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Protein

Long-chain-fatty-acid--CoA ligase 1

Gene

ACSL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:HS07766-MONOMER

BRENDA Comprehensive Enzyme Information System

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BRENDAi
6.2.1.3 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1989781 PPARA activates gene expression
R-HSA-2046105 Linoleic acid (LA) metabolism
R-HSA-2046106 alpha-linolenic acid (ALA) metabolism
R-HSA-75876 Synthesis of very long-chain fatty acyl-CoAs

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P33121

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000199
SLP:000001468 [P33121-1]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase 1 (EC:6.2.1.3)
Alternative name(s):
Acyl-CoA synthetase 1
Short name:
ACS1
Long-chain acyl-CoA synthetase 1
Short name:
LACS 1
Long-chain acyl-CoA synthetase 2
Short name:
LACS 2
Long-chain fatty acid-CoA ligase 2
Palmitoyl-CoA ligase 1
Palmitoyl-CoA ligase 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACSL1
Synonyms:FACL1, FACL2, LACS, LACS1, LACS2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000151726.13

Human Gene Nomenclature Database

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HGNCi
HGNC:3569 ACSL1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
152425 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P33121

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei25 – 45Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini46 – 698CytoplasmicSequence analysisAdd BLAST653

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome, Mitochondrion, Mitochondrion outer membrane, Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2180

Open Targets

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OpenTargetsi
ENSG00000151726

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27966

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00131 Adenosine monophosphate
DB00171 Adenosine triphosphate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ACSL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
417241

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001931041 – 698Long-chain-fatty-acid--CoA ligase 1Add BLAST698

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionine1 Publication1
Modified residuei9Nitrated tyrosineBy similarity1
Modified residuei84PhosphotyrosineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi135O-linked (GlcNAc) serineBy similarity1
Modified residuei207N6-acetyllysineBy similarity1
Modified residuei356N6-acetyllysineBy similarity1
Modified residuei386N6-acetyllysineBy similarity1
Modified residuei620PhosphoserineCombined sources1
Modified residuei632N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Glycoprotein, Nitration, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P33121

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P33121

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P33121

PeptideAtlas

More...
PeptideAtlasi
P33121

PRoteomics IDEntifications database

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PRIDEi
P33121

ProteomicsDB human proteome resource

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ProteomicsDBi
54898
54899 [P33121-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P33121

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P33121

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P33121

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during the early stages of erythroid development while expression is very low in reticulocytes and young erythrocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000151726 Expressed in 232 organ(s), highest expression level in parietal pleura

CleanEx database of gene expression profiles

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CleanExi
HS_ACSL1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P33121 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P33121 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA011316
HPA011964

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108476, 14 interactors

Protein interaction database and analysis system

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IntActi
P33121, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000281455

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P33121

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P33121

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1256 Eukaryota
COG1022 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154508

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000159459

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG050452

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P33121

KEGG Orthology (KO)

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KOi
K01897

Identification of Orthologs from Complete Genome Data

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OMAi
TCYEWGV

Database of Orthologous Groups

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OrthoDBi
EOG091G03G9

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P33121

TreeFam database of animal gene trees

More...
TreeFami
TF313877

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455 AMP_BINDING, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P33121-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQAHELFRYF RMPELVDFRQ YVRTLPTNTL MGFGAFAALT TFWYATRPKP
60 70 80 90 100
LKPPCDLSMQ SVEVAGSGGA RRSALLDSDE PLVYFYDDVT TLYEGFQRGI
110 120 130 140 150
QVSNNGPCLG SRKPDQPYEW LSYKQVAELS ECIGSALIQK GFKTAPDQFI
160 170 180 190 200
GIFAQNRPEW VIIEQGCFAY SMVIVPLYDT LGNEAITYIV NKAELSLVFV
210 220 230 240 250
DKPEKAKLLL EGVENKLIPG LKIIVVMDAY GSELVERGQR CGVEVTSMKA
260 270 280 290 300
MEDLGRANRR KPKPPAPEDL AVICFTSGTT GNPKGAMVTH RNIVSDCSAF
310 320 330 340 350
VKATENTVNP CPDDTLISFL PLAHMFERVV ECVMLCHGAK IGFFQGDIRL
360 370 380 390 400
LMDDLKVLQP TVFPVVPRLL NRMFDRIFGQ ANTTLKRWLL DFASKRKEAE
410 420 430 440 450
LRSGIIRNNS LWDRLIFHKV QSSLGGRVRL MVTGAAPVSA TVLTFLRAAL
460 470 480 490 500
GCQFYEGYGQ TECTAGCCLT MPGDWTAGHV GAPMPCNLIK LVDVEEMNYM
510 520 530 540 550
AAEGEGEVCV KGPNVFQGYL KDPAKTAEAL DKDGWLHTGD IGKWLPNGTL
560 570 580 590 600
KIIDRKKHIF KLAQGEYIAP EKIENIYMRS EPVAQVFVHG ESLQAFLIAI
610 620 630 640 650
VVPDVETLCS WAQKRGFEGS FEELCRNKDV KKAILEDMVR LGKDSGLKPF
660 670 680 690
EQVKGITLHP ELFSIDNGLL TPTMKAKRPE LRNYFRSQID DLYSTIKV
Length:698
Mass (Da):77,943
Last modified:October 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD6669453589D362
GO
Isoform 2 (identifier: P33121-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     508-517: Missing.

