fliR

Functionⁱ

Role in flagellar biosynthesis.

GO - Biological processⁱ

bacterial-type flagellum assembly Source: InterPro
protein targeting Source: InterPro

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

BioCycⁱ	EcoCyc:EG11977-MONOMER

BioCycⁱ

EcoCyc:EG11977-MONOMER

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Flagellar biosynthetic protein FliR
Gene namesⁱ	Name:fliR Synonyms:flaP Ordered Locus Names:b1950, JW1934
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG11977 fliR

EcoGeneⁱ

EG11977 fliR

Subcellular locationⁱ

Cell inner membrane
1 Publication
Manual assertion based on experiment inⁱ
- Ref.5
  "Global topology analysis of the Escherichia coli inner membrane proteome."
  Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
  Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION.
; Multi-pass membrane protein
1 Publication
Manual assertion based on experiment inⁱ
- Ref.5
  "Global topology analysis of the Escherichia coli inner membrane proteome."
  Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
  Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION.
Bacterial flagellum basal body
1 Publication
Manual assertion based on experiment inⁱ
- Ref.5
  "Global topology analysis of the Escherichia coli inner membrane proteome."
  Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
  Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION.

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	13 – 33	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	45 – 65	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	66 – 86	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	90 – 110	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	131 – 151	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	184 – 204	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	213 – 233	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	235 – 255	HelicalSequence analysisAdd BLAST	21

GO - Cellular componentⁱ

bacterial-type flagellum basal body Source: UniProtKB-SubCell
integral component of membrane Source: UniProtKB-KW
intracellular Source: GOC
plasma membrane
Source: EcoCyc
Inferred from direct assayⁱ
- 15919996

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Bacterial flagellum, Cell inner membrane, Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000192055	1 – 261	Flagellar biosynthetic protein FliRAdd BLAST		261

Proteomic databases

PaxDbⁱ	P33135
PRIDEⁱ	P33135

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	4261046, 276 interactors
IntActⁱ	P33135, 4 interactors
STRINGⁱ	316385.ECDH10B_2092

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P33135
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the FliR/MopE/SpaR family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG4105D19 Bacteria COG1684 LUCA
HOGENOMⁱ	HOG000253545
InParanoidⁱ	P33135
KEGG Orthology (KO) More...KOⁱ	K02421
OMAⁱ	APQFNIF
PhylomeDBⁱ	P33135

Family and domain databases

InterProⁱ	View protein in InterPro IPR006303 FliR IPR002010 T3SS_IM_R
PANTHERⁱ	PTHR30065 PTHR30065, 1 hit PTHR30065:SF1 PTHR30065:SF1, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01311 Bac_export_1, 1 hit
PRINTSⁱ	PR00953 TYPE3IMRPROT
TIGRFAMsⁱ	TIGR01400 fliR, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P33135-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLQVTSEQWL SWLNLYFWPL LRVLALISTA PILSERSVPK RVKLGLAMMI 
        60         70         80         90        100
TFAIAPSLPA NDVPVFSFFA LWLAVQQILI GIALGFTMQF AFAAVRTAGE 
       110        120        130        140        150
IIGLQMGLSF ATFVDPASHL NMPVLARIMD MLALLLFLTF NGHLWLISLL 
       160        170        180        190        200
VDTFHTLPIG GEPLNSNAFL ALTKAGSLIF LNGLMLALPL ITLLLTLNLA 
       210        220        230        240        250
LGLLNRMAPQ LSIFVIGFPL TLTVGISLMA ALMPLIAPFC EHLFSEIFNL 
       260 
LADIISELPL I

Length:261

Mass (Da):28,543

Last modified:November 1, 1997 - v2

Checksum:ⁱ55405C88D4542B7F

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	223	T → A in AAC36861 (PubMed:8282695).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L22182 Genomic DNA Translation: AAC36861.1 U00096 Genomic DNA Translation: AAC75017.1 AP009048 Genomic DNA Translation: BAA15775.1
PIRⁱ	C64959
NCBI Reference Sequences More...RefSeqⁱ	NP_416460.1, NC_000913.3 WP_000942319.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC75017; AAC75017; b1950 BAA15775; BAA15775; BAA15775
GeneIDⁱ	946464
KEGGⁱ	ecj:JW1934 eco:b1950
PATRICⁱ	fig\|1411691.4.peg.301

Protein	Similar proteins		Species	Score	Length
P33135	Flagellar biosynthetic protein FliR		ECOBD		261
Flagellar biosynthetic protein FliR		Escherichia coli 3-373-03_S4_C2		261
Flagellar biosynthesis protein FliR		ECOLX		261
UPI0007EAEAD0		ECOLX		203
UPI000D6F1A1C		ECOLX		252

Protein	Similar proteins		Species	Score	Length
P33135	Flagellar biosynthetic protein FliR		ECOBD		261
Flagellar biosynthetic protein FliR		Escherichia coli 3-373-03_S4_C2		261
Flagellar biosynthesis protein FliR		ECOLX		261
Flagellar biosynthetic protein FliR		Escherichia albertii KF1		263
Flagellar type III secretion system protein FliR		Escherichia albertii		263
+557

Protein	Similar proteins		Species	Score	Length
P33135	Flagellar biosynthetic protein FliR		ECOBD		261
Flagellar biosynthetic protein FliR		Escherichia coli 3-373-03_S4_C2		261
Flagellar biosynthesis protein FliR		ECOLX		261
UPI000507708D		Escherichia albertii		263
Flagellar biosynthetic protein FliR		Escherichia albertii B156		263
+570

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L22182 Genomic DNA Translation: AAC36861.1 U00096 Genomic DNA Translation: AAC75017.1 AP009048 Genomic DNA Translation: BAA15775.1
PIRⁱ	C64959
NCBI Reference Sequences More...RefSeqⁱ	NP_416460.1, NC_000913.3 WP_000942319.1, NZ_LN832404.1

3D structure databases

ProteinModelPortalⁱ	P33135
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4261046, 276 interactors
IntActⁱ	P33135, 4 interactors
STRINGⁱ	316385.ECDH10B_2092

Proteomic databases

PaxDbⁱ	P33135
PRIDEⁱ	P33135

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC75017; AAC75017; b1950 BAA15775; BAA15775; BAA15775
GeneIDⁱ	946464
KEGGⁱ	ecj:JW1934 eco:b1950
PATRICⁱ	fig\|1411691.4.peg.301

Organism-specific databases

EchoBASEⁱ	EB1920
EcoGeneⁱ	EG11977 fliR

Phylogenomic databases

eggNOGⁱ	ENOG4105D19 Bacteria COG1684 LUCA
HOGENOMⁱ	HOG000253545
InParanoidⁱ	P33135
KEGG Orthology (KO) More...KOⁱ	K02421
OMAⁱ	APQFNIF
PhylomeDBⁱ	P33135

Enzyme and pathway databases

BioCycⁱ	EcoCyc:EG11977-MONOMER

BioCycⁱ

EcoCyc:EG11977-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P33135

PROⁱ

PR:P33135

Family and domain databases

InterProⁱ	View protein in InterPro IPR006303 FliR IPR002010 T3SS_IM_R
PANTHERⁱ	PTHR30065 PTHR30065, 1 hit PTHR30065:SF1 PTHR30065:SF1, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01311 Bac_export_1, 1 hit
PRINTSⁱ	PR00953 TYPE3IMRPROT
TIGRFAMsⁱ	TIGR01400 fliR, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FLIR_ECOLI
Accessionⁱ	P33135Primary (citable) accession number: P33135 Secondary accession number(s): P76327
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
	Last sequence update:	November 1, 1997
	Last modified:	March 28, 2018
	This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P33135 (FLIR_ECOLI)

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Flagellar biosynthetic protein FliR

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