We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - P33074 (SDHB_PEPAS)
Protein
L-serine dehydratase, beta chain
Gene
sdhB
Organism
Peptoniphilus asaccharolyticus (Peptostreptococcus asaccharolyticus)
Status
Functioni
Catalytic activityi
- EC:4.3.1.17
Cofactori
[4Fe-4S] clusterNote: Binds 1 [4Fe-4S] cluster.
: gluconeogenesis Pathwayi
This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.
GO - Molecular functioni
- 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
- L-serine ammonia-lyase activity Source: UniProtKB-EC
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- gluconeogenesis Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Lyase |
Biological process | Gluconeogenesis |
Ligand | 4Fe-4S, Iron, Iron-sulfur, Metal-binding |
Enzyme and pathway databases
UniPathwayi | UPA00138 |
Names & Taxonomyi
Protein namesi | Recommended name: L-serine dehydratase, beta chain (EC:4.3.1.17)Short name: SDH Alternative name(s): L-serine deaminase Short name: L-SD |
Gene namesi | Name:sdhB |
Organismi | Peptoniphilus asaccharolyticus (Peptostreptococcus asaccharolyticus) |
Taxonomic identifieri | 1258 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Tissierellia › Tissierellales › Peptoniphilaceae › Peptoniphilus |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000171918 | 1 – 222 | L-serine dehydratase, beta chainAdd BLAST | 222 |
Interactioni
Subunit structurei
Heterooctamer of four alpha chains and four beta chains.
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 150 – 222 | ACTPROSITE-ProRule annotationAdd BLAST | 73 |
Sequence similaritiesi
Belongs to the iron-sulfur dependent L-serine dehydratase family.Curated
Family and domain databases
Gene3Di | 3.30.1330.90, 1 hit |
InterProi | View protein in InterPro IPR045865, ACT-like_dom_sf IPR002912, ACT_dom IPR029009, ASB_dom_sf IPR004643, Fe-S_L-Ser_bsu IPR005131, Ser_deHydtase_bsu |
Pfami | View protein in Pfam PF03315, SDH_beta, 1 hit |
PIRSFi | PIRSF036692, SDH_B, 1 hit |
SUPFAMi | SSF143548, SSF143548, 1 hit SSF55021, SSF55021, 1 hit |
TIGRFAMsi | TIGR00719, sda_beta, 1 hit |
PROSITEi | View protein in PROSITE PS51671, ACT, 1 hit |
i Sequence
Sequence statusi: Complete.
P33074-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTDYSAFEVM GPIMVGPSSS HTAGACKIAN VATSIVSNNY NQVEFQLHGS
60 70 80 90 100
FAHTFKGHGT DRALVGGILG FEPDDDRIKT SFELAKQAGL NYIFTTTNLG
110 120 130 140 150
DNYHPNSVKI VFSYPNGEEE YVIGSSIGGG AMKIVNINGI AIEFRGEYST
160 170 180 190 200
ILLEYPEQRG VISYVSSLLT GSEYNIESLN TKKNKLTNIV TLTVEIDKPL
210 220
TESLKSAILG VERFTTAKYV EV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U76260 Genomic DNA Translation: AAC45545.1 |
PIRi | S16376 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U76260 Genomic DNA Translation: AAC45545.1 |
PIRi | S16376 |
3D structure databases
SMRi | P33074 |
ModBasei | Search... |
Enzyme and pathway databases
UniPathwayi | UPA00138 |
Family and domain databases
Gene3Di | 3.30.1330.90, 1 hit |
InterProi | View protein in InterPro IPR045865, ACT-like_dom_sf IPR002912, ACT_dom IPR029009, ASB_dom_sf IPR004643, Fe-S_L-Ser_bsu IPR005131, Ser_deHydtase_bsu |
Pfami | View protein in Pfam PF03315, SDH_beta, 1 hit |
PIRSFi | PIRSF036692, SDH_B, 1 hit |
SUPFAMi | SSF143548, SSF143548, 1 hit SSF55021, SSF55021, 1 hit |
TIGRFAMsi | TIGR00719, sda_beta, 1 hit |
PROSITEi | View protein in PROSITE PS51671, ACT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SDHB_PEPAS | |
Accessioni | P33074Primary (citable) accession number: P33074 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | July 15, 1999 | |
Last modified: | February 23, 2022 | |
This is version 86 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families