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Entry version 193 (26 Feb 2020)
Sequence version 2 (15 Mar 2004)
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Protein

Nuclear hormone receptor FTZ-F1

Gene

ftz-f1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a cofactor to fushi tarazu (ftz). Facilitates the binding of ftz to DNA. Binds the sequence element 5'-YCYYGGYCR-3' in the zebra element of ftz. Probably also functions as a receptor for a yet unknown ligand.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi505 – 580Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri508 – 528NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri544 – 568NR C4-typePROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-383280 Nuclear Receptor transcription pathway
R-DME-4090294 SUMOylation of intracellular receptors

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P33244

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear hormone receptor FTZ-F1
Alternative name(s):
FTZ-F1 alpha
Nuclear receptor subfamily 5 group A member 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ftz-f1
Synonyms:NR5A3
ORF Names:CG4059
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0001078 ftz-f1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Ftz-like pair-rule cuticular defects.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi563C → S: 100-fold less binding. 1 Publication1
Mutagenesisi579R → Q: 100-fold less binding. 1 Publication1
Mutagenesisi582R → Q: 100-fold less binding. 1 Publication1
Mutagenesisi583M → I: 10-fold less binding. 1 Publication1
Mutagenesisi584R → Q: 10-fold less binding. 1 Publication1
Mutagenesisi585 – 586GG → AA: No binding. 1 Publication2
Mutagenesisi587R → Q: 10-fold less reduced binding. 1 Publication1
Mutagenesisi589K → Q: No effect on binding. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000537391 – 1027Nuclear hormone receptor FTZ-F1Add BLAST1027

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P33244

PRoteomics IDEntifications database

More...
PRIDEi
P33244

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expression in the parasegmental primordia of the embryonic blastoderm.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

First appears in blastoderm embryos. It is absent in subsequent embryo stages, and then reappears in late embryogenesis to be found in larvae, pupae and adults.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0001078 Expressed in cleaving embryo and 33 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P33244 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P33244 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer; forms a complex with ftz.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P028353EBI-160447,EBI-125786

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
65326, 42 interactors

Protein interaction database and analysis system

More...
IntActi
P33244, 3 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0074853

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11027
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P33244

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini792 – 1024NR LBDPROSITE-ProRule annotationAdd BLAST233

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi29 – 45Gln-rich (OPA repeat)Add BLAST17
Compositional biasi155 – 169Poly-AsnAdd BLAST15
Compositional biasi359 – 365Poly-Gln (OPA repeat)7
Compositional biasi412 – 495Gly-richAdd BLAST84
Compositional biasi686 – 738Gly-richAdd BLAST53

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri508 – 528NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri544 – 568NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4218 Eukaryota
ENOG410YWC2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153391

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011437_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P33244

KEGG Orthology (KO)

More...
KOi
K08705

Identification of Orthologs from Complete Genome Data

More...
OMAi
SAIQNMH

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P33244

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.565.10, 1 hit
3.30.50.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035500 NHR-like_dom_sf
IPR016355 NR5_fam
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA

The PANTHER Classification System

More...
PANTHERi
PTHR24086 PTHR24086, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00398 STRDHORMONER
PR00047 STROIDFINGER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48508 SSF48508, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform B (identifier: P33244-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDTFNVPMLA ESSNTNYATE ATSNHHHLQH QHQQQHSHQQ QQQQQLLMPH
60 70 80 90 100
HHKDQMLAAG SSPMLPFYSH LQLQQKDATA TIGPAAAAAA VEAATTSANA
110 120 130 140 150
DNFSSLQTID ASQLDGGISL SGLCDRFFVA SPNPHSNSNM TLMGTATAAT
160 170 180 190 200
TTTTNNNNNN NTNNNNNNNV EAKTVRPSNG NSVIIESVTM PSFANILFPT
210 220 230 240 250
HRSANECIDP ALLQKNPQNP NGNNSSIIVP PVEYHQLKPL EVNSSTSVST
260 270 280 290 300
SNFLSSTTAQ LLDFEVQVGK DDGHISTTTT TGPGSGSASG SGSGSGSGSG
310 320 330 340 350
SIARTIGTAT PTTTTSMSNT ANPTRSSLHS IEELAASSCA PRAASPNSNH
360 370 380 390 400
TSSASTTPQQ QQQQQHHMQS GNHSGSNLSS DDESMSEDEF GLEIDDNGGY
410 420 430 440 450
QDTTSSHSQQ SGGGGGGGGG NLLNGSSGGS SAGGGYMLLP QAASSSGNNG
460 470 480 490 500
NPNAGHMSSG SVGNGSGGAG NGGAGGNSGP GNPMGGTSAT PGHGGEVIDF
510 520 530 540 550
KHLFEELCPV CGDKVSGYHY GLLTCESCKG FFKRTVQNKK VYTCVAERSC
560 570 580 590 600
HIDKTQRKRC PYCRFQKCLE VGMKLEAVRA DRMRGGRNKF GPMYKRDRAR
610 620 630 640 650
KLQVMRQRQL ALQALRNSMG PDIKPTPISP GYQQAYPNMN IKQEIQIPQV
660 670 680 690 700
SSLTQSPDSS PSPIAIALGQ VNASTGGVIA TPMNAGTGGS GGGGLNGPSS
710 720 730 740 750
VGNGNSSNGS SNGNNNSSTG NGTSGGGGGN NAGGGGGGTN SNDGLHRNGG
760 770 780 790 800
NGNSSCHEAG IGSLQNTADS KLCFDSGTHP SSTADALIEP LRVSPMIREF
810 820 830 840 850
VQSIDDREWQ TQLFALLQKQ TYNQVEVDLF ELMCKVLDQN LFSQVDWARN
860 870 880 890 900
TVFFKDLKVD DQMKLLQHSW SDMLVLDHLH HRIHNGLPDE TQLNNGQVFN
910 920 930 940 950
LMSLGLLGVP QLGDYFNELQ NKLQDLKFDM GDYVCMKFLI LLNPSVRGIV
960 970 980 990 1000
NRKTVSEGHD NVQAALLDYT LTCYPSVNDK FRGLVNILPE IHAMAVRGED
1010 1020
HLYTKHCAGS APTQTLLMEM LHAKRKG
Length:1,027
Mass (Da):108,418
Last modified:March 15, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6A2240934830290D
GO
Isoform A (identifier: P33244-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-174: MDTFNVPMLA...NNNNNVEAKT → MLLEMDQQQA...NFDSQYIFPT
     175-398: Missing.

Show »
Length:803
Mass (Da):85,900
Checksum:iF20BE9D5EC07D015
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9NFK2M9NFK2_DROME
Ftz transcription factor 1, isoform...
ftz-f1 alphaFTZ-F1, alphaftz-f1, alphaFTZF1, beta FTZ-F1, beta Ftz-f1
803Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0S0WH29A0A0S0WH29_DROME
Ftz transcription factor 1, isoform...
ftz-f1 alphaFTZ-F1, alphaftz-f1, alphaFTZF1, beta FTZ-F1, beta Ftz-f1
853Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA28542 differs from that shown. Reason: Frameshift.Curated
The sequence AAA28915 differs from that shown. Reason: Frameshift.Curated
The sequence AAK93269 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti45Q → QQQ AA sequence (PubMed:1709303).Curated1
Sequence conflicti304R → S in AAA28542 (PubMed:1709303).Curated1
Sequence conflicti752 – 753GN → DS in AAA28542 (PubMed:1709303).Curated2
Sequence conflicti752 – 753GN → DS in AAA28915 (PubMed:8096644).Curated2
Sequence conflicti832L → LL in AAA28542 (PubMed:1709303).Curated1
Sequence conflicti832L → LL in AAA28915 (PubMed:8096644).Curated1
Sequence conflicti912L → P in AAA28542 (PubMed:1709303).Curated1
Sequence conflicti912L → P in AAA28915 (PubMed:8096644).Curated1
Isoform A (identifier: P33244-2)
Sequence conflicti67 – 68NN → N in AAA28915 (PubMed:8096644).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0129171 – 174MDTFN…VEAKT → MLLEMDQQQATVQFISSLNI SPFSMQLEQQQQPSSPALAA GGNSSNNAASGSNNNSASGN NTSSSSNNNNNNNNDNDAHV LTKFEHEYNAYTLQLAGGGG SGSGNQQHHSNHSNHGNHHQ QQQQQQQQQQQHQQQQQEHY QQQQQQNIANNANQFNSSSY SYIYNFDSQYIFPT in isoform A. 1 PublicationAdd BLAST174
Alternative sequenceiVSP_012918175 – 398Missing in isoform A. 1 PublicationAdd BLAST224

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M63711 mRNA Translation: AAA28542.1 Frameshift.
M98397 mRNA Translation: AAA28915.1 Frameshift.
AE014296 Genomic DNA Translation: AAF49231.2
AE014296 Genomic DNA Translation: AAN11667.1
BT058016 mRNA Translation: ACM16732.1
AY051845 mRNA Translation: AAK93269.1 Different initiation.

Protein sequence database of the Protein Information Resource

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PIRi
A47303
T13733

NCBI Reference Sequences

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RefSeqi
NP_001246824.1, NM_001259895.2 [P33244-2]
NP_524143.2, NM_079419.3 [P33244-1]
NP_730359.1, NM_168775.2 [P33244-2]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0075086; FBpp0074853; FBgn0001078 [P33244-1]
FBtr0075087; FBpp0074854; FBgn0001078 [P33244-2]
FBtr0304627; FBpp0293169; FBgn0001078 [P33244-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
40045

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG4059

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63711 mRNA Translation: AAA28542.1 Frameshift.
M98397 mRNA Translation: AAA28915.1 Frameshift.
AE014296 Genomic DNA Translation: AAF49231.2
AE014296 Genomic DNA Translation: AAN11667.1
BT058016 mRNA Translation: ACM16732.1
AY051845 mRNA Translation: AAK93269.1 Different initiation.
PIRiA47303
T13733
RefSeqiNP_001246824.1, NM_001259895.2 [P33244-2]
NP_524143.2, NM_079419.3 [P33244-1]
NP_730359.1, NM_168775.2 [P33244-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XHSX-ray2.80A790-1027[»]
SMRiP33244
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi65326, 42 interactors
IntActiP33244, 3 interactors
STRINGi7227.FBpp0074853

Proteomic databases

PaxDbiP33244
PRIDEiP33244

Genome annotation databases

EnsemblMetazoaiFBtr0075086; FBpp0074853; FBgn0001078 [P33244-1]
FBtr0075087; FBpp0074854; FBgn0001078 [P33244-2]
FBtr0304627; FBpp0293169; FBgn0001078 [P33244-2]
GeneIDi40045
KEGGidme:Dmel_CG4059

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
40045
FlyBaseiFBgn0001078 ftz-f1

Phylogenomic databases

eggNOGiKOG4218 Eukaryota
ENOG410YWC2 LUCA
GeneTreeiENSGT00940000153391
HOGENOMiCLU_011437_2_0_1
InParanoidiP33244
KOiK08705
OMAiSAIQNMH
PhylomeDBiP33244

Enzyme and pathway databases

ReactomeiR-DME-383280 Nuclear Receptor transcription pathway
R-DME-4090294 SUMOylation of intracellular receptors
SignaLinkiP33244

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ftz-f1 fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
40045

Protein Ontology

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PROi
PR:P33244

Gene expression databases

BgeeiFBgn0001078 Expressed in cleaving embryo and 33 other tissues
ExpressionAtlasiP33244 baseline and differential
GenevisibleiP33244 DM

Family and domain databases

Gene3Di1.10.565.10, 1 hit
3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR-like_dom_sf
IPR016355 NR5_fam
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PANTHERiPTHR24086 PTHR24086, 1 hit
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFTZF1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P33244
Secondary accession number(s): B9EQU1
, Q24538, Q8IQT5, Q960U2, Q9VVS8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: March 15, 2004
Last modified: February 26, 2020
This is version 193 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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