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Protein

Cadherin-15

Gene

Cdh15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.

GO - Molecular functioni

  • cadherin binding Source: GO_Central
  • calcium ion binding Source: GO_Central
  • cytoskeletal protein binding Source: GO_Central
  • protein homodimerization activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-375170 CDO in myogenesis
R-MMU-418990 Adherens junctions interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-15
Alternative name(s):
Cadherin-14
Muscle cadherin
Short name:
M-cadherin
Gene namesi
Name:Cdh15
Synonyms:Cdh14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:106672 Cdh15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini60 – 605ExtracellularSequence analysisAdd BLAST546
Transmembranei606 – 625HelicalSequence analysisAdd BLAST20
Topological domaini626 – 784CytoplasmicSequence analysisAdd BLAST159

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000000380722 – 59Sequence analysisAdd BLAST38
ChainiPRO_000000380860 – 784Cadherin-15Add BLAST725

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi106N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi226N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi530N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi537N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi575N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PaxDbiP33146
PeptideAtlasiP33146
PRIDEiP33146

PTM databases

iPTMnetiP33146
PhosphoSitePlusiP33146

Expressioni

Tissue specificityi

Skeletal muscle.

Gene expression databases

BgeeiENSMUSG00000031962 Expressed in 102 organ(s), highest expression level in spinal cord
CleanExiMM_CDH15
GenevisibleiP33146 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198634, 2 interactors
STRINGi10090.ENSMUSP00000034443

Structurei

3D structure databases

ProteinModelPortaliP33146
SMRiP33146
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 151Cadherin 1PROSITE-ProRule annotationAdd BLAST92
Domaini152 – 259Cadherin 2PROSITE-ProRule annotationAdd BLAST108
Domaini260 – 374Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini375 – 480Cadherin 4PROSITE-ProRule annotationAdd BLAST106
Domaini481 – 589Cadherin 5PROSITE-ProRule annotationAdd BLAST109

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi745 – 756Ser-richAdd BLAST12

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00760000118906
HOGENOMiHOG000231254
HOVERGENiHBG106438
InParanoidiP33146
KOiK06809
OMAiLDYESCE
OrthoDBiEOG091G02MA
TreeFamiTF316817

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PANTHERiPTHR24027 PTHR24027, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 4 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 2 hits
PS50268 CADHERIN_2, 5 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33146-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSALLLALG LLAQSLGLSW AVPEPKPSTL YPWRRASAPG RVRRAWVIPP
60 70 80 90 100
ISVSENHKRL PYPLVQIKSD KQQLGSVIYS IQGPGVDEEP RNVFSIDKFT
110 120 130 140 150
GRVYLNATLD REKTDRFRLR AFALDLGGST LEDPTDLEIV VVDQNDNRPA
160 170 180 190 200
FLQDVFRGRI LEGAIPGTFV TRAEATDADD PETDNAALRF SILEQGSPEF
210 220 230 240 250
FSIDEHTGEI RTVQVGLDRE VVAVYNLTLQ VADMSGDGLT ATASAIISID
260 270 280 290 300
DINDNAPEFT KDEFFMEAAE AVSGVDVGRL EVEDKDLPGS PNWVARFTIL
310 320 330 340 350
EGDPDGQFKI YTDPKTNEGV LSVVKPLDYE SREQYELRVS VQNEAPLQAA
360 370 380 390 400
APRARRGQTR VSVWVQDTNE APVFPENPLR TSIAEGAPPG TSVATFSARD
410 420 430 440 450
PDTEQLQRIS YSKDYDPEDW LQVDGATGRI QTQRVLSPAS PFLKDGWYRA
460 470 480 490 500
IILALDNAIP PSTATGTLSI EILEVNDHAP ALALPPSGSL CSEPDQGPGL
510 520 530 540 550
LLGATDEDLP PHGAPFHFQL NPRVPDLGRN WSVSQINVSH ARLRLRHQVS
560 570 580 590 600
EGLHRLSLLL QDSGEPPQQR EQTLNVTVCR CGSDGTCLPG AAALRGGGVG
610 620 630 640 650
VSLGALVIVL ASTVVLLVLI LLAALRTRFR GHSRGKSLLH GLQEDLRDNI
660 670 680 690 700
LNYDEQGGGE EDQDAYDINQ LRHPVEPRAT SRSLGRPPLR RDAPFSYVPQ
710 720 730 740 750
PHRVLPTSPS DIANFISDGL EAADSDPSVP PYDTALIYDY EGDGSVAGTL
760 770 780
SSILSSLGDE DQDYDYLRDW GPRFARLADM YGHQ
Length:784
Mass (Da):85,644
Last modified:July 27, 2011 - v3
Checksum:iA21D73960A6F0063
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26K → E in AAC23585 (PubMed:1840697).Curated1
Sequence conflicti159R → H in AAC23585 (PubMed:1840697).Curated1
Sequence conflicti622L → F in AAC23585 (PubMed:1840697).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC157978 mRNA Translation: AAI57979.1
M74541 mRNA Translation: AAC23585.1
AJ245402 Genomic DNA Translation: CAB57281.2
CCDSiCCDS22746.1
PIRiA40986 IJMSCM
RefSeqiNP_031688.2, NM_007662.2
UniGeneiMm.1976

Genome annotation databases

EnsembliENSMUST00000034443; ENSMUSP00000034443; ENSMUSG00000031962
GeneIDi12555
KEGGimmu:12555
UCSCiuc009ntv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC157978 mRNA Translation: AAI57979.1
M74541 mRNA Translation: AAC23585.1
AJ245402 Genomic DNA Translation: CAB57281.2
CCDSiCCDS22746.1
PIRiA40986 IJMSCM
RefSeqiNP_031688.2, NM_007662.2
UniGeneiMm.1976

3D structure databases

ProteinModelPortaliP33146
SMRiP33146
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198634, 2 interactors
STRINGi10090.ENSMUSP00000034443

PTM databases

iPTMnetiP33146
PhosphoSitePlusiP33146

Proteomic databases

PaxDbiP33146
PeptideAtlasiP33146
PRIDEiP33146

Protocols and materials databases

DNASUi12555
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034443; ENSMUSP00000034443; ENSMUSG00000031962
GeneIDi12555
KEGGimmu:12555
UCSCiuc009ntv.1 mouse

Organism-specific databases

CTDi1013
MGIiMGI:106672 Cdh15

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00760000118906
HOGENOMiHOG000231254
HOVERGENiHBG106438
InParanoidiP33146
KOiK06809
OMAiLDYESCE
OrthoDBiEOG091G02MA
TreeFamiTF316817

Enzyme and pathway databases

ReactomeiR-MMU-375170 CDO in myogenesis
R-MMU-418990 Adherens junctions interactions

Miscellaneous databases

PROiPR:P33146
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031962 Expressed in 102 organ(s), highest expression level in spinal cord
CleanExiMM_CDH15
GenevisibleiP33146 MM

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PANTHERiPTHR24027 PTHR24027, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 4 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 2 hits
PS50268 CADHERIN_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCAD15_MOUSE
AccessioniPrimary (citable) accession number: P33146
Secondary accession number(s): B2RXU1, Q9QYZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 144 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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