UniProtKB - P33148 (CADHF_XENLA)
Protein
EP-cadherin
Gene
N/A
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
GO - Molecular functioni
- calcium ion binding Source: InterPro
GO - Biological processi
- homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Keywordsi
Biological process | Cell adhesion |
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: EP-cadherinAlternative name(s): C-cadherin |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-6254663, cdh3.S |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 156 – 703 | ExtracellularSequence analysisAdd BLAST | 548 | |
Transmembranei | 704 – 728 | HelicalSequence analysisAdd BLAST | 25 | |
Topological domaini | 729 – 880 | CytoplasmicSequence analysisAdd BLAST | 152 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
PropeptideiPRO_0000003725 | 29 – 155 | Sequence analysisAdd BLAST | 127 | |
ChainiPRO_0000003726 | 156 – 880 | EP-cadherinAdd BLAST | 725 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 61 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 343 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 382 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 400 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 425 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 428 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 469 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 471 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 473 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 475 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 558 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 562 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 576 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 578 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 580 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Disulfide bondi | 603 ↔ 687 | |||
Glycosylationi | 681 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 685 ↔ 694 |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinPTM databases
iPTMneti | P33148 |
Expressioni
Developmental stagei
Unfertilized eggs and early Xenopus embryos.
Interactioni
Subunit structurei
Interacts with CTNNB1.
1 PublicationBinary interactionsi
Hide detailsP33148
With | #Exp. | IntAct |
---|---|---|
Ctnnb1 [Q02248] from Mus musculus. | 4 | EBI-15603953,EBI-397872 |
nmo [Q23993] from Drosophila melanogaster. | 4 | EBI-15603953,EBI-876224 |
Protein-protein interaction databases
DIPi | DIP-59585N |
IntActi | P33148, 4 interactors |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P33148 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P33148 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 156 – 263 | Cadherin 1PROSITE-ProRule annotationAdd BLAST | 108 | |
Domaini | 264 – 376 | Cadherin 2PROSITE-ProRule annotationAdd BLAST | 113 | |
Domaini | 377 – 487 | Cadherin 3PROSITE-ProRule annotationAdd BLAST | 111 | |
Domaini | 488 – 593 | Cadherin 4PROSITE-ProRule annotationAdd BLAST | 106 | |
Domaini | 594 – 704 | Cadherin 5PROSITE-ProRule annotationAdd BLAST | 111 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 837 – 850 | Ser-richAdd BLAST | 14 | |
Compositional biasi | 876 – 880 | Asp/Glu-rich (acidic) | 5 |
Domaini
Three calcium ions are usually bound at the interface of each cadherin domain.
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
OrthoDBi | 182239at2759 |
Family and domain databases
Gene3Di | 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR000233, Cadherin_cytoplasmic-dom IPR014868, Cadherin_pro_dom IPR027397, Catenin-bd_sf |
PANTHERi | PTHR24027, PTHR24027, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 4 hits PF01049, Cadherin_C, 1 hit PF08758, Cadherin_pro, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 4 hits SM01055, Cadherin_pro, 1 hit |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 3 hits PS50268, CADHERIN_2, 4 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P33148-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSTRLRNAS VWLCGLLCLL QVVPSINADV SGCKPGFSSA EYIFSVNRRE
60 70 80 90 100
LERGRKLGKV NFSDCTTRKH GLYDVGDSRF RVLPDGTVLV KRHVKLHKDT
110 120 130 140 150
KFTISTWDAR GIKHSTNIAV ASKRHRSGEE AHSRSSKLPV LTFPETHTGL
160 170 180 190 200
KRKKRDWVIP PIKVSENERG PFPKRLVQIK SNKDRFNKVY YSITGQGADN
210 220 230 240 250
PPQGVFRIEW ETGWMLVTRP LDREEYDKYV LSSHAVSENG SPVEEPMEIT
260 270 280 290 300
INVIDQNDNR PKFTQDVFRG SVREGVQPGT QVMAVSATDE DDNIDSLNGV
310 320 330 340 350
LSYSILKQDP EEPIPNLFTI NRETGVISLI GTGLDREKFP EYTLTVQATD
360 370 380 390 400
LEGAGLSVEG KAIIQITDAN DNAPIFDPKT YTALVPENEI GFEVQRLSVT
410 420 430 440 450
DLDMPGTPAW QAVYKIRVNE GGFFNITTDP ESNQGILTTA KGLDFELRKQ
460 470 480 490 500
YVLQITVENA EPFSVPLPTS TATVTVTVED VNEAPFFVPA VSRVDVSEDL
510 520 530 540 550
SRGEKIISLV AQDPDKQQIQ KLSYFIGNDP ARWLTVNKDN GIVTGNGNLD
560 570 580 590 600
RESEYVKNNT YTVIMLVTDD GVSVGTGTGT LILHVLDVND NGPVPSPRVF
610 620 630 640 650
TMCDQNPEPQ VLTISDADIP PNTYPYKVSL SHGSDLTWKA ELDSKGTSML
660 670 680 690 700
LSPTQQLKKG DYSIYVLLSD AQNNPQLTVV NATVCSCEGK AIKCQEKLVG
710 720 730 740 750
GFDLPIILVI LGSVLALLIL FLLLLLFLKR KKVVKEPLLL PEDDTRDNIF
760 770 780 790 800
YYGEEGGGEE DQDYDLSQLH RGLDSRPDIM RNDVVPTLMP APHYRPRPSN
810 820 830 840 850
PDEIGNFIDE NLDAADNDPT APPYDSLLVF DYEGSGSEAA SLSSLNSSNS
860 870 880
NDEHDYNYLS DWGSRFRKLA DMYGGDDDEE
Sequence cautioni
The sequence CAA45252 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3 | S → G in AAC16910 (Ref. 2) Curated | 1 | |
Sequence conflicti | 112 | I → N in AAC16910 (Ref. 2) Curated | 1 | |
Sequence conflicti | 163 | K → I AA sequence (PubMed:1879345).Curated | 1 | |
Sequence conflicti | 169 | R → K AA sequence (PubMed:1879345).Curated | 1 | |
Sequence conflicti | 176 | L → I AA sequence (PubMed:1879345).Curated | 1 | |
Sequence conflicti | 573 | S → P in AAC16910 (Ref. 2) Curated | 1 | |
Sequence conflicti | 864 | S → P in AAC16910 (Ref. 2) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X63720 mRNA Translation: CAA45252.1 Different initiation. U04707 mRNA Translation: AAC16910.1 |
PIRi | B43785, IJXLCP |
RefSeqi | NP_001080946.1, NM_001087477.1 |
Genome annotation databases
GeneIDi | 394290 |
KEGGi | xla:394290 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X63720 mRNA Translation: CAA45252.1 Different initiation. U04707 mRNA Translation: AAC16910.1 |
PIRi | B43785, IJXLCP |
RefSeqi | NP_001080946.1, NM_001087477.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1L3W | X-ray | 3.08 | A | 156-695 | [»] | |
SMRi | P33148 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-59585N |
IntActi | P33148, 4 interactors |
PTM databases
iPTMneti | P33148 |
Genome annotation databases
GeneIDi | 394290 |
KEGGi | xla:394290 |
Organism-specific databases
CTDi | 394290 |
Xenbasei | XB-GENE-6254663, cdh3.S |
Phylogenomic databases
OrthoDBi | 182239at2759 |
Miscellaneous databases
EvolutionaryTracei | P33148 |
Family and domain databases
Gene3Di | 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR000233, Cadherin_cytoplasmic-dom IPR014868, Cadherin_pro_dom IPR027397, Catenin-bd_sf |
PANTHERi | PTHR24027, PTHR24027, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 4 hits PF01049, Cadherin_C, 1 hit PF08758, Cadherin_pro, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 4 hits SM01055, Cadherin_pro, 1 hit |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 3 hits PS50268, CADHERIN_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CADHF_XENLA | |
Accessioni | P33148Primary (citable) accession number: P33148 Secondary accession number(s): Q91543 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | April 27, 2001 | |
Last modified: | April 7, 2021 | |
This is version 126 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references