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Protein

Kinesin-like protein KIF1A

Gene

Kif1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Motor for anterograde axonal transport of synaptic vesicle precursors.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi97 – 104ATP8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF1A
Alternative name(s):
Axonal transporter of synaptic vesicles
Gene namesi
Name:Kif1a
Synonyms:Atsv, Kif1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:108391 Kif1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254061 – 1695Kinesin-like protein KIF1AAdd BLAST1695

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei416PhosphoserineBy similarity1
Modified residuei418PhosphoserineBy similarity1
Modified residuei419PhosphoserineBy similarity1
Modified residuei607PhosphothreonineCombined sources1
Modified residuei612PhosphothreonineCombined sources1
Modified residuei932PhosphoserineCombined sources1
Modified residuei937PhosphoserineBy similarity1
Modified residuei1315PhosphoserineBy similarity1
Modified residuei1342PhosphoserineCombined sources1
Modified residuei1524PhosphothreonineCombined sources1
Modified residuei1528PhosphothreonineCombined sources1
Modified residuei1533PhosphoserineCombined sources1
Modified residuei1537PhosphoserineCombined sources1
Modified residuei1553PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP33173
PaxDbiP33173
PeptideAtlasiP33173
PRIDEiP33173

PTM databases

iPTMnetiP33173
PhosphoSitePlusiP33173

Expressioni

Tissue specificityi

Expressed almost exclusively in adult brain tissue (mainly in the cerebellum and cerebrum) within a single type of neuronal cell. Within the neuronal cell levels are concentrated around the axon, with smaller amounts in the perinuclear and synaptic regions.

Gene expression databases

CleanExiMM_KIF1A

Interactioni

Subunit structurei

Monomer. Interacts with PPFIA1 and PPFIA4 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-46956N
IntActiP33173, 1 interactor
STRINGi10090.ENSMUSP00000128432

Structurei

Secondary structure

11695
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP33173
SMRiP33173
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP33173

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 354Kinesin motorPROSITE-ProRule annotationAdd BLAST350
Domaini516 – 572FHAPROSITE-ProRule annotationAdd BLAST57
Domaini1580 – 1678PHPROSITE-ProRule annotationAdd BLAST99

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili366 – 383Sequence analysisAdd BLAST18
Coiled coili429 – 462Sequence analysisAdd BLAST34
Coiled coili622 – 681Sequence analysisAdd BLAST60
Coiled coili801 – 822Sequence analysisAdd BLAST22

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0245 Eukaryota
COG5059 LUCA
HOVERGENiHBG052251
InParanoidiP33173
PhylomeDBiP33173

Family and domain databases

CDDicd00060 FHA, 1 hit
Gene3Di2.30.29.30, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR022164 Kinesin-like
IPR027640 Kinesin-like_fam
IPR022140 Kinesin-like_KIF1-typ
IPR032405 Kinesin_assoc
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR008984 SMAD_FHA_dom_sf
PANTHERiPTHR24115 PTHR24115, 2 hits
PfamiView protein in Pfam
PF12473 DUF3694, 1 hit
PF00498 FHA, 1 hit
PF12423 KIF1B, 1 hit
PF00225 Kinesin, 1 hit
PF16183 Kinesin_assoc, 1 hit
PF00169 PH, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00240 FHA, 1 hit
SM00129 KISc, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

P33173-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGASVKVAV RVRPFNSREM SRDSKCIIQM SGSTTTIVNP KQPKETPKSF
60 70 80 90 100
SFDYSYWSHT SPEDINYASQ KQVYRDIGEE MLQHAFEGYN VCIFAYGQTG
110 120 130 140 150
AGKSYTMMGK QEKDQQGIIP QLCEDLFSRI NDTTNDNMSY SVEVSYMEIY
160 170 180 190 200
CERVRDLLNP KNKGNLRVRE HPLLGPYVED LSKLAVTSYN DIQDLMDSGN
210 220 230 240 250
KPRTVAATNM NETSSRSHAV FNIIFTQKRH DAETNITTEK VSKISLVDLA
260 270 280 290 300
GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEMDS GPNKNKKKKK
310 320 330 340 350
TDFIPYRDSV LTWLLRENLG GNSRTAMVAA LSPADINYDE TLSTLRYADR
360 370 380 390 400
AKQIRCNAII NEDPNNKLIR ELKDEVTRLR DLLYAQGLGD ITDMTNALVG
410 420 430 440 450
MSPSSSLSAL SSRAASVSSL HERILFAPGS EEAIERLKET EKIIAELNET
460 470 480 490 500
WEEKLRRTEA IRMEREALLA EMGVAMREDG GTLGVFSPKK TPHLVNLNED
510 520 530 540 550
PLMSECLLYY IKDGVTRVGR EDAERRQDIV LSGHFIKEEH CIFRSDSRGG
560 570 580 590 600
GEAVVTLEPC EGADTYVNGK KVTEPSILRS GNRIIMGKSH VFRFNHPEQA
610 620 630 640 650
RQERERTPCA ETPAEPVDWA FAQRELLEKQ GIDMKQEMEQ RLQELEDQYR
660 670 680 690 700
REREEATYLL EQQRLDYESK LEALQKQMDS RYYPEVNEEE EEPEDEVQWT
710 720 730 740 750
ERECELALWA FRKWKWYQFT SLRDLLWGNA IFLKEANAIS VELKKKVQFQ
760 770 780 790 800
FVLLTDTLYS PLPPDLLPPE AAKDRETRPF PRTIVAVEVQ DQKNGATHYW
810 820 830 840 850
TLEKLRQRLD LMREMYDRAA EVPSSVVEDC DNVVTGGDPF YDRFPWFRLV
860 870 880 890 900
GRAFVYLSNL LYPVPLVHRV AIVSEKGEVK GFLRVAVQAI SADEEAPDYG
910 920 930 940 950
SGVRQSGTAK ISFDDQHFEK FQSESCPVVG MSRSGTSQEE LRIVEGQGQG
960 970 980 990 1000
ADAGPSADEV NNNTCSAVPP EGLMDSPEKA ALDGPLDTAL DHLRLGSTFT
1010 1020 1030 1040 1050
FRVTVLQASS ISAEYADIFC QFNFIHRHDE AFSTEPLKNT GRGPPLGFYH
1060 1070 1080 1090 1100
VQNIAVEVTK SFIEYIKSQP IVFEVFGHYQ QHPFPPLCKD VLSPLRPSRR
1110 1120 1130 1140 1150
HFPRVMPLSK PVPATKLSTM TRPSPGPCHC KYDLLVYFEI CELEANGDYI
1160 1170 1180 1190 1200
PAVVDHRGAC MGTFLLHQGI QRRITVTLLH ETGSHIRWKE VRELVVGRIR
1210 1220 1230 1240 1250
NTPETDEALI DPNILSLNIL SSGYVHPAQD DRVFFGNDTR TFYQFEAAWD
1260 1270 1280 1290 1300
SSMHNSLLLN RVTPYREKIY MTLSAYIEME NCTQPAVITK DFCMVFYSRD
1310 1320 1330 1340 1350
AKLPASRSIR NLFGSGSLRA TEGNRVTGVY ELSLCHVADA GSPGMQRRRR
1360 1370 1380 1390 1400
RVLDTSVAYV RGEENLAGWR PRSDSLILDH QWELEKLSLL QEVEKTRHYL
1410 1420 1430 1440 1450
LLREKLETTQ RPGPEVLSPA SSEDSESRSS SGASSPLSAE GQPSPLEAPN
1460 1470 1480 1490 1500
ERQRELAVKC LRLLMHTFNR EYTHSHVCIS ASESKLSEMS VTLMRDPSMS
1510 1520 1530 1540 1550
PLGAATLTPS STCPSLIEGR YGATDVRTPQ PCSRPASPEP ELLPELDSKK
1560 1570 1580 1590 1600
TPSPVRATET EKEPQRLLVP DIQEIRVSPI VSKKGYLHFL EPHTAGWAKR
1610 1620 1630 1640 1650
FVVVRRPYAY MYNSDKDTVE RFVLNLSTAQ VEYSEDQQAM LKTPNTFAVC
1660 1670 1680 1690
TEHRGILLQA NSDKDMHDWL YAFNPLLAGT IRSKLSRRRS AQMRV
Length:1,695
Mass (Da):191,725
Last modified:November 1, 1997 - v2
Checksum:iD6EC3B88CBC9CCC6
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q9G6E9Q9G6_MOUSE
Kinesin-like protein KIF1A
Kif1a
1,698Annotation score:
E9QAN4E9QAN4_MOUSE
Kinesin-like protein KIF1A
Kif1a
1,689Annotation score:
Q6TA13Q6TA13_MOUSE
Kinesin-like protein KIF1A
Kif1a
1,698Annotation score:
A0A087WQE8A0A087WQE8_MOUSE
Kinesin-like protein KIF1A
Kif1a
1,791Annotation score:
G3UW47G3UW47_MOUSE
Kinesin family member 1A
Kif1a mCG_133020
1,697Annotation score:
A0A087WSU7A0A087WSU7_MOUSE
Kinesin-like protein KIF1A
Kif1a
109Annotation score:
A0A087WNM0A0A087WNM0_MOUSE
Kinesin-like protein KIF1A
Kif1a
78Annotation score:
A0A087WRJ3A0A087WRJ3_MOUSE
Kinesin-like protein KIF1A
Kif1a
46Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29951 mRNA Translation: BAA06221.1
PIRiA56921
E44259
UniGeneiMm.276408

