UniProtKB - P33261 (CP2CJ_HUMAN)
Protein
Cytochrome P450 2C19
Gene
CYP2C19
Organism
Homo sapiens (Human)
Status
Functioni
A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) (PubMed:18577768, PubMed:19965576, PubMed:20972997). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:18577768, PubMed:19965576, PubMed:20972997). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates PUFA specifically at the omega-1 position (PubMed:18577768). Catalyzes the epoxidation of double bonds of PUFA (PubMed:20972997, PubMed:19965576). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794). Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. Hydroxylates fenbendazole at the 4' position (PubMed:23959307).5 Publications
Caution
P450-254C was originally listed as a separate gene (CYP2C17). Resequencing demonstrated that it is not a separate gene, but a chimera. The 5'-portion corresponds to a partial 2C18 clone, and the 3'-portion corresponds to a partial 2C19 clone.Curated
Catalytic activityi
- an organic molecule + O2 + reduced [NADPH—hemoprotein reductase] = an alcohol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationEC:1.14.14.11 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH—hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH—hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH—hemoprotein reductase] = 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward2 Publications direction.
- (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH—hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH—hemoprotein reductase] = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH—hemoprotein reductase] = (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (4R)-limonene + O2 + reduced [NADPH—hemoprotein reductase] = (1R,5S)-carveol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationEC:1.14.14.531 Publication
- (4S)-limonene + O2 + reduced [NADPH—hemoprotein reductase] = (1S,5R)-carveol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationEC:1.14.14.511 Publication
- (4S)-limonene + O2 + reduced [NADPH—hemoprotein reductase] = (4S)-perillyl alcohol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationEC:1.14.14.521 Publication
- fenbendazole + O2 + reduced [NADPH—hemoprotein reductase] = 4'-hydroxyfenbendazole + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationEC:1.14.14.751 Publication
Cofactori
heme1 Publication
: fatty acid metabolism Pathwayi
This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.3 PublicationsView all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.
Pathwayi: (4R)-limonene degradation
This protein is involved in the pathway (4R)-limonene degradation, which is part of Terpene metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway (4R)-limonene degradation and in Terpene metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 435 | Iron (heme axial ligand)Combined sources1 Publication | 1 |
GO - Molecular functioni
- (R)-limonene 6-monooxygenase activity Source: UniProtKB-EC
- (S)-limonene 6-monooxygenase activity Source: UniProtKB-EC
- (S)-limonene 7-monooxygenase activity Source: UniProtKB-EC
- arachidonic acid epoxygenase activity Source: GO_Central
- aromatase activity Source: UniProtKB-EC
- enzyme binding Source: BHF-UCL
- heme binding Source: UniProtKB
- iron ion binding Source: InterPro
- monooxygenase activity Source: BHF-UCL
- oxidoreductase activity Source: BHF-UCL
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: GO_Central
- oxygen binding Source: ProtInc
- steroid hydroxylase activity Source: BHF-UCL
GO - Biological processi
- drug metabolic process Source: BHF-UCL
- epoxygenase P450 pathway Source: GO_Central
- exogenous drug catabolic process Source: BHF-UCL
- heterocycle metabolic process Source: BHF-UCL
- monoterpenoid metabolic process Source: BHF-UCL
- omega-hydroxylase P450 pathway Source: Reactome
- organic acid metabolic process Source: GO_Central
- oxidation-reduction process Source: BHF-UCL
- steroid metabolic process Source: BHF-UCL
- xenobiotic metabolic process Source: GO_Central
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Ligand | Heme, Iron, Metal-binding, NADP |
Enzyme and pathway databases
BioCyci | MetaCyc:HS09293-MONOMER |
PathwayCommonsi | P33261 |
Reactomei | R-HSA-211981, Xenobiotics R-HSA-211999, CYP2E1 reactions R-HSA-2142670, Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142816, Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) |
SABIO-RKi | P33261 |
UniPathwayi | UPA00199 UPA00987 |
Chemistry databases
SwissLipidsi | SLP:000001589 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome P450 2C19 (EC:1.14.14.11 Publication)Alternative name(s): (R)-limonene 6-monooxygenase (EC:1.14.14.531 Publication) (S)-limonene 6-monooxygenase (EC:1.14.14.511 Publication) (S)-limonene 7-monooxygenase (EC:1.14.14.521 Publication) CYPIIC17 CYPIIC19 Cytochrome P450-11A Cytochrome P450-254C Fenbendazole monooxygenase (4'-hydroxylating)Curated (EC:1.14.14.751 Publication) Mephenytoin 4-hydroxylase |
Gene namesi | Name:CYP2C19 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000165841.9 |
HGNCi | HGNC:2621, CYP2C19 |
MIMi | 124020, gene |
neXtProti | NX_P33261 |
Subcellular locationi
Endoplasmic reticulum
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: Reactome
Other locations
- cytoplasm Source: GO_Central
- intracellular membrane-bounded organelle Source: GO_Central
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 1557 |
MalaCardsi | CYP2C19 |
MIMi | 609535, phenotype |
Orphaneti | 413667, Antidepressant or antipsychotic toxicity or dose selection 240935, Resistance to clopidogrel 240921, Voriconazole toxicity |
PharmGKBi | PA124 |
Miscellaneous databases
Pharosi | P33261, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3622 |
DrugBanki | DB08496, (R)-warfarin DB14055, (S)-Warfarin DB05812, Abiraterone DB01418, Acenocoumarol DB00945, Acetylsalicylic acid DB00546, Adinazolam DB00518, Albendazole DB00918, Almotriptan DB12015, Alpelisib DB06403, Ambrisentan DB00357, Aminoglutethimide DB01424, Aminophenazone DB01118, Amiodarone DB00321, Amitriptyline DB00701, Amprenavir DB01435, Antipyrine DB11901, Apalutamide DB06605, Apixaban DB00673, Aprepitant DB01274, Arformoterol DB06413, Armodafinil DB06697, Artemether DB11638, Artenimol DB11586, Asunaprevir DB00289, Atomoxetine DB01076, Atorvastatin DB06442, Avasimibe DB06626, Axitinib DB00972, Azelastine DB01483, Barbital DB12319, Benzbromarone DB00443, Betamethasone DB01128, Bicalutamide DB11967, Binimetinib DB13746, Bioallethrin DB00188, Bortezomib DB05541, Brivaracetam DB01558, Bromazepam DB01222, Budesonide DB00297, Bupivacaine DB00921, Buprenorphine DB09061, Cannabidiol DB08502, Capravirine DB00564, Carbamazepine DB00395, Carisoprodol DB06119, Cenobamate DB00446, Chloramphenicol DB00672, Chlorpropamide DB01166, Cilostazol DB00501, Cimetidine DB00604, Cisapride DB00215, Citalopram DB04920, Clevidipine DB14025, Clinafloxacin DB00349, Clobazam DB06470, Clomethiazole DB01242, Clomipramine DB00758, Clopidogrel DB01559, Clotiazepam DB00363, Clozapine DB14635, Curcumin sulfate DB00531, Cyclophosphamide DB00091, Cyclosporine DB00250, Dapsone DB00705, Delavirdine DB01234, Dexamethasone DB14649, Dexamethasone acetate DB09213, Dexibuprofen DB05351, Dexlansoprazole DB13762, Dexrabeprazole DB00514, Dextromethorphan DB00829, Diazepam DB00586, Diclofenac DB00343, Diltiazem DB01093, Dimethyl sulfoxide DB01075, Diphenhydramine DB09167, Dosulepin DB05928, Dovitinib DB00590, Doxazosin DB01142, Doxepin DB00625, Efavirenz DB00216, Eletriptan DB15444, Elexacaftor DB13874, Enasidenib DB11718, Encorafenib DB00109, Enfuvirtide DB08899, Enzalutamide