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Protein

Cytochrome P450 2C20

Gene

CYP2C20

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi435Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C20 (EC:1.14.14.1)
Alternative name(s):
CYPIIC20
Cytochrome P450-MK1
Cytochrome P450-MKMP13
Gene namesi
Name:CYP2C20
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517091 – 490Cytochrome P450 2C20Add BLAST490

Proteomic databases

PRIDEiP33262

Expressioni

Inductioni

By 3-methylcholanthrene (3MC).

Structurei

3D structure databases

ProteinModelPortaliP33262
SMRiP33262
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG015789
KOiK17718

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

P33262-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPFVVLVLC LSFVLLFSLW RQSSGRRKLP PGPTPLPIIG NILQIDVKDI
60 70 80 90 100
CKSFSNFSKV YGPVFTVYFG MNPVVVLHGY ETVKEALIDN AEEFSGRGIL
110 120 130 140 150
PISERITNGL GIISSNGKRW KETRRFSLTT LRNFGMGKRS IEDRVQEEAR
160 170 180 190 200
CLVEELRKTK ASPCDPTFIL GCAPCNVICS VVFQKRFDYK DENFLTLIKR
210 220 230 240 250
FTVNFRILTS PWIQVCNNFP LLIDCFPGTH NKLLKNVALT KSYIREKVKE
260 270 280 290 300
HQATLDVNNP RDFIDCFLIK MEQEKDNQQS EFTIENLVGT VADLFVAGTE
310 320 330 340 350
TTSTTLRYGL LLLLKHPEVT AKVQEEIDHV IGRHRSPCMQ DRSHMPYTDA
360 370 380 390 400
VIHEIQRYID LVPTGVPHAV TTDIKFRNYL IPKGTIIITL LTSVLHDDKE
410 420 430 440 450
FPNPKIFDPG HFLDENGNFK KSDYFMPFSA GKRICAGEGL ARMELFLFLT
460 470 480 490
TILQNFNLKS VADLKNLNTT SATRGIISLP PSYQICFIPV
Length:490
Mass (Da):55,638
Last modified:February 1, 1994 - v1
Checksum:i7CEC7078C2F25990
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S53046 mRNA Translation: AAB24950.1
PIRiS28166
RefSeqiNP_001270692.1, NM_001283763.1
UniGeneiMfa.8192

Genome annotation databases

GeneIDi102117212
KEGGimcf:102117212

Similar proteinsi

Entry informationi

Entry nameiCP2CK_MACFA
AccessioniPrimary (citable) accession number: P33262
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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