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Protein

Cytochrome P450 2E1

Gene

CYP2E1

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites.By similarity

Catalytic activityi

4-nitrophenol + NADPH + O2 = 4-nitrocatechol + NADP+ + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi393Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2E1 (EC:1.14.13.-)
Alternative name(s):
4-nitrophenol 2-hydroxylase (EC:1.14.13.n7)
CYPIIE1
Cytochrome P450-MKJ1
Gene namesi
Name:CYP2E1
Synonyms:CYP2E
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000051752‹1 – 449Cytochrome P450 2E1Add BLAST›449

Expressioni

Inductioni

By ethanol.

Structurei

3D structure databases

ProteinModelPortaliP33266
SMRiP33266
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni254 – 259Substrate bindingBy similarity6

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG015789

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008070 Cyt_P450_E_grp-I_CYP2E-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01687 EP450ICYP2E
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Fragment.

P33266-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LFQLELKNIP KSFTRLAQRF GPVFTLYVGS RRVVVVHGIK AVKEVLPGPQ
60 70 80 90 100
GRVLGQRRHP AFHAHRDRGI IFNNGPTWKD IRRFSLTTLR NYGMGKQGNE
110 120 130 140 150
SRIQREAHFL LEALRKTQGQ PFDPTFLIGC APCNVIADIL FRKRFDYNDE
160 170 180 190 200
KFLRLMYLFN ENFQGLSCPW LQLYNNFPSL LHYLPGSHRK VMKNVAEIKE
210 220 230 240 250
YVSERVKEHH QSLDPNCPRD LTDCLLVEME KEKHSAERLY TMDGITVTVA
260 270 280 290 300
DLFFAGTETT STTLRYGLLI LMKYPEIEEK LHEEIDRVIG PSRIPAIKDR
310 320 330 340 350
QEMPYMHAVV HEIQRFITLV PSNLPHEATR DTIFRGYIIP KGTVIVPTLD
360 370 380 390 400
SVLYHNQEFP DPEKFKPEHL VDESGKFKYS DYFKPFSAGK RVCAGEGLAR
410 420 430 440
MELFLLLSAI LQHFNLKPLV DPKDIDISPV NIGFGCIPPR FKLCVIPRS
Length:449
Mass (Da):51,790
Last modified:February 1, 1994 - v1
Checksum:i3C8099DB2D5DE9C4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S55205 mRNA Translation: AAB24951.2
PIRiS28167

Similar proteinsi

Entry informationi

Entry nameiCP2E1_MACFA
AccessioniPrimary (citable) accession number: P33266
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 25, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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