DB01175, Escitalopram DB11823, Esketamine DB14575, Eslicarbazepine DB09119, Eslicarbazepine acetate DB00736, Esomeprazole DB00783, Estradiol DB13952, Estradiol acetate DB13953, Estradiol benzoate DB13954, Estradiol cypionate DB13955, Estradiol dienanthate DB13956, Estradiol valerate DB00898, Ethanol DB00977, Ethinylestradiol DB09166, Etizolam DB01628, Etoricoxib DB06414, Etravirine DB12500, Fedratinib DB00949, Felbamate DB01039, Fenofibrate DB00196, Fluconazole DB01544, Flunitrazepam DB00472, Fluoxetine DB00499, Flutamide DB01095, Fluvastatin DB00176, Fluvoxamine DB00983, Formoterol DB01320, Fosphenytoin DB00317, Gefitinib DB01241, Gemfibrozil DB06730, Gestodene DB01120, Gliclazide DB01016, Glyburide DB01018, Guanfacine DB00502, Haloperidol DB01355, Hexobarbital DB00956, Hydrocodone DB00741, Hydrocortisone DB06789, Hydroxyprogesterone caproate DB01050, Ibuprofen DB09054, Idelalisib DB01181, Ifosfamide DB00619, Imatinib DB00458, Imipramine DB00328, Indomethacin DB11633, Isavuconazole DB00951, Isoniazid DB09570, Ixazomib DB06738, Ketobemidone DB01026, Ketoconazole DB00598, Labetalol DB06218, Lacosamide DB00448, Lansoprazole DB01259, Lapatinib DB09078, Lenvatinib DB12070, Letermovir DB01006, Letrozole DB08918, Levomilnacipran DB09198, Lobeglitazone DB04948, Lofexidine DB01601, Lopinavir DB00455, Loratadine DB04871, Lorcaserin DB12130, Lorlatinib DB00678, Losartan DB00227, Lovastatin DB08933, Luliconazole DB09280, Lumacaftor DB01283, Lumiracoxib DB12474, Lynestrenol DB08932, Macitentan DB09238, Manidipine DB14009, Medical Cannabis DB01065, Melatonin DB01043, Memantine DB00454, Meperidine DB00532, Mephenytoin DB00333, Methadone DB00763, Methimazole DB00474, Methohexital DB05246, Methsuximide DB09241, Methylene blue DB00849, Methylphenobarbital DB00959, Methylprednisolone DB01110, Miconazole DB06595, Midostaurin DB01171, Moclobemide DB00745, Modafinil DB14011, Nabiximols DB09049, Naloxegol DB04861, Nebivolol DB00220, Nelfinavir DB00622, Nicardipine DB00184, Nicotine DB00665, Nilutamide DB06712, Nilvadipine DB00717, Norethisterone DB00540, Nortriptyline DB00334, Olanzapine DB00338, Omeprazole DB11632, Opicapone DB04911, Oritavancin DB11837, Osilodrostat DB04938, Ospemifene DB00776, Oxcarbazepine DB00239, Oxiconazole DB00213, Pantoprazole DB00715, Paroxetine DB00738, Pentamidine DB00312, Pentobarbital DB00850, Perphenazine DB03783, Phenacetin DB00780, Phenelzine DB01174, Phenobarbital DB00252, Phenytoin DB13941, Piperaquine DB01621, Pipotiazine DB06209, Prasugrel DB01058, Praziquantel DB14631, Prednisolone phosphate DB00635, Prednisone DB00794, Primidone DB00396, Progesterone DB01131, Proguanil DB00420, Promazine DB00818, Propofol DB00571, Propranolol DB01589, Quazepam DB01224, Quetiapine DB00468, Quinine DB01129, Rabeprazole DB00980, Ramelteon DB00615, Rifabutin DB01045, Rifampicin DB11753, Rifamycin DB01201, Rifapentine DB01220, Rifaximin DB08864, Rilpivirine DB00503, Ritonavir DB06176, Romidepsin DB12332, Rucaparib DB11614, Rupatadine DB06654, Safinamide DB00418, Secobarbital DB01037, Selegiline DB11689, Selumetinib DB06731, Seproxetine DB06739, Seratrodast DB01104, Sertraline DB00203, Sildenafil DB00641, Simvastatin DB06268, Sitaxentan DB00398, Sorafenib DB01323, St. John's Wort DB09118, Stiripentol DB00259, Sulfanilamide DB00675, Tamoxifen DB06204, Tapentadol DB00966, Telmisartan DB00444, Teniposide DB00857, Terbinafine DB00624, Testosterone DB13943, Testosterone cypionate DB13944, Testosterone enanthate DB13946, Testosterone undecanoate DB01041, Thalidomide DB00599, Thiopental DB00679, Thioridazine DB00208, Ticlopidine DB00373, Timolol DB01007, Tioconazole DB00932, Tipranavir DB08895, Tofacitinib DB01124, Tolbutamide DB01036, Tolterodine DB00273, Topiramate DB01685, Topiroxostat DB05109, Trabectedin DB00752, Tranylcypromine DB12245, Triclabendazole DB00347, Trimethadione DB00726, Trimipramine DB00197, Troglitazone DB15328, Ubrogepant DB00313, Valproic acid DB00661, Verapamil DB06684, Vilazodone DB08828, Vismodegib DB00582, Voriconazole DB09068, Vortioxetine DB14975, Voxelotor DB00682, Warfarin DB00549, Zafirlukast DB00425, Zolpidem DB00909, Zonisamide DB09120, Zucapsaicin |
