UniProtKB - P33204 (ARPC4_YEAST)
Protein
Actin-related protein 2/3 complex subunit 4
Gene
ARC19
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity).By similarity
Miscellaneous
Present with 9020 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- molecular adaptor activity Source: SGD
GO - Biological processi
- actin cortical patch organization Source: SGD
- actin filament polymerization Source: InterPro
- Arp2/3 complex-mediated actin nucleation Source: InterPro
Keywordsi
Molecular function | Actin-binding |
Enzyme and pathway databases
Reactomei | R-SCE-8856828, Clathrin-mediated endocytosis |
Names & Taxonomyi
Protein namesi | Recommended name: Actin-related protein 2/3 complex subunit 4Alternative name(s): Arp2/3 complex 20 kDa Short name: p20-ARC |
Gene namesi | Name:ARC19 Ordered Locus Names:YKL013C ORF Names:YKL166 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YKL013C |
SGDi | S000001496, ARC19 |
Subcellular locationi
Cytoskeleton
Cytoskeleton
- actin cortical patch Source: UniProtKB-SubCell
- Arp2/3 protein complex Source: SGD
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000124053 | 1 – 171 | Actin-related protein 2/3 complex subunit 4Add BLAST | 171 |
Proteomic databases
MaxQBi | P33204 |
PaxDbi | P33204 |
PRIDEi | P33204 |
Interactioni
Subunit structurei
Component of the Arp2/3 complex composed of ARP2, ARP3, ARC40/p41-ARC, ARC35/p34-ARC, ARC18/p21-ARC, ARC19/p20-ARC and ARC16/p16-ARC.
1 PublicationBinary interactionsi
Hide detailsP33204
With | #Exp. | IntAct |
---|---|---|
ARC18 [Q05933] | 3 | EBI-2757,EBI-2764 |
ARC35 [P53731] | 3 | EBI-2757,EBI-2770 |
ARC40 [P38328] | 4 | EBI-2757,EBI-2777 |
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 34119, 27 interactors |
ComplexPortali | CPX-607, Arp2/3 complex |
DIPi | DIP-1819N |
IntActi | P33204, 14 interactors |
MINTi | P33204 |
STRINGi | 4932.YKL013C |
Miscellaneous databases
RNActi | P33204, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the ARPC4 family.Curated
Phylogenomic databases
eggNOGi | KOG1876, Eukaryota |
GeneTreei | ENSGT00390000016233 |
HOGENOMi | CLU_084855_1_0_1 |
InParanoidi | P33204 |
OMAi | RFMMQRA |
Family and domain databases
Gene3Di | 3.30.1460.20, 1 hit |
InterProi | View protein in InterPro IPR034666, ARPC2/4 IPR008384, ARPC4 |
PANTHERi | PTHR22629, PTHR22629, 1 hit |
Pfami | View protein in Pfam PF05856, ARPC4, 1 hit |
PIRSFi | PIRSF039100, ARPC4, 1 hit |
SUPFAMi | SSF69645, SSF69645, 1 hit |
i Sequence
Sequence statusi: Complete.
P33204-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQSLRPYLT AVRYSLEAAL TLSNFSSQEV ERHNRPEVEV PNTSAELLLQ
60 70 80 90 100
PMHISRNENE QVLIEPSVNS VRMSLMVKQA DEIEQILVHK FTRFLEQRAE
110 120 130 140 150
AFYILRRVPI PGYSISFLIT NKHTESMKTG KLVDFIIEFM EDVDKEISEI
160 170
KLFLNARARF VAEAYLDEFV Y
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X74152 Genomic DNA No translation available. S53418 Genomic DNA Translation: AAB24905.1 Different termination. Z28013 Genomic DNA Translation: CAA81848.1 AY558348 Genomic DNA Translation: AAS56674.1 BK006944 Genomic DNA Translation: DAA09143.1 |
PIRi | S37826 |
RefSeqi | NP_012912.1, NM_001179579.1 |
Genome annotation databases
EnsemblFungii | YKL013C_mRNA; YKL013C; YKL013C |
GeneIDi | 853856 |
KEGGi | sce:YKL013C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X74152 Genomic DNA No translation available. S53418 Genomic DNA Translation: AAB24905.1 Different termination. Z28013 Genomic DNA Translation: CAA81848.1 AY558348 Genomic DNA Translation: AAS56674.1 BK006944 Genomic DNA Translation: DAA09143.1 |
PIRi | S37826 |
RefSeqi | NP_012912.1, NM_001179579.1 |
3D structure databases
SMRi | P33204 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 34119, 27 interactors |
ComplexPortali | CPX-607, Arp2/3 complex |
DIPi | DIP-1819N |
IntActi | P33204, 14 interactors |
MINTi | P33204 |
STRINGi | 4932.YKL013C |
Proteomic databases
MaxQBi | P33204 |
PaxDbi | P33204 |
PRIDEi | P33204 |
Genome annotation databases
EnsemblFungii | YKL013C_mRNA; YKL013C; YKL013C |
GeneIDi | 853856 |
KEGGi | sce:YKL013C |
Organism-specific databases
EuPathDBi | FungiDB:YKL013C |
SGDi | S000001496, ARC19 |
Phylogenomic databases
eggNOGi | KOG1876, Eukaryota |
GeneTreei | ENSGT00390000016233 |
HOGENOMi | CLU_084855_1_0_1 |
InParanoidi | P33204 |
OMAi | RFMMQRA |
Enzyme and pathway databases
Reactomei | R-SCE-8856828, Clathrin-mediated endocytosis |
Miscellaneous databases
PROi | PR:P33204 |
RNActi | P33204, protein |
Family and domain databases
Gene3Di | 3.30.1460.20, 1 hit |
InterProi | View protein in InterPro IPR034666, ARPC2/4 IPR008384, ARPC4 |
PANTHERi | PTHR22629, PTHR22629, 1 hit |
Pfami | View protein in Pfam PF05856, ARPC4, 1 hit |
PIRSFi | PIRSF039100, ARPC4, 1 hit |
SUPFAMi | SSF69645, SSF69645, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ARPC4_YEAST | |
Accessioni | P33204Primary (citable) accession number: P33204 Secondary accession number(s): D6VXS3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 152 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast chromosome XI
Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names - SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD