UniProtKB - P33260 (CP2CI_HUMAN)
Protein
Cytochrome P450 2C18
Gene
CYP2C18
Organism
Homo sapiens (Human)
Status
Functioni
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activityi
- an organic molecule + O2 + reduced [NADPH—hemoprotein reductase] = an alcohol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]EC:1.14.14.1
Cofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 435 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- arachidonic acid epoxygenase activity Source: GO_Central
- aromatase activity Source: UniProtKB-EC
- heme binding Source: GO_Central
- iron ion binding Source: InterPro
- monooxygenase activity Source: ProtInc
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: GO_Central
- oxygen binding Source: ProtInc
- retinoic acid 4-hydroxylase activity Source: UniProtKB
- steroid hydroxylase activity Source: GO_Central
GO - Biological processi
- epoxygenase P450 pathway Source: GO_Central
- exogenous drug catabolic process Source: GO_Central
- organic acid metabolic process Source: GO_Central
- oxidation-reduction process Source: GO_Central
- retinoic acid metabolic process Source: UniProtKB
- xenobiotic metabolic process Source: GO_Central
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | P33260 |
Reactomei | R-HSA-211981, Xenobiotics |
SABIO-RKi | P33260 |
Chemistry databases
SwissLipidsi | SLP:000001875 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome P450 2C18 (EC:1.14.14.1)Alternative name(s): CYPIIC18 Cytochrome P450-6b/29c |
Gene namesi | Name:CYP2C18 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000108242.12 |
HGNCi | HGNC:2620, CYP2C18 |
MIMi | 601131, gene |
neXtProti | NX_P33260 |
Subcellular locationi
Endoplasmic reticulum
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: Reactome
Other locations
- cytoplasm Source: GO_Central
- intracellular membrane-bounded organelle Source: GO_Central
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 1562 |
OpenTargetsi | ENSG00000108242 |
PharmGKBi | PA127 |
Miscellaneous databases
Pharosi | P33260, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2408 |
DrugBanki | DB08496, (R)-warfarin DB14055, (S)-Warfarin DB01424, Aminophenazone DB01435, Antipyrine DB00921, Buprenorphine DB00349, Clobazam DB01559, Clotiazepam DB00531, Cyclophosphamide DB00250, Dapsone DB00829, Diazepam DB00586, Diclofenac DB09166, Etizolam DB01181, Ifosfamide DB00458, Imipramine DB11757, Istradefylline DB00448, Lansoprazole DB00333, Methadone DB07670, N,4-Dimethyl-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide DB00338, Omeprazole DB00082, Pegvisomant DB00850, Perphenazine DB01174, Phenobarbital DB00252, Phenytoin DB00818, Propofol DB01124, Tolbutamide DB00755, Tretinoin DB00661, Verapamil DB00682, Warfarin |
GuidetoPHARMACOLOGYi | 1327 |
Polymorphism and mutation databases
BioMutai | CYP2C18 |
DMDMi | 67476954 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051707 | 1 – 490 | Cytochrome P450 2C18Add BLAST | 490 |
Proteomic databases
MassIVEi | P33260 |
PaxDbi | P33260 |
PeptideAtlasi | P33260 |
PRIDEi | P33260 |
ProteomicsDBi | 54905 [P33260-1] 54906 [P33260-2] |
PTM databases
iPTMneti | P33260 |
PhosphoSitePlusi | P33260 |
Expressioni
Inductioni
P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