DrugCentrali | P33261 |
GuidetoPHARMACOLOGYi | 1328 |
Polymorphism and mutation databases
BioMutai | CYP2C19 |
DMDMi | 60416369 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051708 | 1 – 490 | Cytochrome P450 2C19Add BLAST | 490 |
Proteomic databases
jPOSTi | P33261 |
MassIVEi | P33261 |
PaxDbi | P33261 |
PeptideAtlasi | P33261 |
PRIDEi | P33261 |
ProteomicsDBi | 54907 |
PTM databases
iPTMneti | P33261 |
PhosphoSitePlusi | P33261 |
Expressioni
Inductioni
P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
Gene expression databases
Bgeei | ENSG00000165841, Expressed in liver and 38 other tissues |
ExpressionAtlasi | P33261, baseline and differential |
Genevisiblei | P33261, HS |
Organism-specific databases
HPAi | ENSG00000165841, Group enriched (intestine, liver) |
Interactioni
GO - Molecular functioni
- enzyme binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 107935, 2 interactors |
IntActi | P33261, 1 interactor |
STRINGi | 9606.ENSP00000360372 |
Chemistry databases
BindingDBi | P33261 |
Miscellaneous databases
RNActi | P33261, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P33261 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0156, Eukaryota |
HOGENOMi | CLU_001570_22_3_1 |
InParanoidi | P33261 |
OrthoDBi | 702827at2759 |
PhylomeDBi | P33261 |
TreeFami | TF352043 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P33261-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDPFVVLVLC LSCLLLLSIW RQSSGRGKLP PGPTPLPVIG NILQIDIKDV
60 70 80 90 100
SKSLTNLSKI YGPVFTLYFG LERMVVLHGY EVVKEALIDL GEEFSGRGHF
110 120 130 140 150
PLAERANRGF GIVFSNGKRW KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR
160 170 180 190 200
CLVEELRKTK ASPCDPTFIL GCAPCNVICS IIFQKRFDYK DQQFLNLMEK
210 220 230 240 250
LNENIRIVST PWIQICNNFP TIIDYFPGTH NKLLKNLAFM ESDILEKVKE
260 270 280 290 300
HQESMDINNP RDFIDCFLIK MEKEKQNQQS EFTIENLVIT AADLLGAGTE
310 320 330 340 350
TTSTTLRYAL LLLLKHPEVT AKVQEEIERV VGRNRSPCMQ DRGHMPYTDA
360 370 380 390 400
VVHEVQRYID LIPTSLPHAV TCDVKFRNYL IPKGTTILTS LTSVLHDNKE
410 420 430 440 450
FPNPEMFDPR HFLDEGGNFK KSNYFMPFSA GKRICVGEGL ARMELFLFLT
460 470 480 490
FILQNFNLKS LIDPKDLDTT PVVNGFASVP PFYQLCFIPV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087X125 | A0A087X125_HUMAN | Cytochrome P450 2C19 | CYP2C19 | 162 | Annotation score: |
Polymorphismi
Genetic variation in CYP2C19 is responsible for poor drug metabolism [MIMi:609535]. Individuals can be characterized as either extensive metabolizers (EM) or poor metabolizers (PM). The PM phenotype is inherited in an autosomal recessive manner, with the EM phenotype comprising both homozygous dominant and heterozygote genotypes. There are marked interracial differences in the frequency of this polymorphism. Poor metabolizers represent 2-5% of Caucasians, 13-23% of Asian populations, and as many as 38-79% of individuals of some of the islands of Polynesia and Micronesia. Different alleles of CYP2C19 are known: CYP2C19*1A CYP2C19*1B, CYP2C19*1C, CYP2C19*2A (CYP2C19m1 or CYP2C19m1A), CYP2C19*2B (CYP2C19m1B), CYP2C19*2C (CYP2C19*21), CYP2C19*3A (CYP2C19m2), CYP2C19*3B (CYP2C19*20), CYP2C19*4 (CYP2C19m3), CYP2C19*5A (CYP2C19m4), CYP2C19*5B, CYP2C19*6, CYP2C19*7, CYP2C19*8, CYP2C19*9, CYP2C19*10, CYP2C19*11 CYP2C19*12, CYP2C19*13, CYP2C19*14 CYP2C19*15, CYP2C19*16, CYP2C19*18, CYP2C19*19. Defective CYP2C19*2 and CYP2C19*3 alleles are characterized by a splice mutation and a stop codon, respectively, and account for most of the PM alleles. The sequence shown is that of allele CYP2C19*1B.
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021268 | 17 | L → P in allele CYP2C19*14. 1 PublicationCorresponds to variant dbSNP:rs55752064EnsemblClinVar. | 1 | |
Natural variantiVAR_021269 | 19 | I → L in allele CYP2C19*15. 2 PublicationsCorresponds to variant dbSNP:rs17882687EnsemblClinVar. | 1 | |
Natural variantiVAR_024083 | 51 | S → G in allele CYP2C19*19. 1 PublicationCorresponds to variant dbSNP:rs1564657013EnsemblClinVar. | 1 | |
Natural variantiVAR_024718 | 74 | M → T1 PublicationCorresponds to variant dbSNP:rs28399505Ensembl. | 1 | |
Natural variantiVAR_021270 | 92 | E → D2 PublicationsCorresponds to variant dbSNP:rs17878459Ensembl. | 1 | |
Natural variantiVAR_008357 | 120 | W → R in allele CYP2C19*8; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs41291556EnsemblClinVar. | 1 | |
Natural variantiVAR_021271 | 122 | E → A1 PublicationCorresponds to variant dbSNP:rs17885179Ensembl. | 1 | |
Natural variantiVAR_008358 | 132 | R → Q in allele CYP2C19*6; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs72552267EnsemblClinVar. | 1 | |
Natural variantiVAR_021272 | 144 | R → H in allele CYP2C19*9. 3 PublicationsCorresponds to variant dbSNP:rs17884712EnsemblClinVar. | 1 | |
Natural variantiVAR_021273 | 150 | R → H in allele CYP2C19*11. 1 PublicationCorresponds to variant dbSNP:rs58973490EnsemblClinVar. | 1 | |
Natural variantiVAR_024084 | 161 | A → P1 PublicationCorresponds to variant dbSNP:rs181297724Ensembl. | 1 | |
Natural variantiVAR_024719 | 168 | F → L1 PublicationCorresponds to variant dbSNP:rs28399510Ensembl. | 1 | |
Natural variantiVAR_020123 | 227 | P → L in allele CYP2C19*10. 1 PublicationCorresponds to variant dbSNP:rs6413438EnsemblClinVar. | 1 | |
Natural variantiVAR_024085 | 329 | R → H in allele CYP2C19*18. 1 PublicationCorresponds to variant dbSNP:rs138142612EnsemblClinVar. | 1 | |
Natural variantiVAR_001255 | 331 | V → I in allele CYP2C19*1A, allele CYP2C19*5A, allele CYP2C19*8 and allele CYP2C19*16. 4 PublicationsCorresponds to variant dbSNP:rs3758581Ensembl. | 1 | |
Natural variantiVAR_021274 | 410 | R → C in allele CYP2C19*13. 2 PublicationsCorresponds to variant dbSNP:rs17879685EnsemblClinVar. | 1 | |
Natural variantiVAR_008359 | 433 | R → W in allele CYP2C19*5A and allele CYP2C19*5B; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs56337013EnsemblClinVar. | 1 | |
Natural variantiVAR_021275 | 442 | R → C in allele CYP2C19*16; lowered catalytic activity. 1 PublicationCorresponds to variant dbSNP:rs192154563EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M61854 mRNA Translation: AAB59426.1 M61858 mRNA Translation: AAA52145.1 Sequence problems. L07093 mRNA Translation: AAA36660.1 Sequence problems. AY796203 Genomic DNA Translation: AAV41877.1 AL583836 Genomic DNA No translation available. AL133513 Genomic DNA No translation available. L39098, L39097 Genomic DNA Translation: AAL31347.1 L39102 , L39099, L39100, L39101 Genomic DNA Translation: AAL31348.1 L31506 Genomic DNA No translation available. L31507 Genomic DNA No translation available. L32982 Genomic DNA No translation available. L32983 Genomic DNA No translation available. |
CCDSi | CCDS7436.1 |
PIRi | F38462 G38462 I52418 |
RefSeqi | NP_000760.1, NM_000769.2 |
