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UniProtKB - P33260 (CP2CI_HUMAN)

Entry version 186 (02 Jun 2021)
Sequence version 3 (07 Jun 2005)
Previous versions | rss
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Protein

Cytochrome P450 2C18

Gene

CYP2C18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

A cytochrome P450 monooxygenase involved in retinoid metabolism. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may modulate atRA signaling and clearance. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

hemeBy similarity

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=16 µM for all-trans-retinoate1 Publication
  1. Vmax=251 pmol/min/nmol enzyme toward all-trans-retinoate1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: retinol metabolism

This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi435Iron (heme axial ligand)By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P33260

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-211981, Xenobiotics

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P33260

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00912

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001875

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome P450 2C18 (EC:1.14.14.11 Publication)
Alternative name(s):
CYPIIC18
Cytochrome P450-6b/29c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYP2C181 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2620, CYP2C18

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601131, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P33260

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000108242.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1562

Open Targets

More...OpenTargetsi		ENSG00000108242

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA127

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P33260, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2408

Drug and drug target database

More...DrugBanki		DB08496, (R)-warfarin
DB14055, (S)-Warfarin
DB01424, Aminophenazone
DB01435, Antipyrine
DB00921, Buprenorphine
DB00349, Clobazam
DB01559, Clotiazepam
DB00531, Cyclophosphamide
DB00250, Dapsone
DB00829, Diazepam
DB00586, Diclofenac
DB09166, Etizolam
DB01181, Ifosfamide
DB00458, Imipramine
DB11757, Istradefylline
DB00448, Lansoprazole
DB00333, Methadone
DB07670, N,4-Dimethyl-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide
DB00338, Omeprazole
DB00082, Pegvisomant
DB00850, Perphenazine
DB01174, Phenobarbital
DB00252, Phenytoin
DB00818, Propofol
DB01124, Tolbutamide
DB00755, Tretinoin
DB00661, Verapamil
DB00682, Warfarin

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1327

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CYP2C18

Domain mapping of disease mutations (DMDM)

More...DMDMi		67476954

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000005170726 – 490Cytochrome P450 2C18Sequence analysisAdd BLAST465

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P33260

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P33260

PeptideAtlas

More...PeptideAtlasi		P33260

PRoteomics IDEntifications database

More...PRIDEi		P33260

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54905 [P33260-1]
54906 [P33260-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P33260

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P33260

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000108242, Expressed in jejunal mucosa and 99 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P33260, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000108242, Tissue enhanced (intestine, liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107938, 10 interactors

Protein interaction database and analysis system

More...IntActi		P33260, 6 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000285979

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P33260

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P33260, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P33260

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P33260

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0156, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162913

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001570_22_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P33260

Identification of Orthologs from Complete Genome Data

More...OMAi		HMAYNGR

Database of Orthologous Groups

More...OrthoDBi		1591226at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P33260

TreeFam database of animal gene trees

More...TreeFami		TF352043

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.630.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001128, Cyt_P450
IPR017972, Cyt_P450_CS
IPR002401, Cyt_P450_E_grp-I
IPR036396, Cyt_P450_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00067, p450, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00463, EP450I
PR00385, P450

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48264, SSF48264, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00086, CYTOCHROME_P450, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P33260-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPAVALVLC LSCLFLLSLW RQSSGRGRLP SGPTPLPIIG NILQLDVKDM 
        60         70         80         90        100
SKSLTNFSKV YGPVFTVYFG LKPIVVLHGY EAVKEALIDH GEEFSGRGSF 
       110        120        130        140        150
PVAEKVNKGL GILFSNGKRW KEIRRFCLMT LRNFGMGKRS IEDRVQEEAR 
       160        170        180        190        200
CLVEELRKTN ASPCDPTFIL GCAPCNVICS VIFHDRFDYK DQRFLNLMEK 
       210        220        230        240        250
FNENLRILSS PWIQVCNNFP ALIDYLPGSH NKIAENFAYI KSYVLERIKE 
       260        270        280        290        300
HQESLDMNSA RDFIDCFLIK MEQEKHNQQS EFTVESLIAT VTDMFGAGTE 
       310        320        330        340        350
TTSTTLRYGL LLLLKYPEVT AKVQEEIECV VGRNRSPCMQ DRSHMPYTDA 
       360        370        380        390        400
VVHEIQRYID LLPTNLPHAV TCDVKFKNYL IPKGTTIITS LTSVLHNDKE 
       410        420        430        440        450
FPNPEMFDPG HFLDKSGNFK KSDYFMPFSA GKRMCMGEGL ARMELFLFLT 
       460        470        480        490
TILQNFNLKS QVDPKDIDIT PIANAFGRVP PLYQLCFIPV
Length:490
Mass (Da):55,711
Last modified:June 7, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC933CF31F078FD1E
GO
Isoform 2 (identifier: P33260-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     214-272: Missing.

