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Protein

Lymphocyte-specific protein 1

Gene

LSP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in mediating neutrophil activation and chemotaxis.By similarity

GO - Molecular functioni

  • actin binding Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

SignaLinkiP33241
SIGNORiP33241

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte-specific protein 1
Alternative name(s):
47 kDa actin-binding protein
52 kDa phosphoprotein
Short name:
pp52
Lymphocyte-specific antigen WP34
Gene namesi
Name:LSP1
Synonyms:WP34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000130592.13
HGNCiHGNC:6707 LSP1
MIMi153432 gene
neXtProtiNX_P33241

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4046
OpenTargetsiENSG00000130592
PharmGKBiPA30472

Polymorphism and mutation databases

BioMutaiLSP1
DMDMi462553

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000845031 – 339Lymphocyte-specific protein 1Add BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphoserineCombined sources1
Modified residuei111PhosphoserineCombined sources1
Modified residuei175PhosphothreonineBy similarity1
Modified residuei177PhosphoserineBy similarity1
Modified residuei188PhosphoserineCombined sources1
Modified residuei189PhosphoserineCombined sources1
Modified residuei193PhosphoserineCombined sources1
Modified residuei252Phosphoserine; by MAPKAPK2Combined sources1 Publication1
Modified residuei327N6-acetyllysineCombined sources1

Post-translational modificationi

Phosphorylated by casein kinase II, protein kinase C and MAPKAPK2. Phosphorylation by PKC induces translocation from membrane to cytoplasm. Phosphorylation by MAPKAPK2 may regulate neutrophil chemotaxis (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP33241
MaxQBiP33241
PaxDbiP33241
PeptideAtlasiP33241
PRIDEiP33241
ProteomicsDBi54904

2D gel databases

SWISS-2DPAGEiP33241

PTM databases

iPTMnetiP33241
PhosphoSitePlusiP33241

Expressioni

Tissue specificityi

Activated T-lymphocytes.

Gene expression databases

BgeeiENSG00000130592 Expressed in 202 organ(s), highest expression level in blood
CleanExiHS_LSP1
ExpressionAtlasiP33241 baseline and differential
GenevisibleiP33241 HS

Organism-specific databases

HPAiCAB017781
HPA019693
HPA071843

Interactioni

Subunit structurei

Binds actin.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110224, 30 interactors
IntActiP33241, 7 interactors
MINTiP33241
STRINGi9606.ENSP00000308383

Structurei

Secondary structure

1339
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP33241
SMRiP33241
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP33241

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00730000111324
HOGENOMiHOG000231050
HOVERGENiHBG001610
InParanoidiP33241
KOiK14957
OMAiRLTAQWS
OrthoDBiEOG091G0I0H
PhylomeDBiP33241
TreeFamiTF336257

Family and domain databases

InterProiView protein in InterPro
IPR006018 Caldesmon_LSP
IPR002211 Lymphspecific
PANTHERiPTHR18949 PTHR18949, 2 hits
PfamiView protein in Pfam
PF02029 Caldesmon, 1 hit
PRINTSiPR01083 LYMPHSPCIFIC

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P33241-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEASSDPGA EEREELLGPT AQWSVEDEEE AVHEQCQHER DRQLQAQDEE
60 70 80 90 100
GGGHVPERPK QEMLLSLKPS EAPELDEDEG FGDWSQRPEQ RQQHEGAQGA
110 120 130 140 150
LDSGEPPQCR SPEGEQEDRP GLHAYEKEDS DEVHLEELSL SKEGPGPEDT
160 170 180 190 200
VQDNLGAAGA EEEQEEHQKC QQPRTPSPLV LEGTIEQSSP PLSPTTKLID
210 220 230 240 250
RTESLNRSIE KSNSVKKSQP DLPISKIDQW LEQYTQAIET AGRTPKLARQ
260 270 280 290 300
ASIELPSMAV ASTKSRWETG EVQAQSAAKT PSCKDIVAGD MSKKSLWEQK
310 320 330
GGSKTSSTIK STPSGKRYKF VATGHGKYEK VLVEGGPAP
Length:339
Mass (Da):37,192
Last modified:February 1, 1994 - v1
Checksum:iF2A18533500611D9
GO
Isoform 2 (identifier: P33241-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.

Note: No experimental confirmation available.
Show »
Length:277
Mass (Da):30,213
Checksum:iDA869746FA7B7C6D
GO
Isoform 3 (identifier: P33241-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MAEASSDPGAEEREELLG → MAPIWSPPGR...SGPSTNCSPR

Note: No experimental confirmation available.Curated
Show »
Length:467
Mass (Da):50,389
Checksum:iA3F09D8EECD570D6
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EMG9E7EMG9_HUMAN
Lymphocyte-specific protein 1
LSP1
275Annotation score:
E9PBD8E9PBD8_HUMAN
Lymphocyte-specific protein 1
LSP1
222Annotation score:
C9JU59C9JU59_HUMAN
Lymphocyte-specific protein 1
LSP1
175Annotation score:
C9JKF7C9JKF7_HUMAN
Lymphocyte-specific protein 1
LSP1
126Annotation score:
C9JDV1C9JDV1_HUMAN
Lymphocyte-specific protein 1
LSP1
122Annotation score:
C9J9B9C9J9B9_HUMAN
Lymphocyte-specific protein 1
LSP1
60Annotation score:
C9JNQ1C9JNQ1_HUMAN
Lymphocyte-specific protein 1
LSP1
64Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15Missing in AAB29545 (PubMed:8274738).Curated1
Sequence conflicti24S → T in CAA38971 (PubMed:2174784).Curated1
Sequence conflicti100 – 101Missing in AAB29545 (PubMed:8274738).Curated2
Sequence conflicti148E → D in BAG52478 (PubMed:14702039).Curated1
Isoform 3 (identifier: P33241-3)
Sequence conflicti31G → Q in BAG52478 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011867100A → T3 PublicationsCorresponds to variant dbSNP:rs621679Ensembl.1
Natural variantiVAR_061680108Q → L. Corresponds to variant dbSNP:rs11545725Ensembl.1
Natural variantiVAR_011868229Q → K. Corresponds to variant dbSNP:rs1803928Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0456551 – 62Missing in isoform 2. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_0459831 – 18MAEAS…EELLG → MAPIWSPPGRVSGCHLSSGP APGSAVGPWLGTPHPSLPLP LAPHKPPPPGLPGSAGQTSL PAQRECVFPGDAAVHQELCG LGFEECLGSIPQAHQCYLTN GPKRRKCSPRRRGRAPAWLC GGSPPCHQGLGHEHPSSGPS TNCSPR in isoform 3. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33552 mRNA Translation: AAA59534.1
X55188 mRNA Translation: CAA38971.1
S67783 mRNA Translation: AAB29545.1
CR541728 mRNA Translation: CAG46529.1
CR541754 mRNA Translation: CAG46554.1
AK056576 mRNA Translation: BAG51753.1
AK092071 mRNA Translation: BAG52478.1
AK222733 mRNA Translation: BAD96453.1
AC051649 Genomic DNA No translation available.
BC001785 mRNA Translation: AAH01785.1
CCDSiCCDS31334.1 [P33241-1]
CCDS31335.1 [P33241-2]
CCDS58110.1 [P33241-3]
PIRiA43542
RefSeqiNP_001013271.1, NM_001013253.1 [P33241-2]
NP_001013272.1, NM_001013254.1 [P33241-2]
NP_001013273.1, NM_001013255.1 [P33241-2]
NP_001229861.1, NM_001242932.1 [P33241-3]
NP_001275934.1, NM_001289005.1 [P33241-2]
NP_002330.1, NM_002339.2 [P33241-1]
UniGeneiHs.56729

Genome annotation databases

EnsembliENST00000311604; ENSP00000308383; ENSG00000130592 [P33241-1]
ENST00000381775; ENSP00000371194; ENSG00000130592 [P33241-3]
ENST00000405957; ENSP00000383932; ENSG00000130592 [P33241-2]
ENST00000406638; ENSP00000384022; ENSG00000130592 [P33241-2]
ENST00000612798; ENSP00000484140; ENSG00000130592 [P33241-2]
GeneIDi4046
KEGGihsa:4046
UCSCiuc001lui.3 human [P33241-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33552 mRNA Translation: AAA59534.1
X55188 mRNA Translation: CAA38971.1
S67783 mRNA Translation: AAB29545.1
CR541728 mRNA Translation: CAG46529.1
CR541754 mRNA Translation: CAG46554.1
AK056576 mRNA Translation: BAG51753.1
AK092071 mRNA Translation: BAG52478.1
AK222733 mRNA Translation: BAD96453.1
AC051649 Genomic DNA No translation available.
BC001785 mRNA Translation: AAH01785.1
CCDSiCCDS31334.1 [P33241-1]
CCDS31335.1 [P33241-2]
CCDS58110.1 [P33241-3]
PIRiA43542
RefSeqiNP_001013271.1, NM_001013253.1 [P33241-2]
NP_001013272.1, NM_001013254.1 [P33241-2]
NP_001013273.1, NM_001013255.1 [P33241-2]
NP_001229861.1, NM_001242932.1 [P33241-3]
NP_001275934.1, NM_001289005.1 [P33241-2]
NP_002330.1, NM_002339.2 [P33241-1]
UniGeneiHs.56729

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BH8X-ray1.65C249-258[»]
4NO0X-ray2.70C249-260[»]
4NO2X-ray2.00C249-260[»]
ProteinModelPortaliP33241
SMRiP33241
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110224, 30 interactors
IntActiP33241, 7 interactors
MINTiP33241
STRINGi9606.ENSP00000308383

PTM databases

iPTMnetiP33241
PhosphoSitePlusiP33241

Polymorphism and mutation databases

BioMutaiLSP1
DMDMi462553

2D gel databases

SWISS-2DPAGEiP33241

Proteomic databases

EPDiP33241
MaxQBiP33241
PaxDbiP33241
PeptideAtlasiP33241
PRIDEiP33241
ProteomicsDBi54904

Protocols and materials databases

DNASUi4046
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311604; ENSP00000308383; ENSG00000130592 [P33241-1]
ENST00000381775; ENSP00000371194; ENSG00000130592 [P33241-3]
ENST00000405957; ENSP00000383932; ENSG00000130592 [P33241-2]
ENST00000406638; ENSP00000384022; ENSG00000130592 [P33241-2]
ENST00000612798; ENSP00000484140; ENSG00000130592 [P33241-2]
GeneIDi4046
KEGGihsa:4046
UCSCiuc001lui.3 human [P33241-1]

Organism-specific databases

CTDi4046
DisGeNETi4046
EuPathDBiHostDB:ENSG00000130592.13
GeneCardsiLSP1
HGNCiHGNC:6707 LSP1
HPAiCAB017781
HPA019693
HPA071843
MIMi153432 gene
neXtProtiNX_P33241
OpenTargetsiENSG00000130592
PharmGKBiPA30472
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00730000111324
HOGENOMiHOG000231050
HOVERGENiHBG001610
InParanoidiP33241
KOiK14957
OMAiRLTAQWS
OrthoDBiEOG091G0I0H
PhylomeDBiP33241
TreeFamiTF336257

Enzyme and pathway databases

SignaLinkiP33241
SIGNORiP33241

Miscellaneous databases

ChiTaRSiLSP1 human
EvolutionaryTraceiP33241
GeneWikiiLSP1
GenomeRNAii4046
PROiPR:P33241
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130592 Expressed in 202 organ(s), highest expression level in blood
CleanExiHS_LSP1
ExpressionAtlasiP33241 baseline and differential
GenevisibleiP33241 HS

Family and domain databases

InterProiView protein in InterPro
IPR006018 Caldesmon_LSP
IPR002211 Lymphspecific
PANTHERiPTHR18949 PTHR18949, 2 hits
PfamiView protein in Pfam
PF02029 Caldesmon, 1 hit
PRINTSiPR01083 LYMPHSPCIFIC
ProtoNetiSearch...

Entry informationi

Entry nameiLSP1_HUMAN
AccessioniPrimary (citable) accession number: P33241
Secondary accession number(s): B3KPP1
, B3KRR6, E9PBV6, E9PFP3, Q16096, Q53H48, Q6FHM3, Q9BUY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 12, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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