Genome annotation databases
Ensembli | ENST00000371321; ENSP00000360372; ENSG00000165841 |
GeneIDi | 1557 |
KEGGi | hsa:1557 |
UCSCi | uc010qnz.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Cytochrome P450 Allele Nomenclature Committee CYP2C19 alleles |
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M61854 mRNA Translation: AAB59426.1 M61858 mRNA Translation: AAA52145.1 Sequence problems. L07093 mRNA Translation: AAA36660.1 Sequence problems. AY796203 Genomic DNA Translation: AAV41877.1 AL583836 Genomic DNA No translation available. AL133513 Genomic DNA No translation available. L39098, L39097 Genomic DNA Translation: AAL31347.1 L39102 , L39099, L39100, L39101 Genomic DNA Translation: AAL31348.1 L31506 Genomic DNA No translation available. L31507 Genomic DNA No translation available. L32982 Genomic DNA No translation available. L32983 Genomic DNA No translation available. |
CCDSi | CCDS7436.1 |
PIRi | F38462 G38462 I52418 |
RefSeqi | NP_000760.1, NM_000769.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4GQS | X-ray | 2.87 | A/B/C/D | 23-489 | [»] | |
SMRi | P33261 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107935, 2 interactors |
IntActi | P33261, 1 interactor |
STRINGi | 9606.ENSP00000360372 |
Chemistry databases
BindingDBi | P33261 |
ChEMBLi | CHEMBL3622 |
DrugBanki | DB08496, (R)-warfarin DB14055, (S)-Warfarin DB05812, Abiraterone DB01418, Acenocoumarol DB00945, Acetylsalicylic acid DB00546, Adinazolam DB00518, Albendazole DB00918, Almotriptan DB12015, Alpelisib DB06403, Ambrisentan DB00357, Aminoglutethimide DB01424, Aminophenazone DB01118, Amiodarone DB00321, Amitriptyline DB00701, Amprenavir DB01435, Antipyrine DB11901, Apalutamide DB06605, Apixaban DB00673, Aprepitant DB01274, Arformoterol DB06413, Armodafinil DB06697, Artemether DB11638, Artenimol DB11586, Asunaprevir DB00289, Atomoxetine DB01076, Atorvastatin DB06442, Avasimibe DB06626, Axitinib DB00972, Azelastine DB01483, Barbital DB12319, Benzbromarone DB00443, Betamethasone DB01128, Bicalutamide DB11967, Binimetinib DB13746, Bioallethrin DB00188, Bortezomib DB05541, Brivaracetam DB01558, Bromazepam DB01222, Budesonide DB00297, Bupivacaine DB00921, Buprenorphine DB09061, Cannabidiol DB08502, Capravirine DB00564, Carbamazepine DB00395, Carisoprodol DB06119, Cenobamate DB00446, Chloramphenicol DB00672, Chlorpropamide DB01166, Cilostazol DB00501, Cimetidine DB00604, Cisapride DB00215, Citalopram DB04920, Clevidipine DB14025, Clinafloxacin DB00349, Clobazam DB06470, Clomethiazole DB01242, Clomipramine DB00758, Clopidogrel DB01559, Clotiazepam DB00363, Clozapine DB14635, Curcumin sulfate DB00531, Cyclophosphamide DB00091, Cyclosporine DB00250, Dapsone DB00705, Delavirdine DB01234, Dexamethasone DB14649, Dexamethasone acetate DB09213, Dexibuprofen DB05351, Dexlansoprazole DB13762, Dexrabeprazole DB00514, Dextromethorphan DB00829, Diazepam DB00586, Diclofenac DB00343, Diltiazem DB01093, Dimethyl sulfoxide DB01075, Diphenhydramine DB09167, Dosulepin DB05928, Dovitinib DB00590, Doxazosin DB01142, Doxepin DB00625, Efavirenz DB00216, Eletriptan DB15444, Elexacaftor DB13874, Enasidenib DB11718, Encorafenib DB00109, Enfuvirtide DB08899, Enzalutamide DB01175, Escitalopram DB11823, Esketamine