Nr5a1

Functionⁱ

Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (By similarity). Transcription repressor of the Moloney leukemia virus long terminal repeat in undifferentiated murine embryonal carcinoma cells. Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular phosphatidyl(3,4)bisphosphate, phosphatidyl(3,5)bisphosphate and phosphatidyl(3,4,5)triphosphate. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.By similarity2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	342	Lipid headgroup; via amide nitrogen1 Publication	1
Binding siteⁱ	437	Lipid headgroup1 Publication	1
Binding siteⁱ	441	Lipid headgroup1 Publication	1

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	10 – 85	Nuclear receptorPROSITE-ProRule annotationAdd BLAST	76
Zinc fingerⁱ	13 – 33	NR C4-typePROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	49 – 73	NR C4-typePROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

chromatin binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 19389484
DNA binding
Source: MGI
Inferred from direct assayⁱ
DNA-binding transcription factor activity Source: MGI
double-stranded DNA binding Source: MGI
enzyme binding Source: MGI
nuclear receptor activity Source: MGI
phospholipid binding Source: MGI
RNA polymerase II distal enhancer sequence-specific DNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 19389484
RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
sequence-specific DNA binding Source: MGI
steroid hormone receptor activity Source: InterPro
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: MGI
transcription regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adrenal gland development
Source: MGI
Inferred from mutant phenotypeⁱ
calcineurin-mediated signaling Source: MGI
cell differentiation
Source: MGI
Inferred from genetic interactionⁱ
- 15829514
female gonad development Source: UniProtKB
hormone-mediated signaling pathway Source: MGI
hormone metabolic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 21820362
luteinization
Source: MGI
Inferred from mutant phenotypeⁱ
- 15118069
maintenance of protein location in nucleus
Source: MGI
Inferred from direct assayⁱ
- 12610109
male gonad development
Source: MGI
Inferred from mutant phenotypeⁱ
- 15118069
- 21820362
male sex determination Source: MGI
multicellular organism aging
Source: MGI
Inferred from mutant phenotypeⁱ
- 21820362
negative regulation of female gonad development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19301398
positive regulation of gene expression Source: MGI
positive regulation of male gonad development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19301398
positive regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
- 12730328
positive regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
- 12651892
regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 12861022
reproductive process
Source: MGI
Inferred from mutant phenotypeⁱ
- 21820362
response to gonadotropin-releasing hormone Source: Ensembl
sex determination Source: UniProtKB
tissue development
Source: MGI
Inferred from mutant phenotypeⁱ
- 16176945
transcription by RNA polymerase II Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Receptor, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Lipid-binding, Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-383280 Nuclear Receptor transcription pathway R-MMU-4090294 SUMOylation of intracellular receptors

Reactomeⁱ

R-MMU-383280 Nuclear Receptor transcription pathway
R-MMU-4090294 SUMOylation of intracellular receptors

Chemistry databases

SwissLipidsⁱ	SLP:000001543

SwissLipidsⁱ

SLP:000001543

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Steroidogenic factor 1 Short name: SF-1 Short name: STF-1 Alternative name(s): Adrenal 4-binding protein Embryonal LTR-binding protein Short name: ELP Embryonal long terminal repeat-binding protein Fushi tarazu factor homolog 1 Nuclear receptor subfamily 5 group A member 1 Steroid hormone receptor Ad4BP Steroid hydroxylase positive regulator
Gene namesⁱ	Name:Nr5a1 Synonyms:Ftzf1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:1346833 Nr5a1

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	270	A → W: Reduced lipid binding and transactivation. Abolishes ligand binding and reduces transactivation; when associated with F-345. 2 Publications	1
Mutagenesisⁱ	314	R → M: Strongly reduced transactivation. 1 Publication	1
Mutagenesisⁱ	345	L → F: Abolishes ligand binding and reduces transactivation; when associated with W-270. 2 Publications	1
Mutagenesisⁱ	345	L → W: Strongly reduced transactivation. 2 Publications	1
Mutagenesisⁱ	348	L → W: Strongly reduced transactivation. 1 Publication	1
Mutagenesisⁱ	349	V → W: Strongly reduced transactivation. 1 Publication	1
Mutagenesisⁱ	352	A → W: Strongly reduced transactivation. 1 Publication	1
Mutagenesisⁱ	434	A → W: Strongly reduced transactivation. 1 Publication	1
Mutagenesisⁱ	440	H → D: Strongly reduced transactivation; when associated with D-442.	1
Mutagenesisⁱ	441	K → E: Strongly reduced transactivation. 1 Publication	1
Mutagenesisⁱ	442	H → D: Strongly reduced transactivation; when associated with D-440.	1

Chemistry databases

ChEMBLⁱ

CHEMBL1764943

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000053732	1 – 462	Steroidogenic factor 1Add BLAST		462

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	34	N6-acetyllysineBy similarity	1
Modified residueⁱ	38	N6-acetyllysineBy similarity	1
Modified residueⁱ	72	N6-acetyllysineBy similarity	1
Cross-linkⁱ	119	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linkⁱ	194	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residueⁱ	203	Phosphoserine; by CDK7By similarity	1

Post-translational modificationⁱ

Acetylation stimulates the transcriptional activity.By similarity

Sumoylation reduces CDK7-mediated phosphorylation on Ser-203.By similarity

Phosphorylated on Ser-203 by CDK7. This phosphorylation promotes transcriptional activity (By similarity).By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	P33242
PRIDEⁱ	P33242

PTM databases

iPTMnetⁱ	P33242
PhosphoSitePlusⁱ	P33242

Expressionⁱ

Developmental stageⁱ

Expressed during early embryonic development. Expressed only in undifferentiated embryonal carcinoma cells.

Gene expression databases

Bgeeⁱ	ENSMUSG00000026751 Expressed in 118 organ(s), highest expression level in adrenal gland
CleanExⁱ	MM_NR5A1
Genevisibleⁱ	P33242 MM

Interactionⁱ

Subunit structureⁱ

Binds DNA as a monomer (By similarity). Part of a complex consisting of SFPQ, NONO and NR5A1. Interacts with DGKQ and CDK7 (By similarity). Interacts with NR0B2, NCOA2 and PPARGC1A. Binds to and activated by HIPK3.By similarity5 Publications

GO - Molecular functionⁱ

enzyme binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	204975, 16 interactors
ELMⁱ	P33242
IntActⁱ	P33242, 1 interactor
STRINGⁱ	10090.ENSMUSP00000028084

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	14 – 16	Combined sources	3
Beta strandⁱ	22 – 24	Combined sources	3
Beta strandⁱ	27 – 29	Combined sources	3
Helixⁱ	31 – 41	Combined sources	11
Turnⁱ	42 – 44	Combined sources	3
Helixⁱ	61 – 64	Combined sources	4
Helixⁱ	66 – 76	Combined sources	11
Helixⁱ	80 – 82	Combined sources	3
Turnⁱ	94 – 97	Combined sources	4
Helixⁱ	98 – 106	Combined sources	9
Beta strandⁱ	220 – 222	Combined sources	3
Helixⁱ	226 – 234	Combined sources	9
Helixⁱ	238 – 249	Combined sources	12
Beta strandⁱ	252 – 254	Combined sources	3
Turnⁱ	255 – 257	Combined sources	3
Helixⁱ	263 – 283	Combined sources	21
Helixⁱ	287 – 289	Combined sources	3
Helixⁱ	292 – 318	Combined sources	27
Beta strandⁱ	323 – 325	Combined sources	3
Beta strandⁱ	331 – 333	Combined sources	3
Helixⁱ	334 – 340	Combined sources	7
Helixⁱ	343 – 361	Combined sources	19
Helixⁱ	366 – 377	Combined sources	12
Helixⁱ	382 – 384	Combined sources	3
Helixⁱ	388 – 409	Combined sources	22
Turnⁱ	411 – 413	Combined sources	3
Helixⁱ	416 – 443	Combined sources	28
Helixⁱ	452 – 458	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	P33242
SMRⁱ	P33242
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P33242

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	223 – 460	NR LBDPROSITE-ProRule annotationAdd BLAST		238

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family. NR5 subfamily.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	13 – 33	NR C4-typePROSITE-ProRule annotationAdd BLAST		21
Zinc fingerⁱ	49 – 73	NR C4-typePROSITE-ProRule annotationAdd BLAST		25

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG4218 Eukaryota ENOG410YWC2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00870000136388
HOVERGENⁱ	HBG106677
InParanoidⁱ	P33242
KEGG Orthology (KO) More...KOⁱ	K08560
OMAⁱ	LQEPAKG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06RK
TreeFamⁱ	TF350737

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR016355 NR5_fam IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
PANTHERⁱ	PTHR24086 PTHR24086, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PIRSFⁱ	PIRSF002530 Nuc_orph_FTZ-F1, 1 hit
PRINTSⁱ	PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P33242-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDYSYDEDLD ELCPVCGDKV SGYHYGLLTC ESCKGFFKRT VQNNKHYTCT 
        60         70         80         90        100
ESQSCKIDKT QRKRCPFCRF QKCLTVGMRL EAVRADRMRG GRNKFGPMYK 
       110        120        130        140        150
RDRALKQQKK AQIRANGFKL ETGPPMGVPP PPPPPPDYML PPSLHAPEPK 
       160        170        180        190        200
ALVSGPPSGP LGDFGAPSLP MAVPGPHGPL AGYLYPAFSN RTIKSEYPEP 
       210        220        230        240        250
YASPPQQPGP PYSYPEPFSG GPNVPELILQ LLQLEPEEDQ VRARIVGCLQ 
       260        270        280        290        300
EPAKSRSDQP APFSLLCRMA DQTFISIVDW ARRCMVFKEL EVADQMTLLQ 
       310        320        330        340        350
NCWSELLVLD HIYRQVQYGK EDSILLVTGQ EVELSTVAVQ AGSLLHSLVL 
       360        370        380        390        400
RAQELVLQLH ALQLDRQEFV CLKFLILFSL DVKFLNNHSL VKDAQEKANA 
       410        420        430        440        450
ALLDYTLCHY PHCGDKFQQL LLCLVEVRAL SMQAKEYLYH KHLGNEMPRN 
       460 
NLLIEMLQAK QT

Length:462

Mass (Da):52,077

Last modified:July 27, 2011 - v3

Checksum:ⁱ67045B563403CF5A

GO

Isoform 2 (identifier: P33242-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
333-462: ELSTVAVQAG...LIEMLQAKQT → TELVKPLVLH...GMVSGSSYRR

« Hide

        10         20         30         40         50
MDYSYDEDLD ELCPVCGDKV SGYHYGLLTC ESCKGFFKRT VQNNKHYTCT 
        60         70         80         90        100
ESQSCKIDKT QRKRCPFCRF QKCLTVGMRL EAVRADRMRG GRNKFGPMYK 
       110        120        130        140        150
RDRALKQQKK AQIRANGFKL ETGPPMGVPP PPPPPPDYML PPSLHAPEPK 
       160        170        180        190        200
ALVSGPPSGP LGDFGAPSLP MAVPGPHGPL AGYLYPAFSN RTIKSEYPEP 
       210        220        230        240        250
YASPPQQPGP PYSYPEPFSG GPNVPELILQ LLQLEPEEDQ VRARIVGCLQ 
       260        270        280        290        300
EPAKSRSDQP APFSLLCRMA DQTFISIVDW ARRCMVFKEL EVADQMTLLQ 
       310        320        330        340        350
NCWSELLVLD HIYRQVQYGK EDSILLVTGQ EVTELVKPLV LHNPRPLRAD 
       360        370        380 
SGHPKFQIQG HALARLLCVL GPFEEPQCGM VSGSSYRR

Show »

Length:388

Mass (Da):43,387

Checksum:ⁱE9A38FD8427F5888

GO

Sequence cautionⁱ

The sequence BAA01441 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	164	F → I in BAA01441 (PubMed:1545809).Curated	1
Sequence conflictⁱ	256	R → G in BAA01441 (PubMed:1545809).Curated	1
Sequence conflictⁱ	328	T → S in BAA01441 (PubMed:1545809).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱ	172	A → S in strain: C3H/HeJ and DBA/2J; does not change transcriptional activity. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_003715	333 – 462	ELSTV…QAKQT → TELVKPLVLHNPRPLRADSG HPKFQIQGHALARLLCVLGP FEEPQCGMVSGSSYRR in isoform 2. 1 PublicationAdd BLAST		130

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D10584 mRNA Translation: BAA01441.1 Different initiation. S65878 , S65875, S65919, S65876, S65877 Genomic DNA Translation: AAB28338.1 S65876, S65875, S65919 Genomic DNA Translation: AAB28339.1 AF511594 mRNA Translation: AAM43952.1 AK134378 mRNA Translation: BAE22121.1 AK144376 mRNA Translation: BAE25855.1 AL844842 Genomic DNA Translation: CAM21930.1 BC110476 mRNA Translation: AAI10477.1 BC110477 mRNA Translation: AAI10478.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS16011.1 [P33242-1]
PIRⁱ	A40716 A42128
NCBI Reference Sequences More...RefSeqⁱ	NP_001303616.1, NM_001316687.1 [P33242-1] NP_620639.1, NM_139051.3 [P33242-1]
UniGeneⁱ	Mm.31387

Genome annotation databases

Ensemblⁱ	ENSMUST00000028084; ENSMUSP00000028084; ENSMUSG00000026751 [P33242-1] ENSMUST00000112883; ENSMUSP00000108504; ENSMUSG00000026751 [P33242-1]
GeneIDⁱ	26423
KEGGⁱ	mmu:26423
UCSC genome browser More...UCSCⁱ	uc008jnr.1 mouse [P33242-1] uc008jnt.1 mouse [P33242-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P33242	Steroidogenic factor 1	)	HUMAN		461	UniRef90_Q13285
Steroidogenic factor 1		RAT		462
Steroidogenic factor 1		BOVIN		461
Steroidogenic factor 1		HORSE		461
Steroidogenic factor 1		PIG		461
+109

Protein	Similar proteins		Species	Score	Length	Source
P33242	Steroidogenic factor 1	)	HUMAN		461	UniRef50_Q13285
Steroidogenic factor 1		RAT		462
Steroidogenic factor 1		BOVIN		461
Steroidogenic factor 1		HORSE		461
Steroidogenic factor 1		PIG		461
+374
P33242-2	Nuclear receptor subfamily 5 group A member 1		MYOLU		346	UniRef50_P33242-2
Steroidogenic factor 1 (Fragment)		ESCRO		387
Nuclear receptor subfamily 5 group A member 1		HORSE		358
steroidogenic factor 1		TARSY		379
Nuclear receptor subfamily 5 group A member 1		SHEEP		439
+8

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D10584 mRNA Translation: BAA01441.1 Different initiation. S65878 , S65875, S65919, S65876, S65877 Genomic DNA Translation: AAB28338.1 S65876, S65875, S65919 Genomic DNA Translation: AAB28339.1 AF511594 mRNA Translation: AAM43952.1 AK134378 mRNA Translation: BAE22121.1 AK144376 mRNA Translation: BAE25855.1 AL844842 Genomic DNA Translation: CAM21930.1 BC110476 mRNA Translation: AAI10477.1 BC110477 mRNA Translation: AAI10478.1
CCDSⁱ	CCDS16011.1 [P33242-1]
PIRⁱ	A40716 A42128
RefSeqⁱ	NP_001303616.1, NM_001316687.1 [P33242-1] NP_620639.1, NM_139051.3 [P33242-1]
UniGeneⁱ	Mm.31387

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1YMT	X-ray	1.20	A	219-462	[»]
	1YP0	X-ray	1.50	A	223-461	[»]
	2FF0	NMR	-	A	10-111	[»]
	3F7D	X-ray	2.20	A	219-462	[»]
ProteinModelPortalⁱ	P33242
SMRⁱ	P33242
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	204975, 16 interactors
ELMⁱ	P33242
IntActⁱ	P33242, 1 interactor
STRINGⁱ	10090.ENSMUSP00000028084

Chemistry databases

ChEMBLⁱ	CHEMBL1764943
SwissLipidsⁱ	SLP:000001543

PTM databases

iPTMnetⁱ	P33242
PhosphoSitePlusⁱ	P33242

Proteomic databases

PaxDbⁱ	P33242
PRIDEⁱ	P33242

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000028084; ENSMUSP00000028084; ENSMUSG00000026751 [P33242-1] ENSMUST00000112883; ENSMUSP00000108504; ENSMUSG00000026751 [P33242-1]
GeneIDⁱ	26423
KEGGⁱ	mmu:26423
UCSCⁱ	uc008jnr.1 mouse [P33242-1] uc008jnt.1 mouse [P33242-2]

Organism-specific databases

CTDⁱ	2516
MGIⁱ	MGI:1346833 Nr5a1

Phylogenomic databases

eggNOGⁱ	KOG4218 Eukaryota ENOG410YWC2 LUCA
GeneTreeⁱ	ENSGT00870000136388
HOVERGENⁱ	HBG106677
InParanoidⁱ	P33242
KOⁱ	K08560
OMAⁱ	LQEPAKG
OrthoDBⁱ	EOG091G06RK
TreeFamⁱ	TF350737

Enzyme and pathway databases

Reactomeⁱ	R-MMU-383280 Nuclear Receptor transcription pathway R-MMU-4090294 SUMOylation of intracellular receptors

Reactomeⁱ

R-MMU-383280 Nuclear Receptor transcription pathway
R-MMU-4090294 SUMOylation of intracellular receptors

Miscellaneous databases

EvolutionaryTraceⁱ	P33242
Protein Ontology More...PROⁱ	PR:P33242
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000026751 Expressed in 118 organ(s), highest expression level in adrenal gland
CleanExⁱ	MM_NR5A1
Genevisibleⁱ	P33242 MM

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR016355 NR5_fam IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
PANTHERⁱ	PTHR24086 PTHR24086, 1 hit
Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PIRSFⁱ	PIRSF002530 Nuc_orph_FTZ-F1, 1 hit
PRINTSⁱ	PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	STF1_MOUSE
Accessionⁱ	P33242Primary (citable) accession number: P33242 Secondary accession number(s): Q812G5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 171 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P33242 (STF1_MOUSE)

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Steroidogenic factor 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