UniProtKB - P33260 (CP2CI_HUMAN)

BLAST

>sp|P33260|CP2CI_HUMAN Cytochrome P450 2C18 OS=Homo sapiens OX=9606 GN=CYP2C18 PE=1 SV=3
MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV
YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW
KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS
VIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYI
KSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTE
TTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID
LLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFK
KSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP
PLYQLCFIPV

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History
Entry version 169 (07 Nov 2018)
Sequence version 3 (07 Jun 2005)
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Protein

Cytochrome P450 2C18

Gene

CYP2C18

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityⁱ

RH + [reduced NADPH--hemoprotein reductase] + O₂ = ROH + [oxidized NADPH--hemoprotein reductase] + H₂O.

Cofactorⁱ

hemeBy similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Metal bindingⁱ	435	Iron (heme axial ligand)By similarity		1

GO - Molecular functionⁱ

arachidonic acid epoxygenase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
aromatase activity Source: UniProtKB-EC
heme binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
iron ion binding Source: InterPro
monooxygenase activity Source: Reactome
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
oxygen binding
Source: ProtInc
Traceable author statementⁱ
- 8110777
steroid hydroxylase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

epoxygenase P450 pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
exogenous drug catabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
organic acid metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
oxidation-reduction process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
xenobiotic metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Monooxygenase, Oxidoreductase
Ligand	Heme, Iron, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-211981 Xenobiotics
SABIO-RKⁱ	P33260

Chemistry databases

SwissLipidsⁱ	SLP:000001875

SwissLipidsⁱ

SLP:000001875

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cytochrome P450 2C18 (EC:1.14.14.1) Alternative name(s): CYPIIC18 Cytochrome P450-6b/29c
Gene namesⁱ	Name:CYP2C18
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000108242.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2620 CYP2C18
MIMⁱ	601131 gene
neXtProtⁱ	NX_P33260

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1562
Open Targets More...OpenTargetsⁱ	ENSG00000108242
PharmGKBⁱ	PA127

Chemistry databases

ChEMBLⁱ	CHEMBL2408
Drug and drug target database More...DrugBankⁱ	DB07670 4-METHYL-N-METHYL-N-(2-PHENYL-2H-PYRAZOL-3-YL)BENZENESULFONAMIDE DB01424 Aminophenazone DB01435 Antipyrine DB00921 Buprenorphine DB00349 Clobazam DB01559 Clotiazepam DB00531 Cyclophosphamide DB00250 Dapsone DB01151 Desipramine DB00829 Diazepam DB00586 Diclofenac DB01075 Diphenhydramine DB01181 Ifosfamide DB00458 Imipramine DB00448 Lansoprazole DB00281 Lidocaine DB00333 Methadone DB00338 Omeprazole DB00082 Pegvisomant DB00850 Perphenazine DB01174 Phenobarbital DB00252 Phenytoin DB00818 Propofol DB01124 Tolbutamide DB00755 Tretinoin DB01361 Troleandomycin DB00313 Valproic Acid DB00661 Verapamil DB06684 Vilazodone DB00682 Warfarin
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1327

Polymorphism and mutation databases

BioMutaⁱ	CYP2C18
DMDMⁱ	67476954

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051707	1 – 490	Cytochrome P450 2C18Add BLAST		490

Proteomic databases

PaxDbⁱ	P33260
PeptideAtlas More...PeptideAtlasⁱ	P33260
PRIDEⁱ	P33260
ProteomicsDBⁱ	54905 54906 [P33260-2]

PTM databases

iPTMnetⁱ	P33260
PhosphoSitePlusⁱ	P33260

Expressionⁱ

Inductionⁱ

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

Bgeeⁱ	ENSG00000108242 Expressed in 80 organ(s), highest expression level in jejunal mucosa
CleanExⁱ	HS_CYP2C18
Genevisibleⁱ	P33260 HS