DB14575, Eslicarbazepine DB09119, Eslicarbazepine acetate DB00736, Esomeprazole DB00783, Estradiol DB13952, Estradiol acetate DB13953, Estradiol benzoate DB13954, Estradiol cypionate DB13955, Estradiol dienanthate DB13956, Estradiol valerate DB00898, Ethanol DB00977, Ethinylestradiol DB09166, Etizolam DB01628, Etoricoxib DB06414, Etravirine DB12500, Fedratinib DB00949, Felbamate DB01039, Fenofibrate DB00196, Fluconazole DB01544, Flunitrazepam DB00472, Fluoxetine DB00499, Flutamide DB01095, Fluvastatin DB00176, Fluvoxamine DB00983, Formoterol DB01320, Fosphenytoin DB00317, Gefitinib DB01241, Gemfibrozil DB06730, Gestodene DB01120, Gliclazide DB01016, Glyburide DB01018, Guanfacine DB00502, Haloperidol DB01355, Hexobarbital DB00956, Hydrocodone DB00741, Hydrocortisone DB06789, Hydroxyprogesterone caproate DB01050, Ibuprofen DB09054, Idelalisib DB01181, Ifosfamide DB00619, Imatinib DB00458, Imipramine DB00328, Indomethacin DB11633, Isavuconazole DB00951, Isoniazid DB09570, Ixazomib DB06738, Ketobemidone DB01026, Ketoconazole DB00598, Labetalol DB06218, Lacosamide DB00448, Lansoprazole DB01259, Lapatinib DB09078, Lenvatinib DB12070, Letermovir DB01006, Letrozole DB08918, Levomilnacipran DB09198, Lobeglitazone DB04948, Lofexidine DB01601, Lopinavir DB00455, Loratadine DB04871, Lorcaserin DB12130, Lorlatinib DB00678, Losartan DB00227, Lovastatin DB08933, Luliconazole DB09280, Lumacaftor DB01283, Lumiracoxib DB12474, Lynestrenol DB08932, Macitentan DB09238, Manidipine DB14009, Medical Cannabis DB01065, Melatonin DB01043, Memantine DB00454, Meperidine DB00532, Mephenytoin DB00333, Methadone DB00763, Methimazole DB00474, Methohexital DB05246, Methsuximide DB09241, Methylene blue DB00849, Methylphenobarbital DB00959, Methylprednisolone DB01110, Miconazole DB06595, Midostaurin DB01171, Moclobemide DB00745, Modafinil DB14011, Nabiximols DB09049, Naloxegol DB04861, Nebivolol DB00220, Nelfinavir DB00622, Nicardipine DB00184, Nicotine DB00665, Nilutamide DB06712, Nilvadipine DB00717, Norethisterone DB00540, Nortriptyline DB00334, Olanzapine DB00338, Omeprazole DB11632, Opicapone DB04911, Oritavancin DB11837, Osilodrostat DB04938, Ospemifene DB00776, Oxcarbazepine DB00239, Oxiconazole DB00213, Pantoprazole DB00715, Paroxetine DB00738, Pentamidine DB00312, Pentobarbital DB00850, Perphenazine DB03783, Phenacetin DB00780, Phenelzine DB01174, Phenobarbital DB00252, Phenytoin DB13941, Piperaquine DB01621, Pipotiazine DB06209, Prasugrel DB01058, Praziquantel DB14631, Prednisolone phosphate DB00635, Prednisone DB00794, Primidone DB00396, Progesterone DB01131, Proguanil DB00420, Promazine DB00818, Propofol DB00571, Propranolol DB01589, Quazepam DB01224, Quetiapine DB00468, Quinine DB01129, Rabeprazole DB00980, Ramelteon DB00615, Rifabutin DB01045, Rifampicin DB11753, Rifamycin DB01201, Rifapentine DB01220, Rifaximin DB08864, Rilpivirine DB00503, Ritonavir DB06176, Romidepsin DB12332, Rucaparib DB11614, Rupatadine DB06654, Safinamide DB00418, Secobarbital DB01037, Selegiline DB11689, Selumetinib DB06731, Seproxetine DB06739, Seratrodast DB01104, Sertraline DB00203, Sildenafil DB00641, Simvastatin DB06268, Sitaxentan DB00398, Sorafenib DB01323, St. John's Wort DB09118, Stiripentol DB00259, Sulfanilamide