Gene expression databases
Bgeei | ENSG00000108242, Expressed in jejunal mucosa and 98 other tissues |
Genevisiblei | P33260, HS |
Organism-specific databases
HPAi | ENSG00000108242, Tissue enhanced (intestine, liver) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 107938, 10 interactors |
IntActi | P33260, 6 interactors |
STRINGi | 9606.ENSP00000285979 |
Chemistry databases
BindingDBi | P33260 |
Miscellaneous databases
RNActi | P33260, protein |
Structurei
3D structure databases
SMRi | P33260 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P33260 |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0156, Eukaryota |
GeneTreei | ENSGT00940000162913 |
HOGENOMi | CLU_001570_22_0_1 |
InParanoidi | P33260 |
OMAi | HMAYNGR |
OrthoDBi | 1591226at2759 |
PhylomeDBi | P33260 |
TreeFami | TF352043 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: P33260-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDPAVALVLC LSCLFLLSLW RQSSGRGRLP SGPTPLPIIG NILQLDVKDM
60 70 80 90 100
SKSLTNFSKV YGPVFTVYFG LKPIVVLHGY EAVKEALIDH GEEFSGRGSF
110 120 130 140 150
PVAEKVNKGL GILFSNGKRW KEIRRFCLMT LRNFGMGKRS IEDRVQEEAR
160 170 180 190 200
CLVEELRKTN ASPCDPTFIL GCAPCNVICS VIFHDRFDYK DQRFLNLMEK
210 220 230 240 250
FNENLRILSS PWIQVCNNFP ALIDYLPGSH NKIAENFAYI KSYVLERIKE
260 270 280 290 300
HQESLDMNSA RDFIDCFLIK MEQEKHNQQS EFTVESLIAT VTDMFGAGTE
310 320 330 340 350
TTSTTLRYGL LLLLKYPEVT AKVQEEIECV VGRNRSPCMQ DRSHMPYTDA
360 370 380 390 400
VVHEIQRYID LLPTNLPHAV TCDVKFKNYL IPKGTTIITS LTSVLHNDKE
410 420 430 440 450
FPNPEMFDPG HFLDKSGNFK KSDYFMPFSA GKRMCMGEGL ARMELFLFLT
460 470 480 490
TILQNFNLKS QVDPKDIDIT PIANAFGRVP PLYQLCFIPV
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_001254 | 385 | T → M2 PublicationsCorresponds to variant dbSNP:rs1126545Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042520 | 214 – 272 | Missing in isoform 2. 1 PublicationAdd BLAST | 59 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M61853 mRNA No translation available. M61856 mRNA Translation: AAB59356.1 L16876 , L16871, L16872, L16869, L16870, L16875, L16873, L16874 Genomic DNA Translation: AAA02630.1 AK313403 mRNA Translation: BAG36199.1 AL583836 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW50024.1 BC069666 mRNA Translation: AAH69666.1 BC096257 mRNA Translation: AAH96257.1 BC096258 mRNA Translation: AAH96258.1 BC096260 mRNA Translation: AAH96260.1 |
CCDSi | CCDS44460.1 [P33260-2] CCDS7435.1 [P33260-1] |
PIRi | A61269 |
RefSeqi | NP_000763.1, NM_000772.2 [P33260-1] NP_001122397.1, NM_001128925.1 [P33260-2] |
Genome annotation databases
Ensembli | ENST00000285979; ENSP00000285979; ENSG00000108242 [P33260-1] ENST00000339022; ENSP00000341293; ENSG00000108242 [P33260-2] |
GeneIDi | 1562 |
KEGGi | hsa:1562 |
UCSCi | uc001kjv.6, human [P33260-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M61853 mRNA No translation available. M61856 mRNA Translation: AAB59356.1 L16876 , L16871, L16872, L16869, L16870, L16875, L16873, L16874 Genomic DNA Translation: AAA02630.1 AK313403 mRNA Translation: BAG36199.1 AL583836 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW50024.1 BC069666 mRNA Translation: AAH69666.1 BC096257 mRNA Translation: AAH96257.1 BC096258 mRNA Translation: AAH96258.1 BC096260 mRNA Translation: AAH96260.1 |
