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UniProtKB - P33235 (FLGK_ECOLI)

Entry version 150 (10 Feb 2021)
Sequence version 3 (23 Jan 2007)
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Protein

Flagellar hook-associated protein 1

Gene

flgK

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:EG11967-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Flagellar hook-associated protein 1
Short name:
HAP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:flgK
Synonyms:flaS, flaW
Ordered Locus Names:b1082, JW1069
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Bacterial flagellum, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001808622 – 547Flagellar hook-associated protein 1Add BLAST546

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P33235

PRoteomics IDEntifications database

More...PRIDEi		P33235

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4261021, 10 interactors
850020, 2 interactors

Database of interacting proteins

More...DIPi		DIP-9639N

Protein interaction database and analysis system

More...IntActi		P33235, 7 interactors

STRING: functional protein association networks

More...STRINGi		511145.b1082

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P33235

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the flagella basal body rod proteins family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG1256, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012762_0_1_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P33235

Database for complete collections of gene phylogenies

More...PhylomeDBi		P33235

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001444, Flag_bb_rod_N
IPR010930, Flg_bb/hook_C_dom
IPR002371, FlgK

The PANTHER Classification System

More...PANTHERi		PTHR30033, PTHR30033, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00460, Flg_bb_rod, 1 hit
PF06429, Flg_bbr_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01005, FLGHOOKAP1

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR02492, flgK_ends, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P33235-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSLINNAMS GLNAAQAALN TASNNISSYN VAGYTRQTTI MAQANSTLGA 
        60         70         80         90        100
GGWVGNGVYV SGVQREYDAF ITNQLRAAQT QSSGLTARYE QMSKIDNMLS 
       110        120        130        140        150
TSTSSLATQM QDFFTSLQTL VSNAEDPAAR QALIGKSEGL VNQFKTTDQY 
       160        170        180        190        200
LRDQDKQVNI AIGASVDQIN NYAKQIASLN DQISRLTGVG AGASPNNLLD 
       210        220        230        240        250
QRDQLVSELN QIVGVEVSVQ DGGTYNITMA NGYSLVQGST ARQLAAVPSS 
       260        270        280        290        300
ADPSRTTVAY VDGTAGNIEI PEKLLNTGSL GGILTFRSQD LDQTRNTLGQ 
       310        320        330        340        350
LALAFAEAFN TQHKAGFDAN GDAGEDFFAI GKPAVLQNTK NKGDVAIGAT 
       360        370        380        390        400
VTDASAVLAT DYKISFDNNQ WQVTRLASNT TFTVTPDANG KVAFDGLELT 
       410        420        430        440        450
FTGTPAVNDS FTLKPVSDAI VNMDVLITDE AKIAMASEED AGDSDNRNGQ 
       460        470        480        490        500
ALLDLQSNSK TVGGAKSFND AYASLVSDIG NKTATLKTSS ATQGNVVTQL 
       510        520        530        540 
SNQQQSISGV NLDEEYGNLQ RFQQYYLANA QVLQTANAIF DALINIR
Length:547
Mass (Da):57,930
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2A7D15933C0F999C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74166.1
AP009048 Genomic DNA Translation: BAA35891.1
U02514 Unassigned DNA Translation: AAA18321.1

Protein sequence database of the Protein Information Resource

More...PIRi		G64851

NCBI Reference Sequences

More...RefSeqi		NP_415600.1, NC_000913.3
WP_000096479.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC74166; AAC74166; b1082
BAA35891; BAA35891; BAA35891

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57731869
945648

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW1069
eco:b1082

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.1186

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74166.1
AP009048 Genomic DNA Translation: BAA35891.1
U02514 Unassigned DNA Translation: AAA18321.1
PIRiG64851
RefSeqiNP_415600.1, NC_000913.3
WP_000096479.1, NZ_LN832404.1

3D structure databases

SMRiP33235
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4261021, 10 interactors
850020, 2 interactors
DIPiDIP-9639N
IntActiP33235, 7 interactors
STRINGi511145.b1082

Proteomic databases

PaxDbiP33235
PRIDEiP33235

Genome annotation databases

EnsemblBacteriaiAAC74166; AAC74166; b1082
BAA35891; BAA35891; BAA35891
GeneIDi57731869
945648
KEGGiecj:JW1069
eco:b1082
PATRICifig|1411691.4.peg.1186

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB1910

Phylogenomic databases

eggNOGiCOG1256, Bacteria
HOGENOMiCLU_012762_0_1_6
InParanoidiP33235
PhylomeDBiP33235

Enzyme and pathway databases

BioCyciEcoCyc:EG11967-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P33235

Family and domain databases

InterProiView protein in InterPro
IPR001444, Flag_bb_rod_N
IPR010930, Flg_bb/hook_C_dom
IPR002371, FlgK
PANTHERiPTHR30033, PTHR30033, 1 hit
PfamiView protein in Pfam
PF00460, Flg_bb_rod, 1 hit
PF06429, Flg_bbr_C, 1 hit
PRINTSiPR01005, FLGHOOKAP1
TIGRFAMsiTIGR02492, flgK_ends, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFLGK_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P33235
Secondary accession number(s): P77680
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: February 10, 2021
This is version 150 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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