UniProtKB - P33297 (PRS6A_YEAST)
Protein
26S proteasome regulatory subunit 6A
Gene
RPT5
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 222 – 229 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATPase activity Source: SGD
- ATP binding Source: UniProtKB-KW
- proteasome-activating ATPase activity Source: InterPro
GO - Biological processi
- positive regulation of RNA polymerase II transcription preinitiation complex assembly Source: SGD
- proteasome regulatory particle assembly Source: SGD
- ubiquitin-dependent protein catabolic process Source: SGD
Keywordsi
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-SCE-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-SCE-5668541, TNFR2 non-canonical NF-kB pathway R-SCE-5689880, Ub-specific processing proteases R-SCE-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: 26S proteasome regulatory subunit 6AAlternative name(s): Tat-binding protein homolog 1 Short name: TBP-1 |
Gene namesi | Name:RPT5 Synonyms:YTA1 Ordered Locus Names:YOR117W ORF Names:O3258, YOR3258W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000005643, RPT5 |
VEuPathDBi | FungiDB:YOR117W |
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-SubCell
- proteasome regulatory particle, base subcomplex Source: SGD
Keywords - Cellular componenti
Cytoplasm, Nucleus, ProteasomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000084708 | 2 – 434 | 26S proteasome regulatory subunit 6AAdd BLAST | 433 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | |
Modified residuei | 180 | PhosphotyrosineCombined sources | 1 |
Post-translational modificationi
N-acetylated by NAT1.1 Publication
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
MaxQBi | P33297 |
PaxDbi | P33297 |
PRIDEi | P33297 |
PTM databases
iPTMneti | P33297 |
Interactioni
Binary interactionsi
Hide detailsP33297
Protein-protein interaction databases
BioGRIDi | 34513, 639 interactors |
ComplexPortali | CPX-2262, 26S Proteasome complex |
DIPi | DIP-1590N |
IntActi | P33297, 42 interactors |
MINTi | P33297 |
STRINGi | 4932.YOR117W |
Miscellaneous databases
RNActi | P33297, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P33297 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the AAA ATPase family.Curated
Phylogenomic databases
eggNOGi | KOG0652, Eukaryota |
GeneTreei | ENSGT01000000214468 |
HOGENOMi | CLU_000688_2_4_1 |
InParanoidi | P33297 |
OMAi | KPTEQYT |
Family and domain databases
InterProi | View protein in InterPro IPR005937, 26S_Psome_P45-like IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR003959, ATPase_AAA_core IPR003960, ATPase_AAA_CS IPR027417, P-loop_NTPase IPR032501, Prot_ATP_ID_OB IPR035254, PSMC3 |
PANTHERi | PTHR23073:SF90, PTHR23073:SF90, 1 hit |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit PF16450, Prot_ATP_ID_OB, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR01242, 26Sp45, 1 hit |
PROSITEi | View protein in PROSITE PS00674, AAA, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P33297-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATLEELDAQ TLPGDDELDQ EILNLSTQEL QTRAKLLDNE IRIFRSELQR
60 70 80 90 100
LSHENNVMLE KIKDNKEKIK NNRQLPYLVA NVVEVMDMNE IEDKENSEST
110 120 130 140 150
TQGGNVNLDN TAVGKAAVVK TSSRQTVFLP MVGLVDPDKL KPNDLVGVNK
160 170 180 190 200
DSYLILDTLP SEFDSRVKAM EVDEKPTETY SDVGGLDKQI EELVEAIVLP
210 220 230 240 250
MKRADKFKDM GIRAPKGALM YGPPGTGKTL LARACAAQTN ATFLKLAAPQ
260 270 280 290 300
LVQMYIGEGA KLVRDAFALA KEKAPTIIFI DELDAIGTKR FDSEKSGDRE
310 320 330 340 350
VQRTMLELLN QLDGFSSDDR VKVLAATNRV DVLDPALLRS GRLDRKIEFP
360 370 380 390 400
LPSEDSRAQI LQIHSRKMTT DDDINWQELA RSTDEFNGAQ LKAVTVEAGM
410 420 430
IALRNGQSSV KHEDFVEGIS EVQARKSKSV SFYA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X73569 Genomic DNA Translation: CAA51971.1 X90518 Genomic DNA Translation: CAA62114.1 X94335 Genomic DNA Translation: CAA64037.1 Z75025 Genomic DNA Translation: CAA99315.1 BK006948 Genomic DNA Translation: DAA10892.1 |
PIRi | S46605 |
RefSeqi | NP_014760.3, NM_001183536.3 |
Genome annotation databases
EnsemblFungii | YOR117W_mRNA; YOR117W; YOR117W |
GeneIDi | 854284 |
KEGGi | sce:YOR117W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X73569 Genomic DNA Translation: CAA51971.1 X90518 Genomic DNA Translation: CAA62114.1 X94335 Genomic DNA Translation: CAA64037.1 Z75025 Genomic DNA Translation: CAA99315.1 BK006948 Genomic DNA Translation: DAA10892.1 |
PIRi | S46605 |
RefSeqi | NP_014760.3, NM_001183536.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3JCO | electron microscopy | 4.80 | M | 1-434 | [»] | |
3JCP | electron microscopy | 4.60 | M | 1-434 | [»] | |
3WHK | X-ray | 2.60 | A/B/C/D/E/F/G/H | 356-434 | [»] | |
3WHL | X-ray | 4.00 | A/C/E/G | 356-434 | [»] | |
4CR2 | electron microscopy | 7.70 | M | 1-434 | [»] | |
4CR3 | electron microscopy | 9.30 | M | 1-434 | [»] | |
4CR4 | electron microscopy | 8.80 | M | 1-434 | [»] | |
5A5B | electron microscopy | 9.50 | M | 1-434 | [»] | |
5MP9 | electron microscopy | 4.10 | M | 1-434 | [»] | |
5MPA | electron microscopy | 4.50 | M | 1-434 | [»] | |
5MPB | electron microscopy | 7.80 | M | 1-434 | [»] | |
5MPC | electron microscopy | 7.70 | M | 1-434 | [»] | |
5WVI | electron microscopy | 6.30 | M | 1-434 | [»] | |
5WVK | electron microscopy | 4.20 | M | 1-434 | [»] | |
6EF0 | electron microscopy | 4.43 | M | 176-433 | [»] | |
6EF1 | electron microscopy | 4.73 | M | 173-434 | [»] | |
6EF2 | electron microscopy | 4.27 | M | 165-434 | [»] | |
6EF3 | electron microscopy | 4.17 | M | 1-434 | [»] | |
6FVT | electron microscopy | 4.10 | M | 14-434 | [»] | |
6FVU | electron microscopy | 4.50 | M | 14-434 | [»] | |
6FVV | electron microscopy | 5.40 | M | 14-434 | [»] | |
6FVW | electron microscopy | 4.50 | M | 14-434 | [»] | |
6FVX | electron microscopy | 4.90 | M | 14-434 | [»] | |
6FVY | electron microscopy | 6.10 | M | 14-434 | [»] | |
6J2C | electron microscopy | 7.00 | M | 1-434 | [»] | |
6J2N | electron microscopy | 7.50 | M | 1-434 | [»] | |
6J2Q | electron microscopy | 3.80 | M | 1-434 | [»] | |
6J2X | electron microscopy | 3.80 | M | 1-434 | [»] | |
6J30 | electron microscopy | 4.50 | M | 1-434 | [»] | |
SMRi | P33297 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 34513, 639 interactors |
ComplexPortali | CPX-2262, 26S Proteasome complex |
DIPi | DIP-1590N |
IntActi | P33297, 42 interactors |
MINTi | P33297 |
STRINGi | 4932.YOR117W |
PTM databases
iPTMneti | P33297 |
Proteomic databases
MaxQBi | P33297 |
PaxDbi | P33297 |
PRIDEi | P33297 |
Genome annotation databases
EnsemblFungii | YOR117W_mRNA; YOR117W; YOR117W |
GeneIDi | 854284 |
KEGGi | sce:YOR117W |
Organism-specific databases
SGDi | S000005643, RPT5 |
VEuPathDBi | FungiDB:YOR117W |
Phylogenomic databases
eggNOGi | KOG0652, Eukaryota |
GeneTreei | ENSGT01000000214468 |
HOGENOMi | CLU_000688_2_4_1 |
InParanoidi | P33297 |
OMAi | KPTEQYT |
Enzyme and pathway databases
Reactomei | R-SCE-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-SCE-5668541, TNFR2 non-canonical NF-kB pathway R-SCE-5689880, Ub-specific processing proteases R-SCE-6798695, Neutrophil degranulation |
Miscellaneous databases
PROi | PR:P33297 |
RNActi | P33297, protein |
Family and domain databases
InterProi | View protein in InterPro IPR005937, 26S_Psome_P45-like IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR003959, ATPase_AAA_core IPR003960, ATPase_AAA_CS IPR027417, P-loop_NTPase IPR032501, Prot_ATP_ID_OB IPR035254, PSMC3 |
PANTHERi | PTHR23073:SF90, PTHR23073:SF90, 1 hit |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit PF16450, Prot_ATP_ID_OB, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR01242, 26Sp45, 1 hit |
PROSITEi | View protein in PROSITE PS00674, AAA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PRS6A_YEAST | |
Accessioni | P33297Primary (citable) accession number: P33297 Secondary accession number(s): D6W2H6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 194 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XV
Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families