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Protein

Nuclear hormone receptor FTZ-F1

Gene

ftz-f1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a cofactor to fushi tarazu (ftz). Facilitates the binding of ftz to DNA. Binds the sequence element 5'-YCYYGGYCR-3' in the zebra element of ftz. Probably also functions as a receptor for a yet unknown ligand.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi505 – 580Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri508 – 528NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri544 – 568NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-383280 Nuclear Receptor transcription pathway
R-DME-4090294 SUMOylation of intracellular receptors
SignaLinkiP33244

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear hormone receptor FTZ-F1
Alternative name(s):
FTZ-F1 alpha
Nuclear receptor subfamily 5 group A member 3
Gene namesi
Name:ftz-f1
Synonyms:NR5A3
ORF Names:CG4059
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0001078 ftz-f1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Ftz-like pair-rule cuticular defects.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi563C → S: 100-fold less binding. 1 Publication1
Mutagenesisi579R → Q: 100-fold less binding. 1 Publication1
Mutagenesisi582R → Q: 100-fold less binding. 1 Publication1
Mutagenesisi583M → I: 10-fold less binding. 1 Publication1
Mutagenesisi584R → Q: 10-fold less binding. 1 Publication1
Mutagenesisi585 – 586GG → AA: No binding. 1 Publication2
Mutagenesisi587R → Q: 10-fold less reduced binding. 1 Publication1
Mutagenesisi589K → Q: No effect on binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000537391 – 1027Nuclear hormone receptor FTZ-F1Add BLAST1027

Proteomic databases

PaxDbiP33244
PRIDEiP33244

Expressioni

Tissue specificityi

Expression in the parasegmental primordia of the embryonic blastoderm.1 Publication

Developmental stagei

First appears in blastoderm embryos. It is absent in subsequent embryo stages, and then reappears in late embryogenesis to be found in larvae, pupae and adults.1 Publication

Gene expression databases

BgeeiFBgn0001078 Expressed in 34 organ(s), highest expression level in cleaving embryo
ExpressionAtlasiP33244 baseline and differential
GenevisibleiP33244 DM

Interactioni

Subunit structurei

Monomer; forms a complex with ftz.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ftzP028353EBI-160447,EBI-125786

GO - Molecular functioni

Protein-protein interaction databases

BioGridi65326, 42 interactors
IntActiP33244, 3 interactors
STRINGi7227.FBpp0074853

Structurei

Secondary structure

11027
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP33244
SMRiP33244
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini792 – 1024NR LBDPROSITE-ProRule annotationAdd BLAST233

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi29 – 45Gln-rich (OPA repeat)Add BLAST17
Compositional biasi155 – 169Poly-AsnAdd BLAST15
Compositional biasi359 – 365Poly-Gln (OPA repeat)7
Compositional biasi412 – 495Gly-richAdd BLAST84
Compositional biasi686 – 738Gly-richAdd BLAST53

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri508 – 528NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri544 – 568NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4218 Eukaryota
ENOG410YWC2 LUCA
GeneTreeiENSGT00870000136388
InParanoidiP33244
KOiK08705
OMAiLQEPAKG
OrthoDBiEOG091G06RK
PhylomeDBiP33244

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR016355 NR5_fam
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PANTHERiPTHR24086 PTHR24086, 1 hit
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform B (identifier: P33244-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDTFNVPMLA ESSNTNYATE ATSNHHHLQH QHQQQHSHQQ QQQQQLLMPH
60 70 80 90 100
HHKDQMLAAG SSPMLPFYSH LQLQQKDATA TIGPAAAAAA VEAATTSANA
110 120 130 140 150
DNFSSLQTID ASQLDGGISL SGLCDRFFVA SPNPHSNSNM TLMGTATAAT
160 170 180 190 200
TTTTNNNNNN NTNNNNNNNV EAKTVRPSNG NSVIIESVTM PSFANILFPT
210 220 230 240 250
HRSANECIDP ALLQKNPQNP NGNNSSIIVP PVEYHQLKPL EVNSSTSVST
260 270 280 290 300
SNFLSSTTAQ LLDFEVQVGK DDGHISTTTT TGPGSGSASG SGSGSGSGSG
310 320 330 340 350
SIARTIGTAT PTTTTSMSNT ANPTRSSLHS IEELAASSCA PRAASPNSNH
360 370 380 390 400
TSSASTTPQQ QQQQQHHMQS GNHSGSNLSS DDESMSEDEF GLEIDDNGGY
410 420 430 440 450
QDTTSSHSQQ SGGGGGGGGG NLLNGSSGGS SAGGGYMLLP QAASSSGNNG
460 470 480 490 500
NPNAGHMSSG SVGNGSGGAG NGGAGGNSGP GNPMGGTSAT PGHGGEVIDF
510 520 530 540 550
KHLFEELCPV CGDKVSGYHY GLLTCESCKG FFKRTVQNKK VYTCVAERSC
560 570 580 590 600
HIDKTQRKRC PYCRFQKCLE VGMKLEAVRA DRMRGGRNKF GPMYKRDRAR
610 620 630 640 650
KLQVMRQRQL ALQALRNSMG PDIKPTPISP GYQQAYPNMN IKQEIQIPQV
660 670 680 690 700
SSLTQSPDSS PSPIAIALGQ VNASTGGVIA TPMNAGTGGS GGGGLNGPSS
710 720 730 740 750
VGNGNSSNGS SNGNNNSSTG NGTSGGGGGN NAGGGGGGTN SNDGLHRNGG
760 770 780 790 800
NGNSSCHEAG IGSLQNTADS KLCFDSGTHP SSTADALIEP LRVSPMIREF
810 820 830 840 850
VQSIDDREWQ TQLFALLQKQ TYNQVEVDLF ELMCKVLDQN LFSQVDWARN
860 870 880 890 900
TVFFKDLKVD DQMKLLQHSW SDMLVLDHLH HRIHNGLPDE TQLNNGQVFN
910 920 930 940 950
LMSLGLLGVP QLGDYFNELQ NKLQDLKFDM GDYVCMKFLI LLNPSVRGIV
960 970 980 990 1000
NRKTVSEGHD NVQAALLDYT LTCYPSVNDK FRGLVNILPE IHAMAVRGED
1010 1020
HLYTKHCAGS APTQTLLMEM LHAKRKG
Length:1,027
Mass (Da):108,418
Last modified:March 15, 2004 - v2
Checksum:i6A2240934830290D
GO
Isoform A (identifier: P33244-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-174: MDTFNVPMLA...NNNNNVEAKT → MLLEMDQQQA...NFDSQYIFPT
     175-398: Missing.

Show »
Length:803
Mass (Da):85,900
Checksum:iF20BE9D5EC07D015
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9NFK2M9NFK2_DROME
Ftz transcription factor 1, isoform...
ftz-f1 alphaFTZ-F1, alphaftz-f1, alphaFTZF1, beta FTZ-F1, beta Ftz-f1
803Annotation score:
A0A0S0WH29A0A0S0WH29_DROME
Ftz transcription factor 1, isoform...
ftz-f1 alphaFTZ-F1, alphaftz-f1, alphaFTZF1, beta FTZ-F1, beta Ftz-f1
853Annotation score:

Sequence cautioni

The sequence AAA28542 differs from that shown. Reason: Frameshift at positions 1003, 1004 and 1005.Curated
The sequence AAA28915 differs from that shown. Reason: Frameshift at positions 1003, 1004 and 1005.Curated
The sequence AAK93269 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45Q → QQQ AA sequence (PubMed:1709303).Curated1
Sequence conflicti304R → S in AAA28542 (PubMed:1709303).Curated1
Sequence conflicti752 – 753GN → DS in AAA28542 (PubMed:1709303).Curated2
Sequence conflicti752 – 753GN → DS in AAA28915 (PubMed:8096644).Curated2
Sequence conflicti832L → LL in AAA28542 (PubMed:1709303).Curated1
Sequence conflicti832L → LL in AAA28915 (PubMed:8096644).Curated1
Sequence conflicti912L → P in AAA28542 (PubMed:1709303).Curated1
Sequence conflicti912L → P in AAA28915 (PubMed:8096644).Curated1
Isoform A (identifier: P33244-2)
Sequence conflicti67 – 68NN → N in AAA28915 (PubMed:8096644).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0129171 – 174MDTFN…VEAKT → MLLEMDQQQATVQFISSLNI SPFSMQLEQQQQPSSPALAA GGNSSNNAASGSNNNSASGN NTSSSSNNNNNNNNDNDAHV LTKFEHEYNAYTLQLAGGGG SGSGNQQHHSNHSNHGNHHQ QQQQQQQQQQQHQQQQQEHY QQQQQQNIANNANQFNSSSY SYIYNFDSQYIFPT in isoform A. 1 PublicationAdd BLAST174
Alternative sequenceiVSP_012918175 – 398Missing in isoform A. 1 PublicationAdd BLAST224

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63711 mRNA Translation: AAA28542.1 Frameshift.
M98397 mRNA Translation: AAA28915.1 Frameshift.
AE014296 Genomic DNA Translation: AAF49231.2
AE014296 Genomic DNA Translation: AAN11667.1
BT058016 mRNA Translation: ACM16732.1
AY051845 mRNA Translation: AAK93269.1 Different initiation.
PIRiA47303
T13733
RefSeqiNP_001246824.1, NM_001259895.2 [P33244-2]
NP_524143.2, NM_079419.3 [P33244-1]
NP_730359.1, NM_168775.2 [P33244-2]
UniGeneiDm.995

Genome annotation databases

EnsemblMetazoaiFBtr0075086; FBpp0074853; FBgn0001078 [P33244-1]
FBtr0075087; FBpp0074854; FBgn0001078 [P33244-2]
FBtr0304627; FBpp0293169; FBgn0001078 [P33244-2]
GeneIDi40045
KEGGidme:Dmel_CG4059

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63711 mRNA Translation: AAA28542.1 Frameshift.
M98397 mRNA Translation: AAA28915.1 Frameshift.
AE014296 Genomic DNA Translation: AAF49231.2
AE014296 Genomic DNA Translation: AAN11667.1
BT058016 mRNA Translation: ACM16732.1
AY051845 mRNA Translation: AAK93269.1 Different initiation.
PIRiA47303
T13733
RefSeqiNP_001246824.1, NM_001259895.2 [P33244-2]
NP_524143.2, NM_079419.3 [P33244-1]
NP_730359.1, NM_168775.2 [P33244-2]
UniGeneiDm.995

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XHSX-ray2.80A790-1027[»]
ProteinModelPortaliP33244
SMRiP33244
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi65326, 42 interactors
IntActiP33244, 3 interactors
STRINGi7227.FBpp0074853

Proteomic databases

PaxDbiP33244
PRIDEiP33244

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0075086; FBpp0074853; FBgn0001078 [P33244-1]
FBtr0075087; FBpp0074854; FBgn0001078 [P33244-2]
FBtr0304627; FBpp0293169; FBgn0001078 [P33244-2]
GeneIDi40045
KEGGidme:Dmel_CG4059

Organism-specific databases

CTDi40045
FlyBaseiFBgn0001078 ftz-f1

Phylogenomic databases

eggNOGiKOG4218 Eukaryota
ENOG410YWC2 LUCA
GeneTreeiENSGT00870000136388
InParanoidiP33244
KOiK08705
OMAiLQEPAKG
OrthoDBiEOG091G06RK
PhylomeDBiP33244

Enzyme and pathway databases

ReactomeiR-DME-383280 Nuclear Receptor transcription pathway
R-DME-4090294 SUMOylation of intracellular receptors
SignaLinkiP33244

Miscellaneous databases

ChiTaRSiftz-f1 fly
GenomeRNAii40045
PROiPR:P33244

Gene expression databases

BgeeiFBgn0001078 Expressed in 34 organ(s), highest expression level in cleaving embryo
ExpressionAtlasiP33244 baseline and differential
GenevisibleiP33244 DM

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR016355 NR5_fam
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PANTHERiPTHR24086 PTHR24086, 1 hit
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFTZF1_DROME
AccessioniPrimary (citable) accession number: P33244
Secondary accession number(s): B9EQU1
, Q24538, Q8IQT5, Q960U2, Q9VVS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: March 15, 2004
Last modified: November 7, 2018
This is version 184 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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