Show »
Length:431
Mass (Da):48,805
Checksum:i0FF49ECE8F830455
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_001254385T → M2 PublicationsCorresponds to variant dbSNP:rs1126545Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042520214 – 272Missing in isoform 2. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M61853 mRNA No translation available.
M61856 mRNA Translation: AAB59356.1
L16876 L16874 Genomic DNA Translation: AAA02630.1
AK313403 mRNA Translation: BAG36199.1
AL583836 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50024.1
BC069666 mRNA Translation: AAH69666.1
BC096257 mRNA Translation: AAH96257.1
BC096258 mRNA Translation: AAH96258.1
BC096260 mRNA Translation: AAH96260.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44460.1 [P33260-2]
CCDS7435.1 [P33260-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A61269

NCBI Reference Sequences

More...RefSeqi		NP_000763.1, NM_000772.2 [P33260-1]
NP_001122397.1, NM_001128925.1 [P33260-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000285979; ENSP00000285979; ENSG00000108242 [P33260-1]
ENST00000339022; ENSP00000341293; ENSG00000108242 [P33260-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1562

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1562

UCSC genome browser

More...UCSCi		uc001kjv.6, human [P33260-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61853 mRNA No translation available.
M61856 mRNA Translation: AAB59356.1
L16876 L16874 Genomic DNA Translation: AAA02630.1
AK313403 mRNA Translation: BAG36199.1
AL583836 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50024.1
BC069666 mRNA Translation: AAH69666.1
BC096257 mRNA Translation: AAH96257.1
BC096258 mRNA Translation: AAH96258.1
BC096260 mRNA Translation: AAH96260.1
CCDSiCCDS44460.1 [P33260-2]
CCDS7435.1 [P33260-1]
PIRiA61269
RefSeqiNP_000763.1, NM_000772.2 [P33260-1]
NP_001122397.1, NM_001128925.1 [P33260-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CIKX-ray1.75C72-80[»]
2H6PX-ray1.90C72-80[»]
SMRiP33260
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107938, 10 interactors
IntActiP33260, 6 interactors
STRINGi9606.ENSP00000285979

Chemistry databases

BindingDBiP33260
ChEMBLiCHEMBL2408
DrugBankiDB08496, (R)-warfarin
DB14055, (S)-Warfarin
DB01424, Aminophenazone
DB01435, Antipyrine
DB00921, Buprenorphine
DB00349, Clobazam
DB01559, Clotiazepam
DB00531, Cyclophosphamide
DB00250, Dapsone
DB00829, Diazepam
DB00586, Diclofenac
DB09166, Etizolam
DB01181, Ifosfamide
DB00458, Imipramine
DB11757, Istradefylline
DB00448, Lansoprazole
DB00333, Methadone
DB07670, N,4-Dimethyl-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide
DB00338, Omeprazole
DB00082, Pegvisomant
DB00850, Perphenazine
DB01174, Phenobarbital
DB00252, Phenytoin
DB00818, Propofol
DB01124, Tolbutamide
DB00755, Tretinoin
DB00661, Verapamil
DB00682, Warfarin
GuidetoPHARMACOLOGYi1327
SwissLipidsiSLP:000001875

PTM databases

iPTMnetiP33260
PhosphoSitePlusiP33260

Genetic variation databases

BioMutaiCYP2C18
DMDMi67476954

Proteomic databases

MassIVEiP33260
PaxDbiP33260
PeptideAtlasiP33260
PRIDEiP33260
ProteomicsDBi54905 [P33260-1]
54906 [P33260-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30592, 109 antibodies

The DNASU plasmid repository

More...DNASUi		1562

Genome annotation databases

EnsembliENST00000285979; ENSP00000285979; ENSG00000108242 [P33260-1]
ENST00000339022; ENSP00000341293; ENSG00000108242 [P33260-2]
GeneIDi1562
KEGGihsa:1562
UCSCiuc001kjv.6, human [P33260-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1562
DisGeNETi1562

GeneCards: human genes, protein and diseases

More...GeneCardsi		CYP2C18
HGNCiHGNC:2620, CYP2C18
HPAiENSG00000108242, Tissue enhanced (intestine, liver)
MIMi601131, gene
neXtProtiNX_P33260
OpenTargetsiENSG00000108242
PharmGKBiPA127
VEuPathDBiHostDB:ENSG00000108242.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0156, Eukaryota
GeneTreeiENSGT00940000162913
HOGENOMiCLU_001570_22_0_1
InParanoidiP33260
OMAiHMAYNGR
OrthoDBi1591226at2759
PhylomeDBiP33260
TreeFamiTF352043

Enzyme and pathway databases

UniPathwayiUPA00912
PathwayCommonsiP33260
ReactomeiR-HSA-211981, Xenobiotics
SABIO-RKiP33260

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1562, 11 hits in 981 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CYP2C18, human
EvolutionaryTraceiP33260

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CYP2C18

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1562
PharosiP33260, Tchem

Protein Ontology

More...PROi		PR:P33260
RNActiP33260, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000108242, Expressed in jejunal mucosa and 99 other tissues
GenevisibleiP33260, HS

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128, Cyt_P450
IPR017972, Cyt_P450_CS
IPR002401, Cyt_P450_E_grp-I
IPR036396, Cyt_P450_sf
PfamiView protein in Pfam
PF00067, p450, 1 hit
PRINTSiPR00463, EP450I
PR00385, P450
SUPFAMiSSF48264, SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086, CYTOCHROME_P450, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCP2CI_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P33260
Secondary accession number(s): B2R8K2
, Q16703, Q16751, Q4VAT5, Q6GRG1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 7, 2005
Last modified: June 2, 2021
This is version 186 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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