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Entry version 170 (13 Nov 2019)
Sequence version 1 (01 Feb 1994)
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Protein

Lymphocyte-specific protein 1

Gene

LSP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in mediating neutrophil activation and chemotaxis.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P33241

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P33241

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lymphocyte-specific protein 1
Alternative name(s):
47 kDa actin-binding protein
52 kDa phosphoprotein
Short name:
pp52
Lymphocyte-specific antigen WP34
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LSP1
Synonyms:WP34
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:6707 LSP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
153432 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P33241

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4046

Open Targets

More...
OpenTargetsi
ENSG00000130592

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30472

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P33241

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LSP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
462553

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000845031 – 339Lymphocyte-specific protein 1Add BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei24PhosphoserineCombined sources1
Modified residuei111PhosphoserineCombined sources1
Modified residuei175PhosphothreonineBy similarity1
Modified residuei177PhosphoserineBy similarity1
Modified residuei188PhosphoserineCombined sources1
Modified residuei189PhosphoserineCombined sources1
Modified residuei193PhosphoserineCombined sources1
Modified residuei252Phosphoserine; by MAPKAPK2Combined sources1 Publication1
Modified residuei327N6-acetyllysineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by casein kinase II, protein kinase C and MAPKAPK2. Phosphorylation by PKC induces translocation from membrane to cytoplasm. Phosphorylation by MAPKAPK2 may regulate neutrophil chemotaxis (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P33241

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P33241

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P33241

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P33241

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P33241

PeptideAtlas

More...
PeptideAtlasi
P33241

PRoteomics IDEntifications database

More...
PRIDEi
P33241

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
19304
20148
54904 [P33241-1]

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P33241

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P33241

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P33241

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Activated T-lymphocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000130592 Expressed in 202 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P33241 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P33241 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB017781
HPA019693
HPA071843

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds actin.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110224, 32 interactors

Protein interaction database and analysis system

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IntActi
P33241, 22 interactors

Molecular INTeraction database

More...
MINTi
P33241

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000371194

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1339
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P33241

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P33241

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153901

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231050

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P33241

KEGG Orthology (KO)

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KOi
K14957

Identification of Orthologs from Complete Genome Data

More...
OMAi
QENHYDF

Database of Orthologous Groups

More...
OrthoDBi
1385709at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P33241

TreeFam database of animal gene trees

More...
TreeFami
TF336257

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006018 Caldesmon_LSP
IPR002211 Lymphspecific

The PANTHER Classification System

More...
PANTHERi
PTHR18949 PTHR18949, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02029 Caldesmon, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01083 LYMPHSPCIFIC

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P33241-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEASSDPGA EEREELLGPT AQWSVEDEEE AVHEQCQHER DRQLQAQDEE
60 70 80 90 100
GGGHVPERPK QEMLLSLKPS EAPELDEDEG FGDWSQRPEQ RQQHEGAQGA
110 120 130 140 150
LDSGEPPQCR SPEGEQEDRP GLHAYEKEDS DEVHLEELSL SKEGPGPEDT
160 170 180 190 200
VQDNLGAAGA EEEQEEHQKC QQPRTPSPLV LEGTIEQSSP PLSPTTKLID
210 220 230 240 250
RTESLNRSIE KSNSVKKSQP DLPISKIDQW LEQYTQAIET AGRTPKLARQ
260 270 280 290 300
ASIELPSMAV ASTKSRWETG EVQAQSAAKT PSCKDIVAGD MSKKSLWEQK
310 320 330
GGSKTSSTIK STPSGKRYKF VATGHGKYEK VLVEGGPAP
Length:339
Mass (Da):37,192
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF2A18533500611D9
GO
Isoform 2 (identifier: P33241-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.

Note: No experimental confirmation available.
Show »
Length:277
Mass (Da):30,213
Checksum:iDA869746FA7B7C6D
GO
Isoform 3 (identifier: P33241-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MAEASSDPGAEEREELLG → MAPIWSPPGR...SGPSTNCSPR

Note: No experimental confirmation available.Curated
Show »
Length:467
Mass (Da):50,389
Checksum:iA3F09D8EECD570D6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JKF7C9JKF7_HUMAN
Lymphocyte-specific protein 1
LSP1
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JU59C9JU59_HUMAN
Lymphocyte-specific protein 1
LSP1
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EMG9E7EMG9_HUMAN
Lymphocyte-specific protein 1
LSP1
275Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JDV1C9JDV1_HUMAN
Lymphocyte-specific protein 1
LSP1
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PBD8E9PBD8_HUMAN
Lymphocyte-specific protein 1
LSP1
222Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J9B9C9J9B9_HUMAN
Lymphocyte-specific protein 1
LSP1
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JNQ1C9JNQ1_HUMAN
Lymphocyte-specific protein 1
LSP1
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti15Missing in AAB29545 (PubMed:8274738).Curated1
Sequence conflicti24S → T in CAA38971 (PubMed:2174784).Curated1
Sequence conflicti100 – 101Missing in AAB29545 (PubMed:8274738).Curated2
Sequence conflicti148E → D in BAG52478 (PubMed:14702039).Curated1
Isoform 3 (identifier: P33241-3)
Sequence conflicti31G → Q in BAG52478 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_011867100A → T3 PublicationsCorresponds to variant dbSNP:rs621679Ensembl.1
Natural variantiVAR_061680108Q → L. Corresponds to variant dbSNP:rs11545725Ensembl.1
Natural variantiVAR_011868229Q → K. Corresponds to variant dbSNP:rs1803928Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0456551 – 62Missing in isoform 2. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_0459831 – 18MAEAS…EELLG → MAPIWSPPGRVSGCHLSSGP APGSAVGPWLGTPHPSLPLP LAPHKPPPPGLPGSAGQTSL PAQRECVFPGDAAVHQELCG LGFEECLGSIPQAHQCYLTN GPKRRKCSPRRRGRAPAWLC GGSPPCHQGLGHEHPSSGPS TNCSPR in isoform 3. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M33552 mRNA Translation: AAA59534.1
X55188 mRNA Translation: CAA38971.1
S67783 mRNA Translation: AAB29545.1
CR541728 mRNA Translation: CAG46529.1
CR541754 mRNA Translation: CAG46554.1
AK056576 mRNA Translation: BAG51753.1
AK092071 mRNA Translation: BAG52478.1
AK222733 mRNA Translation: BAD96453.1
AC051649 Genomic DNA No translation available.
BC001785 mRNA Translation: AAH01785.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31334.1 [P33241-1]
CCDS31335.1 [P33241-2]
CCDS58110.1 [P33241-3]

Protein sequence database of the Protein Information Resource

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PIRi
A43542

NCBI Reference Sequences

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RefSeqi
NP_001013271.1, NM_001013253.1 [P33241-2]
NP_001013272.1, NM_001013254.1 [P33241-2]
NP_001013273.1, NM_001013255.1 [P33241-2]
NP_001229861.1, NM_001242932.1 [P33241-3]
NP_001275934.1, NM_001289005.1 [P33241-2]
NP_002330.1, NM_002339.2 [P33241-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000311604; ENSP00000308383; ENSG00000130592 [P33241-1]
ENST00000381775; ENSP00000371194; ENSG00000130592 [P33241-3]
ENST00000405957; ENSP00000383932; ENSG00000130592 [P33241-2]
ENST00000406638; ENSP00000384022; ENSG00000130592 [P33241-2]
ENST00000612798; ENSP00000484140; ENSG00000130592 [P33241-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
4046

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4046

UCSC genome browser

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UCSCi
uc001lui.3 human [P33241-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33552 mRNA Translation: AAA59534.1
X55188 mRNA Translation: CAA38971.1
S67783 mRNA Translation: AAB29545.1
CR541728 mRNA Translation: CAG46529.1
CR541754 mRNA Translation: CAG46554.1
AK056576 mRNA Translation: BAG51753.1
AK092071 mRNA Translation: BAG52478.1
AK222733 mRNA Translation: BAD96453.1
AC051649 Genomic DNA No translation available.
BC001785 mRNA Translation: AAH01785.1
CCDSiCCDS31334.1 [P33241-1]
CCDS31335.1 [P33241-2]
CCDS58110.1 [P33241-3]
PIRiA43542
RefSeqiNP_001013271.1, NM_001013253.1 [P33241-2]
NP_001013272.1, NM_001013254.1 [P33241-2]
NP_001013273.1, NM_001013255.1 [P33241-2]
NP_001229861.1, NM_001242932.1 [P33241-3]
NP_001275934.1, NM_001289005.1 [P33241-2]
NP_002330.1, NM_002339.2 [P33241-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BH8X-ray1.65C249-258[»]
4NO0X-ray2.70C249-260[»]
4NO2X-ray2.00C249-260[»]
SMRiP33241
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi110224, 32 interactors
IntActiP33241, 22 interactors
MINTiP33241
STRINGi9606.ENSP00000371194

PTM databases

iPTMnetiP33241
PhosphoSitePlusiP33241

Polymorphism and mutation databases

BioMutaiLSP1
DMDMi462553

2D gel databases

SWISS-2DPAGEiP33241

Proteomic databases

EPDiP33241
jPOSTiP33241
MassIVEiP33241
MaxQBiP33241
PaxDbiP33241
PeptideAtlasiP33241
PRIDEiP33241
ProteomicsDBi19304
20148
54904 [P33241-1]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
P33241

The DNASU plasmid repository

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DNASUi
4046

Genome annotation databases

EnsembliENST00000311604; ENSP00000308383; ENSG00000130592 [P33241-1]
ENST00000381775; ENSP00000371194; ENSG00000130592 [P33241-3]
ENST00000405957; ENSP00000383932; ENSG00000130592 [P33241-2]
ENST00000406638; ENSP00000384022; ENSG00000130592 [P33241-2]
ENST00000612798; ENSP00000484140; ENSG00000130592 [P33241-2]
GeneIDi4046
KEGGihsa:4046
UCSCiuc001lui.3 human [P33241-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4046
DisGeNETi4046

GeneCards: human genes, protein and diseases

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GeneCardsi
LSP1
HGNCiHGNC:6707 LSP1
HPAiCAB017781
HPA019693
HPA071843
MIMi153432 gene
neXtProtiNX_P33241
OpenTargetsiENSG00000130592
PharmGKBiPA30472

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00940000153901
HOGENOMiHOG000231050
InParanoidiP33241
KOiK14957
OMAiQENHYDF
OrthoDBi1385709at2759
PhylomeDBiP33241
TreeFamiTF336257

Enzyme and pathway databases

SignaLinkiP33241
SIGNORiP33241

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LSP1 human
EvolutionaryTraceiP33241

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
LSP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4046
PharosiP33241

Protein Ontology

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PROi
PR:P33241

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000130592 Expressed in 202 organ(s), highest expression level in blood
ExpressionAtlasiP33241 baseline and differential
GenevisibleiP33241 HS

Family and domain databases

InterProiView protein in InterPro
IPR006018 Caldesmon_LSP
IPR002211 Lymphspecific
PANTHERiPTHR18949 PTHR18949, 1 hit
PfamiView protein in Pfam
PF02029 Caldesmon, 1 hit
PRINTSiPR01083 LYMPHSPCIFIC

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLSP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P33241
Secondary accession number(s): B3KPP1
, B3KRR6, E9PBV6, E9PFP3, Q16096, Q53H48, Q6FHM3, Q9BUY8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 13, 2019
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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