CCDSi | CCDS44460.1 [P33260-2] CCDS7435.1 [P33260-1] |
PIRi | A61269 |
RefSeqi | NP_000763.1, NM_000772.2 [P33260-1] NP_001122397.1, NM_001128925.1 [P33260-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CIK | X-ray | 1.75 | C | 72-80 | [»] | |
2H6P | X-ray | 1.90 | C | 72-80 | [»] | |
SMRi | P33260 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107938, 10 interactors |
IntActi | P33260, 6 interactors |
STRINGi | 9606.ENSP00000285979 |
Chemistry databases
BindingDBi | P33260 |
ChEMBLi | CHEMBL2408 |
DrugBanki | DB08496, (R)-warfarin DB14055, (S)-Warfarin DB01424, Aminophenazone DB01435, Antipyrine DB00921, Buprenorphine DB00349, Clobazam DB01559, Clotiazepam DB00531, Cyclophosphamide DB00250, Dapsone DB00829, Diazepam DB00586, Diclofenac DB09166, Etizolam DB01181, Ifosfamide DB00458, Imipramine DB11757, Istradefylline DB00448, Lansoprazole DB00333, Methadone DB07670, N,4-Dimethyl-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide DB00338, Omeprazole DB00082, Pegvisomant DB00850, Perphenazine DB01174, Phenobarbital DB00252, Phenytoin DB00818, Propofol DB01124, Tolbutamide DB00755, Tretinoin DB00661, Verapamil DB00682, Warfarin |
GuidetoPHARMACOLOGYi | 1327 |
SwissLipidsi | SLP:000001875 |
PTM databases
iPTMneti | P33260 |
PhosphoSitePlusi | P33260 |
Polymorphism and mutation databases
BioMutai | CYP2C18 |
DMDMi | 67476954 |
Proteomic databases
MassIVEi | P33260 |
PaxDbi | P33260 |
PeptideAtlasi | P33260 |
PRIDEi | P33260 |
ProteomicsDBi | 54905 [P33260-1] 54906 [P33260-2] |
Protocols and materials databases
Antibodypediai | 30592, 102 antibodies |
DNASUi | 1562 |
Genome annotation databases
Ensembli | ENST00000285979; ENSP00000285979; ENSG00000108242 [P33260-1] ENST00000339022; ENSP00000341293; ENSG00000108242 [P33260-2] |
GeneIDi | 1562 |
KEGGi | hsa:1562 |
UCSCi | uc001kjv.6, human [P33260-1] |
Organism-specific databases
CTDi | 1562 |
DisGeNETi | 1562 |
EuPathDBi | HostDB:ENSG00000108242.12 |
GeneCardsi | CYP2C18 |
HGNCi | HGNC:2620, CYP2C18 |
HPAi | ENSG00000108242, Tissue enhanced (intestine, liver) |
MIMi | 601131, gene |
neXtProti | NX_P33260 |
OpenTargetsi | ENSG00000108242 |
PharmGKBi | PA127 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0156, Eukaryota |
GeneTreei | ENSGT00940000162913 |
HOGENOMi | CLU_001570_22_0_1 |
InParanoidi | P33260 |
OMAi | HMAYNGR |
OrthoDBi | 1591226at2759 |
PhylomeDBi | P33260 |
TreeFami | TF352043 |
Enzyme and pathway databases
PathwayCommonsi | P33260 |
Reactomei | R-HSA-211981, Xenobiotics |
SABIO-RKi | P33260 |
Miscellaneous databases
BioGRID-ORCSi | 1562, 9 hits in 839 CRISPR screens |
ChiTaRSi | CYP2C18, human |
EvolutionaryTracei | P33260 |
GeneWikii | CYP2C18 |
GenomeRNAii | 1562 |
Pharosi | P33260, Tchem |
PROi | PR:P33260 |
RNActi | P33260, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000108242, Expressed in jejunal mucosa and 98 other tissues |
Genevisiblei | P33260, HS |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CP2CI_HUMAN | |
Accessioni | P33260Primary (citable) accession number: P33260 Secondary accession number(s): B2R8K2 Q6GRG1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | June 7, 2005 | |
Last modified: | December 2, 2020 | |
This is version 183 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations