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Entry version 156 (12 Aug 2020)
Sequence version 2 (01 Oct 1994)
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Protein

Transcription factor PDR3

Gene

PDR3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

PDR1 and PDR3 jointly control the transcription level of both SNQ2 and PDR5.

Miscellaneous

Present with 166 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi15 – 41Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST27

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-28911-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription factor PDR3
Alternative name(s):
Pleiotropic drug resistance protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDR3
Ordered Locus Names:YBL005W
ORF Names:YBL0323
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YBL005W

Saccharomyces Genome Database

More...
SGDi
S000000101, PDR3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001149621 – 976Transcription factor PDR3Add BLAST976

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P33200

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P33200

PRoteomics IDEntifications database

More...
PRIDEi
P33200

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P33200

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P33200

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
32694, 105 interactors

Database of interacting proteins

More...
DIPi
DIP-793N

Protein interaction database and analysis system

More...
IntActi
P33200, 4 interactors

Molecular INTeraction database

More...
MINTi
P33200

STRING: functional protein association networks

More...
STRINGi
4932.YBL005W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P33200, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P33200

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QV4Q, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176364

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_304446_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P33200

Identification of Orthologs from Complete Genome Data

More...
OMAi
PANDAIC

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00067, GAL4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007219, Transcription_factor_dom_fun
IPR001138, Zn2-C6_fun-type_DNA-bd
IPR036864, Zn2-C6_fun-type_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04082, Fungal_trans, 1 hit
PF00172, Zn_clus, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00066, GAL4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57701, SSF57701, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00463, ZN2_CY6_FUNGAL_1, 1 hit
PS50048, ZN2_CY6_FUNGAL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P33200-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVKKSTRSK VSTACVNCRK RKIKCTGKYP CTNCISYDCT CVFLKKHLPQ
60 70 80 90 100
KEDSSQSLPT TAVAPPSSHA NVEASADVQH LDTAIKLDNQ YYFKLMNDLI
110 120 130 140 150
QTPVSPSATH APDTSNNPTN DNNILFKDDS KYQNQLVTYQ NILTNLYALP
160 170 180 190 200
PCDDTQLLID KTKSQLNNLI NSWNPEINYP KLSSFSPRPQ RSIETYLLTN
210 220 230 240 250
KYRNKIHMTR FSFWTDQMVK SQSPDSFLAT TPLVDEVFGL FSPIQAFSLR
260 270 280 290 300
GIGYLIKKNI ENTGSSMLID TKETIYLILR LFDLCYEHLI QGCISISNPL
310 320 330 340 350
ENYLQKIKQT PTTTASASLP TSPAPLSNDL VISVIHQLPQ PFIQSITGFT
360 370 380 390 400
TTQLIENLHD SFSMFRIVTQ MYAQHRKRFA EFLNQAFSLP HQEKSVLFSS
410 420 430 440 450
FCSSEYLLST LCYAYYNVTL YHMLDINTLD YLEILVSLLE IQNEIDERFG
460 470 480 490 500
FEKMLEVAVT CSTKMGLSRW EYYVGIDENT AERRRKIWWK IYSLEKRFLT
510 520 530 540 550
DLGDLSLINE HQMNCLLPKD FRDMGFINHK EFLTKIGTSS LSPSSPKLKN
560 570 580 590 600
LSLSRLIEYG ELAIAQIVGD FFSETLYNEK FTSLEVSVKP TIIRQKLLEK
610 620 630 640 650
VFEDIESFRL KLAKIKLHTS RVFQVAHCKY PEYPKNDLIE AAKFVSYHKN
660 670 680 690 700
TWFSILGAVN NLIARLSEDP EVITEQSMKY ANEMFQEWRE INQFLIQVDT
710 720 730 740 750
DFIVWACLDF YELIFFVMAS KFYVEDPHIT LEDVINTLKV FKRITNIISF
760 770 780 790 800
FNNNLDEKDY DCQTFREFSR SSSLVAISIR IIFLKYCYAE QIDRAEFIER
810 820 830 840 850
LKEVEPGLSD LLREFFDTRS FIYRYMLKSV EKSGFHLIIR KMLESDYKFL
860 870 880 890 900
YRDKLATGNI PDQGNSSQIS QLYDSTAPSY NNASASAANS PLKLSSLLNS
910 920 930 940 950
GEESYTQDAS ENVPCNLRHQ DRSLQQTKRQ HSAPSQISAN ENNIYNLGTL
960 970
EEFVSSGDLT DLYHTLWNDN TSYPFL
Length:976
Mass (Da):112,571
Last modified:October 1, 1994 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB7601269D01DF663
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti355I → V in AAT93143 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X79803 Genomic DNA Translation: CAA56198.1
Z35766 Genomic DNA Translation: CAA84822.1
AY693124 Genomic DNA Translation: AAT93143.1
S47695 Genomic DNA Translation: AAB23986.2
BK006936 Genomic DNA Translation: DAA07115.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S45738

NCBI Reference Sequences

More...
RefSeqi
NP_009548.1, NM_001178245.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YBL005W_mRNA; YBL005W; YBL005W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852278

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YBL005W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79803 Genomic DNA Translation: CAA56198.1
Z35766 Genomic DNA Translation: CAA84822.1
AY693124 Genomic DNA Translation: AAT93143.1
S47695 Genomic DNA Translation: AAB23986.2
BK006936 Genomic DNA Translation: DAA07115.1
PIRiS45738
RefSeqiNP_009548.1, NM_001178245.1

3D structure databases

SMRiP33200
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi32694, 105 interactors
DIPiDIP-793N
IntActiP33200, 4 interactors
MINTiP33200
STRINGi4932.YBL005W

PTM databases

iPTMnetiP33200

Proteomic databases

MaxQBiP33200
PaxDbiP33200
PRIDEiP33200
TopDownProteomicsiP33200

Genome annotation databases

EnsemblFungiiYBL005W_mRNA; YBL005W; YBL005W
GeneIDi852278
KEGGisce:YBL005W

Organism-specific databases

EuPathDBiFungiDB:YBL005W
SGDiS000000101, PDR3

Phylogenomic databases

eggNOGiENOG502QV4Q, Eukaryota
GeneTreeiENSGT00940000176364
HOGENOMiCLU_304446_0_0_1
InParanoidiP33200
OMAiPANDAIC

Enzyme and pathway databases

BioCyciYEAST:G3O-28911-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P33200
RNActiP33200, protein

Family and domain databases

CDDicd00067, GAL4, 1 hit
Gene3Di4.10.240.10, 1 hit
InterProiView protein in InterPro
IPR007219, Transcription_factor_dom_fun
IPR001138, Zn2-C6_fun-type_DNA-bd
IPR036864, Zn2-C6_fun-type_DNA-bd_sf
PfamiView protein in Pfam
PF04082, Fungal_trans, 1 hit
PF00172, Zn_clus, 1 hit
SMARTiView protein in SMART
SM00066, GAL4, 1 hit
SUPFAMiSSF57701, SSF57701, 1 hit
PROSITEiView protein in PROSITE
PS00463, ZN2_CY6_FUNGAL_1, 1 hit
PS50048, ZN2_CY6_FUNGAL_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDR3_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P33200
Secondary accession number(s): D6VPZ5, E9P920
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 1, 1994
Last modified: August 12, 2020
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names
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