UniProtKB - P33261 (CP2CJ_HUMAN)

>sp|P33261|CP2CJ_HUMAN Cytochrome P450 2C19 OS=Homo sapiens OX=9606 GN=CYP2C19 PE=1 SV=3
MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI
YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM
ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYID
LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK
KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP
PFYQLCFIPV

Entry version 184 (31 Jul 2019)
Sequence version 3 (01 Mar 2005)
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Protein

Cytochrome P450 2C19

Gene

CYP2C19

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) (PubMed:18577768, PubMed:19965576, PubMed:20972997). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:18577768, PubMed:19965576, PubMed:20972997). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates PUFA specifically at the omega-1 position (PubMed:18577768). Catalyzes the epoxidation of double bonds of PUFA (PubMed:20972997, PubMed:19965576). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794). Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. Hydroxylates fenbendazole at the 4' position (PubMed:23959307).5 Publications

Caution

P450-254C was originally listed as a separate gene (CYP2C17). Resequencing demonstrated that it is not a separate gene, but a chimera. The 5'-portion corresponds to a partial 2C18 clone, and the 3'-portion corresponds to a partial 2C19 clone.Curated

Catalytic activityⁱ

Cofactorⁱ

heme1 Publication

Pathwayⁱ: fatty acid metabolism

This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.3 Publications
View all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.

Pathwayⁱ: (4R)-limonene degradation

This protein is involved in the pathway (4R)-limonene degradation, which is part of Terpene metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway (4R)-limonene degradation and in Terpene metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Metal bindingⁱ	435	Iron (heme axial ligand)Combined sources1 Publication		1

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Monooxygenase, Oxidoreductase
Biological process	Fatty acid metabolism, Lipid metabolism
Ligand	Heme, Iron, Metal-binding, NADP

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS09293-MONOMER
Reactomeⁱ	R-HSA-211981 Xenobiotics R-HSA-211999 CYP2E1 reactions R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
SABIO-RKⁱ	P33261
UniPathwayⁱ	UPA00199 UPA00987

Chemistry databases

SwissLipidsⁱ	SLP:000001589

SwissLipidsⁱ

SLP:000001589

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cytochrome P450 2C19 (EC:1.14.14.-1 Publication) Alternative name(s): (R)-limonene 6-monooxygenase (EC:1.14.14.531 Publication) (S)-limonene 6-monooxygenase (EC:1.14.14.511 Publication) (S)-limonene 7-monooxygenase (EC:1.14.14.521 Publication) CYPIIC17 CYPIIC19 Cytochrome P450-11A Cytochrome P450-254C Fenbendazole monooxygenase (4'-hydroxylating)Curated (EC:1.14.14.751 Publication) Mephenytoin 4-hydroxylase
Gene namesⁱ	Name:CYP2C19
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2621 CYP2C19
MIMⁱ	124020 gene
neXtProtⁱ	NX_P33261

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1557
MalaCards human disease database More...MalaCardsⁱ	CYP2C19
MIMⁱ	609535 phenotype
Orphanetⁱ	413667 Antidepressant or antipsychotic toxicity or dose selection 240935 Resistance to clopidogrel 240921 Voriconazole toxicity
PharmGKBⁱ	PA124

Chemistry databases

ChEMBLⁱ	CHEMBL3622
Drug and drug target database More...DrugBankⁱ	DB05812 Abiraterone DB01418 Acenocoumarol DB00945 Acetylsalicylic acid DB00546 Adinazolam DB00918 Almotriptan DB06403 Ambrisentan DB00357 Aminoglutethimide DB01424 Aminophenazone DB01118 Amiodarone DB00321 Amitriptyline DB01060 Amoxicillin DB00701 Amprenavir DB01435 Antipyrine DB06605 Apixaban DB00673 Aprepitant DB01274 Arformoterol DB06413 Armodafinil DB06697 Artemether DB00289 Atomoxetine DB01076 Atorvastatin DB06626 Axitinib DB00972 Azelastine DB00245 Benzatropine DB01128 Bicalutamide DB04794 Bifonazole DB00188 Bortezomib DB01558 Bromazepam DB00835 Brompheniramine DB00297 Bupivacaine DB00921 Buprenorphine DB00564 Carbamazepine DB00748 Carbinoxamine DB00395 Carisoprodol DB00439 Cerivastatin DB00446 Chloramphenicol DB00672 Chlorpropamide DB00169 Cholecalciferol DB01166 Cilostazol DB00501 Cimetidine DB00604 Cisapride DB00215 Citalopram DB01211 Clarithromycin DB04920 Clevidipine DB00349 Clobazam DB01242 Clomipramine DB00758 Clopidogrel DB01559 Clotiazepam DB00257 Clotrimazole DB00363 Clozapine DB00531 Cyclophosphamide DB00091 Cyclosporine DB00250 Dapsone DB00705 Delavirdine DB01151 Desipramine DB00967 Desloratadine DB01234 Dexamethasone DB01191 Dexfenfluramine DB00514 Dextromethorphan DB00829 Diazepam DB00586 Diclofenac DB00343 Diltiazem DB01093 Dimethyl sulfoxide DB01075 Diphenhydramine DB00988 Dopamine DB00590 Doxazosin DB01142 Doxepin DB00470 Dronabinol DB00625 Efavirenz DB00216 Eletriptan DB00109 Enfuvirtide DB08899 Enzalutamide DB01175 Escitalopram DB09119 Eslicarbazepine acetate DB00736 Esomeprazole DB00783 Estradiol DB00898 Ethanol DB00754 Ethotoin DB01628 Etoricoxib DB06414 Etravirine DB00927 Famotidine DB00949 Felbamate DB00196 Fluconazole DB01544 Flunitrazepam DB00472 Fluoxetine DB00499 Flutamide DB01095 Fluvastatin DB00176 Fluvoxamine DB00983 Formoterol DB01320 Fosphenytoin DB00317 Gefitinib DB01241 Gemfibrozil DB01120 Gliclazide DB01296 Glucosamine DB01016 Glyburide DB01018 Guanfacine DB00502 Haloperidol DB01355 Hexobarbital DB06789 Hydroxyprogesterone caproate DB01050 Ibuprofen DB09054 Idelalisib DB01181 Ifosfamide DB00619 Imatinib DB00458 Imipramine DB00224 Indinavir DB00328 Indomethacin DB00951 Isoniazid DB09570 Ixazomib DB06738 Ketobemidone DB01026 Ketoconazole DB00448 Lansoprazole DB01259 Lapatinib DB08918 Levomilnacipran DB01601 Lopinavir DB00455 Loratadine DB04871 Lorcaserin DB00678 Losartan DB00227 Lovastatin DB08933 Luliconazole DB09280 Lumacaftor DB01283 Lumiracoxib DB08932 Macitentan DB01065 Melatonin DB01043 Memantine DB00532 Mephenytoin DB00371 Meprobamate DB00333 Methadone DB00703 Methazolamide DB00763 Methimazole DB05246 Methsuximide DB00849 Methylphenobarbital DB00264 Metoprolol DB01110 Miconazole DB01171 Moclobemide DB00745 Modafinil DB09049 Naloxegol DB00220 Nelfinavir DB00622 Nicardipine DB00184 Nicotine DB00665 Nilutamide DB06712 Nilvadipine DB00717 Norethisterone DB00540 Nortriptyline DB00334 Olanzapine DB00338 Omeprazole DB04938 Ospemifene DB00776 Oxcarbazepine DB00239 Oxiconazole DB06412 Oxymetholone DB00213 Pantoprazole DB00082 Pegvisomant DB00738 Pentamidine DB00312 Pentobarbital DB00850 Perphenazine DB00454 Pethidine DB03783 Phenacetin DB00780 Phenelzine DB01174 Phenobarbital DB00832 Phensuximide DB00252 Phenytoin DB01100 Pimozide DB01132 Pioglitazone DB01621 Pipotiazine DB01179 Podofilox DB06209 Prasugrel DB01058 Praziquantel DB00635 Prednisone DB00794 Primidone DB01032 Probenecid DB00396 Progesterone DB01131 Proguanil DB00420 Promazine DB00818 Propofol DB00571 Propranolol DB01589 Quazepam DB01224 Quetiapine DB00468 Quinine DB01129 Rabeprazole DB00980 Ramelteon DB00863 Ranitidine DB08896 Regorafenib DB01045 Rifampicin DB08864 Rilpivirine DB00503 Ritonavir DB06176 Romidepsin DB00412 Rosiglitazone DB01098 Rosuvastatin DB01232 Saquinavir DB01037 Selegiline DB01104 Sertraline DB00203 Sildenafil DB00641 Simvastatin DB06268 Sitaxentan DB00398 Sorafenib DB09118 Stiripentol DB00259 Sulfanilamide DB00675 Tamoxifen DB06204 Tapentadol DB00966 Telmisartan DB00231 Temazepam DB00444 Teniposide DB00857 Terbinafine DB00624 Testosterone DB01041 Thalidomide DB00679 Thioridazine DB00208 Ticlopidine DB00373 Timolol DB01007 Tioconazole DB00932 Tipranavir DB08895 Tofacitinib DB01124 Tolbutamide DB01036 Tolterodine DB00273 Topiramate DB00214 Torasemide DB05109 Trabectedin DB00752 Tranylcypromine DB00347 Trimethadione DB00726 Trimipramine DB00197 Troglitazone DB01361 Troleandomycin DB00580 Valdecoxib DB00313 Valproic Acid DB00285 Venlafaxine DB00661 Verapamil DB08828 Vismodegib DB00582 Voriconazole DB09068 Vortioxetine DB00682 Warfarin DB00549 Zafirlukast DB00495 Zidovudine DB00425 Zolpidem DB00909 Zonisamide
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1328

Polymorphism and mutation databases

BioMutaⁱ	CYP2C19
DMDMⁱ	60416369

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051708	1 – 490	Cytochrome P450 2C19Add BLAST		490

Proteomic databases

PaxDbⁱ	P33261
PeptideAtlas More...PeptideAtlasⁱ	P33261
PRIDEⁱ	P33261
ProteomicsDBⁱ	54907

PTM databases

iPTMnetⁱ	P33261
PhosphoSitePlusⁱ	P33261

Expressionⁱ

Inductionⁱ

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

Bgeeⁱ	ENSG00000165841 Expressed in 26 organ(s), highest expression level in right lobe of liver
ExpressionAtlasⁱ	P33261 baseline and differential
Genevisibleⁱ	P33261 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA015066

HPAⁱ

HPA015066

Interactionⁱ

GO - Molecular functionⁱ

enzyme binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- "Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b(5) enzymes."
  Shimada T., Mernaugh R.L., Guengerich F.P.
  Arch. Biochem. Biophys. 435:207-216(2005) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107935, 2 interactors
STRINGⁱ	9606.ENSP00000360372

Chemistry databases

BindingDBⁱ

P33261

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	37 – 39	Combined sources	3
Helixⁱ	42 – 44	Combined sources	3
Helixⁱ	47 – 49	Combined sources	3
Helixⁱ	50 – 61	Combined sources	12
Beta strandⁱ	63 – 69	Combined sources	7
Beta strandⁱ	72 – 77	Combined sources	6
Helixⁱ	80 – 87	Combined sources	8
Turnⁱ	88 – 90	Combined sources	3
Helixⁱ	91 – 94	Combined sources	4
Helixⁱ	103 – 106	Combined sources	4
Turnⁱ	107 – 109	Combined sources	3
Helixⁱ	117 – 130	Combined sources	14
Beta strandⁱ	135 – 139	Combined sources	5
Helixⁱ	141 – 158	Combined sources	18
Turnⁱ	159 – 161	Combined sources	3
Turnⁱ	166 – 168	Combined sources	3
Helixⁱ	169 – 182	Combined sources	14
Beta strandⁱ	183 – 185	Combined sources	3
Helixⁱ	192 – 209	Combined sources	18
Helixⁱ	211 – 218	Combined sources	8
Helixⁱ	222 – 225	Combined sources	4
Helixⁱ	228 – 254	Combined sources	27
Helixⁱ	263 – 273	Combined sources	11
Turnⁱ	274 – 276	Combined sources	3
Helixⁱ	284 – 297	Combined sources	14
Helixⁱ	300 – 315	Combined sources	16
Helixⁱ	317 – 330	Combined sources	14
Beta strandⁱ	333 – 335	Combined sources	3
Helixⁱ	339 – 344	Combined sources	6
Helixⁱ	346 – 359	Combined sources	14
Beta strandⁱ	377 – 379	Combined sources	3
Beta strandⁱ	386 – 389	Combined sources	4
Helixⁱ	391 – 395	Combined sources	5
Turnⁱ	398 – 400	Combined sources	3
Beta strandⁱ	401 – 403	Combined sources	3
Helixⁱ	409 – 412	Combined sources	4
Beta strandⁱ	415 – 417	Combined sources	3
Helixⁱ	438 – 455	Combined sources	18
Beta strandⁱ	456 – 462	Combined sources	7
Turnⁱ	464 – 466	Combined sources	3
Beta strandⁱ	475 – 477	Combined sources	3
Beta strandⁱ	485 – 489	Combined sources	5

Show more details

3D structure databases

SMRⁱ	P33261
ModBaseⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0156 Eukaryota COG2124 LUCA
HOGENOMⁱ	HOG000036992
InParanoidⁱ	P33261
KEGG Orthology (KO) More...KOⁱ	K17721
Database of Orthologous Groups More...OrthoDBⁱ	702827at2759
PhylomeDBⁱ	P33261
TreeFamⁱ	TF352043

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR036396 Cyt_P450_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00463 EP450I PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P33261-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MDPFVVLVLC LSCLLLLSIW RQSSGRGKLP PGPTPLPVIG NILQIDIKDV 
        60         70         80         90        100
SKSLTNLSKI YGPVFTLYFG LERMVVLHGY EVVKEALIDL GEEFSGRGHF 
       110        120        130        140        150
PLAERANRGF GIVFSNGKRW KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR 
       160        170        180        190        200
CLVEELRKTK ASPCDPTFIL GCAPCNVICS IIFQKRFDYK DQQFLNLMEK 
       210        220        230        240        250
LNENIRIVST PWIQICNNFP TIIDYFPGTH NKLLKNLAFM ESDILEKVKE 
       260        270        280        290        300
HQESMDINNP RDFIDCFLIK MEKEKQNQQS EFTIENLVIT AADLLGAGTE 
       310        320        330        340        350
TTSTTLRYAL LLLLKHPEVT AKVQEEIERV VGRNRSPCMQ DRGHMPYTDA 
       360        370        380        390        400
VVHEVQRYID LIPTSLPHAV TCDVKFRNYL IPKGTTILTS LTSVLHDNKE 
       410        420        430        440        450
FPNPEMFDPR HFLDEGGNFK KSNYFMPFSA GKRICVGEGL ARMELFLFLT 
       460        470        480        490
FILQNFNLKS LIDPKDLDTT PVVNGFASVP PFYQLCFIPV

Length:490

Mass (Da):55,931

Last modified:March 1, 2005 - v3

Checksum:ⁱ17DB04C50A132C53

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A087X125	A0A087X125_HUMAN		Cytochrome P450 2C19 Cytochrome P450 2C19	CYP2C19	162	Annotation score:

Polymorphismⁱ

Genetic variation in CYP2C19 is responsible for poor drug metabolism [MIMⁱ:609535]. Individuals can be characterized as either extensive metabolizers (EM) or poor metabolizers (PM). The PM phenotype is inherited in an autosomal recessive manner, with the EM phenotype comprising both homozygous dominant and heterozygote genotypes. There are marked interracial differences in the frequency of this polymorphism. Poor metabolizers represent 2-5% of Caucasians, 13-23% of Asian populations, and as many as 38-79% of individuals of some of the islands of Polynesia and Micronesia. Different alleles of CYP2C19 are known: CYP2C19*1A CYP2C19*1B, CYP2C19*1C, CYP2C19*2A (CYP2C19m1 or CYP2C19m1A), CYP2C19*2B (CYP2C19m1B), CYP2C19*2C (CYP2C19*21), CYP2C19*3A (CYP2C19m2), CYP2C19*3B (CYP2C19*20), CYP2C19*4 (CYP2C19m3), CYP2C19*5A (CYP2C19m4), CYP2C19*5B, CYP2C19*6, CYP2C19*7, CYP2C19*8, CYP2C19*9, CYP2C19*10, CYP2C19*11 CYP2C19*12, CYP2C19*13, CYP2C19*14 CYP2C19*15, CYP2C19*16, CYP2C19*18, CYP2C19*19. Defective CYP2C19*2 and CYP2C19*3 alleles are characterized by a splice mutation and a stop codon, respectively, and account for most of the PM alleles. The sequence shown is that of allele CYP2C19*1B.

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_021268	17	L → P in allele CYP2C19*14. 1 PublicationCorresponds to variant dbSNP:rs55752064Ensembl.	1
Natural variantⁱVAR_021269	19	I → L in allele CYP2C19*15. 2 PublicationsCorresponds to variant dbSNP:rs17882687Ensembl.	1
Natural variantⁱVAR_024083	51	S → G in allele CYP2C19*19. 1 Publication	1
Natural variantⁱVAR_024718	74	M → T1 PublicationCorresponds to variant dbSNP:rs28399505Ensembl.	1
Natural variantⁱVAR_021270	92	E → D2 PublicationsCorresponds to variant dbSNP:rs17878459Ensembl.	1
Natural variantⁱVAR_008357	120	W → R in allele CYP2C19*8; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs41291556EnsemblClinVar.	1
Natural variantⁱVAR_021271	122	E → A1 PublicationCorresponds to variant dbSNP:rs17885179Ensembl.	1
Natural variantⁱVAR_008358	132	R → Q in allele CYP2C19*6; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs72552267EnsemblClinVar.	1
Natural variantⁱVAR_021272	144	R → H in allele CYP2C19*9. 3 PublicationsCorresponds to variant dbSNP:rs17884712EnsemblClinVar.	1
Natural variantⁱVAR_021273	150	R → H in allele CYP2C19*11. 1 PublicationCorresponds to variant dbSNP:rs58973490Ensembl.	1
Natural variantⁱVAR_024084	161	A → P1 PublicationCorresponds to variant dbSNP:rs181297724Ensembl.	1
Natural variantⁱVAR_024719	168	F → L1 PublicationCorresponds to variant dbSNP:rs28399510Ensembl.	1
Natural variantⁱVAR_020123	227	P → L in allele CYP2C19*10. 1 PublicationCorresponds to variant dbSNP:rs6413438EnsemblClinVar.	1
Natural variantⁱVAR_024085	329	R → H in allele CYP2C19*18. 1 PublicationCorresponds to variant dbSNP:rs138142612Ensembl.	1
Natural variantⁱVAR_001255	331	V → I in allele CYP2C191A, allele CYP2C195A, allele CYP2C198 and allele CYP2C1916. 4 PublicationsCorresponds to variant dbSNP:rs3758581Ensembl.	1
Natural variantⁱVAR_021274	410	R → C in allele CYP2C19*13. 2 PublicationsCorresponds to variant dbSNP:rs17879685Ensembl.	1
Natural variantⁱVAR_008359	433	R → W in allele CYP2C195A and allele CYP2C195B; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs56337013EnsemblClinVar.	1
Natural variantⁱVAR_021275	442	R → C in allele CYP2C19*16; lowered catalytic activity. 1 PublicationCorresponds to variant dbSNP:rs192154563Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M61854 mRNA Translation: AAB59426.1 M61858 mRNA Translation: AAA52145.1 Sequence problems. L07093 mRNA Translation: AAA36660.1 Sequence problems. AY796203 Genomic DNA Translation: AAV41877.1 AL583836 Genomic DNA No translation available. AL133513 Genomic DNA No translation available. L39098, L39097 Genomic DNA Translation: AAL31347.1 L39102 , L39099, L39100, L39101 Genomic DNA Translation: AAL31348.1 L31506 Genomic DNA No translation available. L31507 Genomic DNA No translation available. L32982 Genomic DNA No translation available. L32983 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7436.1
PIRⁱ	F38462 G38462 I52418
NCBI Reference Sequences More...RefSeqⁱ	NP_000760.1, NM_000769.2

Genome annotation databases

Ensemblⁱ	ENST00000371321; ENSP00000360372; ENSG00000165841
GeneIDⁱ	1557
KEGGⁱ	hsa:1557
UCSC genome browser More...UCSCⁱ	uc010qnz.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P33261	Cytochrome P450 (Fragment)		HUMAN		59	UniRef100_P33261
UPI0008F52877		GORGO		85

Protein	Similar proteins		Species	Score	Length	Source
P33261	Cytochrome P450 (Fragment)		HUMAN		59	UniRef90_P33261
Uncharacterized protein		PANPA		490
Cytochrome P450 family 2 subfamily C member 19		GORGO		490
Uncharacterized protein		NOMLE		490
UPI000D0A0224		PANTR		497
+7

Protein	Similar proteins		Species	Score	Length	Source
P33261	Cytochrome P450 2C9	)	HUMAN		490	UniRef50_P11712
Cytochrome P450 2C55		MOUSE		490
Cytochrome P450 2C27		MESAU		490
Cytochrome P450 2C42 (Fragment)		PIG		327
Cytochrome P450 2C20		MACFA		490
+428

Cross-referencesⁱ

Web resourcesⁱ

Cytochrome P450 Allele Nomenclature Committee

CYP2C19 alleles

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M61854 mRNA Translation: AAB59426.1 M61858 mRNA Translation: AAA52145.1 Sequence problems. L07093 mRNA Translation: AAA36660.1 Sequence problems. AY796203 Genomic DNA Translation: AAV41877.1 AL583836 Genomic DNA No translation available. AL133513 Genomic DNA No translation available. L39098, L39097 Genomic DNA Translation: AAL31347.1 L39102 , L39099, L39100, L39101 Genomic DNA Translation: AAL31348.1 L31506 Genomic DNA No translation available. L31507 Genomic DNA No translation available. L32982 Genomic DNA No translation available. L32983 Genomic DNA No translation available.
CCDSⁱ	CCDS7436.1
PIRⁱ	F38462 G38462 I52418
RefSeqⁱ	NP_000760.1, NM_000769.2

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4GQS	X-ray	2.87	A/B/C/D	23-489	[»]
SMRⁱ	P33261
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107935, 2 interactors
STRINGⁱ	9606.ENSP00000360372

Chemistry databases

BindingDBⁱ	P33261
ChEMBLⁱ	CHEMBL3622
DrugBankⁱ	DB05812 Abiraterone DB01418 Acenocoumarol DB00945 Acetylsalicylic acid DB00546 Adinazolam DB00918 Almotriptan DB06403 Ambrisentan DB00357 Aminoglutethimide DB01424 Aminophenazone DB01118 Amiodarone DB00321 Amitriptyline DB01060 Amoxicillin DB00701 Amprenavir DB01435 Antipyrine DB06605 Apixaban DB00673 Aprepitant DB01274 Arformoterol DB06413 Armodafinil DB06697 Artemether DB00289 Atomoxetine DB01076 Atorvastatin DB06626 Axitinib DB00972 Azelastine DB00245 Benzatropine DB01128 Bicalutamide DB04794 Bifonazole DB00188 Bortezomib DB01558 Bromazepam DB00835 Brompheniramine DB00297 Bupivacaine DB00921 Buprenorphine DB00564 Carbamazepine DB00748 Carbinoxamine DB00395 Carisoprodol DB00439 Cerivastatin DB00446 Chloramphenicol DB00672 Chlorpropamide DB00169 Cholecalciferol DB01166 Cilostazol DB00501 Cimetidine DB00604 Cisapride DB00215 Citalopram DB01211 Clarithromycin DB04920 Clevidipine DB00349 Clobazam DB01242 Clomipramine DB00758 Clopidogrel DB01559 Clotiazepam DB00257 Clotrimazole DB00363 Clozapine DB00531 Cyclophosphamide DB00091 Cyclosporine DB00250 Dapsone DB00705 Delavirdine DB01151 Desipramine DB00967 Desloratadine DB01234 Dexamethasone DB01191 Dexfenfluramine DB00514 Dextromethorphan DB00829 Diazepam DB00586 Diclofenac DB00343 Diltiazem DB01093 Dimethyl sulfoxide DB01075 Diphenhydramine DB00988 Dopamine DB00590 Doxazosin DB01142 Doxepin DB00470 Dronabinol DB00625 Efavirenz DB00216 Eletriptan DB00109 Enfuvirtide DB08899 Enzalutamide DB01175 Escitalopram DB09119 Eslicarbazepine acetate DB00736 Esomeprazole DB00783 Estradiol DB00898 Ethanol DB00754 Ethotoin DB01628 Etoricoxib DB06414 Etravirine DB00927 Famotidine DB00949 Felbamate DB00196 Fluconazole DB01544 Flunitrazepam DB00472 Fluoxetine DB00499 Flutamide DB01095 Fluvastatin DB00176 Fluvoxamine DB00983 Formoterol DB01320 Fosphenytoin DB00317 Gefitinib DB01241 Gemfibrozil DB01120 Gliclazide DB01296 Glucosamine DB01016 Glyburide DB01018 Guanfacine DB00502 Haloperidol DB01355 Hexobarbital DB06789 Hydroxyprogesterone caproate DB01050 Ibuprofen DB09054 Idelalisib DB01181 Ifosfamide DB00619 Imatinib DB00458 Imipramine DB00224 Indinavir DB00328 Indomethacin DB00951 Isoniazid DB09570 Ixazomib DB06738 Ketobemidone DB01026 Ketoconazole DB00448 Lansoprazole DB01259 Lapatinib DB08918 Levomilnacipran DB01601 Lopinavir DB00455 Loratadine DB04871 Lorcaserin DB00678 Losartan DB00227 Lovastatin DB08933 Luliconazole DB09280 Lumacaftor DB01283 Lumiracoxib DB08932 Macitentan DB01065 Melatonin DB01043 Memantine DB00532 Mephenytoin DB00371 Meprobamate DB00333 Methadone DB00703 Methazolamide DB00763 Methimazole DB05246 Methsuximide DB00849 Methylphenobarbital DB00264 Metoprolol DB01110 Miconazole DB01171 Moclobemide DB00745 Modafinil DB09049 Naloxegol DB00220 Nelfinavir DB00622 Nicardipine DB00184 Nicotine DB00665 Nilutamide DB06712 Nilvadipine DB00717 Norethisterone DB00540 Nortriptyline DB00334 Olanzapine DB00338 Omeprazole DB04938 Ospemifene DB00776 Oxcarbazepine DB00239 Oxiconazole DB06412 Oxymetholone DB00213 Pantoprazole DB00082 Pegvisomant DB00738 Pentamidine DB00312 Pentobarbital DB00850 Perphenazine DB00454 Pethidine DB03783 Phenacetin DB00780 Phenelzine DB01174 Phenobarbital DB00832 Phensuximide DB00252 Phenytoin DB01100 Pimozide DB01132 Pioglitazone DB01621 Pipotiazine DB01179 Podofilox DB06209 Prasugrel DB01058 Praziquantel DB00635 Prednisone DB00794 Primidone DB01032 Probenecid DB00396 Progesterone DB01131 Proguanil DB00420 Promazine DB00818 Propofol DB00571 Propranolol DB01589 Quazepam DB01224 Quetiapine DB00468 Quinine DB01129 Rabeprazole DB00980 Ramelteon DB00863 Ranitidine DB08896 Regorafenib DB01045 Rifampicin DB08864 Rilpivirine DB00503 Ritonavir DB06176 Romidepsin DB00412 Rosiglitazone DB01098 Rosuvastatin DB01232 Saquinavir DB01037 Selegiline DB01104 Sertraline DB00203 Sildenafil DB00641 Simvastatin DB06268 Sitaxentan DB00398 Sorafenib DB09118 Stiripentol DB00259 Sulfanilamide DB00675 Tamoxifen DB06204 Tapentadol DB00966 Telmisartan DB00231 Temazepam DB00444 Teniposide DB00857 Terbinafine DB00624 Testosterone DB01041 Thalidomide DB00679 Thioridazine DB00208 Ticlopidine DB00373 Timolol DB01007 Tioconazole DB00932 Tipranavir DB08895 Tofacitinib DB01124 Tolbutamide DB01036 Tolterodine DB00273 Topiramate DB00214 Torasemide DB05109 Trabectedin DB00752 Tranylcypromine DB00347 Trimethadione DB00726 Trimipramine DB00197 Troglitazone DB01361 Troleandomycin DB00580 Valdecoxib DB00313 Valproic Acid DB00285 Venlafaxine DB00661 Verapamil DB08828 Vismodegib DB00582 Voriconazole DB09068 Vortioxetine DB00682 Warfarin DB00549 Zafirlukast DB00495 Zidovudine DB00425 Zolpidem DB00909 Zonisamide
GuidetoPHARMACOLOGYⁱ	1328
SwissLipidsⁱ	SLP:000001589

PTM databases

iPTMnetⁱ	P33261
PhosphoSitePlusⁱ	P33261

Polymorphism and mutation databases

BioMutaⁱ	CYP2C19
DMDMⁱ	60416369

Proteomic databases

PaxDbⁱ	P33261
PeptideAtlasⁱ	P33261
PRIDEⁱ	P33261
ProteomicsDBⁱ	54907

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1557
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000371321; ENSP00000360372; ENSG00000165841
GeneIDⁱ	1557
KEGGⁱ	hsa:1557
UCSCⁱ	uc010qnz.3 human

Organism-specific databases

CTDⁱ	1557
DisGeNETⁱ	1557
GeneCardsⁱ	CYP2C19
HGNCⁱ	HGNC:2621 CYP2C19
HPAⁱ	HPA015066
MalaCardsⁱ	CYP2C19
MIMⁱ	124020 gene 609535 phenotype
neXtProtⁱ	NX_P33261
Orphanetⁱ	413667 Antidepressant or antipsychotic toxicity or dose selection 240935 Resistance to clopidogrel 240921 Voriconazole toxicity
PharmGKBⁱ	PA124
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0156 Eukaryota COG2124 LUCA
HOGENOMⁱ	HOG000036992
InParanoidⁱ	P33261
KOⁱ	K17721
OrthoDBⁱ	702827at2759
PhylomeDBⁱ	P33261
TreeFamⁱ	TF352043

Enzyme and pathway databases

UniPathwayⁱ	UPA00199 UPA00987
BioCycⁱ	MetaCyc:HS09293-MONOMER
Reactomeⁱ	R-HSA-211981 Xenobiotics R-HSA-211999 CYP2E1 reactions R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
SABIO-RKⁱ	P33261

Miscellaneous databases

GeneWikiⁱ	CYP2C19
GenomeRNAiⁱ	1557
Protein Ontology More...PROⁱ	PR:P33261
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000165841 Expressed in 26 organ(s), highest expression level in right lobe of liver
ExpressionAtlasⁱ	P33261 baseline and differential
Genevisibleⁱ	P33261 HS

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR036396 Cyt_P450_sf
Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00463 EP450I PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CP2CJ_HUMAN
Accessionⁱ	P33261Primary (citable) accession number: P33261 Secondary accession number(s): P33259 , Q8WZB1, Q8WZB2, Q9UCD4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
	Last sequence update:	March 1, 2005
	Last modified:	July 31, 2019
	This is version 184 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

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UniProtKB - P33261 (CP2CJ_HUMAN)

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Cytochrome P450 2C19

CYP2C19

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: fatty acid metabolism

Pathwayi: (4R)-limonene degradation

Sites

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GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Catalytic activityⁱ

Pathwayⁱ: fatty acid metabolism

Pathwayⁱ: (4R)-limonene degradation

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