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29951 mRNA Translation: BAA06221.1
PIRiA56921
E44259
UniGeneiMm.276408

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I5SX-ray2.20A1-355[»]
1I6IX-ray2.00A1-355[»]
1IA0electron microscopy15.00K1-355[»]
1VFVX-ray1.85A1-355[»]
1VFWX-ray2.30A1-355[»]
1VFXX-ray2.55A1-355[»]
1VFZX-ray2.24A1-355[»]
2HXFelectron microscopy10.00C3-355[»]
2HXHelectron microscopy11.00C3-355[»]
2ZFIX-ray1.55A1-355[»]
2ZFJX-ray3.20A1-355[»]
2ZFKX-ray3.61A1-355[»]
2ZFLX-ray2.70A1-355[»]
2ZFMX-ray2.31A1-355[»]
ProteinModelPortaliP33173
SMRiP33173
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46956N
IntActiP33173, 1 interactor
STRINGi10090.ENSMUSP00000128432

PTM databases

iPTMnetiP33173
PhosphoSitePlusiP33173

Proteomic databases

MaxQBiP33173
PaxDbiP33173
PeptideAtlasiP33173
PRIDEiP33173

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:108391 Kif1a

Phylogenomic databases

eggNOGiKOG0245 Eukaryota
COG5059 LUCA
HOVERGENiHBG052251
InParanoidiP33173
PhylomeDBiP33173

Miscellaneous databases

ChiTaRSiKif1a mouse
EvolutionaryTraceiP33173
PROiPR:P33173
SOURCEiSearch...

Gene expression databases

CleanExiMM_KIF1A

Family and domain databases

CDDicd00060 FHA, 1 hit
Gene3Di2.30.29.30, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR022164 Kinesin-like
IPR027640 Kinesin-like_fam
IPR022140 Kinesin-like_KIF1-typ
IPR032405 Kinesin_assoc
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR008984 SMAD_FHA_dom_sf
PANTHERiPTHR24115 PTHR24115, 2 hits
PfamiView protein in Pfam
PF12473 DUF3694, 1 hit
PF00498 FHA, 1 hit
PF12423 KIF1B, 1 hit
PF00225 Kinesin, 1 hit
PF16183 Kinesin_assoc, 1 hit
PF00169 PH, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00240 FHA, 1 hit
SM00129 KISc, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKIF1A_MOUSE
AccessioniPrimary (citable) accession number: P33173
Secondary accession number(s): Q61770
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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