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Protein

Squalene--hopene cyclase

Gene

shc

Organism
Alicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC 27009 / DSM 446 / JCM 5260 / NBRC 15652 / NCIMB 11725 / NRRL B-14509 / 104-1A) (Bacillus acidocaldarius)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the cyclization of squalene into hopene.

Catalytic activityi

Squalene = hop-22(29)-ene.
Hopan-22-ol = squalene + H2O.

Pathwayi: hopanoid biosynthesis

This protein is involved in the pathway hopanoid biosynthesis, which is part of Secondary metabolite biosynthesis.
View all proteins of this organism that are known to be involved in the pathway hopanoid biosynthesis and in Secondary metabolite biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Lyase

Enzyme and pathway databases

BioCyciAACI521098:G1GFZ-2471-MONOMER
MetaCyc:MONOMER-17503
BRENDAi5.4.99.17 243
SABIO-RKiP33247
UniPathwayiUPA00337

Names & Taxonomyi

Protein namesi
Recommended name:
Squalene--hopene cyclase (EC:4.2.1.129, EC:5.4.99.17)
Alternative name(s):
Squalene--hopanol cyclase
Gene namesi
Name:shc
Ordered Locus Names:Aaci_2443
OrganismiAlicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC 27009 / DSM 446 / JCM 5260 / NBRC 15652 / NCIMB 11725 / NRRL B-14509 / 104-1A) (Bacillus acidocaldarius)
Taxonomic identifieri521098 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesAlicyclobacillaceaeAlicyclobacillus
Proteomesi
  • UP000001917 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3569
DrugBankiDB02139 (2e)-N-Allyl-4-{[3-(4-Bromophenyl)-5-Fluoro-1-Methyl-1h-Indazol-6-Yl]Oxy}-N-Methyl-2-Buten-1-Amine
DB08458 (4-BROMOPHENYL)[4-({(2E)-4-[CYCLOPROPYL(METHYL)AMINO]BUT-2-ENYL}OXY)PHENYL]METHANONE
DB04233 (Hydroxyethyloxy)Tri(Ethyloxy)Octane
DB03771 Allyl-{4-[3-(4-Bromo-Phenyl)-Benzofuran-6-Yloxy]-but-2-Enyl}-Methyl-Amine
DB03888 Allyl-{6-[3-(4-Bromo-Phenyl)-1-Methyl-1h-Indazol-6-Yl]Oxy}Hexyl)-N-Methylamine
DB02339 Allyl-{6-[3-(4-Bromo-Phenyl)-Benzofuran-6-Yloxy]-Hexyl-}-Methyl-Amin
DB04147 Lauryl Dimethylamine-N-Oxide
DB03748 Methyl-[4-(4-Piperidine-1-Ylmethyl-Phenyl)-Cyclohexyl]-Carbaminic Acid-(4-Chlorophenyl)-Ester

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000726502 – 631Squalene--hopene cyclaseAdd BLAST630

Proteomic databases

PRIDEiP33247

Interactioni

Protein-protein interaction databases

STRINGi521098.Aaci_2443

Chemistry databases

BindingDBiP33247

Structurei

Secondary structure

1631
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 25Combined sources16
Beta strandi28 – 30Combined sources3
Helixi41 – 52Combined sources12
Helixi58 – 71Combined sources14
Beta strandi79 – 81Combined sources3
Helixi88 – 101Combined sources14
Beta strandi105 – 107Combined sources3
Helixi108 – 119Combined sources12
Helixi123 – 125Combined sources3
Helixi128 – 136Combined sources9
Helixi142 – 144Combined sources3
Helixi150 – 154Combined sources5
Beta strandi157 – 159Combined sources3
Helixi163 – 165Combined sources3
Helixi168 – 183Combined sources16
Helixi191 – 193Combined sources3
Helixi196 – 199Combined sources4
Beta strandi210 – 212Combined sources3
Helixi216 – 230Combined sources15
Helixi237 – 251Combined sources15
Beta strandi256 – 258Combined sources3
Helixi262 – 274Combined sources13
Helixi281 – 288Combined sources8
Helixi289 – 293Combined sources5
Beta strandi294 – 296Combined sources3
Turni298 – 300Combined sources3
Beta strandi302 – 304Combined sources3
Helixi310 – 323Combined sources14
Helixi331 – 342Combined sources12
Helixi350 – 353Combined sources4
Beta strandi365 – 368Combined sources4
Helixi375 – 385Combined sources11
Helixi393 – 409Combined sources17
Beta strandi415 – 417Combined sources3
Beta strandi419 – 423Combined sources5
Helixi428 – 431Combined sources4
Beta strandi432 – 434Combined sources3
Beta strandi436 – 438Combined sources3
Helixi446 – 457Combined sources12
Turni458 – 460Combined sources3
Beta strandi463 – 465Combined sources3
Helixi466 – 478Combined sources13
Beta strandi488 – 492Combined sources5
Helixi493 – 506Combined sources14
Helixi514 – 525Combined sources12
Helixi537 – 540Combined sources4
Helixi543 – 545Combined sources3
Beta strandi549 – 551Combined sources3
Helixi553 – 565Combined sources13
Beta strandi569 – 571Combined sources3
Helixi572 – 584Combined sources13
Beta strandi587 – 589Combined sources3
Beta strandi598 – 601Combined sources4
Turni602 – 604Combined sources3
Beta strandi605 – 609Combined sources5
Helixi612 – 629Combined sources18

3D structure databases

ProteinModelPortaliP33247
SMRiP33247
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP33247

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati15 – 56PFTB 1Add BLAST42
Repeati61 – 102PFTB 2Add BLAST42
Repeati241 – 282PFTB 3Add BLAST42
Repeati400 – 441PFTB 4Add BLAST42
Repeati468 – 508PFTB 5Add BLAST41
Repeati516 – 557PFTB 6Add BLAST42
Repeati574 – 622PFTB 7Add BLAST49

Sequence similaritiesi

Belongs to the terpene cyclase/mutase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105EWU Bacteria
COG1657 LUCA
HOGENOMiHOG000220823
KOiK06045
OMAiGRQTWTY
OrthoDBiPOG091H0DNT

Family and domain databases

CDDicd02892 SQCY_1, 1 hit
InterProiView protein in InterPro
IPR006400 Hopene-cyclase
IPR032696 SQ_cyclase_C
IPR032697 SQ_cyclase_N
IPR018333 Squalene_cyclase
IPR002365 Terpene_synthase_CS
IPR008930 Terpenoid_cyclase/PrenylTrfase
PfamiView protein in Pfam
PF13243 SQHop_cyclase_C, 1 hit
PF13249 SQHop_cyclase_N, 1 hit
SUPFAMiSSF48239 SSF48239, 2 hits
TIGRFAMsiTIGR01507 hopene_cyclase, 1 hit
TIGR01787 squalene_cyclas, 1 hit
PROSITEiView protein in PROSITE
PS01074 TERPENE_SYNTHASES, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33247-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEQLVEAPA YARTLDRAVE YLLSCQKDEG YWWGPLLSNV TMEAEYVLLC
60 70 80 90 100
HILDRVDRDR MEKIRRYLLH EQREDGTWAL YPGGPPDLDT TIEAYVALKY
110 120 130 140 150
IGMSRDEEPM QKALRFIQSQ GGIESSRVFT RMWLALVGEY PWEKVPMVPP
160 170 180 190 200
EIMFLGKRMP LNIYEFGSWA RATVVALSIV MSRQPVFPLP ERARVPELYE
210 220 230 240 250
TDVPPRRRGA KGGGGWIFDA LDRALHGYQK LSVHPFRRAA EIRALDWLLE
260 270 280 290 300
RQAGDGSWGG IQPPWFYALI ALKILDMTQH PAFIKGWEGL ELYGVELDYG
310 320 330 340 350
GWMFQASISP VWDTGLAVLA LRAAGLPADH DRLVKAGEWL LDRQITVPGD
360 370 380 390 400
WAVKRPNLKP GGFAFQFDNV YYPDVDDTAV VVWALNTLRL PDERRRRDAM
410 420 430 440 450
TKGFRWIVGM QSSNGGWGAY DVDNTSDLPN HIPFCDFGEV TDPPSEDVTA
460 470 480 490 500
HVLECFGSFG YDDAWKVIRR AVEYLKREQK PDGSWFGRWG VNYLYGTGAV
510 520 530 540 550
VSALKAVGID TREPYIQKAL DWVEQHQNPD GGWGEDCRSY EDPAYAGKGA
560 570 580 590 600
STPSQTAWAL MALIAGGRAE SEAARRGVQY LVETQRPDGG WDEPYYTGTG
610 620 630
FPGDFYLGYT MYRHVFPTLA LGRYKQAIER R
Length:631
Mass (Da):71,570
Last modified:January 23, 2007 - v4
Checksum:iE389635BD6486C3A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti600 – 601GF → AS in AAA75452 (PubMed:1729216).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73834 Genomic DNA Translation: AAA75452.1
AB007002 Genomic DNA Translation: BAA25185.1
CP001727 Genomic DNA Translation: ACV59449.1
PIRiA43300
RefSeqiWP_012811690.1, NC_013205.1

Genome annotation databases

EnsemblBacteriaiACV59449; ACV59449; Aaci_2443
KEGGiaac:Aaci_2443

Similar proteinsi

Entry informationi

Entry nameiSQHC_ALIAD
AccessioniPrimary (citable) accession number: P33247
Secondary accession number(s): C8WSG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 137 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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