuei533PhosphoserineCombined sources1
Modified residuei534PhosphoserineCombined sources1
Modified residuei553PhosphoserineCombined sources1
Modified residuei555PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P33301

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P33301

PRoteomics IDEntifications database

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PRIDEi
P33301

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P33301

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
32428, 371 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1872 MRE11-RAD50-XRS2 meiotic recombination initiation complex

Database of interacting proteins

More...
DIPi
DIP-2420N

Protein interaction database and analysis system

More...
IntActi
P33301, 17 interactors

Molecular INTeraction database

More...
MINTi
P33301

STRING: functional protein association networks

More...
STRINGi
4932.YDR369C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P33301 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi836 – 843Poly-Asp8

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_017587_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P33301

KEGG Orthology (KO)

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KOi
K10868

Identification of Orthologs from Complete Genome Data

More...
OMAi
FEWINEV

Family and domain databases

Conserved Domains Database

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CDDi
cd00060 FHA, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000253 FHA_dom
IPR008984 SMAD_FHA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00498 FHA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49879 SSF49879, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P33301-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWVVRYQNTL EDGSISFISC CLQAFKTYSI GRSSKNPLII KNDKSISRQH
60 70 80 90 100
ITFKWEINNS SDLKHSSLCL VNKGKLTSLN KKFMKVGETF TINASDVLKS
110 120 130 140 150
TIIELGTTPI RIEFEWINEV WNIPPHLTQF RTMLSEYGIS TEISINDIPA
160 170 180 190 200
NLMISDYPKS EDNSIRELYA LVSTIPMKKS RFLMELCNTL LPTSKTNLKF
210 220 230 240 250
DEMWNDMISN PEYNVFDFDP NILLSKFMRL NNIRVLTTIK SEPRLSSLLR
260 270 280 290 300
TFNINLFAFD NIDSLYKYVD SLEASTEYLI LTTTDKKENG KILCTIKTML
310 320 330 340 350
TSIIDGTLSA VINMKGASSR TLDNGKFDQI SEGMSTILKT SRAPEVEASP
360 370 380 390 400
VVSKKRKLNR RRVLPLDSLD FFAGGLSTKT LSENRSLTDA KRLNCGAESK
410 420 430 440 450
TVISSPNIAE ADEKHAPFLQ NALKPTEDIG KKSGHSSPGA IIVSSPNLGT
460 470 480 490 500
VNTSEDSLDK SLQSHKLPQP SLPEVAGIGS QTISSNSADY ETAAVNSMDD
510 520 530 540 550
AEVTKNFRVN HHQNIEQPSK NIRKLSNYSR EISSPLQENC KSPVKELSIK
560 570 580 590 600
EKSGTPHAFV EAIQETKNRE VKRVKSTIVE LKDEELSEEA INQLKNLAIV
610 620 630 640 650
EPSNNLLRKS FDSEGNKTSR TTEKWENSLM EPEWHKRKNF KTFVKVRPKS
660 670 680 690 700
KAHKEEGKNN TQSSDFIRNA AFLITRNYVP LKKYSKKDTT TKWGTEENED
710 720 730 740 750
MFALTEMERF GSNTFMSDNI NSNTIQKRSQ ALNRFTNEDS SNEGEEDSFS
760 770 780 790 800
FSRCSGTAAS VQPLKNKIFI TDEDDLGDID DKSDRLNHRE NNRNLFVVKE
810 820 830 840 850
MNLRPNLSEE CSKQSRHSRS ATSRSRGSFG ASNNGDGDDD DDDGPKFTFK

RRKG
Length:854
Mass (Da):96,365
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i833DAD6D20F6693E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L22856 Genomic DNA Translation: AAA35220.1
U28373 Genomic DNA Translation: AAB64805.1
X80642 Genomic DNA Translation: CAA56687.1
BK006938 Genomic DNA Translation: DAA12210.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S61164

NCBI Reference Sequences

More...
RefSeqi
NP_010657.3, NM_001180677.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YDR369C_mRNA; YDR369C; YDR369C

Database of genes from NCBI RefSeq genomes

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GeneIDi
851975

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YDR369C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22856 Genomic DNA Translation: AAA35220.1
U28373 Genomic DNA Translation: AAB64805.1
X80642 Genomic DNA Translation: CAA56687.1
BK006938 Genomic DNA Translation: DAA12210.1
PIRiS61164
RefSeqiNP_010657.3, NM_001180677.3

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi32428, 371 interactors
ComplexPortaliCPX-1872 MRE11-RAD50-XRS2 meiotic recombination initiation complex
DIPiDIP-2420N
IntActiP33301, 17 interactors
MINTiP33301
STRINGi4932.YDR369C

PTM databases

iPTMnetiP33301

Proteomic databases

MaxQBiP33301
PaxDbiP33301
PRIDEiP33301

Genome annotation databases

EnsemblFungiiYDR369C_mRNA; YDR369C; YDR369C
GeneIDi851975
KEGGisce:YDR369C

Organism-specific databases

EuPathDBiFungiDB:YDR369C
SGDiS000002777 XRS2

Phylogenomic databases

HOGENOMiCLU_017587_0_0_1
InParanoidiP33301
KOiK10868
OMAiFEWINEV

Enzyme and pathway databases

BioCyciYEAST:G3O-29919-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P33301
RNActiP33301 protein

Family and domain databases

CDDicd00060 FHA, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR008984 SMAD_FHA_dom_sf
PfamiView protein in Pfam
PF00498 FHA, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXRS2_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P33301
Secondary accession number(s): D6VT00
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 17, 2020
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
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