DB00675, Tamoxifen DB06204, Tapentadol DB00966, Telmisartan DB00444, Teniposide DB00857, Terbinafine DB00624, Testosterone DB13943, Testosterone cypionate DB13944, Testosterone enanthate DB13946, Testosterone undecanoate DB01041, Thalidomide DB00599, Thiopental DB00679, Thioridazine DB00208, Ticlopidine DB00373, Timolol DB01007, Tioconazole DB00932, Tipranavir DB08895, Tofacitinib DB01124, Tolbutamide DB01036, Tolterodine DB00273, Topiramate DB01685, Topiroxostat DB05109, Trabectedin DB00752, Tranylcypromine DB12245, Triclabendazole DB00347, Trimethadione DB00726, Trimipramine DB00197, Troglitazone DB15328, Ubrogepant DB00313, Valproic acid DB00661, Verapamil DB06684, Vilazodone DB08828, Vismodegib DB00582, Voriconazole DB09068, Vortioxetine DB14975, Voxelotor DB00682, Warfarin DB00549, Zafirlukast DB00425, Zolpidem DB00909, Zonisamide DB09120, Zucapsaicin |
DrugCentrali | P33261 |
GuidetoPHARMACOLOGYi | 1328 |
SwissLipidsi | SLP:000001589 |
PTM databases
iPTMneti | P33261 |
PhosphoSitePlusi | P33261 |
Polymorphism and mutation databases
BioMutai | CYP2C19 |
DMDMi | 60416369 |
Proteomic databases
jPOSTi | P33261 |
MassIVEi | P33261 |
PaxDbi | P33261 |
PeptideAtlasi | P33261 |
PRIDEi | P33261 |
ProteomicsDBi | 54907 |
Protocols and materials databases
Antibodypediai | 3077, 221 antibodies |
DNASUi | 1557 |
Genome annotation databases
Ensembli | ENST00000371321; ENSP00000360372; ENSG00000165841 |
GeneIDi | 1557 |
KEGGi | hsa:1557 |
UCSCi | uc010qnz.3, human |
Organism-specific databases
CTDi | 1557 |
DisGeNETi | 1557 |
EuPathDBi | HostDB:ENSG00000165841.9 |
GeneCardsi | CYP2C19 |
HGNCi | HGNC:2621, CYP2C19 |
HPAi | ENSG00000165841, Group enriched (intestine, liver) |
MalaCardsi | CYP2C19 |
MIMi | 124020, gene 609535, phenotype |
neXtProti | NX_P33261 |
Orphaneti | 413667, Antidepressant or antipsychotic toxicity or dose selection 240935, Resistance to clopidogrel 240921, Voriconazole toxicity |
PharmGKBi | PA124 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0156, Eukaryota |
HOGENOMi | CLU_001570_22_3_1 |
InParanoidi | P33261 |
OrthoDBi | 702827at2759 |
PhylomeDBi | P33261 |
TreeFami | TF352043 |
Enzyme and pathway databases
UniPathwayi | UPA00199 UPA00987 |
BioCyci | MetaCyc:HS09293-MONOMER |
PathwayCommonsi | P33261 |
Reactomei | R-HSA-211981, Xenobiotics R-HSA-211999, CYP2E1 reactions R-HSA-2142670, Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142816, Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) |
SABIO-RKi | P33261 |
Miscellaneous databases
BioGRID-ORCSi | 1557, 2 hits in 819 CRISPR screens |
GeneWikii | CYP2C19 |
GenomeRNAii | 1557 |
Pharosi | P33261, Tchem |
PROi | PR:P33261 |
RNActi | P33261, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000165841, Expressed in liver and 38 other tissues |
ExpressionAtlasi | P33261, baseline and differential |
Genevisiblei | P33261, HS |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CP2CJ_HUMAN | |
Accessioni | P33261Primary (citable) accession number: P33261 Secondary accession number(s): P33259 Q9UCD4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | March 1, 2005 | |
Last modified: | December 2, 2020 | |
This is version 194 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations