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UniProtKB - P33261 (CP2CJ_HUMAN)

Protein

Cytochrome P450 2C19

Gene

CYP2C19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.

Caution

P450-254C was originally listed as a separate gene (CYP2C17). Resequencing demonstrated that it is not a separate gene, but a chimera. The 5'-portion corresponds to a partial 2C18 clone, and the 3'-portion corresponds to a partial 2C19 clone.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

heme1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi435Iron (heme axial ligand)Combined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • arachidonic acid epoxygenase activity Source: GO_Central
  • enzyme binding Source: BHF-UCL
  • heme binding Source: UniProtKB
  • iron ion binding Source: InterPro
  • monooxygenase activity Source: BHF-UCL
  • oxidoreductase activity Source: BHF-UCL
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: GO_Central
  • oxygen binding Source: ProtInc
  • steroid hydroxylase activity Source: BHF-UCL
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding, NADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS09293-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-211981 Xenobiotics
R-HSA-211999 CYP2E1 reactions
R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P33261

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001589

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome P450 2C19 (EC:1.14.13.-)
Alternative name(s):
(R)-limonene 6-monooxygenase (EC:1.14.14.531 Publication)
(S)-limonene 6-monooxygenase (EC:1.14.14.511 Publication)
(S)-limonene 7-monooxygenase (EC:1.14.14.521 Publication)
CYPIIC17
CYPIIC19
Cytochrome P450-11A
Cytochrome P450-254C
Mephenytoin 4-hydroxylase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYP2C19
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000165841.9

Human Gene Nomenclature Database

More...HGNCi		HGNC:2621 CYP2C19

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		124020 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P33261

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1557

MalaCards human disease database

More...MalaCardsi		CYP2C19
MIMi609535 phenotype

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		413667 Antidepressant or antipsychotic toxicity or dose selection
240935 Resistance to clopidogrel
240921 Voriconazole toxicity

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA124

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3622

Drug and drug target database

More...DrugBanki		DB05812 Abiraterone
DB01418 Acenocoumarol
DB00945 Acetylsalicylic acid
DB00546 Adinazolam
DB00918 Almotriptan
DB06403 Ambrisentan
DB00357 Aminoglutethimide
DB01424 Aminophenazone
DB01118 Amiodarone
DB00321 Amitriptyline
DB01060 Amoxicillin
DB00701 Amprenavir
DB01435 Antipyrine
DB06605 Apixaban
DB00673 Aprepitant
DB01274 Arformoterol
DB06413 Armodafinil
DB06697 Artemether
DB00289 Atomoxetine
DB01076 Atorvastatin
DB06626 Axitinib
DB00972 Azelastine
DB00245 Benzatropine
DB01128 Bicalutamide
DB04794 Bifonazole
DB00188 Bortezomib
DB01558 Bromazepam
DB00835 Brompheniramine
DB00297 Bupivacaine
DB00921 Buprenorphine
DB00564 Carbamazepine
DB00748 Carbinoxamine
DB00395 Carisoprodol
DB00439 Cerivastatin
DB00446 Chloramphenicol
DB00672 Chlorpropamide
DB00169 Cholecalciferol
DB01166 Cilostazol
DB00501 Cimetidine
DB00604 Cisapride
DB00215 Citalopram
DB01211 Clarithromycin
DB04920 Clevidipine
DB00349 Clobazam
DB01242 Clomipramine
DB00758 Clopidogrel
DB01559 Clotiazepam
DB00257 Clotrimazole
DB00363 Clozapine
DB00531 Cyclophosphamide
DB00091 Cyclosporine
DB00250 Dapsone
DB00705 Delavirdine
DB01151 Desipramine
DB00967 Desloratadine
DB01234 Dexamethasone
DB01191 Dexfenfluramine
DB00514 Dextromethorphan
DB00829 Diazepam
DB00586 Diclofenac
DB00343 Diltiazem
DB01093 Dimethyl sulfoxide
DB01075 Diphenhydramine
DB00988 Dopamine
DB00590 Doxazosin
DB01142 Doxepin
DB00470 Dronabinol
DB00625 Efavirenz
DB00216 Eletriptan
DB00109 Enfuvirtide
DB08899 Enzalutamide
DB01175 Escitalopram
DB09119 Eslicarbazepine acetate
DB00736 Esomeprazole
DB00783 Estradiol
DB00898 Ethanol
DB00754 Ethotoin
DB01628 Etoricoxib
DB06414 Etravirine
DB00927 Famotidine
DB00949 Felbamate
DB00196 Fluconazole
DB01544 Flunitrazepam
DB00472 Fluoxetine
DB00499 Flutamide
DB01095 Fluvastatin
DB00176 Fluvoxamine
DB00983 Formoterol
DB01320 Fosphenytoin
DB00317 Gefitinib
DB01241 Gemfibrozil
DB01120 Gliclazide
DB01296 Glucosamine
DB01016 Glyburide
DB01018 Guanfacine
DB00502 Haloperidol
DB01355 Hexobarbital
DB06789 Hydroxyprogesterone caproate
DB01050 Ibuprofen
DB09054 Idelalisib
DB01181 Ifosfamide
DB00619 Imatinib
DB00458 Imipramine
DB00224 Indinavir
DB00328 Indomethacin
DB00951 Isoniazid
DB09570 Ixazomib
DB06738 Ketobemidone
DB01026 Ketoconazole
DB00448 Lansoprazole
DB01259 Lapatinib
DB08918 Levomilnacipran
DB01601 Lopinavir
DB00455 Loratadine
DB04871 Lorcaserin
DB00678 Losartan
DB00227 Lovastatin
DB08933 Luliconazole
DB09280 Lumacaftor
DB01283 Lumiracoxib
DB08932 Macitentan
DB01065 Melatonin
DB01043 Memantine
DB00532 Mephenytoin
DB00371 Meprobamate
DB00333 Methadone
DB00703 Methazolamide
DB00763 Methimazole
DB05246 Methsuximide
DB00849 Methylphenobarbital
DB00264 Metoprolol
DB01110 Miconazole
DB01171 Moclobemide
DB00745 Modafinil
DB09049 Naloxegol
DB00220 Nelfinavir
DB00622 Nicardipine
DB00184 Nicotine
DB00665 Nilutamide
DB06712 Nilvadipine
DB00717 Norethisterone
DB00540 Nortriptyline
DB00334 Olanzapine
DB00338 Omeprazole
DB04938 Ospemifene
DB00776 Oxcarbazepine
DB00239 Oxiconazole
DB06412 Oxymetholone
DB00213 Pantoprazole
DB00082 Pegvisomant
DB00738 Pentamidine
DB00312 Pentobarbital
DB00850 Perphenazine
DB00454 Pethidine
DB03783 Phenacetin
DB00780 Phenelzine
DB01174 Phenobarbital
DB00832 Phensuximide
DB00252 Phenytoin
DB01100 Pimozide
DB01132 Pioglitazone
DB01621 Pipotiazine
DB01179 Podofilox
DB06209 Prasugrel
DB01058 Praziquantel
DB00635 Prednisone
DB00794 Primidone
DB01032 Probenecid
DB00396 Progesterone
DB01131 Proguanil
DB00420 Promazine
DB00818 Propofol
DB00571 Propranolol
DB01589 Quazepam
DB01224 Quetiapine
DB00468 Quinine
DB01129 Rabeprazole
DB00980 Ramelteon
DB00863 Ranitidine
DB08896 Regorafenib
DB01045 Rifampicin
DB08864 Rilpivirine
DB00503 Ritonavir
DB06176 Romidepsin
DB00412 Rosiglitazone
DB01098 Rosuvastatin
DB01232 Saquinavir
DB01037 Selegiline
DB01104 Sertraline
DB00203 Sildenafil
DB00641 Simvastatin
DB06268 Sitaxentan
DB00398 Sorafenib
DB09118 Stiripentol
DB00259 Sulfanilamide
DB00675 Tamoxifen
DB06204 Tapentadol
DB00966 Telmisartan
DB00231 Temazepam
DB00444 Teniposide
DB00857 Terbinafine
DB00624 Testosterone
DB01041 Thalidomide
DB00679 Thioridazine
DB00208 Ticlopidine
DB00373 Timolol
DB01007 Tioconazole
DB00932 Tipranavir
DB08895 Tofacitinib
DB01124 Tolbutamide
DB01036 Tolterodine
DB00273 Topiramate
DB00214 Torasemide
DB05109 Trabectedin
DB00752 Tranylcypromine
DB00347 Trimethadione
DB00726 Trimipramine
DB00197 Troglitazone
DB01361 Troleandomycin
DB00580 Valdecoxib
DB00313 Valproic Acid
DB00285 Venlafaxine
DB00661 Verapamil
DB08828 Vismodegib
DB00582 Voriconazole
DB09068 Vortioxetine
DB00682 Warfarin
DB00549 Zafirlukast
DB00495 Zidovudine
DB00425 Zolpidem
DB00909 Zonisamide

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1328

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CYP2C19

Domain mapping of disease mutations (DMDM)

More...DMDMi		60416369

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000517081 – 490Cytochrome P450 2C19Add BLAST490

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P33261

PeptideAtlas

More...PeptideAtlasi		P33261

PRoteomics IDEntifications database

More...PRIDEi		P33261

ProteomicsDB human proteome resource

More...ProteomicsDBi		54907

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P33261

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P33261

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000165841 Expressed in 26 organ(s), highest expression level in right lobe of liver

CleanEx database of gene expression profiles

More...CleanExi		HS_CYP2C19

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P33261 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P33261 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA015066

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		107935, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000360372

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P33261

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1490
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P33261

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P33261

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0156 Eukaryota
COG2124 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000036992

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG015789

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P33261

KEGG Orthology (KO)

More...KOi		K17721

Database of Orthologous Groups

More...OrthoDBi		EOG091G0BT8

Database for complete collections of gene phylogenies

More...PhylomeDBi		P33261

TreeFam database of animal gene trees

More...TreeFami		TF352043

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.630.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00067 p450, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00463 EP450I
PR00385 P450

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48264 SSF48264, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P33261-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPFVVLVLC LSCLLLLSIW RQSSGRGKLP PGPTPLPVIG NILQIDIKDV 
        60         70         80         90        100
SKSLTNLSKI YGPVFTLYFG LERMVVLHGY EVVKEALIDL GEEFSGRGHF 
       110        120        130        140        150
PLAERANRGF GIVFSNGKRW KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR 
       160        170        180        190        200
CLVEELRKTK ASPCDPTFIL GCAPCNVICS IIFQKRFDYK DQQFLNLMEK 
       210        220        230        240        250
LNENIRIVST PWIQICNNFP TIIDYFPGTH NKLLKNLAFM ESDILEKVKE 
       260        270        280        290        300
HQESMDINNP RDFIDCFLIK MEKEKQNQQS EFTIENLVIT AADLLGAGTE 
       310        320        330        340        350
TTSTTLRYAL LLLLKHPEVT AKVQEEIERV VGRNRSPCMQ DRGHMPYTDA 
       360        370        380        390        400
VVHEVQRYID LIPTSLPHAV TCDVKFRNYL IPKGTTILTS LTSVLHDNKE 
       410        420        430        440        450
FPNPEMFDPR HFLDEGGNFK KSNYFMPFSA GKRICVGEGL ARMELFLFLT 
       460        470        480        490
FILQNFNLKS LIDPKDLDTT PVVNGFASVP PFYQLCFIPV
Length:490
Mass (Da):55,931
Last modified:March 1, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i17DB04C50A132C53
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X125A0A087X125_HUMAN
Cytochrome P450 2C19
CYP2C19
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variation in CYP2C19 is responsible for poor drug metabolism [MIMi:609535]. Individuals can be characterized as either extensive metabolizers (EM) or poor metabolizers (PM). The PM phenotype is inherited in an autosomal recessive manner, with the EM phenotype comprising both homozygous dominant and heterozygote genotypes. There are marked interracial differences in the frequency of this polymorphism. Poor metabolizers represent 2-5% of Caucasians, 13-23% of Asian populations, and as many as 38-79% of individuals of some of the islands of Polynesia and Micronesia. Different alleles of CYP2C19 are known: CYP2C19*1A CYP2C19*1B, CYP2C19*1C, CYP2C19*2A (CYP2C19m1 or CYP2C19m1A), CYP2C19*2B (CYP2C19m1B), CYP2C19*2C (CYP2C19*21), CYP2C19*3A (CYP2C19m2), CYP2C19*3B (CYP2C19*20), CYP2C19*4 (CYP2C19m3), CYP2C19*5A (CYP2C19m4), CYP2C19*5B, CYP2C19*6, CYP2C19*7, CYP2C19*8, CYP2C19*9, CYP2C19*10, CYP2C19*11 CYP2C19*12, CYP2C19*13, CYP2C19*14 CYP2C19*15, CYP2C19*16, CYP2C19*18, CYP2C19*19. Defective CYP2C19*2 and CYP2C19*3 alleles are characterized by a splice mutation and a stop codon, respectively, and account for most of the PM alleles. The sequence shown is that of allele CYP2C19*1B.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02126817L → P in allele CYP2C19*14. 1 PublicationCorresponds to variant dbSNP:rs55752064Ensembl.1
Natural variantiVAR_02126919I → L in allele CYP2C19*15. 2 PublicationsCorresponds to variant dbSNP:rs17882687Ensembl.1
Natural variantiVAR_02408351S → G in allele CYP2C19*19. 1 Publication1
Natural variantiVAR_02471874M → T1 PublicationCorresponds to variant dbSNP:rs28399505Ensembl.1
Natural variantiVAR_02127092E → D2 PublicationsCorresponds to variant dbSNP:rs17878459Ensembl.1
Natural variantiVAR_008357120W → R in allele CYP2C19*8; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs41291556EnsemblClinVar.1
Natural variantiVAR_021271122E → A1 PublicationCorresponds to variant dbSNP:rs17885179Ensembl.1
Natural variantiVAR_008358132R → Q in allele CYP2C19*6; loss of activity. 1 Publication1
Natural variantiVAR_021272144R → H in allele CYP2C19*9. 3 PublicationsCorresponds to variant dbSNP:rs17884712Ensembl.1
Natural variantiVAR_021273150R → H in allele CYP2C19*11. 1 PublicationCorresponds to variant dbSNP:rs58973490Ensembl.1
Natural variantiVAR_024084161A → P1 PublicationCorresponds to variant dbSNP:rs181297724Ensembl.1
Natural variantiVAR_024719168F → L1 PublicationCorresponds to variant dbSNP:rs28399510Ensembl.1
Natural variantiVAR_020123227P → L in allele CYP2C19*10. 1 PublicationCorresponds to variant dbSNP:rs6413438Ensembl.1
Natural variantiVAR_024085329R → H in allele CYP2C19*18. 1 Publication1
Natural variantiVAR_001255331V → I in allele CYP2C19*1A, allele CYP2C19*5A, allele CYP2C19*8 and allele CYP2C19*16. 4 PublicationsCorresponds to variant dbSNP:rs3758581Ensembl.1
Natural variantiVAR_021274410R → C in allele CYP2C19*13. 2 PublicationsCorresponds to variant dbSNP:rs17879685Ensembl.1
Natural variantiVAR_008359433R → W in allele CYP2C19*5A and allele CYP2C19*5B; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs56337013EnsemblClinVar.1
Natural variantiVAR_021275442R → C in allele CYP2C19*16; lowered catalytic activity. 1 PublicationCorresponds to variant dbSNP:rs192154563Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M61854 mRNA Translation: AAB59426.1
M61858 mRNA Translation: AAA52145.1 Sequence problems.
L07093 mRNA Translation: AAA36660.1 Sequence problems.
AY796203 Genomic DNA Translation: AAV41877.1
AL583836 Genomic DNA No translation available.
AL133513 Genomic DNA No translation available.
L39098, L39097 Genomic DNA Translation: AAL31347.1
L39102
, L39099, L39100, L39101 Genomic DNA Translation: AAL31348.1
L31506 Genomic DNA No translation available.
L31507 Genomic DNA No translation available.
L32982 Genomic DNA No translation available.
L32983 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7436.1