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	107938, 10 interactors
IntActⁱ	P33260, 3 interactors
STRINGⁱ	9606.ENSP00000285979

Chemistry databases

BindingDBⁱ

P33260

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P33260
SMRⁱ	P33260
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P33260

EvolutionaryTraceⁱ

P33260

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0156 Eukaryota COG2124 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137861
HOGENOMⁱ	HOG000036992
HOVERGENⁱ	HBG015789
InParanoidⁱ	P33260
KEGG Orthology (KO) More...KOⁱ	K17720
OMAⁱ	YTNGLNM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BT8
PhylomeDBⁱ	P33260
TreeFamⁱ	TF352043

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR036396 Cyt_P450_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00463 EP450I PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P33260-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPAVALVLC LSCLFLLSLW RQSSGRGRLP SGPTPLPIIG NILQLDVKDM 
        60         70         80         90        100
SKSLTNFSKV YGPVFTVYFG LKPIVVLHGY EAVKEALIDH GEEFSGRGSF 
       110        120        130        140        150
PVAEKVNKGL GILFSNGKRW KEIRRFCLMT LRNFGMGKRS IEDRVQEEAR 
       160        170        180        190        200
CLVEELRKTN ASPCDPTFIL GCAPCNVICS VIFHDRFDYK DQRFLNLMEK 
       210        220        230        240        250
FNENLRILSS PWIQVCNNFP ALIDYLPGSH NKIAENFAYI KSYVLERIKE 
       260        270        280        290        300
HQESLDMNSA RDFIDCFLIK MEQEKHNQQS EFTVESLIAT VTDMFGAGTE 
       310        320        330        340        350
TTSTTLRYGL LLLLKYPEVT AKVQEEIECV VGRNRSPCMQ DRSHMPYTDA 
       360        370        380        390        400
VVHEIQRYID LLPTNLPHAV TCDVKFKNYL IPKGTTIITS LTSVLHNDKE 
       410        420        430        440        450
FPNPEMFDPG HFLDKSGNFK KSDYFMPFSA GKRMCMGEGL ARMELFLFLT 
       460        470        480        490
TILQNFNLKS QVDPKDIDIT PIANAFGRVP PLYQLCFIPV

Length:490

Mass (Da):55,711

Last modified:June 7, 2005 - v3

Checksum:ⁱC933CF31F078FD1E

Isoform 2 (identifier: P33260-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
214-272: Missing.

« Hide

        10         20         30         40         50
MDPAVALVLC LSCLFLLSLW RQSSGRGRLP SGPTPLPIIG NILQLDVKDM 
        60         70         80         90        100
SKSLTNFSKV YGPVFTVYFG LKPIVVLHGY EAVKEALIDH GEEFSGRGSF 
       110        120        130        140        150
PVAEKVNKGL GILFSNGKRW KEIRRFCLMT LRNFGMGKRS IEDRVQEEAR 
       160        170        180        190        200
CLVEELRKTN ASPCDPTFIL GCAPCNVICS VIFHDRFDYK DQRFLNLMEK 
       210        220        230        240        250
FNENLRILSS PWIQEKHNQQ SEFTVESLIA TVTDMFGAGT ETTSTTLRYG 
       260        270        280        290        300
LLLLLKYPEV TAKVQEEIEC VVGRNRSPCM QDRSHMPYTD AVVHEIQRYI 
       310        320        330        340        350
DLLPTNLPHA VTCDVKFKNY LIPKGTTIIT SLTSVLHNDK EFPNPEMFDP 
       360        370        380        390        400
GHFLDKSGNF KKSDYFMPFS AGKRMCMGEG LARMELFLFL TTILQNFNLK 
       410        420        430 
SQVDPKDIDI TPIANAFGRV PPLYQLCFIP V

Note: No experimental confirmation available.

Show »

Length:431

Mass (Da):48,805

Checksum:ⁱ0FF49ECE8F830455

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_001254	385	T → M2 PublicationsCorresponds to variant dbSNP:rs1126545Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_042520	214 – 272	Missing in isoform 2. 1 PublicationAdd BLAST		59

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M61853 mRNA No translation available. M61856 mRNA Translation: AAB59356.1 L16876 L16874 Genomic DNA Translation: AAA02630.1 AK313403 mRNA Translation: BAG36199.1 AL583836 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW50024.1 BC069666 mRNA Translation: AAH69666.1 BC096257 mRNA Translation: AAH96257.1 BC096258 mRNA Translation: AAH96258.1 BC096260 mRNA Translation: AAH96260.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44460.1 [P33260-2] CCDS7435.1 [P33260-1]
PIRⁱ	A61269
NCBI Reference Sequences More...RefSeqⁱ	NP_000763.1, NM_000772.2 [P33260-1] NP_001122397.1, NM_001128925.1 [P33260-2]
UniGeneⁱ	Hs.511872

Genome annotation databases

Ensemblⁱ	ENST00000285979; ENSP00000285979; ENSG00000108242 [P33260-1] ENST00000339022; ENSP00000341293; ENSG00000108242 [P33260-2]
GeneIDⁱ	1562
KEGGⁱ	hsa:1562
UCSC genome browser More...UCSCⁱ	uc001kjv.6 human [P33260-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P33260	Unspecific monooxygenase (Fragment)		HUMAN		56	UniRef100_P33260

Protein	Similar proteins		Species	Score	Length	Source
P33260	Unspecific monooxygenase (Fragment)		HUMAN		56	UniRef90_P33260
Uncharacterized protein		AOTNA		499
Uncharacterized protein		CALJA		490
Uncharacterized protein		PAPAN		490
Cytochrome P450 2C18		MACFA		490
+15
P33260-2	Uncharacterized protein		AOTNA		440	UniRef90_P33260-2
Uncharacterized protein		PAPAN		431
Uncharacterized protein		MACFA		431
Uncharacterized protein		MACMU		431
Uncharacterized protein		CERAT		431
+5

Protein	Similar proteins		Species	Score	Length	Source
P33260	Cytochrome P450 2C9	)	HUMAN		490	UniRef50_P11712
Cytochrome P450 2C55		MOUSE		490
Cytochrome P450 2C27		MESAU		490
Cytochrome P450 2C20		MACFA		490
Cytochrome P450 2C11		RAT		500
+311
P33260-2	Isoform 2 of Cytochrome P450 2C50		MOUSE		431	UniRef50_Q91X77-2
cytochrome P450 2C18-like isoform X2		TARSY		431
Cytochrome P450 2C50		CRIGR		474
cytochrome P450 2C23-like		URSMA		443
cytochrome P450 2C21-like isoform X2		ERIEU		431
+249

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M61853 mRNA No translation available. M61856 mRNA Translation: AAB59356.1 L16876 L16874 Genomic DNA Translation: AAA02630.1 AK313403 mRNA Translation: BAG36199.1 AL583836 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW50024.1 BC069666 mRNA Translation: AAH69666.1 BC096257 mRNA Translation: AAH96257.1 BC096258 mRNA Translation: AAH96258.1 BC096260 mRNA Translation: AAH96260.1
CCDSⁱ	CCDS44460.1 [P33260-2] CCDS7435.1 [P33260-1]
PIRⁱ	A61269
RefSeqⁱ	NP_000763.1, NM_000772.2 [P33260-1] NP_001122397.1, NM_001128925.1 [P33260-2]
UniGeneⁱ	Hs.511872

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2CIK	X-ray	1.75	C	72-80	[»]
	2H6P	X-ray	1.90	C	72-80	[»]
ProteinModelPortalⁱ	P33260
SMRⁱ	P33260
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107938, 10 interactors
IntActⁱ	P33260, 3 interactors
STRINGⁱ	9606.ENSP00000285979

Chemistry databases

BindingDBⁱ	P33260
ChEMBLⁱ	CHEMBL2408
DrugBankⁱ	DB07670 4-METHYL-N-METHYL-N-(2-PHENYL-2H-PYRAZOL-3-YL)BENZENESULFONAMIDE DB01424 Aminophenazone DB01435 Antipyrine DB00921 Buprenorphine DB00349 Clobazam DB01559 Clotiazepam DB00531 Cyclophosphamide DB00250 Dapsone DB01151 Desipramine DB00829 Diazepam DB00586 Diclofenac DB01075 Diphenhydramine DB01181 Ifosfamide DB00458 Imipramine DB00448 Lansoprazole DB00281 Lidocaine DB00333 Methadone DB00338 Omeprazole DB00082 Pegvisomant DB00850 Perphenazine DB01174 Phenobarbital DB00252 Phenytoin DB00818 Propofol DB01124 Tolbutamide DB00755 Tretinoin DB01361 Troleandomycin DB00313 Valproic Acid DB00661 Verapamil DB06684 Vilazodone DB00682 Warfarin
GuidetoPHARMACOLOGYⁱ	1327
SwissLipidsⁱ	SLP:000001875

PTM databases

iPTMnetⁱ	P33260
PhosphoSitePlusⁱ	P33260

Polymorphism and mutation databases

BioMutaⁱ	CYP2C18
DMDMⁱ	67476954

Proteomic databases

PaxDbⁱ	P33260
PeptideAtlasⁱ	P33260
PRIDEⁱ	P33260
ProteomicsDBⁱ	54905 54906 [P33260-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1562
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000285979; ENSP00000285979; ENSG00000108242 [P33260-1] ENST00000339022; ENSP00000341293; ENSG00000108242 [P33260-2]
GeneIDⁱ	1562
KEGGⁱ	hsa:1562
UCSCⁱ	uc001kjv.6 human [P33260-1]

Organism-specific databases

CTDⁱ	1562
DisGeNETⁱ	1562
EuPathDBⁱ	HostDB:ENSG00000108242.12
GeneCardsⁱ	CYP2C18
HGNCⁱ	HGNC:2620 CYP2C18
MIMⁱ	601131 gene
neXtProtⁱ	NX_P33260
OpenTargetsⁱ	ENSG00000108242
PharmGKBⁱ	PA127
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0156 Eukaryota COG2124 LUCA
GeneTreeⁱ	ENSGT00880000137861
HOGENOMⁱ	HOG000036992
HOVERGENⁱ	HBG015789
InParanoidⁱ	P33260
KOⁱ	K17720
OMAⁱ	YTNGLNM
OrthoDBⁱ	EOG091G0BT8
PhylomeDBⁱ	P33260
TreeFamⁱ	TF352043

Enzyme and pathway databases

Reactomeⁱ	R-HSA-211981 Xenobiotics
SABIO-RKⁱ	P33260

Miscellaneous databases

ChiTaRSⁱ	CYP2C18 human
EvolutionaryTraceⁱ	P33260
GeneWikiⁱ	CYP2C18
GenomeRNAiⁱ	1562
Protein Ontology More...PROⁱ	PR:P33260
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000108242 Expressed in 80 organ(s), highest expression level in jejunal mucosa
CleanExⁱ	HS_CYP2C18
Genevisibleⁱ	P33260 HS

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR036396 Cyt_P450_sf
Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00463 EP450I PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CP2CI_HUMAN
Accessionⁱ	P33260Primary (citable) accession number: P33260 Secondary accession number(s): B2R8K2 , Q16703, Q16751, Q4VAT5, Q6GRG1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
	Last sequence update:	June 7, 2005
	Last modified:	November 7, 2018
	This is version 169 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

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UniProtKB - P33260 (CP2CI_HUMAN)

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Cytochrome P450 2C18

CYP2C18

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