Note: May be due to a competing acceptor splice site. No experimental confirmation available.
Show »
Length:688
Mass (Da):76,871
Checksum:i815DF2AA8EE8A6B4
GO
Isoform 3 (identifier: P33121-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     306-331: NTVNPCPDDTLISFLPLAHMFERVVE → KALPLSASDTHISYLPLAHIYEQLLK

Note: No experimental confirmation available.
Show »
Length:698
Mass (Da):77,907
Checksum:i1EDBB04923DD129F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EPM6E7EPM6_HUMAN
Long-chain-fatty-acid--CoA ligase 1
ACSL1
664Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RER0D6RER0_HUMAN
Long-chain-fatty-acid--CoA ligase 1
ACSL1
388Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RG07D6RG07_HUMAN
Long-chain-fatty-acid--CoA ligase 1
ACSL1
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z3Z9B7Z3Z9_HUMAN
Long-chain-fatty-acid--CoA ligase 1
ACSL1
527Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9Z9H0Y9Z9_HUMAN
Long-chain-fatty-acid--CoA ligase 1
ACSL1
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9U7H0Y9U7_HUMAN
Long-chain-fatty-acid--CoA ligase 1
ACSL1
294Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC04704 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti21 – 23YVR → CV in AAB00959 (PubMed:8584017).Curated3
Sequence conflicti37 – 38AA → SRR in AAB00959 (PubMed:8584017).Curated2
Sequence conflicti44 – 47YATR → RPRH in AAB00959 (PubMed:8584017).Curated4
Sequence conflicti55 – 56CD → WH in AAB00959 (PubMed:8584017).Curated2
Sequence conflicti229A → S in AAB00959 (PubMed:8584017).Curated1
Sequence conflicti385L → V in AAB00959 (PubMed:8584017).Curated1
Sequence conflicti400 – 401EL → DV in AAB00959 (PubMed:8584017).Curated2
Sequence conflicti477A → T in AAB00959 (PubMed:8584017).Curated1
Sequence conflicti492 – 494VDV → GWQL in AAB00959 (PubMed:8584017).Curated3
Sequence conflicti502A → S in AAB00959 (PubMed:8584017).Curated1
Sequence conflicti695T → I in AAB00959 (PubMed:8584017).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054391306 – 331NTVNP…ERVVE → KALPLSASDTHISYLPLAHI YEQLLK in isoform 3. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_009604508 – 517Missing in isoform 2. 1 Publication10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D10040 mRNA Translation: BAA00931.1
L09229 mRNA Translation: AAB00959.1
AK096117 mRNA Translation: BAC04704.1 Different initiation.
AK296826 mRNA Translation: BAH12438.1
AC079257 Genomic DNA No translation available.
AC084871 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX04662.1
CH471056 Genomic DNA Translation: EAX04663.1
CH471056 Genomic DNA Translation: EAX04665.1
BC026290 mRNA Translation: AAH26290.1
BC050073 mRNA Translation: AAH50073.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3839.1 [P33121-1]
CCDS68826.1 [P33121-3]

Protein sequence database of the Protein Information Resource

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PIRi
JX0202

NCBI Reference Sequences

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RefSeqi
NP_001273637.1, NM_001286708.1 [P33121-1]
NP_001273639.1, NM_001286710.1 [P33121-3]
NP_001273640.1, NM_001286711.1
NP_001273641.1, NM_001286712.1
NP_001986.2, NM_001995.3 [P33121-1]
XP_005262885.1, XM_005262828.1 [P33121-1]
XP_005262886.1, XM_005262829.1 [P33121-1]
XP_005262888.1, XM_005262831.1 [P33121-1]
XP_011530044.1, XM_011531742.1 [P33121-1]
XP_016863376.1, XM_017007887.1 [P33121-1]
XP_016863377.1, XM_017007888.1 [P33121-3]
XP_016863378.1, XM_017007889.1 [P33121-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.406678

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000281455; ENSP00000281455; ENSG00000151726 [P33121-1]
ENST00000504342; ENSP00000425006; ENSG00000151726 [P33121-1]
ENST00000513317; ENSP00000426150; ENSG00000151726 [P33121-3]
ENST00000515030; ENSP00000422607; ENSG00000151726 [P33121-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2180

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2180

UCSC genome browser

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UCSCi
uc003iwt.2 human [P33121-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10040 mRNA Translation: BAA00931.1
L09229 mRNA Translation: AAB00959.1
AK096117 mRNA Translation: BAC04704.1 Different initiation.
AK296826 mRNA Translation: BAH12438.1
AC079257 Genomic DNA No translation available.
AC084871 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX04662.1
CH471056 Genomic DNA Translation: EAX04663.1
CH471056 Genomic DNA Translation: EAX04665.1
BC026290 mRNA Translation: AAH26290.1
BC050073 mRNA Translation: AAH50073.1
CCDSiCCDS3839.1 [P33121-1]
CCDS68826.1 [P33121-3]
PIRiJX0202
RefSeqiNP_001273637.1, NM_001286708.1 [P33121-1]
NP_001273639.1, NM_001286710.1 [P33121-3]
NP_001273640.1, NM_001286711.1
NP_001273641.1, NM_001286712.1
NP_001986.2, NM_001995.3 [P33121-1]
XP_005262885.1, XM_005262828.1 [P33121-1]
XP_005262886.1, XM_005262829.1 [P33121-1]
XP_005262888.1, XM_005262831.1 [P33121-1]
XP_011530044.1, XM_011531742.1 [P33121-1]
XP_016863376.1, XM_017007887.1 [P33121-1]
XP_016863377.1, XM_017007888.1 [P33121-3]
XP_016863378.1, XM_017007889.1 [P33121-3]
UniGeneiHs.406678

3D structure databases

ProteinModelPortaliP33121
SMRiP33121
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108476, 14 interactors
IntActiP33121, 6 interactors
STRINGi9606.ENSP00000281455

Chemistry databases

DrugBankiDB00131 Adenosine monophosphate
DB00171 Adenosine triphosphate
SwissLipidsiSLP:000000199
SLP:000001468 [P33121-1]

PTM databases

iPTMnetiP33121
PhosphoSitePlusiP33121
SwissPalmiP33121

Polymorphism and mutation databases

BioMutaiACSL1
DMDMi417241

Proteomic databases

EPDiP33121
MaxQBiP33121
PaxDbiP33121
PeptideAtlasiP33121
PRIDEiP33121
ProteomicsDBi54898
54899 [P33121-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281455; ENSP00000281455; ENSG00000151726 [P33121-1]
ENST00000504342; ENSP00000425006; ENSG00000151726 [P33121-1]
ENST00000513317; ENSP00000426150; ENSG00000151726 [P33121-3]
ENST00000515030; ENSP00000422607; ENSG00000151726 [P33121-1]
GeneIDi2180
KEGGihsa:2180
UCSCiuc003iwt.2 human [P33121-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2180
DisGeNETi2180
EuPathDBiHostDB:ENSG00000151726.13

GeneCards: human genes, protein and diseases

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GeneCardsi
ACSL1
HGNCiHGNC:3569 ACSL1
HPAiHPA011316
HPA011964
MIMi152425 gene
neXtProtiNX_P33121
OpenTargetsiENSG00000151726
PharmGKBiPA27966

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1256 Eukaryota
COG1022 LUCA
GeneTreeiENSGT00940000154508
HOGENOMiHOG000159459
HOVERGENiHBG050452
InParanoidiP33121
KOiK01897
OMAiTCYEWGV
OrthoDBiEOG091G03G9
PhylomeDBiP33121
TreeFamiTF313877

Enzyme and pathway databases

BioCyciMetaCyc:HS07766-MONOMER
BRENDAi6.2.1.3 2681
ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-2046105 Linoleic acid (LA) metabolism
R-HSA-2046106 alpha-linolenic acid (ALA) metabolism
R-HSA-75876 Synthesis of very long-chain fatty acyl-CoAs
SIGNORiP33121

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ACSL1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ACSL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2180

Protein Ontology

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PROi
PR:P33121

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000151726 Expressed in 232 organ(s), highest expression level in parietal pleura
CleanExiHS_ACSL1
ExpressionAtlasiP33121 baseline and differential
GenevisibleiP33121 HS

Family and domain databases

InterProiView protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACSL1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P33121
Secondary accession number(s): B7Z452
, D3DP57, P41215, Q8N8V7, Q8TA99
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: December 5, 2018
This is version 178 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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