Protein sequence database of the Protein Information Resource

More...PIRi		F38462
G38462
I52418

NCBI Reference Sequences

More...RefSeqi		NP_000760.1, NM_000769.2

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.282409

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000371321; ENSP00000360372; ENSG00000165841

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1557

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1557

UCSC genome browser

More...UCSCi		uc010qnz.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP2C19 alleles

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61854 mRNA Translation: AAB59426.1
M61858 mRNA Translation: AAA52145.1 Sequence problems.
L07093 mRNA Translation: AAA36660.1 Sequence problems.
AY796203 Genomic DNA Translation: AAV41877.1
AL583836 Genomic DNA No translation available.
AL133513 Genomic DNA No translation available.
L39098, L39097 Genomic DNA Translation: AAL31347.1
L39102
, L39099, L39100, L39101 Genomic DNA Translation: AAL31348.1
L31506 Genomic DNA No translation available.
L31507 Genomic DNA No translation available.
L32982 Genomic DNA No translation available.
L32983 Genomic DNA No translation available.
CCDSiCCDS7436.1
PIRiF38462
G38462
I52418
RefSeqiNP_000760.1, NM_000769.2
UniGeneiHs.282409

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GQSX-ray2.87A/B/C/D23-489[»]
ProteinModelPortaliP33261
SMRiP33261
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107935, 2 interactors
STRINGi9606.ENSP00000360372

Chemistry databases

BindingDBiP33261
ChEMBLiCHEMBL3622
DrugBankiDB05812 Abiraterone
DB01418 Acenocoumarol
DB00945 Acetylsalicylic acid
DB00546 Adinazolam
DB00918 Almotriptan
DB06403 Ambrisentan
DB00357 Aminoglutethimide
DB01424 Aminophenazone
DB01118 Amiodarone
DB00321 Amitriptyline
DB01060 Amoxicillin
DB00701 Amprenavir
DB01435 Antipyrine
DB06605 Apixaban
DB00673 Aprepitant
DB01274 Arformoterol
DB06413 Armodafinil
DB06697 Artemether
DB00289 Atomoxetine
DB01076 Atorvastatin
DB06626 Axitinib
DB00972 Azelastine
DB00245 Benzatropine
DB01128 Bicalutamide
DB04794 Bifonazole
DB00188 Bortezomib
DB01558 Bromazepam
DB00835 Brompheniramine
DB00297 Bupivacaine
DB00921 Buprenorphine
DB00564 Carbamazepine
DB00748 Carbinoxamine
DB00395 Carisoprodol
DB00439 Cerivastatin
DB00446 Chloramphenicol
DB00672 Chlorpropamide
DB00169 Cholecalciferol
DB01166 Cilostazol
DB00501 Cimetidine
DB00604 Cisapride
DB00215 Citalopram
DB01211 Clarithromycin
DB04920 Clevidipine
DB00349 Clobazam
DB01242 Clomipramine
DB00758 Clopidogrel
DB01559 Clotiazepam
DB00257 Clotrimazole
DB00363 Clozapine
DB00531 Cyclophosphamide
DB00091 Cyclosporine
DB00250 Dapsone
DB00705 Delavirdine
DB01151 Desipramine
DB00967 Desloratadine
DB01234 Dexamethasone
DB01191 Dexfenfluramine
DB00514 Dextromethorphan
DB00829 Diazepam
DB00586 Diclofenac
DB00343 Diltiazem
DB01093 Dimethyl sulfoxide
DB01075 Diphenhydramine
DB00988 Dopamine
DB00590 Doxazosin
DB01142 Doxepin
DB00470 Dronabinol
DB00625 Efavirenz
DB00216 Eletriptan
DB00109 Enfuvirtide
DB08899 Enzalutamide
DB01175 Escitalopram
DB09119 Eslicarbazepine acetate
DB00736 Esomeprazole
DB00783 Estradiol
DB00898 Ethanol
DB00754 Ethotoin
DB01628 Etoricoxib
DB06414 Etravirine
DB00927 Famotidine
DB00949 Felbamate
DB00196 Fluconazole
DB01544 Flunitrazepam
DB00472 Fluoxetine
DB00499 Flutamide
DB01095 Fluvastatin
DB00176 Fluvoxamine
DB00983 Formoterol
DB01320 Fosphenytoin
DB00317 Gefitinib
DB01241 Gemfibrozil
DB01120 Gliclazide
DB01296 Glucosamine
DB01016 Glyburide
DB01018 Guanfacine
DB00502 Haloperidol
DB01355 Hexobarbital
DB06789 Hydroxyprogesterone caproate
DB01050 Ibuprofen
DB09054 Idelalisib
DB01181 Ifosfamide
DB00619 Imatinib
DB00458 Imipramine
DB00224 Indinavir
DB00328 Indomethacin
DB00951 Isoniazid
DB09570 Ixazomib
DB06738 Ketobemidone
DB01026 Ketoconazole
DB00448 Lansoprazole
DB01259 Lapatinib
DB08918 Levomilnacipran
DB01601 Lopinavir
DB00455 Loratadine
DB04871 Lorcaserin
DB00678 Losartan
DB00227 Lovastatin
DB08933 Luliconazole
DB09280 Lumacaftor
DB01283 Lumiracoxib
DB08932 Macitentan
DB01065 Melatonin
DB01043 Memantine
DB00532 Mephenytoin
DB00371 Meprobamate
DB00333 Methadone
DB00703 Methazolamide
DB00763 Methimazole
DB05246 Methsuximide
DB00849 Methylphenobarbital
DB00264 Metoprolol
DB01110 Miconazole
DB01171 Moclobemide
DB00745 Modafinil
DB09049 Naloxegol
DB00220 Nelfinavir
DB00622 Nicardipine
DB00184 Nicotine
DB00665 Nilutamide
DB06712 Nilvadipine
DB00717 Norethisterone
DB00540 Nortriptyline
DB00334 Olanzapine
DB00338 Omeprazole
DB04938 Ospemifene
DB00776 Oxcarbazepine
DB00239 Oxiconazole
DB06412 Oxymetholone
DB00213 Pantoprazole
DB00082 Pegvisomant
DB00738 Pentamidine
DB00312 Pentobarbital
DB00850 Perphenazine
DB00454 Pethidine
DB03783 Phenacetin
DB00780 Phenelzine
DB01174 Phenobarbital
DB00832 Phensuximide
DB00252 Phenytoin
DB01100 Pimozide
DB01132 Pioglitazone
DB01621 Pipotiazine
DB01179 Podofilox
DB06209 Prasugrel
DB01058 Praziquantel
DB00635 Prednisone
DB00794 Primidone
DB01032 Probenecid
DB00396 Progesterone
DB01131 Proguanil
DB00420 Promazine
DB00818 Propofol
DB00571 Propranolol
DB01589 Quazepam
DB01224 Quetiapine
DB00468 Quinine
DB01129 Rabeprazole
DB00980 Ramelteon
DB00863 Ranitidine
DB08896 Regorafenib
DB01045 Rifampicin
DB08864 Rilpivirine
DB00503 Ritonavir
DB06176 Romidepsin
DB00412 Rosiglitazone
DB01098 Rosuvastatin
DB01232 Saquinavir
DB01037 Selegiline
DB01104 Sertraline
DB00203 Sildenafil
DB00641 Simvastatin
DB06268 Sitaxentan
DB00398 Sorafenib
DB09118 Stiripentol
DB00259 Sulfanilamide
DB00675 Tamoxifen
DB06204 Tapentadol
DB00966 Telmisartan
DB00231 Temazepam
DB00444 Teniposide
DB00857 Terbinafine
DB00624 Testosterone
DB01041 Thalidomide
DB00679 Thioridazine
DB00208 Ticlopidine
DB00373 Timolol
DB01007 Tioconazole
DB00932 Tipranavir
DB08895 Tofacitinib
DB01124 Tolbutamide
DB01036 Tolterodine
DB00273 Topiramate
DB00214 Torasemide
DB05109 Trabectedin
DB00752 Tranylcypromine
DB00347 Trimethadione
DB00726 Trimipramine
DB00197 Troglitazone
DB01361 Troleandomycin
DB00580 Valdecoxib
DB00313 Valproic Acid
DB00285 Venlafaxine
DB00661 Verapamil
DB08828 Vismodegib
DB00582 Voriconazole
DB09068 Vortioxetine
DB00682 Warfarin
DB00549 Zafirlukast
DB00495 Zidovudine
DB00425 Zolpidem
DB00909 Zonisamide
GuidetoPHARMACOLOGYi1328
SwissLipidsiSLP:000001589

PTM databases

iPTMnetiP33261
PhosphoSitePlusiP33261

Polymorphism and mutation databases

BioMutaiCYP2C19
DMDMi60416369

Proteomic databases

PaxDbiP33261
PeptideAtlasiP33261
PRIDEiP33261
ProteomicsDBi54907

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		1557
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371321; ENSP00000360372; ENSG00000165841
GeneIDi1557
KEGGihsa:1557
UCSCiuc010qnz.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1557
DisGeNETi1557
EuPathDBiHostDB:ENSG00000165841.9

GeneCards: human genes, protein and diseases

More...GeneCardsi		CYP2C19
HGNCiHGNC:2621 CYP2C19
HPAiHPA015066
MalaCardsiCYP2C19
MIMi124020 gene
609535 phenotype
neXtProtiNX_P33261
Orphaneti413667 Antidepressant or antipsychotic toxicity or dose selection
240935 Resistance to clopidogrel
240921 Voriconazole toxicity
PharmGKBiPA124

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
HOGENOMiHOG000036992
HOVERGENiHBG015789
InParanoidiP33261
KOiK17721
OrthoDBiEOG091G0BT8
PhylomeDBiP33261
TreeFamiTF352043

Enzyme and pathway databases

BioCyciMetaCyc:HS09293-MONOMER
ReactomeiR-HSA-211981 Xenobiotics
R-HSA-211999 CYP2E1 reactions
R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
SABIO-RKiP33261

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CYP2C19

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1557

Protein Ontology

More...PROi		PR:P33261

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000165841 Expressed in 26 organ(s), highest expression level in right lobe of liver
CleanExiHS_CYP2C19
ExpressionAtlasiP33261 baseline and differential
GenevisibleiP33261 HS

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCP2CJ_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P33261
Secondary accession number(s): P33259
, Q8WZB1, Q8WZB2, Q9UCD4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: March 1, 2005
Last modified: December 5, 2018
This is version 179 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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